Advances in Zr-mediated radical transformations and applications to total synthesis

• Hiroshige Ogawa and
• Hugh Nakamura

Beilstein J. Org. Chem. 2026, 22, 71–87, doi:10.3762/bjoc.22.3

• radical homo coupling of alkyl chlorides. Zr-catalyzed fluorine atom transfer. Zr-catalyzed C–O bond cleavage. aYield without the use of P(OEt)3. Application to the total synthesis of halichondrins. Zr-catalyzed C3 dimerization of 3-bromotryptophan derivatives. aCp2ZrCl2 was used. Mechanistic studies

Diastereoselective anodic hetero- and homo-coupling of menthol-, 8-methylmenthol- and 8-phenylmenthol-2-alkylmalonates

• Matthias C. Letzel,
• Hans J. Schäfer and
• Roland Fröhlich

Beilstein J. Org. Chem. 2017, 13, 33–42, doi:10.3762/bjoc.13.5

• . Keywords: anodic decarboxylation; diastereoselectivity; Kolbe electrolysis; radical hetero-coupling; radical homo-coupling; Introduction Intermolecular radical additions with high diastereoselectivity have been described for a number of cases [1][2][3][4][5][6][7][8][9]. There are much fewer reports on

• radical have been observed [35][36][37]. In contrast, hardly any side products of that kind were obtained using menthol related auxiliaries in anodic radical coupling reactions. Products analogous to these of the radical homo-coupling above can be obtained by auxiliary controlled oxidative enolate