Electrophotochemical metal-catalyzed synthesis of alkylnitriles from simple aliphatic carboxylic acids

• Yukang Wang,
• Yan Yao and
• Niankai Fu

Beilstein J. Org. Chem. 2024, 20, 1497–1503, doi:10.3762/bjoc.20.133

• metal catalysis as a viable and potentially general approach for reaction discovery and would find broad application in new synthetic contexts. Decarboxylative cyanation: background and our working hypothesis. Scope of electrophotochemical decarboxylative cyanation of aliphatic carboxylic acids. All

• catalytic cycles. Reaction discovery and optimization.a Supporting Information Supporting Information File 18: Experimental procedures, mechanistic studies, analytical data and copies of NMR spectra. Funding We thank the National Natural Science Foundation of China (No. 22071252) and the Chinese Academy

Selectivity in multiple multicomponent reactions: types and synthetic applications

• Ouldouz Ghashghaei,
• Francesca Seghetti and
• Rodolfo Lavilla

Beilstein J. Org. Chem. 2019, 15, 521–534, doi:10.3762/bjoc.15.46

• reactions; reaction discovery; selectivity; Introduction Organic synthesis has become fundamental in science and technology, affecting many aspects of our lives. Therefore, there is a big need for the optimized preparation of a variety of compounds [1][2][3]. In this context, multicomponent reactions (MCRs

Mechanochemical synthesis of thioureas, ureas and guanidines

• Vjekoslav Štrukil

Beilstein J. Org. Chem. 2017, 13, 1828–1849, doi:10.3762/bjoc.13.178

• , mechanochemistry has been demonstrated as an effective tool in reaction discovery, with emphasis on the reactivity differences in solution and in the solid state. These three classes of organic compounds share some structural features which are reflected in their physical and chemical properties, important for

• reactivity, but it also has the potential for reaction discovery and development. Applying the standard milling conditions, a series of sulfonylguanidines was synthesised in ≥90% yields from alkyl or aromatic carbodiimides and aromatic sulfonamides (Scheme 20b). Sterically hindered carbodiimides such as tert

A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines

• Tarn C. Johnson and
• Stephen P. Marsden

Beilstein J. Org. Chem. 2016, 12, 1–4, doi:10.3762/bjoc.12.1

• -amidoalkyl)pyridines that arises from a formally ‘umpoled’ coupling of an α-(amidoalkyl) anion equivalent with a pyridyl electrophile. Results and Discussion Reaction discovery Our research group has a longstanding interest in the synthesis of α,α-disubstituted amino acids [11][12][13][14][15], and in