A Diels–Alder probe for discovery of natural products containing furan moieties

• Alyssa S. Eggly,
• Namuunzul Otgontseren,
• Carson B. Roberts,
• Amir Y. Alwali,
• Haylie E. Hennigan and
• Elizabeth I. Parkinson

Beilstein J. Org. Chem. 2024, 20, 1001–1010, doi:10.3762/bjoc.20.88

• -based probes; Introduction To date, natural products and their derivatives have served as the foundation of many pharmaceuticals used today. These compounds have activity against various diseases such as cancer, bacterial infections, and fungal infections, as well as other indications [1]. Specifically

• products, methylenomycin furan (MMF) hormones, and MMF derivatives. Moreover, the molecular probe has been tested in crude supernatants of various Streptomyces strains and enables identification of MMFs. Keywords: Diels–Alder reaction; furans; methylenomycin furan hormones; natural products; reactivity