Bioinspired total syntheses of natural products: a personal adventure

• Zhengyi Qin,
• Yuting Yang,
• Nuran Yan,
• Xinyu Liang,
• Zhiyu Zhang,
• Yaxuan Duan,
• Huilin Li and
• Xuegong She

Beilstein J. Org. Chem. 2025, 21, 2048–2061, doi:10.3762/bjoc.21.160

• on how to use this important strategy in natural product synthesis. Keywords: bioinspired total synthesis; chabranol; gymnothelignans; monocerin; sarglamides; taberginggine; Introduction Natural products are chemical substances generated within living organisms in nature. They are products of

• divergent coupling approaches, and the stereocontrol with Evans oxazolidinone was always reliable to obtain an sole diastereomer (Scheme 6d). Bioinspired concise and scalable total synthesis sarglamides In 2023, Yue and co-workers investigated the ingredients of the Chinese folk medicine Sarcandra glabra

• [2.2.2] carbocycle fused to CD rings. For sarglamides D and E, another oxygen-bridged E ring shows up at different positions. Overall, sarglamides A–E exhibit unusual unprecedented skeletons as they contain both monoterpenoid and indolidinoid subunits. Such a hybrid structure is rarely found in natural