Synthesis of the 1,5-disubstituted tetrazole-methanesulfonylindole hybrid system via high-order multicomponent reaction

• Cesia M. Aguilar-Morales,
• América A. Frías-López,
• Nadia V. Emilio-Velázquez,
• Alejandro Islas-Jácome,
• Angelica Judith Granados-López,
• Jorge Gustavo Araujo-Huitrado,
• Yamilé López-Hernández,
• Hiram Hernández-López,
• Luis Chacón-García,
• Jesús Adrián López and
• Carlos J. Cortés-García

Beilstein J. Org. Chem. 2024, 20, 3077–3084, doi:10.3762/bjoc.20.256

• synthesis of a novel bis-heterocyclic hybrid, 1,5-disubstituted-tetrazole-indoles. The compounds were achieved through a high-order multicomponent reaction consisting of two sequential processes: an Ugi-azide reaction and a further Pd/Cu-catalyzed heteroannulation (Scheme 1d). Results and Discussion Our

Recent advances in the tandem annulation of 1,3-enynes to functionalized pyridine and pyrrole derivatives

• Yi Liu,
• Puying Luo,
• Yang Fu,
• Tianxin Hao,
• Xuan Liu,
• Qiuping Ding and
• Yiyuan Peng

Beilstein J. Org. Chem. 2021, 17, 2462–2476, doi:10.3762/bjoc.17.163

• (Scheme 10) [52]. The tandem reaction involved a regio- and chemoselective addition of the Blaise reaction intermediate to 1,3-enyne, and the following sequential processes: isomerization, cyclization, and aromatization. Both carbocyclic and acyclic 1,3-enyenes 28 were compatible to give the corresponding

A modular phosphate tether-mediated divergent strategy to complex polyols

• Paul R. Hanson,
• Susanthi Jayasinghe,
• Soma Maitra,
• Cornelius N. Ndi and
• Rambabu Chegondi

Beilstein J. Org. Chem. 2014, 10, 2332–2337, doi:10.3762/bjoc.10.242

• five polyol fragments. Each of the product polyols bears a central 1,3-anti-diol subunit with differential olefinic geometries at the periphery. Keywords: phosphate-tether; one-pot; sequential processes; organophosphorus; polyol; stereodivergent; Introduction 1,3-anti-Diol subunits are a central

• screening decks in early phase drug discovery. One aim of divergent synthetic strategies is to produce multiple scaffolds from a single set of starting materials [12]. In this regard, one-pot, sequential processes [13][14][15][16] are well suited to address this challenge by forming multiple bonds and

One-pot gold-catalyzed synthesis of 3-silylethynyl indoles from unprotected o-alkynylanilines

• Jonathan P. Brand,
• Clara Chevalley and
• Jérôme Waser

Beilstein J. Org. Chem. 2011, 7, 565–569, doi:10.3762/bjoc.7.65

• sequential processes using both Au(I) and Au(III) have not yet been reported. AuCl and TIPS-EBX (1) were added when full conversion of the NaAuCl4-catalyzed cyclization was observed. When 2 mol % of NaAuCl4 and 2 mol % AuCl were added, the second step was unsuccessful. However, with 2 mol % of NaAuCl4 and 4