Silver(I) triflate-catalyzed post-Ugi synthesis of pyrazolodiazepines

• Muhammad Hasan,
• Anatoly A. Peshkov,
• Syed Anis Ali Shah,
• Andrey Belyaev,
• Chang-Keun Lim,
• Shunyi Wang and
• Vsevolod A. Peshkov

Beilstein J. Org. Chem. 2025, 21, 915–925, doi:10.3762/bjoc.21.74

• studied silver(I)-catalyzed intramolecular heteroannulation reaction is depicted in Scheme 5. The process begins with the π-coordination of the silver catalyst to the triple bond in the Ugi-adduct 15a generating intermediate A. This is followed by a nucleophilic attack by the pyrazole nitrogen on the

• . The first step, the Ugi-4CR, introduces molecular diversity, while the second step, an efficient silver(I)-catalyzed heteroannulation, facilitates the formation of the pyrazolodiazepine core via alkyne activation towards the nucleophilic attack by the pyrazole nitrogen. This strategy expands the array

Efficient gold(I)/silver(I)-cocatalyzed cascade intermolecular N-Michael addition/intramolecular hydroalkylation of unactivated alkenes with α-ketones

• Ya-Ping Xiao,
• Xin-Yuan Liu and
• Chi-Ming Che

Beilstein J. Org. Chem. 2011, 7, 1100–1107, doi:10.3762/bjoc.7.126

• AgClO4 catalyzed intermolecular N-Michael addition and the subsequent gold(I)-catalyzed hydroalkylation is proposed. Keywords: cascade; cocatalyzed; gold(I)-catalyzed; intramolecular hydroalkylation; intermolecular N-Michael addition; pyrrolidine; silver(I)-catalyzed; Introduction Gold complexes are

Chiral gold(I) vs chiral silver complexes as catalysts for the enantioselective synthesis of the second generation GSK-hepatitis C virus inhibitor

• María Martín-Rodríguez,
• Carmen Nájera,
• José M. Sansano,
• Abel de Cózar and
• Fernando P. Cossío

Beilstein J. Org. Chem. 2011, 7, 988–996, doi:10.3762/bjoc.7.111

• (Sa,R,R)-9 has also been similarly studied. In this case, the matched combination was determined in previous works that investigated the scope of enantioselective silver(I)-catalyzed 1,3-DC of azomethine ylides and dipolarophiles [25][29]. The enantioselectivities were moderate, even when using AgSbF6

A review of new developments in the Friedel–Crafts alkylation – From green chemistry to asymmetric catalysis

• Magnus Rueping and
• Boris J. Nachtsheim

Beilstein J. Org. Chem. 2010, 6, No. 6, doi:10.3762/bjoc.6.6

• of indole. Pd-catalyzed synthesis of pyrroloindoles from L-tryptophane. Ru(IV)-catalyzed allylation of indole and pyrroles with unique regioselectivity. Silver(I)-catalyzed intramolecular FC-type allylation of arenes and heteroarenes. FC-type alkylations of arenes using propargyl alcohols. (A