Tandem hydrothiocyanation/cyclization of CF₃-iminopropargyl alcohols with NaSCN in the presence of AcOH

• Ruslan S. Shulgin,
• Ol’ga G. Volostnykh,
• Anton V. Stepanov,
• Igor’ A. Ushakov,
• Alexander V. Vashchenko and
• Olesya A. Shemyakina

Beilstein J. Org. Chem. 2025, 21, 2694–2702, doi:10.3762/bjoc.21.207

• acid at the triple bond – vinyl thiocyanates. This protocol features simple operating, readily prepared starting materials and occurs under relatively mild conditions. Keywords: CF3-alkynyl imines; hydrothiocyanation; isothiazolium thiocyanates; propargyl alcohols; sodium thiocyanate; Introduction

• and X-ray diffraction. Synthesis of isothiazolium thiocyanates 2 and 4-thiocyanato-2,5-dihydrofuran-2-amines 3. Typical procedure. A solution of iminopropargyl alcohol 1 (0.5 mmol, 1 equiv) in 3 mL of acetonitrile was quickly added to a mixture of sodium thiocyanate (1 mmol, 2 equiv) and 1 mL of

Harnessing the versatility of hydrazones through electrosynthetic oxidative transformations

• Aurélie Claraz

Beilstein J. Org. Chem. 2024, 20, 1988–2004, doi:10.3762/bjoc.20.175

• direct C(sp2)–H functionalization of aldehyde-derived N,N-dialkylhydrazones has been also explored for constructing various azacycles. In 2021, the group of Ruan and Feng studied the electrochemical C(sp2)–H thiocyanation of aldehyde-derived N,N-dialkylhydrazones 95 with sodium thiocyanate (96) to

From steroids to aqueous supramolecular chemistry: an autobiographical career review

• Bruce C. Gibb

Beilstein J. Org. Chem. 2016, 12, 684–701, doi:10.3762/bjoc.12.69

• will decrease the solubility of a protein causing it to precipitate from solution. In contrast, salts such as sodium thiocyanate cause proteins to become more soluble, and in doing so break apart their tertiary structure. For a long time it has been appreciated that it is the anion that plays the more