Hot shape transformation: the role of PSar dehydration in stomatocyte morphogenesis

• Remi Peters,
• Levy A. Charleston,
• Karinan van Eck,
• Teun van Berlo and
• Daniela A. Wilson

Beilstein J. Org. Chem. 2025, 21, 47–54, doi:10.3762/bjoc.21.5

• glutamate); polysarcosine; shape transformation; stomatocyte; supramolecular chemistry; Introduction Polymeric vesicles represent a promising candidate for usage in drug delivery systems due to their facile assembly and ability to provide a stable soft interface. Among these materials, polyethylene glycol

• -polystyrene block copolymers (PEG-PS) stand out for their versatility and adaptability. These copolymers exhibit a remarkable propensity for self-assembly, allowing the formation of vesicles capable of undergoing diverse shape transformations. Notably, they can adopt the distinctive stomatocyte morphology

• demonstrated their ability to form round vesicles and some tubular shapes, the pursuit of asymmetric structures, such as the stomatocyte, presents a novel challenge and opportunity in the field [16][17]. The stomatocyte shape would be an excellent addition because of its demonstrated suitability for nanomotor

Interactions between cyclodextrins and cellular components: Towards greener medical applications?

• Loïc Leclercq

Beilstein J. Org. Chem. 2016, 12, 2644–2662, doi:10.3762/bjoc.12.261

• stomatocyte or echinocyte) depending on the cavity size of the CDs. For instance, α- and γ-CD induce progressive shape changes from discocytes into stomatocytes and from stomatocytes into spherocytes [58]. In contrast, β-CD leads only to swelling of erythrocytes. Similar effects are found for chemically