Search results

Search for "trichloromethyl group" in Full Text gives 3 result(s) in Beilstein Journal of Organic Chemistry.

Multicomponent syntheses of pyrazoles via (3 + 2)-cyclocondensation and (3 + 2)-cycloaddition key steps

  • Ignaz Betcke,
  • Alissa C. Götzinger,
  • Maryna M. Kornet and
  • Thomas J. J. Müller

Beilstein J. Org. Chem. 2024, 20, 2024–2077, doi:10.3762/bjoc.20.178

Graphical Abstract
  • -phenyl-2,4-hexanedione was generated in situ through acid hydrolysis of 1,1,1-trichloro-4-methoxy-6-phenyl-3-hexen-2-ones 71. Subsequent cyclization with hydrazine hydrochloride followed by hydrolysis of the trichloromethyl group led to 73. This intermediate was then reacted with 2,2,2-trifluoroethanol
PDF
Album
Review
Published 16 Aug 2024

Cyclization of 1-aryl-4,4,4-trichlorobut-2-en-1-ones into 3-trichloromethylindan-1-ones in triflic acid

  • Vladislav A. Sokolov,
  • Andrei A. Golushko,
  • Irina A. Boyarskaya and
  • Aleksander V. Vasilyev

Beilstein J. Org. Chem. 2023, 19, 1460–1470, doi:10.3762/bjoc.19.105

Graphical Abstract
  • ; indanones; trichloromethyl group; triflic acid; Introduction Superelectrophilic activation of organic compounds under the action of strong Brønsted and Lewis acids is an effective method for the synthesis of various carbocycles and heterocycles, and polyfunctional compounds (see books [1][2] and reviews [3
  • form of the starting compound [Cl3CCH=CHC(=OH+)Me]. The presence of two strong electron-withdrawing substituents, the trichloromethyl group (CCl3) and a protonated carbonyl (C(OH+)Me), at the carbon–carbon double bond makes this O-protonated species electrophilic enough to react with arenes (Scheme 1a
PDF
Album
Supp Info
Full Research Paper
Published 27 Sep 2023

Unexpected rearrangements and a novel synthesis of 1,1-dichloro-1-alkenones from 1,1,1-trifluoroalkanones with aluminium trichloride

  • Beatrice Lansbergen,
  • Catherine S. Meister and
  • Michael C. McLeod

Beilstein J. Org. Chem. 2021, 17, 404–409, doi:10.3762/bjoc.17.36

Graphical Abstract
  • trifluoromethyl to a trichloromethyl group with AlCl3 has been previously reported [30][31][32], investigations into the analogous transformation of aliphatic CF3 groups has been limited to adamantly-trifluoromethyl moieties [33][34]. An NMR analysis of the crude product mixture obtained using our original
PDF
Album
Supp Info
Letter
Published 10 Feb 2021
Other Beilstein-Institut Open Science Activities