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Search for "trifluoroalkanes" in Full Text gives 3 result(s) in Beilstein Journal of Organic Chemistry.
Origami with small molecules: exploiting the C–F bond as a conformational tool
Beilstein J. Org. Chem. 2025, 21, 680–716, doi:10.3762/bjoc.21.54
- ][40][41][42]. For example, the diastereoisomeric 1,2,3-trifluoroalkanes 21–24 (Figure 4) adopt distinct conformations, governed in each case by the avoidance of parallel 1,3-C–F bonds and the maximisation of σC–H → σ*C–F hyperconjugation [43]. Notably, the overall shape of diastereoisomer 22 closely
Unexpected rearrangements and a novel synthesis of 1,1-dichloro-1-alkenones from 1,1,1-trifluoroalkanones with aluminium trichloride
Beilstein J. Org. Chem. 2021, 17, 404–409, doi:10.3762/bjoc.17.36
- trichloride; dichloroalkenes; Friedel–Crafts alkylation; rearrangement; trifluoroalkanes; Introduction 1,1-Dichloro-1-alkenes are valuable synthetic intermediates and have been employed in Pd-mediated cross couplings of one or both chlorine atoms [1][2][3][4][5][6][7], carbonylation reactions [8], and C–H
Homologated amino acids with three vicinal fluorines positioned along the backbone: development of a stereoselective synthesis
Beilstein J. Org. Chem. 2017, 13, 2316–2325, doi:10.3762/bjoc.13.228
- trifluoroalkane 40b (Scheme 4) [17]. Trifluoroalkanes 40a and 40b (Scheme 4) were advanced intermediates along the route towards the target trifluorinated amino acids (6). To complete the synthesis, the final requirements were to oxidise the aryl moiety into a carboxylic acid, and to deprotect the amino group
- metaperiodate and ruthenium chloride (Table 2) [39][40], with the desired carboxylic acid 44 being obtained in 31% yield. Having established the conditions necessary for the conversion of the nitroaryl group in model system 41 (Table 2), the procedure could now be applied to the trifluoroalkanes 40a,b (Scheme 4
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