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Search for "zoledronic acid" in Full Text gives 1 result(s) in Beilstein Journal of Organic Chemistry.

Synthesis of imidazol- 1-yl-acetic acid hydrochloride: A key intermediate for zoledronic acid

  • Santosh Kumar Singh,
  • Narendra Manne,
  • Purna Chandra Ray and
  • Manojit Pal

Beilstein J. Org. Chem. 2008, 4, No. 42, doi:10.3762/bjoc.4.42

Graphical Abstract
  • then utilized to prepare zoledronic acid. Keywords: ester; N-alkylation; imidazol-1-yl-acetic acid hydrochloride; zoledronic acid; Introduction Zoledronic acid (Z, Figure 1) [1][2][3][4][5][6][7] is a third-generation bisphosphonate (or diphosphonate) derivative characterized by a side chain that
  • . Zoledronic acid is also used along with the cancer chemotherapy to treat bone damage caused by multiple myeloma (a type of cancer of plasma cells that are part of the immune system cells in bone marrow and produce antibodies) or by cancer that began in another part of the body but has spread to the bones
  • . While the use of zoledronic acid can neither suppress nor stop cancer spreading, it can be used to treat bone disease in patients who are suffering from cancer. It works by slowing bone breakdown and decreasing the amount of calcium released from the bones into the blood. It is commercially available in
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Published 17 Nov 2008
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