Beilstein J. Org. Chem.2008,4, No. 42, doi:10.3762/bjoc.4.42
then utilized to prepare zoledronicacid.
Keywords: ester; N-alkylation; imidazol-1-yl-acetic acid hydrochloride; zoledronicacid; Introduction
Zoledronicacid (Z, Figure 1) [1][2][3][4][5][6][7] is a third-generation bisphosphonate (or diphosphonate) derivative characterized by a side chain that
. Zoledronicacid is also used along with the cancer chemotherapy to treat bone damage caused by multiple myeloma (a type of cancer of plasma cells that are part of the immune system cells in bone marrow and produce antibodies) or by cancer that began in another part of the body but has spread to the bones
. While the use of zoledronicacid can neither suppress nor stop cancer spreading, it can be used to treat bone disease in patients who are suffering from cancer. It works by slowing bone breakdown and decreasing the amount of calcium released from the bones into the blood. It is commercially available in