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Design and synthesis of bioactive molecules

Editors:
Prof. Fengzhi Zhang, Hangzhou Medical College
Prof. David R. Spring, University of Cambridge

The design and synthesis of bioactive molecules is of great importance in advancing drug development, understanding biological processes, and driving technological innovation. This thematic issue aims to cover a diverse range of topics related to the rational design, chemical synthesis, and biological evaluation of molecules with specific bioactivities:

Design and synthesis of bioactive molecules that can interact with specific biological targets
Bifunctional and multifunctional bioactive molecules such as PROTACs
Novel green synthetic methodologies for the fast and efficient preparation of bioactive molecules
Natural-product-inspired synthesis and evaluation
Recent advances and trends, such as artificial intelligence and machine learning in bioactive molecule design and synthesis

Submission deadline: October 15, 2025

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Other Beilstein-Institut Open Science Activities

aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)