Design and synthesis of bioactive molecules
Editors:
Prof. Fengzhi Zhang, Hangzhou Medical College
Prof. David R. Spring, University of Cambridge
Prof. Fengzhi Zhang, Hangzhou Medical College
Prof. David R. Spring, University of Cambridge
The design and synthesis of bioactive molecules is of great importance in advancing drug development, understanding biological processes, and driving technological innovation. This thematic issue aims to cover a diverse range of topics related to the rational design, chemical synthesis, and biological evaluation of molecules with specific bioactivities:
- Design and synthesis of bioactive molecules that can interact with specific biological targets
- Bifunctional and multifunctional bioactive molecules such as PROTACs
- Novel green synthetic methodologies for the fast and efficient preparation of bioactive molecules
- Natural-product-inspired synthesis and evaluation
- Recent advances and trends, such as artificial intelligence and machine learning in bioactive molecule design and synthesis
Submission deadline: January 15, 2026
Synthesis, biological and electrochemical evaluation of glycidyl esters of phosphorus acids as potential anticancer drugs
- Almaz A. Zagidullin,
- Emil R. Bulatov,
- Mikhail N. Khrizanforov,
- Damir R. Davletshin,
- Elvina M. Gilyazova,
- Ivan A. Strelkov and
- Vasily A. Miluykov
Beilstein J. Org. Chem. 2025, 21, 1909–1916, doi:10.3762/bjoc.21.148
Rhodium-catalysed connective synthesis of diverse reactive probes bearing S(VI) electrophilic warheads
- Scott Rice,
- Julian Chesti,
- William R. T. Mosedale,
- Megan H. Wright,
- Stephen P. Marsden,
- Terry K. Smith and
- Adam Nelson
Beilstein J. Org. Chem. 2025, 21, 1924–1931, doi:10.3762/bjoc.21.150
Efficient solid-phase synthesis and structural characterization of segetalins A–H, J and K
- Liangyu Liu,
- Wanqiu Lu,
- Quanping Guo and
- Zhaoqing Xu
Beilstein J. Org. Chem. 2025, 21, 2612–2617, doi:10.3762/bjoc.21.202
Other Beilstein-Institut Open Science Activities
