Beilstein Arch. 2020, 202081. https://doi.org/10.3762/bxiv.2020.81.v1
Published 14 Jul 2020
In this study, we investigated host–guest interactions between Oroxin A (OA) and cucurbit[8]uril (Q[8]) using 1H NMR, MS, UV-Vis and IR spectroscopy. The results showed that OA and Q[8] formed an inclusion compound (OA@Q[8]) with a molar ratio of 1:1 and a binding constant of 1.299 × 107 L·mol−1. In addition, the effect of Q[8] on the properties of OA was investigated through comparative experiments. The solubility of OA in water increased 22.47-fold when the concentration of Q[8] was 1 × 10−4 mol·L−1. Q[8] hardly affected the antioxidant capacity of OA, while the cumulative release of OA in gastric juice increased 2.3-fold after forming the inclusion compound with Q[8].
Keywords: Oroxin A; Cucurbit[8]uril; Host-guest interaction; Inclusion complex; Properties
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Zeng, Z.; Xie, J.; Luo, G.; Tao, Z.; Zhang, Q. Beilstein Arch. 2020, 202081. doi:10.3762/bxiv.2020.81.v1
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