Beilstein Arch. 2024, 202444. https://doi.org/10.3762/bxiv.2024.44.v1
Published 25 Jun 2024
A transition metal-free decarbonyl-oxidation protocol for conversion of 3-Arylbenzofuran-2(3H)-ones to 2-hydroxybenzophenones under mild conditions has been developed. NMR studies confirmed the role of in-situ generated hydroperoxide in the conversion. The protocol was applied to a diverse range of substrates to access the target products in good to excellent yields. A structure-activity study for the 5-substituted-2-hydroxybenzophenones towards UV-protection abilities have been verified by mathematical calculations.
Keywords: 2-Hydroxy benzophenone; decarbonyl-oxidation; transition metal-free; hydroperoxide; UV-protection
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DHOTARE, B. B.; Kanojia, S. V.; Sakhiya, C. K.; Wadawale, A.; Goswami, D. Beilstein Arch. 2024, 202444. doi:10.3762/bxiv.2024.44.v1
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