Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

Scholarly Works

• Figueira, M. I.; Carvalho, T. M. A.; Macário-Monteiro, J.; Cardoso, H. J.; Correia, S.; Vaz, C. V.; Duarte, A. P.; Socorro, S. The Pros and Cons of Estrogens in Prostate Cancer: An Update with a Focus on Phytoestrogens. Biomedicines 2024, 12, 1636. doi:10.3390/biomedicines12081636
• İlkar Erdağı, S. Steroidal konjugatların in vitro biyolojik aktivite ve in silico moleküler bağlanma çalışmaları. Eurasian Journal of Biological and Chemical Sciences 2024, 7, 10–19. doi:10.46239/ejbcs.1418794
• M. Dogheim, G.; A. Abd El-Maksod, E.; A. El-Maradny, Y.; Mamdouh M. Elshindidy, M.; M. Mahdy, D. Emerging Techniques for Herbosomes. Dosage Forms - Emerging Trends and Prospective Drug-Delivery Systems [Working Title]; IntechOpen, 2024. doi:10.5772/intechopen.1005232
• Bhatia, R.; Singh, A.; Singh, S.; Navneesh; Rawal, R. K. Emerging trends in nano-carrier based gene delivery systems for targeted cancer therapy. Journal of Drug Delivery Science and Technology 2024, 95, 105546. doi:10.1016/j.jddst.2024.105546
• Singh, A.; Srivastav, S.; Singh, M. P.; Singh, R.; Kumar, P.; Kush, P. Recent advances in phytosomes for the safe management of cancer. Phytomedicine Plus 2024, 4, 100540. doi:10.1016/j.phyplu.2024.100540
• Fang, F.; Zhang, X.; Fang, Y. Diosgenin inhibits proliferation and migration of ovarian cancer cells and induce apoptosis via upregulation of PTEN. Chemical biology & drug design 2024, 103, e14459. doi:10.1111/cbdd.14459
• Ercelen, S.; Bulkurcuoglu, B.; Oksuz, M.; Nalbantsoy, A.; Sarikahya, N. B. Development and Characterization of Plant-derived Aristatoside C and Davisianoside B Saponin-loaded Phytosomes with Suppressed Hemolytic Activity. ChemistryOpen 2024, 13, e202300254. doi:10.1002/open.202300254
• Ghorbani-Bidkorpeh, F.; Tabarzad, M.; Hosseinabadi, T.; Masoumi, N.; Akhtari, N. Functionalized phytosomes for cancer therapy. Functionalized Nanomaterials for Cancer Research; Elsevier, 2024; pp 307–327. doi:10.1016/b978-0-443-15518-5.00012-4
• Chen, X.; Yu, S.; Wang, P.; Zhao, X.; Sang, G. Development and Evaluation of a Novel Hyaluronic Acid and Chitosan-modified Phytosome for Co-delivery of Oxymatrine and Glycyrrhizin for Combination Therapy. Recent patents on anti-cancer drug discovery 2024, 19, 154–164. doi:10.2174/1574892818666230215112942
• Dutt, Y.; Pandey, R. P.; Dutt, M.; Gupta, A.; Vibhuti, A.; Raj, V. S.; Chang, C.-M.; Priyadarshini, A. Liposomes and phytosomes: Nanocarrier systems and their applications for the delivery of phytoconstituents. Coordination Chemistry Reviews 2023, 491, 215251. doi:10.1016/j.ccr.2023.215251
• da Silva, M. F.; de Lima, L. V. A.; de Oliveira, L. M.; Semprebon, S. C.; Silva, N. d. O.; de Aguiar, A. P.; Mantovani, M. S. Regulation of cytokinesis and necroptosis pathways by diosgenin inhibits the proliferation of NCI-H460 lung cancer cells. Life sciences 2023, 330, 122033. doi:10.1016/j.lfs.2023.122033
• Ansari, A.; Hussain, A.; Wadekar, R.; Altamimi, M. A.; Malik, A.; Mujtaba, M. A.; Ansari, M. Y.; Siddique, M. U. M.; Goyal, S. N. Nanovesicles based drug targeting to control tumor growth and metastasis. Advances in Cancer Biology - Metastasis 2023, 7, 100083. doi:10.1016/j.adcanc.2022.100083
• Masoomzadeh, S.; Gholikhani, T.; Barfar, A.; Asnaashari, S.; Javadzadeh, Y. Different Types of Naturally based Drug Delivery Carriers: An Explanation and Expression of Some Anti-cancer Effects. Current pharmaceutical design 2023, 29, 1173–1179. doi:10.2174/1381612829666230510090433
• Ren, Q.-L.; Wang, Q.; Zhang, X.-Q.; Wang, M.; Hu, H.; Tang, J.-J.; Yang, X.-T.; Ran, Y.-H.; Liu, H.-H.; Song, Z.-X.; Liu, J.-G.; Li, X.-L. Anticancer Activity of Diosgenin and Its Molecular Mechanism. Chinese journal of integrative medicine 2023, 29, 738–749. doi:10.1007/s11655-023-3693-1
• Zhang, S.-Z.; Liang, P.-P.; Feng, Y.-N.; Yin, G.-L.; Sun, F.-C.; Ma, C.-Q.; Zhang, F.-X. Therapeutic potential and research progress of diosgenin for lipid metabolism diseases. Drug development research 2022, 83, 1725–1738. doi:10.1002/ddr.21991
• Fan, R.; He, W.; Fan, Y.; Xu, W.; Xu, W.; Yan, G.; Xu, S. Recent advances in chemical synthesis, biocatalysis, and biological evaluation of diosgenin derivatives - A review. Steroids 2022, 180, 108991. doi:10.1016/j.steroids.2022.108991
• Das, S. K.; Acharya, R.; Sen, K. Phytosomes: a cutting-edge technique for herbal drug delivery and its clinical applications. The Basic Handbook of Indian Ethnobotany and Traditional Medicine; International Academic Publishing House (IAPH), 2022; pp 96–136. doi:10.52756/bhietm.2022.e01.008
• An, R.; Zhang, W.; Huang, X. Developments in the Antitumor Activity, Mechanisms of Action, Structural Modifications, and Structure-Activity Relationships of Steroidal Saponins. Mini reviews in medicinal chemistry 2022, 22, 2188–2212. doi:10.2174/1389557522666220217113719
• Limongi, T.; Susa, F.; Marini, M.; Allione, M.; Torre, B.; Pisano, R.; di Fabrizio, E. Lipid-Based Nanovesicular Drug Delivery Systems. Nanomaterials (Basel, Switzerland) 2021, 11, 3391. doi:10.3390/nano11123391
• Hani, U.; M., Y. B.; Wahab, S.; Siddiqua, A.; Osmani, R. A. M.; Rahamathulla, M. A Comprehensive Review of Current Perspectives on Novel Drug Delivery Systems and Approaches for Lung Cancer Management. Journal of Pharmaceutical Innovation 2021, 17, 1530–1553. doi:10.1007/s12247-021-09582-1

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