Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

Jonathan-Gabriel Nimz, Pichayut Rerkshanandana, Chiraphat Kloypan, Ulrich Kalus, Saranya Chaiwaree, Axel Pruß, Radostina Georgieva, Yu Xiong and Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040. https://doi.org/10.3762/bjnano.14.85

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Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

Jonathan-Gabriel Nimz, Pichayut Rerkshanandana, Chiraphat Kloypan, Ulrich Kalus, Saranya Chaiwaree, Axel Pruß, Radostina Georgieva, Yu Xiong and Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040. https://doi.org/10.3762/bjnano.14.85

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Nimz, J.-G.; Rerkshanandana, P.; Kloypan, C.; Kalus, U.; Chaiwaree, S.; Pruß, A.; Georgieva, R.; Xiong, Y.; Bäumler, H. Beilstein J. Nanotechnol. 2023, 14, 1028–1040. doi:10.3762/bjnano.14.85

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TY  - JOUR
A1  - Nimz, Jonathan-Gabriel
A1  - Rerkshanandana, Pichayut
A1  - Kloypan, Chiraphat
A1  - Kalus, Ulrich
A1  - Chaiwaree, Saranya
A1  - Pruß, Axel
A1  - Georgieva, Radostina
A1  - Xiong, Yu
A1  - Bäumler, Hans
T1  - Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one
JF  - Beilstein Journal of Nanotechnology
PY  - 2023///
VL  - 14
SP  - 1028
EP  - 1040
SN  - 2190-4286
DO  - 10.3762/bjnano.14.85
PB  - Beilstein-Institut
JA  - Beilstein J. Nanotechnol.
UR  - https://doi.org/10.3762/bjnano.14.85
KW  - CD163
KW  - HBOC
KW  - hemoglobin-based oxygen carriers
KW  - monocytes
KW  - phagocytosis
N2  - Hemoglobin-based oxygen carriers (HBOCs) as blood substitutes are one of the great hopes of modern transfusion and emergency medicine. After the major safety-relevant challenges of the last decades seem to be largely overcome, current developments have in common that they are affected by degradation and excretion at an early stage in test organisms. Several possible mechanisms that may be responsible for this are discussed in the literature. One of them is CD163, the receptor of the complex of haptoglobin (Hp) and hemoglobin (Hb). The receptor has been shown in various studies to have a direct affinity for Hb in the absence of Hp. Thus, it seems reasonable that CD163 could possibly also bind Hb within HBOCs and cause phagocytosis of the particles. In this work we investigated the role of CD163 in the uptake of our hemoglobin sub-micron particles (HbMPs) in monocytes and additionally screened for alternative ways of particle recognition by monocytes. In our experiments, blockade of CD163 by specific monoclonal antibodies proved to partly inhibit HbMP uptake by monocytes. It appears, however, that several other phagocytosis pathways for HbMPs might exist, independent of CD163 and also Hb.
ER  -

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