Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease

Niédja Fittipaldi Vasconcelos, Almerinda Agrelli, Rayane Cristine Santos da Silva, Carina Lucena Mendes-Marques, Isabel Renata de Souza Arruda, Priscilla Stela Santana de Oliveira, Mércia Liane de Oliveira and Giovanna Machado
Beilstein J. Nanotechnol. 2025, 16, 1711–1733. https://doi.org/10.3762/bjnano.16.120

Supporting Information

Supporting Information File 1 contains a detailed table of the mass composition of the pre-formulations (O/W(L-1%), O/W(L-2%), O/W(L-3%), O/W(L-4%), and O/W(L-5%)) and ophthalmic nanoformulations (OphtNE-3.70% and OphtNE-3.66%(K1%)), along with visual and experimental data supporting the article. Included are macroscopic images of the pre-formulations, particle size distribution profiles, and linear regression curves used to determine antioxidant activity (IC50). Also, this file contains the two-way and one-way ANOVA tables for the statistically significant treatment:concentration and concentration:time interactions identified in the three-way ANOVA, based on MTT assay absorbance data from L929 cells. Supporting Information File 2 contains the data processing workflow and statistical analyses, including the Shapiro–Wilk test for assessing normality, outlier removal, and Levene’s test for evaluating homoscedasticity.

Supporting Information File 1: Supplementary tables and figures.
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Supporting Information File 2: Complementary statistical data.
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Cite the Following Article

Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease
Niédja Fittipaldi Vasconcelos, Almerinda Agrelli, Rayane Cristine Santos da Silva, Carina Lucena Mendes-Marques, Isabel Renata de Souza Arruda, Priscilla Stela Santana de Oliveira, Mércia Liane de Oliveira and Giovanna Machado
Beilstein J. Nanotechnol. 2025, 16, 1711–1733. https://doi.org/10.3762/bjnano.16.120

How to Cite

Vasconcelos, N. F.; Agrelli, A.; da Silva, R. C. S.; Mendes-Marques, C. L.; Arruda, I. R. d. S.; de Oliveira, P. S. S.; de Oliveira, M. L.; Machado, G. Beilstein J. Nanotechnol. 2025, 16, 1711–1733. doi:10.3762/bjnano.16.120

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