Silica nanoparticles are less toxic to human lung cells when deposited at the air–liquid interface compared to conventional submerged exposure

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• Madl, A. K.; Donnell, M. T.; Covell, L. T. Synthetic vitreous fibers (SVFs): adverse outcome pathways (AOPs) and considerations for next generation new approach methods (NAMs). Critical reviews in toxicology 2024, 1–51. doi:10.1080/10408444.2024.2390020
• Buckley, A.; Guo, C.; Laycock, A.; Cui, X.; Belinga-Desaunay-Nault, M.-F.; Valsami-Jones, E.; Leonard, M.; Smith, R. Aerosol exposure at air-liquid-interface (AE-ALI) in vitro toxicity system characterisation: Particle deposition and the importance of air control responses. Toxicology in vitro : an international journal published in association with BIBRA 2024, 100, 105889. doi:10.1016/j.tiv.2024.105889
• Waye, A. A.; Ticiani, E.; Veiga-Lopez, A. Chemical mixture that targets the epidermal growth factor pathway impairs human trophoblast cell functions. Toxicology and applied pharmacology 2024, 483, 116804. doi:10.1016/j.taap.2024.116804
• Bredeck, G.; Dobner, J.; Stahlmecke, B.; Fomba, K. W.; Herrmann, H.; Rossi, A.; Schins, R. P. F. Saharan dust induces NLRP3-dependent inflammatory cytokines in an alveolar air-liquid interface co-culture model. Particle and fibre toxicology 2023, 20, 39. doi:10.1186/s12989-023-00550-w
• Lin, Y.-J.; Yang, C.-C.; Lee, I.-T.; Wu, W.-B.; Lin, C.-C.; Hsiao, L.-D.; Yang, C.-M. Reactive Oxygen Species-Dependent Activation of EGFR/Akt/p38 Mitogen-Activated Protein Kinase and JNK1/2/FoxO1 and AP-1 Pathways in Human Pulmonary Alveolar Epithelial Cells Leads to Up-Regulation of COX-2/PGE2 Induced by Silica Nanoparticles. Biomedicines 2023, 11, 2628. doi:10.3390/biomedicines11102628
• Dilger, M.; Armant, O.; Ramme, L.; Mülhopt, S.; Sapcariu, S. C.; Schlager, C.; Dilger, E.; Reda, A.; Orasche, J.; Schnelle-Kreis, J.; Conlon, T. M.; Yildirim, A. Ö.; Hartwig, A.; Zimmermann, R.; Hiller, K.; Diabaté, S.; Paur, H.-R.; Weiss, C. Systems toxicology of complex wood combustion aerosol reveals gaseous carbonyl compounds as critical constituents. Environment international 2023, 179, 108169. doi:10.1016/j.envint.2023.108169
• Tilly, T. B.; Ward, R. X.; Morea, A. F.; Nelson, M. T.; Robinson, S. E.; Eiguren-Fernandez, A.; Lewis, G. S.; Lednicky, J. A.; Sabo-Attwood, T.; Hussain, S. M.; Wu, C.-Y. Toxicity assessment of CeO₂ and CuO nanoparticles at the air-liquid interface using bioinspired condensational particle growth. Hygiene and environmental health advances 2023, 7, 100074. doi:10.1016/j.heha.2023.100074
• Bessa, M. J.; Brandão, F.; Rosário, F.; Moreira, L.; Reis, A. T.; Valdiglesias, V.; Laffon, B.; Fraga, S.; Teixeira, J. P. Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models. Journal of toxicology and environmental health. Part B, Critical reviews 2023, 26, 67–96. doi:10.1080/10937404.2023.2166638
• Ruijter, N.; Soeteman-Hernández, L. G.; Carrière, M.; Boyles, M.; McLean, P.; Catalán, J.; Katsumiti, A.; Cabellos, J.; Delpivo, C.; Sánchez Jiménez, A.; Candalija, A.; Rodríguez-Llopis, I.; Vázquez-Campos, S.; Cassee, F. R.; Braakhuis, H. The State of the Art and Challenges of In Vitro Methods for Human Hazard Assessment of Nanomaterials in the Context of Safe-by-Design. Nanomaterials (Basel, Switzerland) 2023, 13, 472. doi:10.3390/nano13030472
• Di Ianni, E.; Jacobsen, N. R.; Vogel, U.; Møller, P. Predicting nanomaterials pulmonary toxicity in animals by cell culture models: Achievements and perspectives. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2022, 14, e1794. doi:10.1002/wnan.1794
• Meldrum, K.; Moura, J. A.; Doak, S. H.; Clift, M. J. D. Dynamic Fluid Flow Exacerbates the (Pro-)Inflammatory Effects of Aerosolised Engineered Nanomaterials In Vitro. Nanomaterials (Basel, Switzerland) 2022, 12, 3431. doi:10.3390/nano12193431
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• Friesen, A.; Fritsch-Decker, S.; Hufnagel, M.; Mülhopt, S.; Stapf, D.; Hartwig, A.; Weiss, C. Comparing α-Quartz-Induced Cytotoxicity and Interleukin-8 Release in Pulmonary Mono- and Co-Cultures Exposed under Submerged and Air-Liquid Interface Conditions. International journal of molecular sciences 2022, 23, 6412. doi:10.3390/ijms23126412
• Huang, Y.; Li, P.; Zhao, R.; Zhao, L.; Liu, J.; Peng, S.; Fu, X.; Wang, X.; Luo, R.; Wang, R.; Zhang, Z. Silica nanoparticles: Biomedical applications and toxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022, 151, 113053. doi:10.1016/j.biopha.2022.113053
• Forest, V. Experimental and Computational Nanotoxicology-Complementary Approaches for Nanomaterial Hazard Assessment. Nanomaterials (Basel, Switzerland) 2022, 12, 1346. doi:10.3390/nano12081346
• Mostafa, M. Y. A.; Khalaf, H. N. B.; Zhukovsky, M. V. Dynamic of Particulate Matter for Quotidian Aerosol Sources in Indoor Air. Atmosphere 2021, 12, 1682. doi:10.3390/atmos12121682
• Bessa, M. J.; Brandão, F.; Fokkens, P. H. B.; Leseman, D. L. A. C.; Boere, A. J. F.; Cassee, F. R.; Salmatonidis, A.; Viana, M.; Vulpoi, A.; Simon, S.; Monfort, E.; Teixeira, J. P.; Fraga, S. In Vitro Toxicity of Industrially Relevant Engineered Nanoparticles in Human Alveolar Epithelial Cells: Air–Liquid Interface versus Submerged Cultures. Nanomaterials (Basel, Switzerland) 2021, 11, 3225. doi:10.3390/nano11123225
• Jiang, J.; Ding, X.; Isaacson, K. P.; Tasoglou, A.; Huber, H.; Shah, A. D.; Jung, N.; Boor, B. E. Ethanol-Based Disinfectant Sprays Drive Rapid Changes in the Chemical Composition of Indoor Air in Residential Buildings. Journal of hazardous materials letters 2021, 2, 100042. doi:10.1016/j.hazl.2021.100042
• Ke, S.; Liu, Q.; Zhang, X.; Yao, Y.; Yang, X.; Sui, G. Cytotoxicity Analysis of Biomass Combustion Particles in Human Pulmonary Alveolar Epithelial Cells on an Air-Liquid Interface/Dynamic Culture Platform. Particle and fibre toxicology 2021, 18, 31. doi:10.1186/s12989-021-00426-x
• Nossa, R.; Costa, J.; Cacopardo, L.; Ahluwalia, A. Breathing in vitro: Designs and applications of engineered lung models. Journal of tissue engineering 2021, 12, 20417314211008696. doi:10.1177/20417314211008696

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