Unraveling the neurotoxicity of titanium dioxide nanoparticles: focusing on molecular mechanisms

Scholarly Works

• Thakur, N.; Yadav, A. N. Nanotechnology in Agriculture: A Review on Precision Farming and Sustainable Crop Production. BioNanoScience 2025, 15. doi:10.1007/s12668-025-01861-2
• Askari, S.; Eskandari, M. Neurotoxicity and Biosafety of Nanomaterials. Advances in Medical Diagnosis, Treatment, and Care; IGI Global, 2024; pp 1–26. doi:10.4018/979-8-3693-3065-4.ch001
• Madhu, A.; Singh, N.; Yadav, M. Challenges and Opportunities in Nanotechnology for Textile Finishing. Materials Horizons: From Nature to Nanomaterials; Springer Nature Singapore, 2024; pp 487–511. doi:10.1007/978-981-97-2696-7_17
• Teixeira, M. I.; Lopes, C. M.; Amaral, M. H.; Costa, P. C. Navigating Neurotoxicity and Safety Assessment of Nanocarriers for Brain Delivery: Strategies and Insights. Acta biomaterialia 2024, 189, 25–56. doi:10.1016/j.actbio.2024.09.027
• Mazahir, F.; Alam, M. I.; Yadav, A. K. Development of nanomedicines for the treatment of Alzheimer's disease: Raison d'être, strategies, challenges and regulatory aspects. Ageing research reviews 2024, 98, 102318. doi:10.1016/j.arr.2024.102318
• Yu, G.; Wu, L.; Su, Q.; Ji, X.; Zhou, J.; Wu, S.; Tang, Y.; Li, H. Neurotoxic effects of heavy metal pollutants in the environment: Focusing on epigenetic mechanisms. Environmental pollution (Barking, Essex : 1987) 2024, 345, 123563. doi:10.1016/j.envpol.2024.123563
• Boulain, M.; Morin, D.; Juvin, L. Multigenerational inheritance of breathing deficits following perinatal exposure to titanium dioxide nanoparticles in the offspring of mice. Discover nano 2024, 19, 16. doi:10.1186/s11671-023-03927-0
• Sobhani-Nasab, A.; Banafshe, H. R.; Atapour, A.; Khaksary Mahabady, M.; Akbari, M.; Daraei, A.; Mansoori, Y.; Moradi Hasan-Abad, A. The use of nanoparticles in the treatment of infectious diseases and cancer, dental applications and tissue regeneration: a review. Frontiers in medical technology 2024, 5, 1330007. doi:10.3389/fmedt.2023.1330007
• Chen, M.; Wu, T. Nanoparticles and neurodegeneration: Insights on multiple pathways of programmed cell death regulated by nanoparticles. The Science of the total environment 2023, 912, 168739. doi:10.1016/j.scitotenv.2023.168739
• Aschner, M.; Skalny, A. V.; Santamaria, A.; Buha Djordjevic, A.; Tizabi, Y.; Jiang, Y.; Lu, R.; Virgolini, M. B.; Tinkov, A. A. From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles. Frontiers in bioscience (Landmark edition) 2023, 28, 204. doi:10.31083/j.fbl2809204
• Garhwal Jha, S.; Tomar, D.; Jawla, S. Neurotoxic Effects of Nanoparticles and Their Pathogenesis. Pharmaceutical nanotechnology 2023, 12, 32–44. doi:10.2174/2211738511666230602143628
• Wang, X.; Li, F.; Teng, Y.; Ji, C.; Wu, H. Characterization of oxidative damage induced by nanoparticles via mechanism-driven machine learning approaches. The Science of the total environment 2023, 871, 162103. doi:10.1016/j.scitotenv.2023.162103
• Mistretta, M.; Farini, A.; Torrente, Y.; Villa, C. Multifaceted nanoparticles: emerging mechanisms and therapies in neurodegenerative diseases. Brain : a journal of neurology 2023, 146, 2227–2240. doi:10.1093/brain/awad014
• Bevacqua, E.; Occhiuzzi, M. A.; Grande, F.; Tucci, P. TiO2-NPs Toxicity and Safety: An Update of the Findings Published over the Last Six Years. Mini reviews in medicinal chemistry 2023, 23, 1050–1057. doi:10.2174/1389557522666220929152403
• Li, L.; Zhang, J.; Huang, X.; Du, J.; Tu, Z.; Wu, H.; Liu, X.; Yuan, M. Research Progress of Nanocarriers for the Treatment of Alzheimer's Disease. Current pharmaceutical design 2023, 29, 95–115. doi:10.2174/1381612829666221216114912
• J. Siddiqi, N.; Fatima, S.; Sharma, B.; Samir Elrobh, M. In-Utero Neurotoxicity of Nanoparticles. Neurotoxicity - New Advances; IntechOpen, 2022. doi:10.5772/intechopen.101452
• Fakhri, S.; Abdian, S.; Zarneshan, S. N.; Moradi, S. Z.; Farzaei, M. H.; Abdollahi, M. Nanoparticles in Combating Neuronal Dysregulated Signaling Pathways: Recent Approaches to the Nanoformulations of Phytochemicals and Synthetic Drugs Against Neurodegenerative Diseases. International journal of nanomedicine 2022, 17, 299–331. doi:10.2147/ijn.s347187
• Huang, W.; Tao, Y.; Zhang, X.; Zhang, X. TGF-β1/SMADs signaling involved in alleviating inflammation induced by nanoparticulate titanium dioxide in BV2 cells. Toxicology in vitro : an international journal published in association with BIBRA 2022, 80, 105303. doi:10.1016/j.tiv.2021.105303
• Re, D. B.; Yan, B.; Calderón-Garcidueñas, L.; Andrew, A. S.; Tischbein, M.; Stommel, E. W. A perspective on persistent toxicants in veterans and amyotrophic lateral sclerosis: identifying exposures determining higher ALS risk. Journal of neurology 2022, 269, 2359–2377. doi:10.1007/s00415-021-10928-5
• Egbuna, C.; Parmar, V. K.; Jeevanandam, J.; Ezzat, S. M.; Patrick-Iwuanyanwu, K. C.; Adetunji, C. O.; Khan, J.; Onyeike, E. N.; Uche, C. Z.; Akram, M.; Ibrahim, M. S.; Mahdy, N. M. E.; Awuchi, C. G.; Saravanan, K.; Tijjani, H.; Odoh, U.; Messaoudi, M.; Ifemeje, J. C.; Olisah, M. C.; Ezeofor, N. J.; Chikwendu, C. J.; Ibeabuchi, C. G. Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology. Journal of toxicology 2021, 2021, 9954443. doi:10.1155/2021/9954443

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