Low uptake of silica nanoparticles in Caco-2 intestinal epithelial barriers

Scholarly Works

• Iriarte‐Mesa, C.; Bergen, J.; Danielyan, K.; Crudo, F.; Marko, D.; Kählig, H.; Del Favero, G.; Kleitz, F. Functionalization of Silica Nanoparticles for Tailored Interactions with Intestinal Cells and Chemical Modulation of Paracellular Permeability. Small Science 2024. doi:10.1002/smsc.202400112
• Rosa, M. A.; Granja, A.; Nunes, C.; Reis, S.; da Silva, A. B. S.; Leal, K. N. d. S.; Arruda, M. A. Z.; Gorup, L. F.; Santos, M. G.; Dias, M. V. S.; Figueiredo, E. C. Magnetic carbon nanotubes modified with proteins and hydrophilic monomers: Cytocompatibility, in-vitro toxicity assays and permeation across biological interfaces. International journal of biological macromolecules 2024, 269, 131962. doi:10.1016/j.ijbiomac.2024.131962
• Bianchi, M. G.; Chiu, M.; Taurino, G.; Bergamaschi, E.; Turroni, F.; Mancabelli, L.; Longhi, G.; Ventura, M.; Bussolati, O. Amorphous silica nanoparticles and the human gut microbiota: a relationship with multiple implications. Journal of nanobiotechnology 2024, 22, 45. doi:10.1186/s12951-024-02305-x
• Zhou, L.; Shang, Y.; Wang, Y.; Wei, X. Transferrin modified PEG–PLGA nanoparticles: highly effective notoginsenoside R1 formulations for the treatment of ulcerative colitis. Journal of Pharmaceutical Investigation 2024, 54, 357–373. doi:10.1007/s40005-023-00657-4
• Erstling, J. A.; Bag, N.; Gardinier, T. C.; Kohle, F. F. E.; DomNwachukwu, N.; Butler, S. D.; Kao, T.; Ma, K.; Turker, M. Z.; Feuer, G. B.; Lee, R.; Naguib, N.; Tallman, J. F.; Malarkey, H. F.; Tsaur, L.; Moore, W. L.; Chapman, D. V.; Aubert, T.; Mehta, S.; Cerione, R. A.; Weiss, R. S.; Baird, B. A.; Wiesner, U. B. Overcoming Barriers Associated with Oral Delivery of Differently Sized Fluorescent Core-Shell Silica Nanoparticles. Advanced materials (Deerfield Beach, Fla.) 2023, 36, e2305937. doi:10.1002/adma.202305937
• Schmid, R.; Volcic, M.; Fischer, S.; Qu, Z.; Barth, H.; Popat, A.; Kirchhoff, F.; Lindén, M. Surface functionalization affects the retention and bio-distribution of orally administered mesoporous silica nanoparticles in a colitis mouse model. Scientific reports 2023, 13, 20175. doi:10.1038/s41598-023-47445-6
• Susnik, E.; Balog, S.; Taladriz-Blanco, P.; Petri-Fink, A.; Rothen-Rutishauser, B. The Functions of Cholera Toxin Subunit B as a Modulator of Silica Nanoparticle Endocytosis. Toxins 2023, 15, 482. doi:10.3390/toxins15080482
• Sousa Ribeiro, I. R.; da Silva, R. F.; Rabelo, R. S.; Marin, T. M.; Bettini, J.; Cardoso, M. B. Flowing through Gastrointestinal Barriers with Model Nanoparticles: From Complex Fluids to Model Human Intestinal Epithelium Permeation. ACS applied materials & interfaces 2023, 15, 36025–36035. doi:10.1021/acsami.3c07048
• Vital, N.; Ventura, C.; Kranendonk, M.; Silva, M. J.; Louro, H. Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure. Nanomaterials (Basel, Switzerland) 2022, 12, 3375. doi:10.3390/nano12193375
• Mortensen, N. P.; Moreno Caffaro, M.; Davis, K.; Aravamudhan, S.; Sumner, S. J.; Fennell, T. R. Investigation of eight cellulose nanomaterials' impact on Differentiated Caco-2 monolayer integrity and cytotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022, 166, 113204. doi:10.1016/j.fct.2022.113204
• Reboredo, C.; González-Navarro, C. J.; Martínez-López, A. L.; Martínez-Ohárriz, C.; Sarmento, B.; Irache, J. M. Zein-Based Nanoparticles as Oral Carriers for Insulin Delivery. Pharmaceutics 2021, 14, 39. doi:10.3390/pharmaceutics14010039
• Winckers, L. A.; Evelo, C. T.; Willighagen, E.; Kutmon, M. Investigating the Molecular Processes behind the Cell-Specific Toxicity Response to Titanium Dioxide Nanobelts. International journal of molecular sciences 2021, 22, 9432. doi:10.3390/ijms22179432
• Poyatos-Racionero, E.; González-Álvarez, I.; Sánchez-Moreno, P.; Sitia, L.; Gatto, F.; Pompa, P. P.; Aznar, E.; González-Álvarez, M.; Martínez-Máñez, R.; Marcos, M. D.; Bernardos, A. Lactose-Gated Mesoporous Silica Particles for Intestinal Controlled Delivery of Essential Oil Components: An In Vitro and In Vivo Study. Pharmaceutics 2021, 13, 982. doi:10.3390/pharmaceutics13070982
• Ogawa, T.; Okumura, R.; Nagano, K.; Minemura, T.; Izumi, M.; Motooka, D.; Nakamura, S.; Iida, T.; Maeda, Y.; Kumanogoh, A.; Tsutsumi, Y.; Takeda, K. Oral intake of silica nanoparticles exacerbates intestinal inflammation. Biochemical and biophysical research communications 2020, 534, 540–546. doi:10.1016/j.bbrc.2020.11.047
• Hempt, C.; Kaiser, J.-P.; Scholder, O.; Buerki-Thurnherr, T.; Hofmann, H.; Rippl, A.; Schuster, T. B.; Wick, P.; Hirsch, C. The impact of synthetic amorphous silica (E 551) on differentiated Caco-2 cells, a model for the human intestinal epithelium. Toxicology in vitro : an international journal published in association with BIBRA 2020, 67, 104903. doi:10.1016/j.tiv.2020.104903
• Tada-Oikawa, S.; Eguchi, M.; Yasuda, M. T.; Izuoka, K.; Ikegami, A.; Vranic, S.; Boland, S.; Tran, L.; Ichihara, G.; Ichihara, S. Functionalized Surface-Charged SiO2 Nanoparticles Induce Pro-Inflammatory Responses, but Are Not Lethal to Caco-2 Cells. Chemical research in toxicology 2020, 33, 1226–1236. doi:10.1021/acs.chemrestox.9b00478
• Cui, X.; Bao, L.; Wang, X.; Chen, C. The Nano-Intestine Interaction: Understanding the Location-Oriented Effects of Engineered Nanomaterials in the Intestine. Small (Weinheim an der Bergstrasse, Germany) 2020, 16, 1907665. doi:10.1002/smll.201907665
• Cornu, R.; Chrétien, C.; Pellequer, Y.; Martin, H.; Béduneau, A. Small silica nanoparticles transiently modulate the intestinal permeability by actin cytoskeleton disruption in both Caco-2 and Caco-2/HT29-MTX models. Archives of toxicology 2020, 94, 1191–1202. doi:10.1007/s00204-020-02694-6
• Mortensen, N. P.; Caffaro, M. M.; Patel, P. R.; Uddin, J.; Aravamudhan, S.; Sumner, S.; Fennell, T. R. Investigation of Twenty Metal, Metal Oxide, and Metal Sulfide Nanoparticles' Impact on Differentiated Caco-2 Monolayer Integrity. NanoImpact 2020, 17, 100212. doi:10.1016/j.impact.2020.100212
• Kobos, L.; Shannahan, J. H. Biocorona-induced modifications in engineered nanomaterial-cellular interactions impacting biomedical applications. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2019, 12, e1608. doi:10.1002/wnan.1608

Explore citations to this article at