NANOSCIENCE – THEORY TO APPLICATION

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1 article(s) from Brannigan, Ruairí P.

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

Ana Cubillo Alvarez,
Dylan Maguire and
Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

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Figure 1: Common chemical modifications used in antisense oligonucleotides (ASOs). First-generation ASOs invo...

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Figure 2: Mechanisms of action of ASOs. (A) RNase H-recruiting ASOs through formation of ASO–mRNA hybrids tha...

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Figure 3: Schematic representation of poly(ʟ-lysine) (PLL). (a) Chemical structure of lysine monomers. (b) (i...

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Figure 4: Illustration of the delivery of ASO-loaded glucosylated-polyion complex micelles (Glu-PIC/Ms) to th...

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Figure 5: Structure of the cationic amino acids, ʟ-ornithine, ʟ-arginine, and ʟ-lysine.

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Figure 6: (A) Chemical structure of PEGylated poly(ʟ-arginine)–chitosan derivatives (PEG-CS-PLR) polymers. (B...

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Figure 7: Polyamines frequently employed in ASO delivery systems include linear and branched poly(ethylene im...

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Figure 8: Impact of unsaturated fatty acids on cellular membrane interactions. (A) Confocal microscopy images...

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Figure 9: Stability of dendriplexes composed of GEM91 and (A) PPI G4, (B) PPI-Mal G4, and (C) PPI-Mal-III G4....

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Figure 10: (A) Depiction of the cationic homopolymer D. (B) Depiction of the polymers for traditional micelles...

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Figure 11: pH-responsive PEGylated systems for antisense oligonucleotide delivery. Figure 11 was reprinted with permiss...

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Published 27 Mar 2025

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