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Search for "large molecules" in Full Text gives 29 result(s) in Beilstein Journal of Nanotechnology.
Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals
Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113
- small or large molecules from the current literature, we highlight the preclinical studies and their results to prove the strategies’ success and limitations. Keywords: antibody delivery; biopharmaceutical delivery; blood–brain barrier (BBB); CNS diseases; drug delivery; hybrid nanoparticles
- , their passage to the brain is limited by the BBB, and they present incompatibilities with the oral route of administration because of their tendency to degrade [33][34]. In fact, this limitation is more pronounced for large molecules than for small molecules. As an alternative, researchers focus on
Fragmentation of metal(II) bis(acetylacetonate) complexes induced by slow electrons
Beilstein J. Nanotechnol. 2023, 14, 980–987, doi:10.3762/bjnano.14.81
- for large molecules, such as phthalocyanine or tetraphenylporphyrin (up to 7–8 eV), because of the long lifetime of the TNIs [22]. Also, the electron can be trapped by long-range forces to form a “multipole”-bound anion. This bound state may then couple to some dissociative valence states, leading to
Molecular nanoarchitectonics: unification of nanotechnology and molecular/materials science
Beilstein J. Nanotechnol. 2023, 14, 434–453, doi:10.3762/bjnano.14.35
- . Thus, rational nanoarchitectonics of single-layer surface COFs with desired functions is expected. The on-surface synthesis of COFs using large molecules such as tetraphenylporphyrin molecules has also been investigated. Wang, Zhong, Ji, and co-workers achieved the on-surface synthesis of COFs from
The steep road to nonviral nanomedicines: Frequent challenges and culprits in designing nanoparticles for gene therapy
Beilstein J. Nanotechnol. 2023, 14, 351–361, doi:10.3762/bjnano.14.30
- , in the case of large molecules (such as plasmids) in smaller particles, significant deviations from this trend can be observed. To better understand the per-particle variations in payload, high-resolution microscopy, such as total internal reflection fluorescence spectroscopy, near-field scanning
Microneedle-based ocular drug delivery systems – recent advances and challenges
Beilstein J. Nanotechnol. 2022, 13, 1167–1184, doi:10.3762/bjnano.13.98
- achieve systemic action, for example, non-steroidal anti-inflammatory drugs (NSAIDs) [107], antihypertensives [108], and lipid-lowering drugs [109]. Moreover, microneedles (MNs) are broadly investigated as very promising platforms for the delivery of large molecules such as insulin [110] or nucleic acids
Design and characterization of polymeric microneedles containing extracts of Brazilian green propolis
Beilstein J. Nanotechnol. 2022, 13, 503–516, doi:10.3762/bjnano.13.42
- of large molecules, nanoparticles, and proteins through the skin [39][40]. Considering the height, the MNs containing EE and P407 exhibited a significant positive interference (p > 0.05) (Supporting Information File 1, Table S2 and Figure S5), being greater for the amount of extract, which
Interfacial nanoarchitectonics for ZIF-8 membranes with enhanced gas separation
Beilstein J. Nanotechnol. 2022, 13, 313–324, doi:10.3762/bjnano.13.26
- effect through the methyl group of 2-methylimidazole. In addition to providing selectivity, ZIF-8 also possesses a high volume of cavities in which the open framework structure provides a passing lane for small molecules while large molecules are trapped [31]. The crystallographic pore aperture of ZIF-8
Self-assembly of amino acids toward functional biomaterials
Beilstein J. Nanotechnol. 2021, 12, 1140–1150, doi:10.3762/bjnano.12.85
- acids. Most of the review articles about self-assembly focus on large molecules, such as peptides and proteins. The preparation of complicated materials by self-assembly of amino acids has not yet been evaluated. Therefore, it is of great significance to systematically summarize the literature of amino
- in vivo [28] compared with the self-assembly of large molecules, such as proteins and peptides. Importantly, amino acids or amino acid derivatives may be self-assembled with other components to form functional architectures, such as drug delivery systems, light collection systems, and imaging systems
Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications
Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64
- ]. However, a few studies have demonstrated that the endocytosis pathway is the main mechanism for the delivery of large molecules mediated by US [33][84][85]. Schlicher et al. investigated the uptake and transfer of different molecular weight fluorescent molecules, including calcein, fluorescein
Controlling the electronic and physical coupling on dielectric thin films
Beilstein J. Nanotechnol. 2020, 11, 1492–1503, doi:10.3762/bjnano.11.132
- until now because many of the standard techniques cannot easily distinguish between charged and neutral species. For reasonably large molecules with delocalized frontier orbitals, the integer charge is spread over many atoms and the resulting chemical shift will be too small to be seen with X-ray
Graphene-enhanced metal oxide gas sensors at room temperature: a review
Beilstein J. Nanotechnol. 2018, 9, 2832–2844, doi:10.3762/bjnano.9.264
- to explore the ability to detect nonpolar and large molecules, such as volatile organic compounds (VOCs) which are extremely harmful to human health and the environment. The interaction of these molecules with graphene/metal-oxide sensors is different from that of the polar molecules, and graphene
The difference in the thermal conductivity of nanofluids measured by different methods and its rationalization
Beilstein J. Nanotechnol. 2016, 7, 2037–2044, doi:10.3762/bjnano.7.194
- will move like large molecules within smaller molecules. Meso-continuum model to estimate heat pickup by nanoparticles from the heat source To predict the heat pickup of the nanoparticle during its collision with the heat source a 2D meso-continuum model has been developed. The software package FLUENT
Effective intercalation of zein into Na-montmorillonite: role of the protein components and use of the developed biointerfaces
Beilstein J. Nanotechnol. 2016, 7, 1772–1782, doi:10.3762/bjnano.7.170
- ]. Particularly, biological species can be employed in the preparation of these materials, giving rise to biohybrids, which represent a growing field of research addressed to produce advanced functional materials [2]. Many studies have demonstrated that even large molecules, such as polypeptides and proteins
Surface-enhanced infrared absorption studies towards a new optical biosensor
Beilstein J. Nanotechnol. 2016, 7, 1736–1742, doi:10.3762/bjnano.7.166
- monitoring of film thickness growth by RIfS interference can be combined as a potential means to identify and quantify large molecules or even bacteria in an aqueous system. As already mentioned in the Introduction, other optical sensors that successfully operate in the visible region of the electromagnetic
Polystyrene-block-poly(ethylene oxide) copolymers as templates for stacked, spherical large-mesopore silica coatings: dependence of silica pore size on the PS/PEO ratio
Beilstein J. Nanotechnol. 2016, 7, 1454–1460, doi:10.3762/bjnano.7.137
- ; mesoporous silica; soft templating; sol–gel; Introduction Mesoporous materials with large, tunable porosity are currently being investigated as selective molecular sieves, finding potential applications in many fields such as catalysis, encapsulation of proteins, filtration and separation of large molecules
Nanoscale effects in the characterization of viscoelastic materials with atomic force microscopy: coupling of a quasi-three-dimensional standard linear solid model with in-plane surface interactions
Beilstein J. Nanotechnol. 2016, 7, 554–571, doi:10.3762/bjnano.7.49
- [19]. Frequently, but not always, relatively large molecules are involved and their cohesive energy is governed by dispersion (van der Waals) and electrostatic forces, which are generally weaker than those generated by stretched covalent bonds or electrostatic interactions in ionic crystals, and which
Charge and heat transport in soft nanosystems in the presence of time-dependent perturbations
Beilstein J. Nanotechnol. 2016, 7, 439–464, doi:10.3762/bjnano.7.39
- molecule, which is expected to have the lowest frequency for large molecules. In fact, in C60 molecules, experimental results provide compelling evidence for a coupling between electron dynamics and the center-of-mass motion where has been estimated to be of the order of 5 meV [9]. Furthermore, as
Electrospray deposition of organic molecules on bulk insulator surfaces
Beilstein J. Nanotechnol. 2015, 6, 1927–1934, doi:10.3762/bjnano.6.195
- reactivity, depositing molecules by thermal evaporation becomes challenging. A recent way to deposit molecules in clean conditions is Electrospray Ionization (ESI). ESI keeps the possibility to work with large molecules, to introduce them in vacuum, and to deposit them on a large variety of surfaces. Here
- necessary and therefore ultra-high vacuum (UHV) conditions are required for these fundamental studies. However, thermal evaporation, the most commonly employed technique under UHV conditions, may lead to a fragmentation of large molecules generally happening before reaching the sublimation temperature
- the molecular structures adsorbed on the surface. We show that UHV-ESI, can be performed on insulating surfaces in the sub-monolayer regime and to single molecules which opens the possibility to study a variety of complex molecules. Keywords: adsorption; electrospray; insulating surface; large
Raman spectroscopy as a tool to investigate the structure and electronic properties of carbon-atom wires
Beilstein J. Nanotechnol. 2015, 6, 480–491, doi:10.3762/bjnano.6.49
- Curl, as reported in the Nobel lecture by Kroto [21]. Even though a new allotrope based on sp carbon has still yet to be found, sp-hybridized carbon nanostructures (or large molecules) in the form of linear atomic wires can be now produced and investigated. Great interest has been shown in the
Interaction of dermatologically relevant nanoparticles with skin cells and skin
Beilstein J. Nanotechnol. 2014, 5, 2363–2373, doi:10.3762/bjnano.5.245
- penetration in moderately disrupted skin. However, secondary translocation through microscopic injuries or slantingly growing hair follicles has to be excluded. In fact, the reservoir function of hair follicles for large molecules and particles is now widely accepted [21][22]. The extension of the hair
Patterning a hydrogen-bonded molecular monolayer with a hand-controlled scanning probe microscope
Beilstein J. Nanotechnol. 2014, 5, 1926–1932, doi:10.3762/bjnano.5.203
- the movements of an operator's hand to the sub-angstrom precise positioning of an SPM tip. Literally moving the tip by hand we write a nanoscale structure in a monolayer of large molecules, thereby showing that our method allows for the successful execution of complex manipulation protocols even when
- behaviour of large molecules on surfaces is generally not well understood. Despite the fact that studies of complex molecular adsorption are progressing quickly, even in the best-studied model cases a full and quantitatively precise picture of the molecular adsorption potential (even in the absence of the
- SPM tip) is not yet available. For systems that contain a larger number of molecules that may simultaneously interact with the surface, the SPM tip and each other, reconstruction of the potential does not seem realistic in the nearest future. How can we nevertheless manipulate large molecules
In vitro and in vivo interactions of selected nanoparticles with rodent serum proteins and their consequences in biokinetics
Beilstein J. Nanotechnol. 2014, 5, 1699–1711, doi:10.3762/bjnano.5.180
- factor of 2 of the median diameter prior to incubation. This contrasts DLS and AFM measurements, which yielded larger diameters of the AuNP surface-modified with large molecules (bis(p-sulfonatophenyl)phenylphosphine, thiol-PEG, polymer shell with or without amino-PEG) even in PBS or distilled water. The
A study on the consequence of swift heavy ion irradiation of Zn–silica nanocomposite thin films: electronic sputtering
Beilstein J. Nanotechnol. 2014, 5, 1691–1698, doi:10.3762/bjnano.5.179
- occurs. It has potential applications in astrophysics, space devices and mass spectrometry of large molecules [10]. Sputtering occurs due to the energy transfer to the atoms in the target by incident ions through nuclear collision cascades (nuclear sputtering) produced in the target as well as electronic
Nanoporous composites prepared by a combination of SBA-15 with Mg–Al mixed oxides. Water vapor sorption properties
Beilstein J. Nanotechnol. 2014, 5, 1226–1234, doi:10.3762/bjnano.5.136
- candidates to be combined homogenously with mesoporous siliceous materials to improve their physicochemical properties. Hydrotalcites are lamellar materials with basic properties, but with a relative low surface area and poor mesoporosity [12]. Thus, large molecules accessibility toward active sites is a
Adsorption of the ionic liquid [BMP][TFSA] on Au(111) and Ag(111): substrate effects on the structure formation investigated by STM
Beilstein J. Nanotechnol. 2013, 4, 903–918, doi:10.3762/bjnano.4.102
- at the elbow sites as compared to the other surface areas, similar to findings for metal epitaxy, e.g., Ni/Au(111) [33], or adsorption of large molecules such as porphyrin molecules [34]. The (short-range) ordering of the adsorbates in the islands was checked by calculating a Fourier transformation
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