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Search for "biocompatibility" in Full Text gives 249 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.
Classification and application of metal-based nanoantioxidants in medicine and healthcare
Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36
- homeostasis in tumors through a series of cascade reactions but also establish cyclic regeneration of relevant substrates. Another study combined MnO2 nanoparticles with bovine serum albumin (BSA) to obtain GPx activity [47]. The in vitro results showed excellent biocompatibility of the MnO2-BSA nanoparticles
- three key components: (1) edaravone and nanoceria were responsible for ROS scavenging; (2) poly(ethylene glycol) increased biocompatibility, monodispersity, and extended the half-life in the bloodstream; and (3) angiopep-2 served as targeting ligand, which specifically binds to the low-density
- delivery but also enhances stability and biocompatibility. Recently, Shang et al. used a Au/Cu1.6O/P–C3N5/Arg@HA nanocomposite hydrogel spray coupled with ultrasound for diabetic wound healing (Figure 4) [162]. This nanocomposite spray exhibited five types of enzyme-like activities, that is, CAT-, SOD
Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors
Beilstein J. Nanotechnol. 2024, 15, 297–309, doi:10.3762/bjnano.15.27
- biocompatibility on NP toxicity. These properties of NPs determine their toxicity and interaction with the cell membrane damaging human health and the environment [12]. The toxic effect of NPs can be used as a medical treatment for diseases at the cellular level, that is, targeting and destroying cancerous cells
Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study
Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24
- nanostructures employed, particular emphasis has been placed on iron oxide (Fe3O4) nanoparticles. The biocompatibility and low toxicity of Fe3O4 nanoparticles have garnered significant attention in magnetic drug delivery for cancer diagnosis and treatment, primarily because of their magnetic properties [11][12
- neurotransmitter naturally occurring in the brain and can spontaneously polymerize into polydopamine (PDA) under alkaline conditions without oxidants [22]. Polydopamine can form a coating with biocompatibility advantages, achieving up to 40% photothermal conversion efficiency, nanoscale dimensions, and
- morphology and a size of 18 nm. After coating with PDA at different ratios, the size reaches up to 28, 61, and 225 nm. Another point is that PEGylation has been applied using SH-PEG polymer to enhance biocompatibility. Notably, our study demonstrates a significantly higher drug loading efficiency of 98
Assessing phytotoxicity and tolerance levels of ZnO nanoparticles on Raphanus sativus: implications for widespread adoptions
Beilstein J. Nanotechnol. 2024, 15, 115–125, doi:10.3762/bjnano.15.11
- , which may be top-down or bottom-up approaches, has facilitated the synthesis of nanoparticles of differing shapes, sizes and properties [11]. When considering zinc oxide nanoparticles (ZnO NPs) in particular, their low toxicity, high biocompatibility, and low cost [12] have enabled them to be applied as
Development and characterization of potential larvicidal nanoemulsions against Aedes aegypti
Beilstein J. Nanotechnol. 2024, 15, 104–114, doi:10.3762/bjnano.15.10
- ]. Biocompatibility assessment is an essential aspect of the development of NEs, particularly for biomedical and cosmetic applications, as it determines the safety and efficacy of the formulations. The assessment involves evaluating the potential cytotoxicity and genotoxicity of the NEs on different cell types and
- present work was (i) to develop stable oil-in-water nanoemulsions containing myrcene or cymene as the dispersed phase, (ii) to determine the required rHLB values for emulsion stability, (iii) to assess the biocompatibility via in vitro and in vivo assays, and (iv) to evaluate the bioefficacy of the NE
- evaluation of the biocompatibility in human cells is an important step in the development and commercialization of any drug [46]. Here, the toxicity of the terpene-based formulations was evaluated in the HaCAT cell line (Table 6). The results show that the IC50 values of the free terpenes were lower those of
Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency
Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7
- strongly affect the release behavior of the drug from nanofiber scaffolds [14][17][18][19]. Polylactic acid (PLA), a synthetic polymer that has been approved by the FDA for biomedical usage, is commonly used for drug delivery systems due to its biocompatibility and biodegradability [20]. Yuan et al. [17
Influence of conductive carbon and MnCo2O4 on morphological and electrical properties of hydrogels for electrochemical energy conversion
Beilstein J. Nanotechnol. 2024, 15, 57–70, doi:10.3762/bjnano.15.6
- history and a wide range of applications, especially in biology, medicine, tissue engineering, and pharmacy. The multitude of application areas is related to their exceptional properties: biocompatibility, biodegradability, nontoxicity, good permeability for substances dissolved in water (e.g., oxygen and
Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review
Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4
- such as enhanced stability, low toxicity, increased shelf life, improved drug loading capacity, and biocompatibility over other conventional lipid-based nanocarriers, such as nanoemulsions and solid lipid nanoparticles [91]. Due to their properties, the use of NLCs has been a successful strategy for
- impact specific drug release kinetics and increase biocompatibility [60]. Different biodegradable polymers have been used for the development of targeted PNPs for the treatment of leishmaniasis [102]. In this scenario, chitosan is an interesting polymer for NP synthesis due to its positive charge, which
- nanoparticles due to its special features such as biocompatibility, biodegradability, low toxicity, and adjuvanticity [109][110]. Given these properties, Tiwari and co-workers produced curcumin-loaded Eudragit-PLGA-nanoparticles (curc-E-PLGA-NPs) and evaluated their leishmanicidal activity with miltefosine
Nanotechnological approaches in the treatment of schistosomiasis: an overview
Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2
- Administration since 1989 [21] and, although no human data attests to chitosan safety, many animal tests prove its safety [22]. Eudragit L 100 is another polymer commonly used in literature because of its biocompatibility [8]. Overall, it is used when a delayed release is required. It is derived from polyacid
- classic nanocarriers are not present in SLN, such as lack of biocompatibility, difficulty to produce on a large scale, and high raw material cost [36]. Many methods are used to prepare SLN, and they are divided into (1) high-energy methods, for dispersion of the lipid phase (such as high-pressure
- molecule, and excellent biocompatibility and safety [38]. Liposomes can also be modified to selectively deliver a drug to a specific site. This is very valuable because it can reduce potential side effects and increase the maximum tolerated dose, which improves therapeutic benefits [39]. For example
Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells
Beilstein J. Nanotechnol. 2023, 14, 1208–1224, doi:10.3762/bjnano.14.100
- applications, especially because of their biocompatibility. We synthesized and characterized fluorescent PDA NPs of 10–25 nm diameter based on a protein containing a lysine–glutamate diad (bovine serum albumin, BSA) and determined whether they can penetrate and accumulate in bacterial cells to serve as a
- bacteria. Inspired by the eumelanin aggregates in human skin, polydopamine nanoaggregates (here referred to as nanoparticles, i.e., PDA NPs) have emerged as promising nanovectors for biomedical applications [11][12], especially because of their biocompatibility [13][14] and photothermic properties [15][16
A combined gas-phase dissociative ionization, dissociative electron attachment and deposition study on the potential FEBID precursor [Au(CH3)2Cl]2
Beilstein J. Nanotechnol. 2023, 14, 1178–1199, doi:10.3762/bjnano.14.98
- ; quantum chemical calculation; ultrahigh vacuum; Introduction In recent years, gold nanostructures have received much attention owing to their dielectric properties [1], their biocompatibility [2], and their electrical properties [3][4], which enable a multitude of exciting applications in the field of
Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems
Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95
- uptake for softer particles [30]. Cell uptake is often the first biological evaluation during the development phase besides toxicity and biocompatibility. However, after application, particles first need to reach the cells and overcome several other biological barriers. During uptake, other biological
Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays
Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82
- non-radiatively in the form of phonons. The phonons generate heat in these materials [36] (Figure 4C). Transition metal sulfide nanomaterials gain much attention in photothermal applications, because of their low cost, high biocompatibility, and considerably high PCE. Nanoparticles of copper sulfide
- , iron oxide nanoparticles are the most prominent ones because of their biocompatibility, low toxicity, ease of synthesis, and high photothermal conversion efficiency. The influence of a magnetic field can also increase temperature generation by such nanoparticles, which is called magnetic hyperthermia
- nanoparticles in the composite can increase the light absorption through surface plasmon resonance. Hence, graphene-based multifunctional nanocomposite materials could be employed as promising photothermal agents [44]. Polymer-based nanomaterials: Because of high biocompatibility, high PCE, and facile synthesis
Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics
Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75
- , detection, and eradication of cancer cells and biomarkers, with great potential in theranostic applications. Despite these advantages, the design and fabrication of targeted NPs for cancer therapy is still very challenging regarding biocompatibility, pharmacokinetics, in vivo targeting efficacy, and cost
Green SPIONs as a novel highly selective treatment for leishmaniasis: an in vitro study against Leishmania amazonensis intracellular amastigotes
Beilstein J. Nanotechnol. 2023, 14, 893–903, doi:10.3762/bjnano.14.73
- exhibit theranostic properties, that is, they can be used simultaneously for diagnosis and therapy. Thus, SPIONs have emerged as one of the best options for the development of new therapeutic methods. SPIONs offer several features such as good biocompatibility, degradability under moderate acid conditions
Industrial perspectives for personalized microneedles
Beilstein J. Nanotechnol. 2023, 14, 857–864, doi:10.3762/bjnano.14.70
- microneedles are most often directly printed onto the medical device and aligned to specific features, such as pores, on the device. Direct microneedle printing has its own set of extensive requirements (e.g., biocompatibility of the material, mechanical robustness, and surface adhesion). Also, FDA’s 510(k
A wearable nanoscale heart sound sensor based on P(VDF-TrFE)/ZnO/GR and its application in cardiac disease detection
Beilstein J. Nanotechnol. 2023, 14, 819–833, doi:10.3762/bjnano.14.67
- polymer material with a wide frequency bandwidth, good biocompatibility, and softness. It is one of the preferred materials for flexible piezoelectric sensors [12]. However, compared to rigid piezoelectric materials such as PZT, pure P(VDF-TrFE) has inferior piezoelectric properties [13]. Researchers have
Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies
Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66
- trypanocidal activity against trypomastigotes compared to that of the free drug [18]. Among the aforementioned nanosystems, SLNs have recently gained special attention owing to their biocompatibility properties, biodegradability, relatively easy surface and composition modification, and efficacy in loading and
Carbon nanotube-cellulose ink for rapid solvent identification
Beilstein J. Nanotechnol. 2023, 14, 535–543, doi:10.3762/bjnano.14.44
- has resurfaced recently as a smart material because of its excellent thermal-mechanical properties, biocompatibility, biodegradability, and flexibility [22][23][30][31]. Composites based on carbon nanotubes or graphene and cellulose have been reported for, among other things, humidity and vapor
Nanoarchitectonics to entrap living cells in silica-based systems: encapsulations with yolk–shell and sepiolite nanomaterials
Beilstein J. Nanotechnol. 2023, 14, 522–534, doi:10.3762/bjnano.14.43
- influence on the characteristics of the final materials. Thus, an optimised protocol yielding biocompatibility and physical stability, as well as suitable transparency to allow for the viability of cyanobacteria was found. Previous results on algae biohybrid systems based on chitosan biocomposites have
- demonstrated great biocompatibility, allowing the cells to survive over long periods of time [38]. However, in the present study using chitosan-based biohybrids, we have observed that the cells did not stay alive for long. The current results point out that chitosan may exhibit antibacterial activity
- . To conclude this section and considering the above-mentioned results, our observations indicate that the utilization of silica gels with low sodium content greatly increases the biocompatibility of the matrix, sustaining the biological activity of the encapsulated microorganisms. However, direct
Microneedle patches – the future of drug delivery and vaccination?
Beilstein J. Nanotechnol. 2023, 14, 494–495, doi:10.3762/bjnano.14.40
- originally developed for the microelectronics industry; they were inevitably made from silicon. Since then, silicon MNs have been largely abandoned in favour of polymer versions because of their superior mechanical properties, biocompatibility, ease of manufacture, and ultimate scalability [5][6]. Polymer
Conjugated photothermal materials and structure design for solar steam generation
Beilstein J. Nanotechnol. 2023, 14, 454–466, doi:10.3762/bjnano.14.36
- broad light absorption, high photothermal conversion efficiency, biocompatibility, and hydrophilicity. The resulting polymer is highly conjugated due to the aromatization of the ethylamine moiety via cyclization and, accordingly, PDA is widely used as a PTM for SSG applications [43][44][45][46][47][48
New trends in nanobiotechnology
Beilstein J. Nanotechnol. 2023, 14, 377–379, doi:10.3762/bjnano.14.32
- biocompatibility of the nanomaterials is also discussed. The thematic issue also recorded a work on the topic of “Self-assembly of amino acids toward functional biomaterials” [5], where the role of biomaterials in nanobiotechnology is discussed. In this review, the latest advances in amino acid self-assembly and
- works on self-assembly have shown low synthesis cost, ease of modelling, and good biocompatibility of the generated biomolecules. The review discusses the introduction and case studies of different types of self-assembly, applying examples on the application of the method. Finally, the review summarizes
Polymer nanoparticles from low-energy nanoemulsions for biomedical applications
Beilstein J. Nanotechnol. 2023, 14, 339–350, doi:10.3762/bjnano.14.29
- , proteins, vaccines, and nucleotides [2]. In spite of biodegradability and biocompatibility, some studies have also demonstrated a certain concentration-dependent toxicologic profile including a mild inflammatory response after treatment with PLGA nanoparticles [49]. Some authors have suggested that the
Overview of mechanism and consequences of endothelial leakiness caused by metal and polymeric nanoparticles
Beilstein J. Nanotechnol. 2023, 14, 329–338, doi:10.3762/bjnano.14.28
- proteins, is determined by the stability, biocompatibility, and solubility of such conjugates, which in turn opens up new perspectives in medical applications [16][42]. Nanotheranostic applications use NPs for diagnostic and therapeutic purposes for serious metabolic, cancer, and neurodegenerative diseases
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