Parylene-coated platinum nanowire electrodes for biomolecular sensing applications

• Chao Liu,
• Peker Milas,
• Michael G. Spencer and
• Birol Ozturk

Beilstein J. Nanotechnol. 2025, 16, 1392–1400, doi:10.3762/bjnano.16.101

• due to their compact size, biocompatibility, and rapid fabrication. Keywords: biosensor; directed electrochemical nanowire assembly (DENA); dopamine; glucose; nanoelectrode; platinum; Introduction Electrodes, a tool used in all walks of life today, were first demonstrated by Max Cremer in 1906 [1

• stability of metal nanoparticles limits their application in biological systems and decreases their performance [12]. Other materials like silicon quantum dots, ion-imprinted polymer, and hydrogels have unique biocompatibility and specificity advantages, but long-term stability and cost make them

• structures [18][19][20][21]. These characteristics allow DENA to create a variety of structures for nanoscale biosensor manufacturing. Parylene-C is a polymer known for its exceptional properties, including high tensile strength, excellent electrical insulation, low water permeability, and biocompatibility

Enhancing the therapeutical potential of metalloantibiotics using nano-based delivery systems

• Alejandro Llamedo,
• Marina Cano,
• Raquel G. Soengas and
• Francisco J. García-Alonso

Beilstein J. Nanotechnol. 2025, 16, 1350–1366, doi:10.3762/bjnano.16.98

• : antimicrobial resistance; biocompatibility; metalloantibiotics; nanocarriers; targeted delivery; Introduction Antimicrobial resistance (AMR), the condition that bacteria no longer respond to drugs used to treat infections, has become one of the biggest public health challenges of the 21st century. According to

• , such as biocompatibility and drug protection, while avoiding many of their limitations. In comparison to conventional colloidal carriers, SLNs demonstrate reduced toxicity, greater surface area, enhanced biocompatibility, extended drug release, improved cellular uptake, and increased drug solubility

• , combining high biocompatibility, prolonged release properties, and the capacity to encapsulate a diverse range of therapeutic agents. Ongoing research efforts are focused on overcoming existing limitations to fully realize the clinical potential of SLNs [76]. Polymer nanoparticles. Polymeric nanoparticles

Ferroptosis induction by engineered liposomes for enhanced tumor therapy

• Alireza Ghasempour,
• Mohammad Amin Tokallou,
• Mohammad Reza Naderi Allaf,
• Mohsen Moradi,
• Hamideh Dehghan,
• Mahsa Sedighi,
• Mohammad-Ali Shahbazi and
• Fahimeh Lavi Arab

Beilstein J. Nanotechnol. 2025, 16, 1325–1349, doi:10.3762/bjnano.16.97

• ferroptosis-based therapy. Among them, engineered liposomes have received more attention due to their biocompatibility, low immunogenicity, and flexibility in chemical and structural modifications. The present review focuses on the mechanisms of ferroptosis and its induction by engineered liposomes to improve

• delivery, owing to their exceptional features such as shielding encapsulated substances from physiological degradation, extending drug half-life, enabling controlled release of drug molecules, and excellent biocompatibility and safety. Beyond medicine, they have also found widespread applications in the

• , hybrid systems can overcome the disadvantages of each component of the hybrid system. Hydrogel systems included with liposomes demonstrate exceptional chemical tunability, biocompatibility, and biodegradability. These hybrid platforms offer enormous potential for facilitating tissue regeneration or for

Acrocomia aculeata oil-loaded nanoemulsion: development, anti-inflammatory properties, and cytotoxicity evaluation

• Verónica Bautista-Robles,
• Hady Keita,
• Edgar Julián Paredes Gamero,
• Layna Tayná Brito Leite,
• Jessica de Araújo Isaías Muller,
• Mônica Cristina Toffoli Kadri,
• Ariadna Lafourcade Prada and
• Jesús Rafael Rodríguez Amado

Beilstein J. Nanotechnol. 2025, 16, 1277–1288, doi:10.3762/bjnano.16.93

• potent hemolytic effect [50]. As shown in Figure 5A, AANE maintained erythrocyte membrane integrity across all tested concentrations, reinforcing its biocompatibility. Furthermore, cytotoxicity evaluation showed that AANE did not inhibit cell growth, as cellular viability remained at 100% across all

• tested concentrations (1, 10, 100, and 1000 μg/mL, Figure 5B). These findings underscore the nanoemulsion’s biocompatibility and support its potential for safe therapeutic applications. This is consistent with the traditional use of bocaiúva oil, which is commonly taken in or applied topically by

Better together: biomimetic nanomedicines for high performance tumor therapy

• Imran Shair Mohammad,
• Gizem Kursunluoglu,
• Anup Kumar Patel,
• Hafiz Muhammad Ishaq,
• Cansu Umran Tunc,
• Dilek Kanarya,
• Mubashar Rehman,
• Omer Aydin and
• Yin Lifang

Beilstein J. Nanotechnol. 2025, 16, 1246–1276, doi:10.3762/bjnano.16.92

• inherent traits endow biomimetic nanoparticles with a suite of intelligent features, including biocompatibility, low immunogenicity, reduced toxicity, immune evasion, prolonged circulation, homotypic binding, enhanced tumor targeting, and the capability of precise delivery. By integrating biologically

• are specialized NPs, where the surface is designed with natural biocompatible biomaterials that can mimic the structure and functions of the natural cells to improve targetability, enhance biocompatibility, and increase retention time with minimum undesired immune reaction [22]. Importantly, efficient

• emerged as an ideal strategy to protect synthetic nanoparticles during circulation. Cell membrane-coated biomimetic nanoparticles act like source cells with significant biomedical properties including biocompatibility, low toxicity, and potent targetability. They are recognized as “own” by the immune

Functional bio-packaging enhanced with nanocellulose from rice straw and cinnamon essential oil Pickering emulsion for fruit preservation

• Tuyen B. Ly,
• Duong D. T. Nguyen,
• Hieu D. Nguyen,
• Yen T. H. Nguyen,
• Bup T. A. Bui,
• Kien A. Le and
• Phung K. Le

Beilstein J. Nanotechnol. 2025, 16, 1234–1245, doi:10.3762/bjnano.16.91

• alternative materials to traditional oil-based plastic packaging that help mitigate environmental and health concerns relating to food preservation. They are used particularly in the food, pharmaceutical, and cosmetic sectors thanks to their good mechanical properties, high biocompatibility, and

• microbial access [7]. PVA also exhibits superior biocompatibility as evidenced by its high safety threshold (LD50 of 15–20 g·kg−1), low systemic absorption, absence of mutagenic effects, and established medical applications, making it a reliable choice for biopackaging without concerns of harmful

• antimicrobial and antioxidation properties that can offer extended shelf life [27][28][29]. Essential oils are great candidates and possess a variety of bioactive properties while maintaining a high biocompatibility [30]. Cinnamon essential oil (CEO) is one of the best-known essential oils with strong activity

Hydrogels and nanogels: effectiveness in dermal applications

• Jéssica da Cruz Ludwig,
• Diana Fortkamp Grigoletto,
• Daniele Fernanda Renzi,
• Wolf-Rainer Abraham,
• Daniel de Paula and
• Najeh Maissar Khalil

Beilstein J. Nanotechnol. 2025, 16, 1216–1233, doi:10.3762/bjnano.16.90

• stability, absorption, and biodistribution impairments. Among the DDSs, we can highlight hydrogels and nanogels, which are easy to obtain, show good biocompatibility, and have several applications in the design of drug carriers for dermal and ocular administration. In this review, we introduce a brief

• , comprising high biocompatibility and three-dimensional conformation. Their structural organization simulates the architecture of living tissues, allowing the flux of nutrients, oxygen, metabolites, and even whole cells. As a result, hydrogels can be molded into body parts, being successfully employed in

• temperature and polymer concentration [130]. Chitosan-based hydrogels have aroused a lot of interest in the health sciences field due to their biocompatibility, biodegradability, and low cytotoxicity [131]. This makes them attractive as a promising material for topical administration of biomolecules such as

Investigation of the solubility of protoporphyrin IX in aqueous and hydroalcoholic solvent systems

• Michelly de Sá Matsuoka,
• Giovanna Carla Cadini Ruiz,
• Marcos Luciano Bruschi and
• Jéssica Bassi da Silva

Beilstein J. Nanotechnol. 2025, 16, 1209–1215, doi:10.3762/bjnano.16.89

• properties, capable of forming micelles that encapsulate PpIX, increasing its solubility and facilitating its administration [7][11][12]. In this context, poloxamer 407 (P407) is notable for its biocompatibility and ability to form stable nanometric micelles [8][13][14]. Its amphiphilic nature allows for the

Chitosan nanocomposite containing rotenoids: an alternative bioinsecticidal approach for the management of Aedes aegypti

• Maria A. A. Bertonceli,
• Vitor D. C. Cristo,
• Ivo J. Vieira,
• Francisco J. A. Lemos,
• Arnoldo R. Façanha,
• Raimundo Braz-Filho,
• Gustavo V. T. Batista,
• Luis G. M. Basso,
• Sérgio H. Seabra,
• Thalya S. R. Nogueira,
• Felipe F. Moreira,
• Arícia L. E. M. Assis,
• Antônia E. A. Oliveira and
• Kátia V. S. Fernandes

Beilstein J. Nanotechnol. 2025, 16, 1197–1208, doi:10.3762/bjnano.16.88

• nanoparticles exhibited no adverse effects on larval survival, which is attributed to the biocompatibility and nontoxic nature of chitosan, a biodegradable polysaccharide structurally related to the insect exoskeleton and widely recognized for its environmental safety. Additionally, neither rotenoids nor the CS

• , surpassed only by cellulose. Its relevance as a biopolymer is due to its properties such as biodegradability, biocompatibility, and nontoxicity to humans, characteristics that make it widely used in various scientific and technological fields [16][17]. Therefore, we used chitosan as the coating material for

Piezoelectricity of hexagonal boron nitrides improves bone tissue generation as tested on osteoblasts

• Sevin Adiguzel,
• Nilay Cicek,
• Zehra Cobandede,
• Feray B. Misirlioglu,
• Hulya Yilmaz and
• Mustafa Culha

Beilstein J. Nanotechnol. 2025, 16, 1068–1081, doi:10.3762/bjnano.16.78

• properties due to its noncentrosymmetric crystal structure, making it a promising material for biomedical applications such as bone regeneration, where it can convert mechanical stimuli into bioelectrical signals. Additionally, the biocompatibility and ability of hBN to be integrated into composite scaffolds

• [30][31]. The piezoelectric property of 2D hBN arises from its noncentrosymmetric structure, supported by these van der Waals interactions [32]. The excellent biocompatibility of hBN makes it attractive for diverse applications, including cosmetics, drug delivery, cancer treatment, orthopedic implants

• results demonstrate that both NMs exhibited robust piezoelectric properties and confirmed their exceptional biocompatibility, with no toxicity observed even at the highest concentrations tested. The mechanical stress induced by the US prompts micromechanical interaction with cells. This, in turn, triggers

Soft materials nanoarchitectonics: liquid crystals, polymers, gels, biomaterials, and others

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2025, 16, 1025–1067, doi:10.3762/bjnano.16.77

• integrated with the solvent [279][280][281]. Furthermore, gel materials with excellent stimuli responsiveness and biocompatibility have also been widely developed. As the nanoarchitectonics of the polymers and molecular aggregates that constitute gels evolve, the design and functionality of gels are becoming

A calix[4]arene-based supramolecular nanoassembly targeting cancer cells and triggering the release of nitric oxide with green light

• Cristina Parisi,
• Loredana Ferreri,
• Tassia J. Martins,
• Francesca Laneri,
• Samantha Sollima,
• Antonina Azzolina,
• Antonella Cusimano,
• Nicola D’Antona,
• Grazia M. L. Consoli and
• Salvatore Sortino

Beilstein J. Nanotechnol. 2025, 16, 1003–1013, doi:10.3762/bjnano.16.75

• , characterized by the presence of a cavity with remarkable hosting properties and synthetic versatility [1][2][3][4][5]. Water soluble calixarenes can be obtained by the introduction of appropriate hydrophilic moieties in the calixarene molecular scaffold, leading to a good biocompatibility and low

Efficiency of single-pulse laser fragmentation of organic nutraceutical dispersions in a circular jet flow-through reactor

• Tina Friedenauer,
• Maximilian Spellauge,
• Alexander Sommereyns,
• Verena Labenski,
• Tuba Esatbeyoglu,
• Christoph Rehbock,
• Heinz P. Huber and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2025, 16, 711–727, doi:10.3762/bjnano.16.55

• required, especially when processing sensitive nutraceuticals intended for the use as food additives or medical applications. This is complemented by evaluations of the biocompatibility and antioxidant features (i.e., suppression of reactive oxygen species (ROS)) of laser-processed curcumin. Results and

• photomechanical effects is fulfilled, causing shock wave formation. Analogously to our previous works on organic drugs [43] and on inorganic oxide MPs [14], it is again shown that the dominant fragmentation effect is due to photomechanical comminution and that thermal effects are negligible. Biocompatibility and

• biocompatibility. In detail, a threshold viability of 80% was reached at a 1:2560 dilution (0.195 mg·L−1) for the unirradiated sample; the tolerance for the laser-fragmented curcumin samples, however, was ca. 30 times higher even at a lower dilution of 1:160 (6.25 mg·L−1) (Figure 8A). The main difference between

Colloidal few layered graphene–tannic acid preserves the biocompatibility of periodontal ligament cells

• Teissir Ben Ammar,
• Naji Kharouf,
• Dominique Vautier,
• Housseinou Ba,
• Nivedita Sudheer,
• Philippe Lavalle and
• Vincent Ball

Beilstein J. Nanotechnol. 2025, 16, 664–677, doi:10.3762/bjnano.16.51

• . In this context, the incorporation of graphene-based materials into dental biomaterials could offer advantages such as increased mechanical strength. Nevertheless, biocompatibility issues still hinder their adoption. In this study, a biocomposite of few-layered graphene and tannic acid (FLG–TA) was

• , demonstrating no cytotoxicity to periodontal ligament cells up to 200 µg·mL−1 while promoting cellular adhesion and maintaining chromatin integrity. Overall, because of its favorable biocompatibility FLG–TA holds promise as a novel biomaterial for dental applications. Keywords: antioxidant properties

• ; biocompatibility; dental applications; few layered graphene–tannic acid biocomposite (FLG–TA); periodontal ligament cells (PDL); Introduction Dental diseases remain a global health challenge [1]. Dental biomaterials are crucial in both therapeutic and preventive strategies, with nanotechnology emerging as a

Polyurethane/silk fibroin-based electrospun membranes for wound healing and skin substitute applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Muhammad Waqas,
• Ahsan Nazir and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 591–612, doi:10.3762/bjnano.16.46

• silk fibroin (SF) and highlights their benefits as a skin substitute. This review also highlights the electrospinning technique used to prepare nanofibers for these biomedical applications. Silk, well-known for its excellent biocompatibility, biodegradability, structural properties, and low immunogenic

• response, is extensively investigated by addressing its molecular structure, composition, and medical uses. PU is a candidate for potential biomedical applications because of its strength, flexibility, biocompatibility, cell-adhesive properties, and high resistance to biodegradation. PU combined with silk

• , produced by silkworms, beetles, mites, and spiders [14]. Silk is an FDA-approved biomaterial for medical applications [15]. SF has distinctive physical, chemical, and mechanical properties [16]. Its characteristics, including biocompatibility, biodegradability, elasticity, solubility in water, and ease of

Nanomaterials in targeting amyloid-β oligomers: current advances and future directions for Alzheimer's disease diagnosis and therapy

• Shiwani Randhawa,
• Trilok Chand Saini,
• Manik Bathla,
• Rahul Bhardwaj,
• Rubina Dhiman and
• Amitabha Acharya

Beilstein J. Nanotechnol. 2025, 16, 561–580, doi:10.3762/bjnano.16.44

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

• (HE12-Luc-ASO), or (dodecane-co-hexaethylene glycol)-ASO ((HE-HEG)6-Luc-ASO). Linear PEI complexes demonstrated high biocompatibility even at high molecular weights, whereas b-PEI induced significant cytotoxicity. Moreover, the cell-uptake efficiency was improved by increasing the N/P ratio. The

• ) (PAMAM) dendrimers have gained significant attention as a versatile platform for antisense delivery, largely owing to their superior biocompatibility, biodegradability, and ASO-loading capabilities compared to other cationic systems including PEI and PPI dendrimers [141]. Moreover, the presence of

Engineered PEG–PCL nanoparticles enable sensitive and selective detection of sodium dodecyl sulfate: a qualitative and quantitative analysis

• Soni Prajapati and
• Ranjana Singh

Beilstein J. Nanotechnol. 2025, 16, 385–396, doi:10.3762/bjnano.16.29

• and PCL to produce amphiphilic nanoparticles which possess both hydrophilic and hydrophobic segments. PEG, known for its water solubility and biocompatibility, provides the hydrophilic component, while PCL, a biodegradable polyester, contributes with hydrophobicity, enabling the formation of

Development of a mucoadhesive drug delivery system and its interaction with gastric cells

• Ahmet Baki Sahin,
• Serdar Karakurt and
• Deniz Sezlev Bilecen

Beilstein J. Nanotechnol. 2025, 16, 371–384, doi:10.3762/bjnano.16.28

• systems because of their ability to form gel-like structures in the presence of divalent cations such as Ca2+. Despite the advantages of alginate polymer such as its biodegradability, biocompatibility, and gelation ability, its instability, fast wettability, and rapid release at high pH result in the

Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review

• Nur Areisman Mohd Salleh,
• Amalina Muhammad Afifi,
• Fathiah Mohamed Zuki and
• Hanna Sofia SalehHudin

Beilstein J. Nanotechnol. 2025, 16, 286–307, doi:10.3762/bjnano.16.22

• biocompatibility, biodegradability, and similarity to the extracellular matrix (ECM) [101]. Electrospinning pure chitosan without any other precursor material, however, presents significant challenges due to its inherent properties. Chitosan has high viscosity and low solubility in most solvents, and it tends to

• spinnability of fibers by reducing repulsive forces within charged polymer solutions [105]. While PVA nanofibers offer advantages such as ease of fabrication and biocompatibility, applications of single-material PVA nanofibers are usually limited by their poor mechanical properties, high water solubility and

• selecting the plasma source and controlling discharge conditions such as voltage, pressure, and gas flow rate, various functional groups can be introduced on the fiber surface, enabling tailored modifications that enhance polymer biocompatibility. Punamshree et al. [162] performed surface modification of

Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide

• Radmila Milenkovska,
• Nikola Geskovski,
• Dushko Shalabalija,
• Ljubica Mihailova,
• Petre Makreski,
• Dushko Lukarski,
• Igor Stojkovski,
• Maja Simonoska Crcarevska and
• Kristina Mladenovska

Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18

• (i.e., oxidation) of their surface, CNs with optimal hydrophobic/hydrophilic properties and increased dispersibility can be obtained as preconditions for biocompatibility and low immunogenicity. Also, improved electronic, mechanical, and thermal properties as preconditions for (photo)thermal and

• exclude their molecular interactions with the GBM cells and a contribution to the cytotoxicity of the formulations. Despite the evidence for excellent biocompatibility of PEG, there are papers demonstrating that PEG (depending on the molecular weight) may show selective dose- and time-dependent cytostatic

• effect of PEG on cell growth and its biocompatibility by inducing metabolism modulations and survival autophagy through creating an intracellular hypoxic environment. Although there is no consensus on whether the role of folate in cancer cells is protective or harmful, a cytotoxic effect was also

Synthesis and the impact of hydroxyapatite nanoparticles on the viability and activity of rhizobacteria

• Bedah Rupaedah,
• Indrika Novella,
• Atiek Rostika Noviyanti,
• Diana Rakhmawaty Eddy,
• Anna Safarrida,
• Abdul Hapid,
• Zhafira Amila Haqqa,
• Suryana Suryana,
• Irwan Kurnia and
• Fathiyah Inayatirrahmi

Beilstein J. Nanotechnol. 2025, 16, 216–228, doi:10.3762/bjnano.16.17

• microorganisms. Nanomaterials, particularly nanohydroxyapatite (nHA), have garnered attention for sustaining rhizobacterial viability, high loading capacity, high biodegradability, and biocompatibility, which facilitate microbial interactions. In this study, nHA was synthesized using a hydrothermal method and

• , biocompatibility, and the ability to absorb organic substances [20][21]. Furthermore, nHA possesses the unique ability to be resorbed within physiological environments while remaining non-toxic, a feature that holds significant promise for synergistic interactions with microorganisms and biological molecules [22

Recent advances in photothermal nanomaterials for ophthalmic applications

• Jiayuan Zhuang,
• Linhui Jia,
• Chenghao Li,
• Rui Yang,
• Jiapeng Wang,
• Wen-an Wang,
• Heng Zhou and
• Xiangxia Luo

Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16

• , including exceptional biocompatibility, biodegradability, wide availability, low cost, and a highly tunable structure, making them well-suited for such uses [67][68][69][70][71]. 2.3 Inorganic semiconductor materials Inorganic semiconductor materials, such as TiO2, SiO2, and Fe2O3, possess conductivity

• synthesis of AuNPs and served as a surface coating for AuNPs, promoting the coupling of DOX, enhancing anti-tumor activity, and improving the biocompatibility of AuNPs. The significant extinction coefficient of these nanoparticles enhances the contrast in photoacoustic imaging within the tumor region

• therapeutic effects in humans [213]. The safety profile of photothermal nanomaterials is influenced by various factors, including their morphology, structure, concentration, photothermal stability, mechanical strength, and surface chemistry [214]. Enhancements in biocompatibility and stability can be achieved

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

• Naths Grazia Sukubo,
• Paolo Bigini and
• Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

Mechanistic insights into endosomal escape by sodium oleate-modified liposomes

• Ebrahim Sadaqa,
• Satrialdi,
• Fransiska Kurniawan and
• Diky Mudhakir

Beilstein J. Nanotechnol. 2024, 15, 1667–1685, doi:10.3762/bjnano.15.131

• , respectively, demonstrating a dose-dependent cytotoxic effect at elevated lipid concentrations. SO-Lipo displayed a similar trend, maintaining non-significant cytotoxicity from 15.625 to 250 µM (p > 0.05), supporting the biocompatibility of the SO modification at lower concentrations. A noticeable reduction in