Extracellular biosynthesis of gadolinium oxide (Gd₂O₃) nanoparticles, their biodistribution and bioconjugation with the chemically modified anticancer drug taxol

• Shadab Ali Khan,
• Sanjay Gambhir and
• Absar Ahmad

Beilstein J. Nanotechnol. 2014, 5, 249–257, doi:10.3762/bjnano.5.27

• extended the work of biosynthesis of Gd2O3 nanoparticles to bioconjugation with taxol. Bioconjugation of taxol with gold and iron oxide nanoparticles has also been reported [15][16]. Taxol is one of the most important anticancer drugs used for breast, ovarian and lung cancers [17][18]. The potent

• fungus Humicola sp. was cultured and maintained by us as described previously [21]. Biosynthesis of gadolinium oxide nanoparticles The harvested mycelial mass weighing 20 g [21] was suspended in 100 mL of 10−3 M aqueous gadolinium chloride solution in a 250 mL Erlenmeyer flask at pH 9. The whole mixture