Preparation of alginate–chitosan–cyclodextrin micro- and nanoparticles loaded with anti-tuberculosis compounds

• Albert Ivancic,
• Fliur Macaev,
• Fatma Aksakal,
• Veaceslav Boldescu,
• Serghei Pogrebnoi and
• Gheorghe Duca

Beilstein J. Nanotechnol. 2016, 7, 1208–1218, doi:10.3762/bjnano.7.112

• , 41400, Turkey 10.3762/bjnano.7.112 Abstract This paper describes the synthesis and application of alginate–chitosan–cyclodextrin micro- and nanoparticulate systems loaded with isoniazid (INH) and isoconazole nitrate (ISN) as antimycobacterial compounds. Preparation and morphology of the obtained

• density distribution. It has been detected that alginate–chitosan–cyclodextrin microparticulate systems loaded with INH and ISN are as effective as pure INH applied in higher dosages. Keywords: chitosan; β-cyclodextrin; density functional theory (DFT); isoconazole; isoniazid; molecular docking

• quantity of the administered drugs, and to avoid first-pass effects and to reduce the side effects, various different micro- and nanoparticle-based alginate–chitosane–cyclodextrin systems loaded with antituberculosis drugs for nebulisation have been proposed. Similar systems have been shown effective for

Gold nanoparticles covalently assembled onto vesicle structures as possible biosensing platform

• M. Fátima Barroso,
• M. Alejandra Luna,
• Juan S. Flores Tabares,
• Cristina Delerue-Matos,
• N. Mariano Correa,
• Fernando Moyano and
• Patricia G. Molina

Beilstein J. Nanotechnol. 2016, 7, 655–663, doi:10.3762/bjnano.7.58

• per-6-thio-β-cyclodextrin accomplished via covalent gold–thiol bonds [10]. These AuNPs provide an excellent platform for drug delivery due to the functional versatility of their monolayers. The vesicles with AuNPs are suitable for applications such as transport inside cells [11], photodynamic

Rigid multipodal platforms for metal surfaces

• Michal Valášek,
• Marcin Lindner and
• Marcel Mayor

Beilstein J. Nanotechnol. 2016, 7, 374–405, doi:10.3762/bjnano.7.34

• ], ß-cyclodextrin-based [119][120][121][122][123] thiols 25 and sufides 26, as well as other thiol-terminated dendrimers 27–28 [104][124]. Although this multipodal approach with several anchoring points enhanced the stability of some of these platforms on gold, the self-assembled monolayers are

• typically poorly ordered due to the presence of long alkyl chains as revealed by IR spectroscopy analysis of ß-cyclodextrin and resorcin[4]arene scaffolds. Substitution of these platforms with long dialkylsulfides with a lower affinity to gold improved the lateral mobility of monolayers. The increased

Optimized design of a nanostructured SPCE-based multipurpose biosensing platform formed by ferrocene-tethered electrochemically-deposited cauliflower-shaped gold nanoparticles

• Wicem Argoubi,
• Maroua Saadaoui,
• Sami Ben Aoun and
• Noureddine Raouafi

Beilstein J. Nanotechnol. 2015, 6, 1840–1852, doi:10.3762/bjnano.6.187

• that were tethered with a β-cyclodextrin/ferrocene inclusion complex as a transducing system. Connection between gold and the ferrocene host was achieved thanks to a thiol terminal group [13]. The ferrocene complex acted as an electron shuttle allowing for glucose oxidation at low potentials. Li et al

Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages

• Dagmar A. Kuhn,
• Dimitri Vanhecke,
• Benjamin Michen,
• Fabian Blank,
• Peter Gehr,
• Alke Petri-Fink and
• Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2014, 5, 1625–1636, doi:10.3762/bjnano.5.174

• , fluorescently labelled transferrin can be used to investigate clathrin-mediated endocytosis [32][41][42]. Caveolae and lipid raft internalizations are known to be inhibited by nystatin, filipin and methyl-β-cyclodextrin (mβcd) through depletion of the cholesterol from the cell membrane by forming inclusion

• (Dansylcadaverine, D4008, Sigma-Aldrich). Inhibition of caveolin-mediated endocytosis was performed in both cell lines using 10 mM methyl-β-cyclodextrin (mβcd) (C4555, Sigma-Aldrich). A 4 µM cytochalasin D (C8273, Sigma-Aldrich) solution was used to inhibit phagocytosis and macropinocytosis in both cell lines. Cell

• monodansylcadaverine (mdc) in J774A.1 cells and methyl-β-cyclodextrin (mβcd) in A549 cells. (D) Negative control. (E–G) Uptake of 1 µm PS particles (particles: green, cytosol: grey). (E) Untreated cells with 1 µm particles. (F–G) 1 µm particles with the same adequate inhibitors. Scale bar: 5 µm. White arrows represent

PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system

• Paula M. Castillo,
• Mario de la Mata,
• Maria F. Casula,
• José A. Sánchez-Alcázar and
• Ana P. Zaderenko

Beilstein J. Nanotechnol. 2014, 5, 1312–1319, doi:10.3762/bjnano.5.144

• by means of nano-formulations cover a wide range of organic nanomaterials [11][12][13][14][15][16][17][18][19]. Noticeably, a cyclodextrin-containing polymer–CPT nano-formulation is currently undergoing phase II clinical trials [20]. Superparamagnetic iron oxide nanoparticles (SPION) are particularly

Cyclodextrin-poly(ε-caprolactone) based nanoparticles able to complex phenolphthalein and adamantyl carboxylate

• Daniela Ailincai and
• Helmut Ritter

Beilstein J. Nanotechnol. 2014, 5, 651–657, doi:10.3762/bjnano.5.76

• Chemie, Geb. 26.33, Eb. 00, Universitätsstr. 1, 40225 Düsseldorf, Germany 10.3762/bjnano.5.76 Abstract A new compound composed of poly(ε-caprolactone) and β-cyclodextrin (β-CD) was synthesized by click chemistry. This compound was used to obtain stable nanoparticles, which have been proven to be able to

• phase, which may serve as an example for the uptake of a drug. The formed nanoparticles were characterized in terms of sizes and morphology by both DLS and TEM. Keywords: click reaction; complexation; cyclodextrin; encapsulation; nanoparticles; Introduction The development of new nanoscale systems for

• phenolphthalein is included in the hydrophobic cavity of β-cyclodextrin (Figure 6b) and the suspension changes its color from pink in white (Figure 5). The affinity of adamantyl carboxylate to β-cyclodextrin is higher than of phenolphthalein to β-cyclodextrin. Thus, the addition of adamantyl carboxylate results

One pot synthesis of silver nanoparticles using a cyclodextrin containing polymer as reductant and stabilizer

• Arkadius Maciollek and
• Helmut Ritter

Beilstein J. Nanotechnol. 2014, 5, 380–385, doi:10.3762/bjnano.5.44

• using silver nitrate and a copolymer 1 from N-isopropylacrylamide (NIPAM) and mono-(1H-triazolylmethyl)-2-methylacryl-β-cyclodextrin acting as reductant and stabilizer without using any additional reducing agent is reported. The reduction was carried out in aqueous solution under pH neutral conditions

• period of several weeks. Furthermore the changes in the optical properties of the nanoparticles due to thermo induced volume phase transition behavior of the thermoresponsive cyclodextrin containing polymer 1 have been characterized by UV–vis spectroscopy. Keywords: cyclodextrin; polymer; silver

• environmental and biological risky reducing agents and solvents such as sodium borohydride, hydrazine or dimethylformamide. Consequently, the interest in a green nanoparticle synthesis using natural reducing agents like saccharides or cyclodextrin (CD) in environmentally benign solvents increased [9][10][11][12

Self-assembled monolayers and titanium dioxide: From surface patterning to potential applications

• Yaron Paz

Beilstein J. Nanotechnol. 2011, 2, 845–861, doi:10.3762/bjnano.2.94