Microneedle-based ocular drug delivery systems – recent advances and challenges

• Piotr Gadziński,
• Anna Froelich,
• Monika Wojtyłko,
• Antoni Białek,
• Julia Krysztofiak and
• Tomasz Osmałek

Beilstein J. Nanotechnol. 2022, 13, 1167–1184, doi:10.3762/bjnano.13.98

• vascular endothelium with tight junctions hampering the permeation of active ingredients to the intraocular area. When designing non-invasive ophthalmic drug dosage forms, the main aim is to improve the bioavailability by increasing the diffusion across sclera, cornea, and conjunctiva [42]. In the case of

• microneedle patches, their manufacturing techniques, and the obtained therapeutic efficacy. In addition to a number of advantages, the questionable aspects related to this dosage form are also discussed. 2 Types of microneedle: materials, fabrication and properties for drug delivery 2.1 Microneedle system

• left to dry afterwards. The drying procedure can be accelerated with the aid of gas-jet drying. Another technique involves spray coating, which is technologically similar to the coating of oral solid dosage forms. Electrohydrodynamic atomisation (EHDA), in which electrically charged droplets are

Rapid fabrication of MgO@g-C₃N₄ heterojunctions for photocatalytic nitric oxide removal

• Minh-Thuan Pham,
• Duyen P. H. Tran,
• Xuan-Thanh Bui and
• Sheng-Jie You

Beilstein J. Nanotechnol. 2022, 13, 1141–1154, doi:10.3762/bjnano.13.96

• the dosage of catalysts was 0.2 g for all experiments. Before each catalytic experiment, 0.2 g of the sample was dispersed in 10 mL of DI water, evaporated at 80 °C, and placed in the dark to achieve adsorption–desorption equilibrium. Finally, the sample was illuminated by a Xenon lamp (300 W) for 30

Solar-light-driven LaFe_xNi_1−xO₃ perovskite oxides for photocatalytic Fenton-like reaction to degrade organic pollutants

• Chao-Wei Huang,
• Shu-Yu Hsu,
• Jun-Han Lin,
• Yun Jhou,
• Wei-Yu Chen,
• Kun-Yi Andrew Lin,
• Yu-Tang Lin and
• Van-Huy Nguyen

Beilstein J. Nanotechnol. 2022, 13, 882–895, doi:10.3762/bjnano.13.79

• , such as pH value, catalyst dosage, and the additional amount of H2O2. LaFe0.7Ni0.3O3 perovskite oxides could operate efficiently under pH 3.5, catalyst dosage of 50 mg/150 mL, and H2O2 concentration of 133 ppm to decompose the MB dye in the 1st order kinetic rate constant of 0.0506 s−1. Keywords

• availability of light energy was reduced, resulting in a reduction of the photocatalytic degradation capability [30]. Accordingly, the degradation performance was calculated by the 1st order kinetics, as shown in Figure 11b. It could be known that when the catalyst dosage was 30 mg (200 ppm), 50 mg (333 ppm

• ), 80 mg (533 ppm), and 100 mg (666 ppm), their reaction rate constants k were 0.007, 0.0242, 0.0314, and 0.0506, respectively. Therefore, the pH of the solution was 3.5, and the catalyst dosage was 50 mg for the following examination. Moreover, the amount of hydrogen peroxide added was manipulated in

Hierarchical Bi₂WO₆/TiO₂-nanotube composites derived from natural cellulose for visible-light photocatalytic treatment of pollutants

• Zehao Lin,
• Zhan Yang and
• Jianguo Huang

Beilstein J. Nanotechnol. 2022, 13, 745–762, doi:10.3762/bjnano.13.66

• nanocomposites deliver higher Kapp values and larger increments as compared to pure TiO2 under more rigorous conditions of visible-light (λ > 420 nm) irradiation and lower dosage of photocatalyst toward the reduction of Cr(VI) or degradation of RhB. The excellent photocatalytic activities of hierarchical Bi2WO6

Photothermal ablation of murine melanomas by Fe₃O₄ nanoparticle clusters

• Xue Wang,
• Lili Xuan and
• Ying Pan

Beilstein J. Nanotechnol. 2022, 13, 255–264, doi:10.3762/bjnano.13.20

• effects of alumina-coated Fe3O4 nanoparticles against bacteria upon exposure to NIR light [13]. Further studies with esophageal cancer demonstrate that Fe3O4 nanoparticles induce hyperthermia post absorption to suppress tumor growth in a dosage-dependent manner [14]. However, due to very high dosage

• needed to elicit sufficient hyperthermia by NIR irradiation, lingering magnetite may impose potential systemic toxicity. Thus, Fe3O4 single nanoparticles must be modified to reduce the dosage while keeping their therapeutic efficacy. In our earlier report, we synthesized Fe3O4 nanoparticle-containing

• photothermal effect was dosage-dependent, because NPCs at higher concentrations performed markedly better than at lower ones (Figure 2a). Importantly, at concentrations as low as 0.0615 mg/mL, Fe3O4 NPCs rapidly and significantly raised the solution temperature after NIR irradiation in only 1 min at a power

Engineered titania nanomaterials in advanced clinical applications

• Padmavati Sahare,
• Paulina Govea Alvarez,
• Juan Manual Sanchez Yanez,
• Gabriel Luna-Bárcenas,
• Samik Chakraborty,
• Sujay Paul and
• Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

• therapeutic index. The use of nanomaterials has increased nowadays for more specific drug targeting and delivery, slowing down the dissolution rate of drugs, increasing therapeutic efficacy with the minimum dosage, and also by ceasing the premature loss of drugs through rapid clearance. Additionally, the

• are the cell key energy centers and are extremely sensitive to heat shock, they contribute to apoptotic cell death by generating ROS. As a result, by lowering the intensity of laser power and dosage, mitochondria-targeted PDT and PTT would provide better results. In the study of Mou and co-workers, a

• NIR laser irradiation at a far lower power density and low intravenous dosage. Phototoxicity essays of G-TiO2−x on HeLa cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) showed 85% cell viability, confirming that G-TiO2−x itself is non-toxic even at higher concentrations

A comprehensive review on electrospun nanohybrid membranes for wastewater treatment

• Senuri Kumarage,
• Imalka Munaweera and
• Nilwala Kottegoda

Beilstein J. Nanotechnol. 2022, 13, 137–159, doi:10.3762/bjnano.13.10

• mixture of PVA, sodium alginate, and PEO with incorporated nano-sized ZSM5 zeolite, which contains hydroxy functional groups (HZSM5). The maximum adsorption values of Th4+ and U6+ ions were found to be 274.6 and 144.7 mg/g, respectively, at a HZSM5 content of 10 wt %, an adsorbent dosage of 1 g/L, and pH

Identifying diverse metal oxide nanomaterials with lethal effects on embryonic zebrafish using machine learning

• Richard Liam Marchese Robinson,
• Haralambos Sarimveis,
• Philip Doganis,
• Xiaodong Jia,
• Marianna Kotzabasaki,
• Christiana Gousiadou,
• Stacey Lynn Harper and
• Terry Wilkins

Beilstein J. Nanotechnol. 2021, 12, 1297–1325, doi:10.3762/bjnano.12.97

• . This entailed (i) allowing for the inclusion of minimally doped ENMs, (ii) allowing for the selection of ENMs with missing numerical characterisation data used as input variables to the original, multi-descriptor models, and (iii) allowing for the selection of materials tested at maximum dosage

Self-assembly of amino acids toward functional biomaterials

• Huan Ren,
• Lifang Wu,
• Lina Tan,
• Yanni Bao,
• Yuchen Ma,
• Yong Jin and
• Qianli Zou

Beilstein J. Nanotechnol. 2021, 12, 1140–1150, doi:10.3762/bjnano.12.85

• metallohydrogels showed fewer toxicological side effects and were highly biocompatible than Ag+ in the administered dosage range. Furthermore, Fmoc-amino acid metallohydrogels tested under the same conditions showed significantly better wound healing than silver sulfadiazine cream and the control group. It has

pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages

• Karishma Berta Cotta,
• Sarika Mehra and
• Rajdip Bandyopadhyaya

Beilstein J. Nanotechnol. 2021, 12, 1127–1139, doi:10.3762/bjnano.12.84

• the intracellular drug concentration in macrophages (having engulfed pathogens, like Mycobacterium) results in high drug dosage requirement for the pathogen clearance. This is a major hurdle in tuberculosis treatment. In turn, a high dosage causes toxic side effects from either the drug or the carrier

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• only a particular tissue or organ may not be entirely feasible, thereby causing dosage uncertainties when administering the treatment, which should be taken into account. Thus, there is still room to improve these types of nanosystems, and/or to develop additional ones [42]. Conventional nanosystems

• , instability at a physiological pH, and rapid metabolization [52]. Although nanocrystals make it possible to improve the solubility of CUR, it has been reported that this type of nanosystem can have certain stability problems, which may compromise the ability to ensure a consistent dosage [53]. Nanococrystals

An overview of microneedle applications, materials, and fabrication methods

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2021, 12, 1034–1046, doi:10.3762/bjnano.12.77

• their high cost and fabrication difficulties, simpler solid microneedles coated with drugs are currently attracting more attention for drug delivery. However, this design will not be suitable for extracting biological fluids. In addition, controlling the dosage of drugs for delivery will be limited by

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

Rapid controlled synthesis of gold–platinum nanorods with excellent photothermal properties under 808 nm excitation

• Jialin Wang,
• Qianqian Duan,
• Min Yang,
• Boye Zhang,
• Li Guo,
• Pengcui Li,
• Wendong Zhang and
• Shengbo Sang

Beilstein J. Nanotechnol. 2021, 12, 462–472, doi:10.3762/bjnano.12.37

• of the Au@Pt NRs close to 808 nm is desirable. The optimized final dosage of each reagent and the experimental procedure are described in detail in part Experimental. What we want to emphasize here is that the synthesis only takes 3 h at 40 °C without the need for elaborate instrumentation. The

A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization

• Gabriel M. Misirli,
• Kishore Sridharan and
• Shirley M. P. Abrantes

Beilstein J. Nanotechnol. 2021, 12, 440–461, doi:10.3762/bjnano.12.36

• , hematological, urinary, physical, or morphological findings. Further studies, however, are needed to observe the threshold toxicity in other human organs upon increasing dosage and time exposure to AgNPs [130]. The toxicity of AgNPs has been evaluated in several studies; however, only a few researchers

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

• regimens, which simply combine different drugs in a conventional dosage form, are far from a perfect chemotherapy approach for leukemia patients. It is logical to assume that loading multiple drugs onto a single nanoscale carrier will synchronize the corresponding therapeutic activities, thus maximizing

Exploring the fabrication and transfer mechanism of metallic nanostructures on carbon nanomembranes via focused electron beam induced processing

• Christian Preischl,
• Linh Hoang Le,
• Elif Bilgilisoy,
• Armin Gölzhäuser and
• Hubertus Marbach

Beilstein J. Nanotechnol. 2021, 12, 319–329, doi:10.3762/bjnano.12.26

• satisfying results [4][9]. However, for certain precursors, EBID yields clean deposits when carried out under ultrahigh vacuum (UHV) conditions. It was shown that in UHV, for some precursors, an autocatalytic growth (AG) process occurs already at room temperature, which leads, upon further precursor dosage

• exploits the AG process [11]. In EBISA, the surface is, in a first step, irradiated and chemically modified without precursor dosage. In a second “development” step, a well-defined deposit is formed at the chemically activated sites, as the precursor is dosed and dissociates locally. Of course, for EBISA a

• the precursor molecules (Figure 1d). Assuming that the two described methods are effective, an initial well-defined local deposit is formed in both cases (Figure 1e). Upon further precursor dosage, the AG process occurs and leads to further agglomeration of material on top of the initial deposit

TiO_x/Pt₃Ti(111) surface-directed formation of electronically responsive supramolecular assemblies of tungsten oxide clusters

• Marco Moors,
• Yun An,
• Agnieszka Kuc and
• Kirill Yu. Monakhov

Beilstein J. Nanotechnol. 2021, 12, 203–212, doi:10.3762/bjnano.12.16

• different surface coverages. While the rectangular z’-TiOx phase is a typical island structure, whose number and size increase with the oxygen dosage, the hexagonal w’-TiOx phase always covers the entire surface. In the latter case, the surface stress would be too high to engage the usually favored

Unravelling the interfacial interaction in mesoporous SiO₂@nickel phyllosilicate/TiO₂ core–shell nanostructures for photocatalytic activity

• Bridget K. Mutuma,
• Xiluva Mathebula,
• Isaac Nongwe,
• Bonakele P. Mtolo,
• Boitumelo J. Matsoso,
• Rudolph Erasmus,
• Zikhona Tetana and
• Neil J. Coville

Beilstein J. Nanotechnol. 2020, 11, 1834–1846, doi:10.3762/bjnano.11.165

• /TiO2 composite for MV degradation was superior to that of other related materials reported in the literature (Table 2) [18][74][75][76][77][78][79][80]. In addition, it was possible to achieve higher photodegradation efficacies at a lower catalyst dosage and within shorter irradiation times. Conclusion

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

• Maria Suciu,
• Corina M. Ionescu,
• Alexandra Ciorita,
• Septimiu C. Tripon,
• Dragos Nica,
• Hani Al-Salami and
• Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

• very important for medical applications. These properties depend on the methods used, targeted organs/tissues, image resolution, administration way and dosage, and toxicity [116]. Fakhar-e-Alam and collaborators [117] observed that above a certain dose cancer cells develop a resistance to ligand

• ]. Therefore, the cytotoxic reaction of the target cells to SPIONs still requires further examination. Cationic ethylamine-SPIONs of ultrasmall dimensions showed improved relaxivity values (at smaller dosage) compared to some of the commercial iron oxides, good renal clearance and no toxicity to rats [157

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

Synthesis and enhanced photocatalytic performance of 0D/2D CuO/tourmaline composite photocatalysts

• Changqiang Yu,
• Min Wen,
• Zhen Tong,
• Shuhua Li,
• Yanhong Yin,
• Xianbin Liu,
• Yesheng Li,
• Tongxiang Liang,
• Ziping Wu and
• Dionysios D. Dionysiou

Beilstein J. Nanotechnol. 2020, 11, 407–416, doi:10.3762/bjnano.11.31

• product was named CuO/tourmaline-1:1 (1:1 in mass ratio of the CuO/tourmaline). By controlling the dosage of Cu(CH3COO)2·H2O and NaOH in proportion the CuO/tourmaline composites in different mass ratios of the CuO/tourmaline were acquired. Characterization X-ray diffraction (XRD) patterns were obtained

Phase inversion-based nanoemulsions of medium chain triglyceride as potential drug delivery system for parenteral applications

• Eike Folker Busmann,
• Dailén García Martínez,
• Henrike Lucas and
• Karsten Mäder

Beilstein J. Nanotechnol. 2020, 11, 213–224, doi:10.3762/bjnano.11.16

• 0.02–0.23. Increasing the mass share of the surfactant Kolliphor HS 15 led to smaller particles and narrower PDI distributions. Influence of the nonionic surfactant Kolliphor HS 15 on the osmolality The osmolality is an important parameter of the toxicity of parenteral dosage forms. The ideal

Frontiers in pharmaceutical nanotechnology

• Matthias G. Wacker

Beilstein J. Nanotechnol. 2019, 10, 2538–2540, doi:10.3762/bjnano.10.244

• science. They have fundamentally changed our understanding of the way dosage forms can facilitate drug therapy. Prof. Jörg Kreuter has been a pioneer in this research area and dedicated his life’s work to nanoparticle research and the blood–brain barrier [2]. One of his most outstanding discoveries, the

Air oxidation of sulfur mustard gas simulants using a pyrene-based metal–organic framework photocatalyst

• Ghada Ayoub,
• Mihails Arhangelskis,
• Xuan Zhang,
• Florencia Son,
• Timur Islamoglu,
• Tomislav Friščić and
• Omar K. Farha

Beilstein J. Nanotechnol. 2019, 10, 2422–2427, doi:10.3762/bjnano.10.232

• ; photocatalysis; singlet oxygen; sulfur mustard gas; Introduction Sulfur mustard gas also known as mustard gas, HD, or Yperite belongs to a class of chemical warfare agents (CWAs) known as vesicants, which have detrimental effects on humans, including the blistering of skin upon contact [1]. Even at a low dosage