The distribution and degradation of radiolabeled superparamagnetic iron oxide nanoparticles and quantum dots in mice

• Denise Bargheer,
• Artur Giemsa,
• Barbara Freund,
• Markus Heine,
• Christian Waurisch,
• Gordon M. Stachowski,
• Stephen G. Hickey,
• Alexander Eychmüller,
• Jörg Heeren and
• Peter Nielsen

Beilstein J. Nanotechnol. 2015, 6, 111–123, doi:10.3762/bjnano.6.11

• sensitivity in insulin-dependent cells [27]. In this model, after interaction, Cr3+ would be excreted via the kidneys and replaced by freshly absorbed Cr [28]. As shown here by the 51Cr-WBR over 28 d, the excretion of 51Cr via the kidneys and gastrointestinal tract is rather slow when using 51Cr-SPIOs and

• very different from 51CrCl3 (Figure 4). Excretion of 51Cr from SPIOs was found mostly in feces and very little in urine (data not shown). After 4 weeks, a small loss of 51Cr from the liver seems to be distributed mainly to the spleen, gastrointestinal tract (GIT), and carcass, whereas from CrCl3, 51Cr

• elegantly used to study the absorption of intact nanoparticles from the gastrointestinal tract, an important topic in nanotoxicology. For this, 59Fe-labeled SPIOs were given by gavage to groups of mice and the 59Fe-WBR was followed in living mice for 14 d using a whole body counter (Figure 5A). Most of the

Functionalized polystyrene nanoparticles as a platform for studying bio–nano interactions

• Cornelia Loos,
• Tatiana Syrovets,
• Anna Musyanovych,
• Volker Mailänder,
• Katharina Landfester,
• G. Ulrich Nienhaus and
• Thomas Simmet

Beilstein J. Nanotechnol. 2014, 5, 2403–2412, doi:10.3762/bjnano.5.250

• et al. is 300 ppm (1,000 µg/m3) [9]. If the level of styrene in the air exceeds this value, there is a possibility of adverse health effects. Among others, the EPA has declared styrene as a suspected carcinogen and a suspected toxin to the gastrointestinal tract, kidney, and respiratory system [10

Coating with luminal gut-constituents alters adherence of nanoparticles to intestinal epithelial cells

• Heike Sinnecker,
• Katrin Ramaker and
• Andreas Frey

Beilstein J. Nanotechnol. 2014, 5, 2308–2315, doi:10.3762/bjnano.5.239

• NP uptake. Considering that NPs are covered by luminal gut-constituents en route through the gastrointestinal tract, we wanted to know if such modifications have an influence on the interaction between NPs and enterocytes. Results: We investigated the consequences of a treatment with various luminal

The gut wall provides an effective barrier against nanoparticle uptake

• Heike Sinnecker,
• Thorsten Krause,
• Sabine Koelling,
• Ingmar Lautenschläger and
• Andreas Frey

Beilstein J. Nanotechnol. 2014, 5, 2092–2101, doi:10.3762/bjnano.5.218

• gastrointestinal tract represents an attractive site of entry, we wanted to take a look on the fate that ingested NPs suffer in the gut. As a model to investigate NP uptake we used the isolated perfused rat small intestine. Differently sized fluorescent latex particles were used as exemplary anthropogenic NPs

• absorbed via the gastrointestinal tract. This is in line, e.g., with a case report in which after chronic inhalation of carbon NPs from toner dust, no respiratory symptoms were reported, but deposition of carbon NPs in the peritoneum were found and the person developed weight loss and diarrhea [12]. In

In vitro and in vivo interactions of selected nanoparticles with rodent serum proteins and their consequences in biokinetics

• Wolfgang G. Kreyling,
• Stefanie Fertsch-Gapp,
• Martin Schäffler,
• Blair D. Johnston,
• Nadine Haberl,
• Christian Pfeiffer,
• Jörg Diendorf,
• Carsten Schleh,
• Stephanie Hirn,
• Manuela Semmler-Behnke,
• Matthias Epple and
• Wolfgang J. Parak

Beilstein J. Nanotechnol. 2014, 5, 1699–1711, doi:10.3762/bjnano.5.180

• biodistributed within and out of the body. The analysis of quantitative biokinetics can be performed after the NP administration by any route of intake, via the respiratory tract, the gastrointestinal tract, the blood circulation or the skin. Basically, the total amount of particles administered and retained in

The protein corona protects against size- and dose-dependent toxicity of amorphous silica nanoparticles

• Dominic Docter,
• Christoph Bantz,
• Dana Westmeier,
• Hajo J. Galla,
• Qiangbin Wang,
• James C. Kirkpatrick,
• Peter Nielsen,
• Michael Maskos and
• Roland H. Stauber

Beilstein J. Nanotechnol. 2014, 5, 1380–1392, doi:10.3762/bjnano.5.151

• interface in general. Keywords: biobarrier; gastrointestinal tract; high-throughput profiling; nanomedicine; nanotoxicity; Introduction Besides the wide use of nanomaterials in industrial products, biomedical applications of nanoparticles (NP) are steadily increasing [1][2][3][4][5]. However, despite

Mimicking exposures to acute and lifetime concentrations of inhaled silver nanoparticles by two different in vitro approaches

• Fabian Herzog,
• Kateryna Loza,
• Sandor Balog,
• Martin J. D. Clift,
• Matthias Epple,
• Peter Gehr,
• Alke Petri-Fink and
• Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2014, 5, 1357–1370, doi:10.3762/bjnano.5.149

• interaction with Ag NPs can occur through the lung, skin, gastrointestinal tract, and bloodstream. However, the inhalation of Ag NP aerosols is a primary concern. To study the possible effects of inhaled Ag NPs, an in vitro triple cell co-culture model of the human alveolar/airway barrier (A549 epithelial

• been demonstrated [11]. Therefore, the effects of Ag NPs on human health and the environment are currently increasingly explored [12]. Human interaction with Ag NPs can occur through the lung, skin, gastrointestinal tract, and bloodstream. However, inhalation of Ag NPs is a primary concern for humans