Beilstein J. Nanotechnol.2015,6, 84–102, doi:10.3762/bjnano.6.9
composites in the presence and absence of a magnetic field [84]. The BNNT–NaGdF4:Eu composites simultaneously show fluorescent and magnetic properties. Thus, imaging and targeting of the composites can be more easily achieved. Human LNCaP prostatecancer cells were treated with the BNNT–NaGdF4:Eu composites
in the presence and absence of a magnetic field and higher cell-associated uptake was found in the presence of a magnetic field. Then, the composites were loaded with doxorubicin (dox) to investigate the viability of LNCaP prostatecancer cells in the magnetic field. It was found that dox-loaded BNNT
pH dependent and both negatively and positively charged structures had the same dox loading capacity. The BNNT–MS–NH2 had higher uptake potential in LNCaP prostatecancer cells due to its charge. Thus, it had a higher toxicity towards LNCaP prostatecancer cells. It was concluded that the prepared
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Figure 1:
SEM images of BNNTs grown based on a CVD method. (a) Experimental setup, (b) stretching of dense BN...
Beilstein J. Nanotechnol.2014,5, 937–945, doi:10.3762/bjnano.5.107
delivery system for bone metastatic prostatecancer was developed, characterized, and evaluated in vitro. NDs were conjugated with the Asp–Gly–Glu–Ala (DGEA) peptide to target α2β1 integrins over-expressed in prostate cancers during metastasis. To facilitate drug delivery, DOX was adsorbed to the surface
; doxorubicin; nanodiamond; prostatecancer; targeted drug delivery; Introduction
Prostatecancer is the most frequently diagnosed malignancy in men [1]. Typically the disease is slow growing, but in some cases it progresses to an aggressively metastatic state. When prostatecancer becomes metastatic, the
current standard of care is chemotherapy, which involves the use of toxic anticancer drugs, like doxorubicin (DOX), to treat cancers by inducing apoptosis. DOX has had high success rates with treating prostatecancer [2]. However, it can cause major side effects such as hair loss, nausea [2][3], and
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Scheme 1:
Nanodiamond-DGEA peptide conjugation. The carbodiimide reaction used EDAC and sulfo NHS to form a s...