PEG/PEI-functionalized single-walled carbon nanotubes as delivery carriers for doxorubicin: synthesis, characterization, and in vitro evaluation

• Shuoye Yang,
• Zhenwei Wang,
• Yahong Ping,
• Yuying Miao,
• Yongmei Xiao,
• Lingbo Qu,
• Lu Zhang,
• Yuansen Hu and
• Jinshui Wang

Beilstein J. Nanotechnol. 2020, 11, 1728–1741, doi:10.3762/bjnano.11.155

• modification with PEG or PEI [40]. It should be noted that LE and EE of CNT carriers in this study are higher than those of other nanocarriers such as mesoporous silica nanoparticles (MSNs) or liposomes [39]. In vitro drug release Due to the encapsulation in the nanocarriers after drug loading, a premature

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

• Matías Guerrero Correa,
• Fernanda B. Martínez,
• Cristian Patiño Vidal,
• Camilo Streitt,
• Juan Escrig and
• Carol Lopez de Dicastillo

Beilstein J. Nanotechnol. 2020, 11, 1450–1469, doi:10.3762/bjnano.11.129

• by using a 60 mg mL−1 SPION solution and applying an alternating current for 8 min. Silica- and carbon-derived nanoparticles Over the last years, several studies have revealed that silica nanoparticles are excellent antimicrobial metal-releasing systems due to their high chemical and thermal

• synthesis method, which is attracting much attention lately due to its reduced environmental impact. Most nanoparticles are based on metal and metal-oxide compounds, and the strategies used to control their delivery and to increase their antimicrobial activity have been related to the use of silica

• nanoparticles in their manufacturing process. Although the oxidative stress is the main mechanism by which the nanoparticles can eliminate microorganisms, other processes may be intimately related to the NP antimicrobial activity. The information presented in this work encourages the search for new

A novel dry-blending method to reduce the coefficient of thermal expansion of polymer templates for OTFT electrodes

• Xiangdong Ye,
• Bo Tian,
• Yuxuan Guo,
• Fan Fan and
• Anjiang Cai

Beilstein J. Nanotechnol. 2020, 11, 671–677, doi:10.3762/bjnano.11.53

• the influence of fullerene (C60) on the CTE of Araldite LY 5052/Aradur HY 5052 cross-linked epoxy resin by molecular dynamics simulations. The CTE was minimized by adding a maximum of 15.9 wt % fullerene to the LY/HY/C60 epoxy system. Liu et al. [14] selected MCM-41 mesoporous silica nanoparticles

Identification of physicochemical properties that modulate nanoparticle aggregation in blood

• Ludovica Soddu,
• Duong N. Trinh,
• Eimear Dunne,
• Dermot Kenny,
• Giorgia Bernardini,
• Ida Kokalari,
• Arianna Marucco,
• Marco P. Monopoli and
• Ivana Fenoglio

Beilstein J. Nanotechnol. 2020, 11, 550–567, doi:10.3762/bjnano.11.44

• causing both pro- and anti-coagulant properties. There is contrasting evidence on how the physicochemical properties of the material modulate these effects. In this work, we developed two sets of tailored carbon and silica nanoparticles with three different diameters in the 100–500 nm range with the

• role. On the other hand, large carbon nanoparticles (but not small carbon nanoparticles or silica nanoparticles) have a clear tendency to form aggregates both in plasma and blood. This effect was observed both in the presence or absence of platelets and was independent of platelet activation. Overall

• platelet deposition in post-capillary venules in the liver and heart, suggesting the role of this protein in nanoparticle-mediated platelet aggregation [14][15]. Silica nanoparticles (SNPs) of different sizes were found to activate glycoprotein IIb/IIIa and to induce the expression of P-selectin in

Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine

• Valentina Francia,
• Daphne Montizaan and
• Anna Salvati

Beilstein J. Nanotechnol. 2020, 11, 338–353, doi:10.3762/bjnano.11.25

• of 100 nm silica nanoparticles incubated with human serum were found to interact with their corresponding receptors, low-density lipoprotein receptor and Fc-gamma receptor I, respectively [17]. Similarly, lipid nanoparticles were efficiently targeted to the hepatocytes upon adsorption of apoE on

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

Molecular architectonics of DNA for functional nanoarchitectures

• Debasis Ghosh,
• Lakshmi P. Datta and
• Thimmaiah Govindaraju

Beilstein J. Nanotechnol. 2020, 11, 124–140, doi:10.3762/bjnano.11.11

• scaffold embedded with Ru(bpy)32+-conjugated silica nanoparticles. The DNA tetrahedron geometry acted as a capture DNA that repelled the nonspecific DNA entanglement along the ECL platform and stimulated the hybridization of glucose oxidase (GOD) enzyme-conjugated DNA (GOD-S). In a programmable cyclic

Advanced hybrid nanomaterials

• Andreas Taubert,
• Fabrice Leroux,
• Pierre Rabu and
• Verónica de Zea Bermudez

Beilstein J. Nanotechnol. 2019, 10, 2563–2567, doi:10.3762/bjnano.10.247

• yield diverse materials, which were found to depend on the P/Ti atom ratio [20]. The ratio was found to determine the particle size and the aggregation state and thereby could strongly tune the porosity of the resulting materials. Colloidal chemistry with patchy silica nanoparticles was employed to

Targeted therapeutic effect against the breast cancer cell line MCF-7 with a CuFe₂O₄/silica/cisplatin nanocomposite formulation

• B. Rabindran Jermy,
• Vijaya Ravinayagam,
• Widyan A. Alamoudi,
• Dana Almohazey,
• Hatim Dafalla,
• Lina Hussain Allehaibi,
• Abdulhadi Baykal,
• Muhammet S. Toprak and
• Thirunavukkarasu Somanathan

Beilstein J. Nanotechnol. 2019, 10, 2217–2228, doi:10.3762/bjnano.10.214

• viability (Figure 8 and Table 1). Interestingly, when cisplatin was loaded into CuFe2O4-coated silica nanoparticles (group E), it was still able to significantly reduce the cell viability in a dose dependent manner. At the highest concentration used (0.5 mg/mL), cisplatin/CuFe2O4/HYPS nanoparticles resulted

Layered double hydroxide/sepiolite hybrid nanoarchitectures for the controlled release of herbicides

• Ediana Paula Rebitski,
• Margarita Darder and
• Pilar Aranda

Beilstein J. Nanotechnol. 2019, 10, 1679–1690, doi:10.3762/bjnano.10.163

• double oxides” in the presence of diverse species, e.g., silica nanoparticles [32]. Nanoarchitectonic materials involving the growth of LDH nanoparticles in the presence of fibrous clay silicates were patented several years ago [33]. Direct co-assembly of already formed particles of each component does

Nanoporous smartPearls for dermal application – Identification of optimal silica types and a scalable production process as prerequisites for marketed products

• David Hespeler,
• Sanaa El Nomeiri,
• Jonas Kaltenbach and
• Rainer H. Müller

Beilstein J. Nanotechnol. 2019, 10, 1666–1678, doi:10.3762/bjnano.10.162

• different solvents (ethanol, butanol, DMSO). DSC thermograms (left) and XRD diffractograms (right) for selected silica nanoparticles, all loaded using ethanol as the solvent for rutin, showing curves with highest amorphous loading. For 72 FP (10 nm pores) the curves obtained with the overloaded system (25

Development of a new hybrid approach combining AFM and SEM for the nanoparticle dimensional metrology

• Loïc Crouzier,
• Alexandra Delvallée,
• Sébastien Ducourtieux,
• Laurent Devoille,
• Guillaume Noircler,
• Christian Ulysse,
• Olivier Taché,
• Elodie Barruet,
• Christophe Tromas and
• Nicolas Feltin

Beilstein J. Nanotechnol. 2019, 10, 1523–1536, doi:10.3762/bjnano.10.150

• systematically lower values obtained during the AFM height measurements [23]. Investigation performed on silica nanoparticles over the whole nanoscale range In order to further investigate the discrepancy observed between AFM and SEM measurements, various nanosilica populations were measured with mean sizes

• . Measurements were performed using AFM and SEM on the same set of 257 PSL NPs. Concerning SEM, the imaging parameters detailed in section “Investigation performed on silica nanoparticles over the whole nanoscale range” have been used. The comparison of size measurements of FD304 NPs and PSL NPs using both

• PSL NPs. With regard to the values of DFmin and DFmax the linear fits follow the equations DFmin = 1.05·HAFM + 0.29 and DFmax = 1.05·HAFM + 3.37 for silica nanoparticles. This indicates that, on average, a discrepancy of 3 nm is observed between DFmin and DFmax. Moreover, this discrepancy is larger

Effects of gold and PCL- or PLLA-coated silica nanoparticles on brain endothelial cells and the blood–brain barrier

• Aniela Bittner,
• Angélique D. Ducray,
• Hans Rudolf Widmer,
• Michael H. Stoffel and
• Meike Mevissen

Beilstein J. Nanotechnol. 2019, 10, 941–954, doi:10.3762/bjnano.10.95

• are foreign objects, careful evaluation of their toxicological and functional aspects prior to medical application is imperative. In this study, we aimed to determine the effects of gold and polymer-coated silica nanoparticles used in laser tissue soldering on brain endothelial cells and the blood

Study of silica-based intrinsically emitting nanoparticles produced by an excimer laser

• Imène Reghioua,
• Mattia Fanetti,
• Sylvain Girard,
• Diego Di Francesca,
• Simonpietro Agnello,
• Layla Martin-Samos,
• Marco Cannas,
• Matjaz Valant,
• Melanie Raine,
• Marc Gaillardin,
• Nicolas Richard,
• Philippe Paillet,
• Aziz Boukenter,
• Youcef Ouerdane and
• Antonino Alessi

Beilstein J. Nanotechnol. 2019, 10, 211–221, doi:10.3762/bjnano.10.19

• , F-91297 Arpajon, France 10.3762/bjnano.10.19 Abstract We report an experimental study demonstrating the feasibility to produce both pure and Ge-doped silica nanoparticles (size ranging from tens up to hundreds of nanometers) using nanosecond pulsed KrF laser ablation of bulk glass. In particular

• , pure silica nanoparticles were produced using a laser pulse energy of 400 mJ on pure silica, whereas Ge-doped nanoparticles were obtained using 33 and 165 mJ per pulse on germanosilicate glass. The difference in the required energy is attributed to the Ge doping, which modifies the optical properties

• be detected in pure silica nanoparticles, evidencing the positive impact of Ge for the development of intrinsically emitting nanoparticles. Transmission electron microscope (TEM) data suggested that the Ge-doped silica nanoparticles are amorphous. SEM and TEM data evidenced that the produced

Mechanism of silica–lysozyme composite formation unravelled by in situ fast SAXS

• Tomasz M. Stawski,
• Daniela B. van den Heuvel,
• Rogier Besselink,
• Dominique J. Tobler and
• Liane G. Benning

Beilstein J. Nanotechnol. 2019, 10, 182–197, doi:10.3762/bjnano.10.17

• Information File 1). Hence, we could treat the system as a system with two different electron densities (silica NPs and solvent matrix). However, because our silica nanoparticles were smaller (ca. 5 nm) compared to silica NPs in previous scattering studies (ca. 20 nm) on silica–protein composite formation [16

Targeting strategies for improving the efficacy of nanomedicine in oncology

• Gonzalo Villaverde and
• Alejandro Baeza

Beilstein J. Nanotechnol. 2019, 10, 168–181, doi:10.3762/bjnano.10.16

• there [15]. These nanocapsules were anchored on the surface of mesoporous silica nanoparticles (MSN) coated with a lipid bilayer (protocells) enhancing their penetration into 3D tumoral tissue models, which yielded a significant enhancement of the therapeutic efficacy of these nanodevices (Figure 1) [16

Colloidal chemistry with patchy silica nanoparticles

• Pierre-Etienne Rouet,
• Cyril Chomette,
• Laurent Adumeau,
• Etienne Duguet and
• Serge Ravaine

Beilstein J. Nanotechnol. 2018, 9, 2989–2998, doi:10.3762/bjnano.9.278

• remain at the bottom of the dimples after the dissolution stage and can be specifically chemically modified providing both enthalpic and entropic characteristics to the patches [20][21]. Here we report the use of these patchy silica nanoparticles with two or four dimples as sp- and sp3-like colloidal

• density of 20 functions per square nanometer, into the suspension of the as-prepared silica nanoparticles. The mixture was stirred at room temperature for 12 h to promote covalent bonding. The particle suspension was purified by three cycles of centrifugation/redispersion (10,000g; 20 min) in absolute

• carboxylic acid groups, (b) zeta potential as a function of pH value, and (c) DRIFT spectra of bare (purple curve), aminated (orange curve) and carboxylated (green curve) silica particles; d) photograph of dimpled silica nanoparticles suspension before (left) and after (right) amination of the PS residues in

Non-agglomerated silicon–organic nanoparticles and their nanocomplexes with oligonucleotides: synthesis and properties

• Asya S. Levina,
• Marina N. Repkova,
• Nadezhda V. Shikina,
• Zinfer R. Ismagilov,
• Svetlana A. Yashnik,
• Dmitrii V. Semenov,
• Yulia I. Savinovskaya,
• Natalia A. Mazurkova,
• Inna A. Pyshnaya and
• Valentina F. Zarytova

Beilstein J. Nanotechnol. 2018, 9, 2516–2525, doi:10.3762/bjnano.9.234

• "Vector", Koltsovo, Novosibirsk region, 630559, Russia 10.3762/bjnano.9.234 Abstract The development of efficient and convenient systems for the delivery of nucleic-acid-based drugs into cells is an urgent task. А promising approach is the use of various nanoparticles. Silica nanoparticles can be used as

• formation of TiO2·PL–DNA nanocomposites [1][2]. Silica nanoparticles can also be used as vehicles to deliver nucleic acid fragments into cells [3][4]. SiO2 nanoparticles bearing amino groups on the surface were shown to bind plasmid DNA, allowing the nanoparticles to penetration into cells, and even nuclei

• known to degrade to orthosilicic acid, Si(OH)4, which is found in almost all human tissues and effectively excreted through the urine [9]. Organically modified silica nanoparticles are known for their low toxicity and biocompatibility and can be used for targeted imaging and therapy [10][11]. The

Enhanced antineoplastic/therapeutic efficacy using 5-fluorouracil-loaded calcium phosphate nanoparticles

• Shanid Mohiyuddin,
• Saba Naqvi and
• Gopinath Packirisamy

Beilstein J. Nanotechnol. 2018, 9, 2499–2515, doi:10.3762/bjnano.9.233

• both in vitro and in vivo studies [5]. Gold nanoparticles conjugated with a trans-activating transcriptional activator (TAT) peptide modification encapsulated with the drug doxorubicin showed enhanced toxicity in brain cancer models [6]. Further, mesoporous silica nanoparticles were successfully used

• for hepatoma targeted delivery of docetaxel with lactose as the targeting molecule [7]. Curcumin-loaded organically modified silica nanoparticles (ORMOSIL) were studied to check the potential anticancer property of ORMOSIL nanocarriers [8]. However, in some instances, after nanoparticle formation, the

• the bulk. Thus metal-based NPs applied to biomedical applications could contradict the success of disease prognosis and treatment. Upon synthesis via solvent-extraction or calcination procedures, mesoporous silica nanoparticles (MSNs) were found to inhibit cellular respiration [10] in the in vivo

SERS active Ag–SiO₂ nanoparticles obtained by laser ablation of silver in colloidal silica

• Cristina Gellini,
• Francesco Muniz-Miranda,
• Alfonso Pedone and
• Maurizio Muniz-Miranda

Beilstein J. Nanotechnol. 2018, 9, 2396–2404, doi:10.3762/bjnano.9.224

• ; silver; Introduction Silica nanoparticles in an aqueous suspension are known to be inert and dispersible – properties which can be quite useful in the preparation of colloidal nanocomposites with silver. For this reason, there are a significant number of studies in the literature on colloidal substrates

• of the present work is to apply laser ablation to the fabrication of new materials for surface enhanced Raman scattering (SERS) [15][16], focusing on silver and silica nanoparticles in aqueous suspension. This research was undertaken for three main reasons. The first is that silver nanoparticles that

• ) that are mostly located on the surface of the silica nanoparticles, which appear as spheres with uniform sizes (about 20 nm), or among them as bridges. There are no silver nanoparticles present that are not attached to silica nanoparticles. This could be due to the interaction of the laser-ablated

Block copolymers for designing nanostructured porous coatings

• Roberto Nisticò

Beilstein J. Nanotechnol. 2018, 9, 2332–2344, doi:10.3762/bjnano.9.218

• silica nanoparticles”); source published under Creative Commons Attribution 2.0 license, https://creativecommons.org/licenses/by/2.0/; copyright the authors. Top-view (left) and tilted 60° (right) SEM micrographs of PS962-b-PEO3409 (a, b), PS563-b-PEO1614 (c, d) and PS385-b-PEO1205 (e, f) soft-templated

• principle behind the sieving method: screen-filter separation is based on size exclusion, whereas depth-filter separation is based also on the interactions between the material forming the functional membrane and the target molecule being separated/isolated. In our recent study [22], colloidal silica

• nanoparticles (produced by using PS-b-PEO block copolymers as templates) are deposited via spin-coating onto a macroporous silicon-based substrate, forming a depth-filtering system (i.e., interparticle voids of 15–200 nm). In order to evaluate the selectivity of this porous membrane, two cationic (macro

Surface characterization of nanoparticles using near-field light scattering

• Eunsoo Yoo,
• Yizhong Liu,
• Chukwuazam A. Nwasike,
• Sebastian R. Freeman,
• Brian C. DiPaolo,
• Bernardo Cordovez and
• Amber L. Doiron

Beilstein J. Nanotechnol. 2018, 9, 1228–1238, doi:10.3762/bjnano.9.114

• and colleagues established that near-field light scattering using the nanophotonic force microscope can be used to measure the size of bare silica and PEG-coated silica nanoparticles very accurately [24]. PEGylation of the nanoparticle slightly altered the particle’s surface chemistry and increased

A simple extension of the commonly used fitting equation for oscillatory structural forces in case of silica nanoparticle suspensions

• Sebastian Schön and
• Regine von Klitzing

Beilstein J. Nanotechnol. 2018, 9, 1095–1107, doi:10.3762/bjnano.9.101

• concentrations of silica nanoparticles. As a consequence, the parameters of the common fit equation vary with the starting point of the fit. Although the wavelength is least affected and seems to be quite robust against the starting point of the fit, all three parameters show distinct oscillations, with a period

• fitting parameters in the system studied here. Keywords: confinement; depletion; fitting; silica nanoparticles; structural forces; Introduction Oscillatory structural forces are a genuine feature observed for simple and complex fluids in the vicinity of smooth surfaces [1][2]. Due to the ubiquitous

• observed in molecular liquids [1][2], but also in complex fluids such as liquid crystals [22][23], micellar or polyelectrolyte solutions [3][24][25][26][27][28][29] and particle suspensions [19][30][31][32][33]. Recent studies showed that for colloidal suspensions of charged silica nanoparticles the period

Cyclodextrin-assisted synthesis of tailored mesoporous silica nanoparticles

• Fuat Topuz and
• Tamer Uyar

Beilstein J. Nanotechnol. 2018, 9, 693–703, doi:10.3762/bjnano.9.64

• /bjnano.9.64 Abstract Mesoporous silica nanoparticles (MSNs) have sparked considerable interest in drug/gene delivery, catalysis, adsorption, separation, sensing, antireflection coatings and bioimaging because of their tunable structural properties. The shape, size and pore structure of MSNs are greatly

• smaller particle size than those produced with HP-functional CDs. FTIR, TGA and solid-state 13C NMR demonstrated the adsorption of CDs on the particle surfaces. The proposed concept allows for the synthesis of silica nanoparticles with control over particle shape and size by adjusting the concentration of

• additives in a simple, one-pot reaction system for a wide range of applications. Keywords: cyclodextrin; faceted particles; mesoporous silica nanoparticles (MSN); microporous; Introduction With the availability of several types of surfactants and the increased understanding of sol–gel chemistry, numerous

Interface conditions of roughness-induced superoleophilic and superoleophobic surfaces immersed in hexadecane and ethylene glycol

• Yifan Li,
• Yunlu Pan and
• Xuezeng Zhao

Beilstein J. Nanotechnol. 2017, 8, 2504–2514, doi:10.3762/bjnano.8.250

• concentration of silica nanoparticles in the composite surfaces from 10 to 30 mg·mL−1 leads to an increase in the amplitude parameters, while the pitch parameters remain random. To decouple the individual effect of the amplitude parameters and pitch parameters on slip, surfaces with the same AR roughness were