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Search for "solubility" in Full Text gives 316 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.
When nanomedicines meet tropical diseases
Beilstein J. Nanotechnol. 2024, 15, 830–832, doi:10.3762/bjnano.15.69
- ]. Potentially beneficial properties of nanomedicines include enhanced drug solubility, improved bioavailability, targeted drug delivery, longer half-life, and reduced toxicity. This thematic issue covers pre-clinical research employing chemotherapeutic or prophylactic nanomedicines against NTDs in a concise
Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material
Beilstein J. Nanotechnol. 2024, 15, 781–796, doi:10.3762/bjnano.15.65
- % of the maximal salt concentration was solubilized after 8 h, which is not in correlation with database information, since the solubility of Zn(O2CCH3)2 at 25 °C is 40 g/100 g of water [55]. This suggests that an interaction between PSI and Zn(O2CCH3)2 prevents the salt from entirely dissolving from
Green synthesis of biomass-derived carbon quantum dots for photocatalytic degradation of methylene blue
Beilstein J. Nanotechnol. 2024, 15, 755–766, doi:10.3762/bjnano.15.63
- equipment, our approach uses green synthesis with biomass, aligning with eco-friendly principles [19][20][21]. Carbon quantum dots are valued for their easy synthesis, good solubility, photostability, nontoxic properties, and versatile applications. They can be synthesized using various methods, including
- oxidation process enhances the solubility of CQDs in water. The spectrum also shows low-intensity signals in the range of 1800 to 2500 cm−1, which are characteristic of aromatic compounds [22][27]. In Figure 3b, the FTIR spectrum of the CQDs synthesized from watermelon peel is shown. Similar characteristics
Laser synthesis of nanoparticles in organic solvents – products, reactions, and perspectives
Beilstein J. Nanotechnol. 2024, 15, 638–663, doi:10.3762/bjnano.15.54
- formation mechanism of the carbon shells schematically shown in Figure 11: (i) Choi et al. proposed a decomposition of the solvent during the plasma phase and a subsequent (partial) solution of carbon in the ablated metal depending on the solubility of carbon in the molten metals (Figure 11a). This would
- nanoparticle diameter dNP and correlated it successfully with experimental results (Figure 11a) [54]. Choi and Jung performed further investigations regarding the carbon solubility in the metal by ablating Au in methanol, n-hexane, acetonitrile, and water. They performed acid resistance tests to confirm the
- treatment found only particles with a size below 50 nm that resisted acid dissolution. They proposed the carbon solubility in the Au nanoparticles to be the reason for the coverage of particles with a size below 50 nm and calculated the carbon solubility as a function of particle radius according to
Radiofrequency enhances drug release from responsive nanoflowers for hepatocellular carcinoma therapy
Beilstein J. Nanotechnol. 2024, 15, 569–579, doi:10.3762/bjnano.15.49
- solubility limit its functionality. In this study, radiofrequency- (RF) enhanced responsive nanoflowers (NFs), containing superparamagnetic ferric oxide nanoclusters (Fe3O4 NCs), – CUR layer, – and MnO2 (CUR-Fe@MnO2 NFs), were verified to have a thermal therapeutic effect. Transmission electron microscopy
- downregulating the expression of VEGFs and the endothelial cell adhesion molecule CD31 [16]. However, disadvantages of CUR include its poor stability, rapid metabolism, and low solubility, which limits its application [17][18][19][20]. To address the aforementioned challenges, intelligent delivery systems have
- been developed based on the abnormal physiological signals in the tumor microenvironment (TME), such as a low pH, high glutathione (GSH) levels, hypoxia, and the expression of specific enzymes [21]. Such intelligent nanoparticles (NPs) have successfully improved the solubility and distribution of CUR
On the additive artificial intelligence-based discovery of nanoparticle neurodegenerative disease drug delivery systems
Beilstein J. Nanotechnol. 2024, 15, 535–555, doi:10.3762/bjnano.15.47
- diseases are characterized by slowly progressing neuronal cell death. Conventional drug treatment strategies often fail because of poor solubility, low bioavailability, and the inability of the drugs to effectively cross the blood–brain barrier. Therefore, the development of new neurodegenerative disease
- inadequate solubility, limited bioavailability, and inability to effectively penetrate the blood–brain barrier (BBB) [6]. Therefore, there is an urgent need to focus on the advancement of novel neurodegenerative disease drugs (NDDs) [7][8]. The major obstacle encountered by NDDs is the selectivity of the BBB
- solubility [90]. Most NDDs of this database are in the PSAdi range of 60–120 Å2. Stephen et al. suggested that CNS drugs should have a PSA value below 90 Å2 for a decent BBB permeability, among other physicochemical characteristics such as number of hydrogen bond donors, molecular size, and shape, with
Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent
Beilstein J. Nanotechnol. 2024, 15, 517–534, doi:10.3762/bjnano.15.46
- Biopharmaceutical Classification System, ALN is a class-III molecule (high solubility and low permeability due to a polar hydrophilic nature) [13]. Its use as a vascular anti-inflammatory agent is limited by its low bioavailability, which after oral administration is minimal (about 0.7%) and highly variable [14][15
- simplicity and resistance to mechanical stress. Recently, we have reported the structural characterization and effect on J774A.1 murine macrophages of ALN loaded in nanoarchaeosomes, that is, nanoARC(ALN) and nanoARC-Chol(ALN). Remarkably, these formulations do not seek to modify the solubility of ALN, but
Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems
Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42
- ]. Nanocrystals can improve many physicochemical properties of drugs such as solubility, size effect, dissolution rate, and adhesiveness to surface membranes [23]. The limitations of conventional medication delivery can be overcome by advanced drug delivery methodologies, such as transdermal drug delivery (TDD
- , matrix, and microneedle systems [24][25][26]. In addition, enteric-coated solid dosage forms for oral administration have shown significant improvement in providing better absorption and targeted delivery [27][28]. In this study, due to high water solubility of DCS (Log P = −1.72) and difficulty to
- polymers can provide gastric protection against gastric-irritating compounds and/or stomach acidity, leading to improved drug release performance. We aimed to fabricate DCS nanocrystals and study their physicochemical and biological properties. The DCS already has great water solubility (Log P = −1.72), so
Classification and application of metal-based nanoantioxidants in medicine and healthcare
Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36
- ingredients of antioxidant supplements. However, these compounds have low bioavailability related to low stability, solubility, and absorbance in the gastrointestinal tract [124][125][126][127]. Recently, with extraordinary progress in nanotechnology development, nanodelivery systems have been considered as
- better anti-aging properties than natural curcumin. By encapsulating curcumin in nanocarriers or by conjugating it to metal oxide nanoparticles, the solubility and bioavailability of curcumin have been substantially improved, leading to a rise in its pharmacological efficiency [136][137][138][139
Nanomedicines against Chagas disease: a critical review
Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30
- still required regarding a realistic use of nanomedicines effective against CD. Keywords: benznidazole; liposomes; nanocrystals; nanomedicines; nanoparticles; Trypanosoma cruzi; Introduction Nanomedicines are used to solve the problems posed by poor solubility and/or permeability and high toxicity of
- opened the theory of genetic background or immunological profile in addition to hypersensitivity reactions to BNZ [25][26]. Accordingly, reducing BNZ doses to decrease its plasma levels would not have an impact on its toxicity [27]. Oral BNZ-based nanomedicines aimed to increase BNZ solubility Besides
- soluble drugs are those whose solubility is below 1 mg/mL over the physiological pH range and the BNZ solubility in distilled water or simulated gastric and enteric fluids oscillates between 0.2 and 0.4 mg/mL [29][30], BNZ is considered a poorly soluble drug. Some authors classify BNZ as a class-II drug
Development and characterization of potential larvicidal nanoemulsions against Aedes aegypti
Beilstein J. Nanotechnol. 2024, 15, 104–114, doi:10.3762/bjnano.15.10
- , and immunity to resistance issues that plague conventional chemicals. However, the practical use of monoterpenes in insect control has been hampered by challenges including their poor solubility and stability in aqueous environments. In recent years, the application of nanotechnology-based
- avenue for overcoming the limitations associated with poor solubility and stability of monoterpenes. This study sheds light on the potential of the nanoemulsions as effective and environmentally friendly insecticides in the ongoing battle against mosquito-borne diseases. Keywords: colloidal stability
- naturally occurring in essential oils (EOs) of various aromatic plants, including the genera Artemisia, Protium, Origanum, and Thymus. Myrcene is an acyclic monoterpene found in hops, lemongrass, basil, and mangos [10]. Some intrinsic characteristics of monoterpenes, mainly poor water solubility and high
New application of bimetallic Ag/Pt nanoplates in a colorimetric biosensor for specific detection of E. coli in water
Beilstein J. Nanotechnol. 2024, 15, 95–103, doi:10.3762/bjnano.15.9
- visual readout signal through peroxidase mimetic activity. The TMB is preferred due to its reliance on a single organic substrate, eliminating the need for a helper molecule. Studies have shown TMB to be non-mutagenic, but it may still be carcinogenic. However, the low solubility of TMB in water requires
- modifications to increase its solubility [7]. Due to its low cost, simplicity, fast response, and the lack of expensive equipment required, the peroxidase-like activity has garnered significant attention in the detection of harmful microorganisms. The naked eye can easily observe the blue hue resulting from the
Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency
Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7
- treatment of central nervous system disorders [2], digestive system diseases [3], cancer, diabetes, inflammation, and infections. Nevertheless, BBR has a low bioavailability due to its poor water solubility, which imposes a regular intake of BBR drugs at a high dose. Recently, innovative technologies have
Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review
Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4
- solving biopharmaceutical challenges associated with drugs, such as curcumin. From a drug delivery standpoint, nanocarriers (1–1000 nm) can improve stability, increase solubility, promote intracellular delivery, and increase biological activity. Thus, this review offers a deep look into curcumin-loaded
- solubility, (ii) poor gastrointestinal absorption, (iii) high rates of metabolism, (iv) inactivity of metabolic products, and (v) rapid elimination and clearance [15][16]. To get around these several limitations, nanotechnological systems such as nanoemulsions [17], microemulsions [18], self-nanoemulsifying
- systems [19], nanoparticles [20], nanoliposomes [21], micelles [22], and nanocrystals [23] have been utilized. These systems can promote (i) protection of the drug against degradation in physiological media, (ii) increase in drug solubility, and (iii) modification/targeting of the drug enabling transport
Nanotechnological approaches in the treatment of schistosomiasis: an overview
Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2
- ]. Praziquantel is a class II compound according to the biopharmaceutical classification system (BCS), so it has low solubility and high permeability in the gastrointestinal tract [6]. This drug is affected by the first-pass effect on the liver, which also impacts its bioavailability [6]. Unfortunately, this
- divided into two types: nanocapsules and nanospheres [18]. Nanocapsules consist of reservoir systems with an oil or water core and an external polymeric shell. They are, overall, used to increase drug solubility [20]. Usually, once in the body, the encapsulated drug diffuses through the polymeric wall in
- (Pilocarpus microphyllus), which has known activity against adult, young, and egg forms of Schistosoma mansoni [57]. Since this is an apolar molecule with poor solubility, the author proposed a nanosystem using liposomes to make this molecule more useful in schistosomiasis therapy. The results showed that
Hierarchically patterned polyurethane microgrooves featuring nanopillars or nanoholes for neurite elongation and alignment
Beilstein J. Nanotechnol. 2023, 14, 1157–1168, doi:10.3762/bjnano.14.96
- polymerized phenolic resin (Novolak) and a diazonaphthoquinone sulfonate photoactive chemical that is converted into a carboxylic acid upon UV exposure, resulting in increased solubility of the photoresist in the alkaline developer [19]. Nevertheless, the solvent of AZ1518 (and many other photoresists
Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study
Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93
- promising biological properties, particularly antioxidant activity. However, its medical applications are limited due to its low water solubility, bioavailability, and pH-instability. CUR-loaded albumin microparticles (CUR-HSA-MPs) of submicron size in the range of 800 to 900 nm and a zeta potential of −15
- to confirm the uptake of CUR-HSA-MPs by cancer cells. Our studies revealed that HSA-MPs are potentially promising vehicles for increasing the solubility and bioavailability of CUR. Keywords: albumin submicron particles; cancer therapy; curcumin; drug delivery; Introduction Curcumin (CUR) is a
- pharmacokinetic drawbacks such as poor water solubility resulting in low bioavailability, low absorption, rapid metabolism, and elimination [6][7]. The reported solubility of free CUR in distilled water at 25 °C is 1.34 µg/mL [8]. The conjugation of CUR with proteins has been confirmed to improve its aqueous
Sulfur nanocomposites with insecticidal effect for the control of Bactericera cockerelli
Beilstein J. Nanotechnol. 2023, 14, 1106–1115, doi:10.3762/bjnano.14.91
- microencapsulation of essential oils protect their active components from degradation and evaporation losses, thus enhancing their stability and solubility [27]. In this framework, this research shows the synthesis of nanocomposites (NCMPs) containing elemental sulfur nanoparticles coated with essential oils of
N-Heterocyclic carbene-based gold etchants
Beilstein J. Nanotechnol. 2023, 14, 865–871, doi:10.3762/bjnano.14.71
- toluene, THF, and DCM at three different time points, near the solubility limit of 1 in each solvent, and at a lower concentration of 1 for the most aggressive formulation. In the solution of 1 in toluene (Figure 3a), for example, there is no visible change to the gold film structure compared to the
- solubility) of 2 and 3 must also be considered as a contributing factor. Similarly, Figure S4 (Supporting Information File 1) shows no apparent gold film loss in a solution of triethylamine and potassium iodide in acetone (chosen instead of THF or DCM to allow for dissolution of KI) tested as a control for
- solvents and concentrations of 1 were (a) toluene (5.00 × 10−3 M), (b) DCM (3.60 × 10−2 M), (c) THF (5.00 × 10−3 M), and (d) THF (2.32 × 10−3 M). In (a–c), the concentrations were chosen to be close to the solubility limit of 1 in each solvent. Scanning electron micrographs of tokens after immersion in
Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies
Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66
- (Benznidazole Evaluation for Interrupting Trypanosomiasis) trial could not prove that the standard treatment with BNZ can prevent disease progression [11]. BNZ has been classified as a class IV drug (low solubility, low permeability) in the Biopharmaceutics Classification System (BCS) [12]. It has an apparent
- efficiently. Many developments have been made in the past years resulting in lipid formulations such as liposomes, solid lipid nanoparticles (SLNs), and nanoemulsions, which increased the apparent solubility of BNZ and its efficacy against parasites [17]. Remarkably, oil-in-water nanoemulsions improved the
Metal-organic framework-based nanomaterials as opto-electrochemical sensors for the detection of antibiotics and hormones: A review
Beilstein J. Nanotechnol. 2023, 14, 631–673, doi:10.3762/bjnano.14.52
Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities
Beilstein J. Nanotechnol. 2023, 14, 362–376, doi:10.3762/bjnano.14.31
- , especially in medicine [1]. Nanomaterials, especially metallic nanomaterials, show good antibacterial and antimicrobial properties due to their physical and chemical properties and are, thus, an alternative approach to antibiotics [2]. In addition, low bioavailability and water solubility problems are the
- biggest problems in the development of new drugs [3]. One of the approaches to overcome these problems is nanoparticle carriers. These carriers are advantageous because their high surface area and good adhesion to biological surfaces increase solubility and dissolution rate [4]. The Gram-positive
Polymer nanoparticles from low-energy nanoemulsions for biomedical applications
Beilstein J. Nanotechnol. 2023, 14, 339–350, doi:10.3762/bjnano.14.29
- solubility of polymers in the used solvents rarely exceeds 10 wt %). Experimental dP/dE ratios are above of those expected if the nanoparticles were to be obtained with a density equal to that of the polymer in the bulk, that is, by applying the formula where mP/mT is the polymer/solvent mass ratio and ρT/ρP
- Ostwald ripening, especially considering that the solubility of ethyl acetate in water is relatively high (about 80 g/L at 20 °C). The hydrodynamic diameter of the particles decreases sharply (from 300–400 nm to ca. 40 nm) at a given electrolyte concentration (Figure 4b), with a concomitant decrease in
Overview of mechanism and consequences of endothelial leakiness caused by metal and polymeric nanoparticles
Beilstein J. Nanotechnol. 2023, 14, 329–338, doi:10.3762/bjnano.14.28
- proteins, is determined by the stability, biocompatibility, and solubility of such conjugates, which in turn opens up new perspectives in medical applications [16][42]. Nanotheranostic applications use NPs for diagnostic and therapeutic purposes for serious metabolic, cancer, and neurodegenerative diseases
Bismuth-based nanostructured photocatalysts for the remediation of antibiotics and organic dyes
Beilstein J. Nanotechnol. 2023, 14, 291–321, doi:10.3762/bjnano.14.26
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