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Search for "PLGA" in Full Text gives 60 result(s) in Beilstein Journal of Nanotechnology.

Template-controlled piezoactivity of ZnO thin films grown via a bioinspired approach

  • Nina J. Blumenstein,
  • Fabian Streb,
  • Stefan Walheim,
  • Thomas Schimmel,
  • Zaklina Burghard and
  • Joachim Bill

Beilstein J. Nanotechnol. 2017, 8, 296–303, doi:10.3762/bjnano.8.32

Graphical Abstract
  • according to Lipowsky et al. with a dipping robot DR 3 from Riegler & Kirstein, Germany [26]. Solutions of poly(styrene sulfonate) (PSS, Sigma-Aldrich, M ≈ 70,000 g mol−1), poly-L-glutamic acid (PLGA, Sigma-Aldrich, M = 15,000–50,000 g mol−1) and poly-L-lysine hydrobromide (PLL, Sigma-Aldrich, M = 15,000
  • –30,000 g mol−1) in Milli-Q water with a concentration of 1 mg mL−1 were prepared. The pH of the PLL solution was adjusted to 9 with 0.3 m KOH. The sequence of the layer-by-layer deposition was (PLL + PLGA)5 + PLL + PSS. The substrates were dipped into the polyelectrolyte solutions for 20 min, followed by
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Published 30 Jan 2017

Nano- and microstructured materials for in vitro studies of the physiology of vascular cells

  • Alexandra M. Greiner,
  • Adria Sales,
  • Hao Chen,
  • Sarah A. Biela,
  • Dieter Kaufmann and
  • Ralf Kemkemer

Beilstein J. Nanotechnol. 2016, 7, 1620–1641, doi:10.3762/bjnano.7.155

Graphical Abstract
  • the vascular system and bladder, showed an increased proliferation rates on a poly(glycolic acid) (PGA) mesh, as well as on poly(ether urethane) (PU) and poly(lactic-co-glycolic acid) (PLGA) substrates with nanoroughness [41][42][44]. ECs: Similar to SMCs, the regulation of ECs proliferation depends
  • also on the shape and size of topography. The proliferation rate of ECs has been reported to increase on metals (Ni, Ti and Co) and polymer substrates (PLGA and PCL) with nanoroughness present on the surface compared to the EC proliferation rate on flat surfaces [10][29][31][45]. Nevertheless, the
  • metal (Ni, Ti and Co) and polymer (PLGA and PCL) surfaces improved EC adhesion compared to flat surfaces [10][29][31][45]. It is possible that the increase in EC adhesion is due to an increase in ECM protein adsorption and/or change of cell adhesions sites of these proteins probably caused by the
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Published 08 Nov 2016

An ellipsometric approach towards the description of inhomogeneous polymer-based Langmuir layers

  • Falko O. Rottke,
  • Burkhard Schulz,
  • Klaus Richau,
  • Karl Kratz and
  • Andreas Lendlein

Beilstein J. Nanotechnol. 2016, 7, 1156–1165, doi:10.3762/bjnano.7.107

Graphical Abstract
  • mapped. In addition to the identification of these structures, the differentiation between a monolayer and bare water was possible. Second, the potential and limitations of this method were verified by applying it to more versatile Langmuir layers of telechelic poly[(rac-lactide)-co-glycolide]-diol (PLGA
  • of PPDL-based Langmuir layers are quite a unique system and to elucidate the limits for the applicability of this methodology, ellipsometric mapping was also applied to a telechelic poly[(rac-lactide)-co-glycolide]-diol (PLGA) layer. PLGA reversibly forms network-like structures above a certain
  • pressure coincidences with the minimal area of the Langmuir trough. In this way maps of the ellipsometric phase shift Δ could be successfully recorded also for more versatile morphologies. This establishes ellipsometric mapping as an additional technique, next to BAM, for the in situ investigation of PLGA
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Published 08 Aug 2016

Tight junction between endothelial cells: the interaction between nanoparticles and blood vessels

  • Yue Zhang and
  • Wan-Xi Yang

Beilstein J. Nanotechnol. 2016, 7, 675–684, doi:10.3762/bjnano.7.60

Graphical Abstract
  • . Research using endothelial cell cultures in order to quantify the uptake of PLGA NPs showed a concentration-dependent uptake of PLGA [47]. Several NPs (COOH100, PEG100, Methyl100, Lysine100) associate with cells through the ability of protein binding on their surfaces [48]. SiO2 causes inflammation and
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Published 06 May 2016

Fabrication and characterization of novel multilayered structures by stereocomplexion of poly(D-lactic acid)/poly(L-lactic acid) and self-assembly of polyelectrolytes

  • Elena Dellacasa,
  • Li Zhao,
  • Gesheng Yang,
  • Laura Pastorino and
  • Gleb B. Sukhorukov

Beilstein J. Nanotechnol. 2016, 7, 81–90, doi:10.3762/bjnano.7.10

Graphical Abstract
  • well as other biocompatible polymers such as poly(methyl methacrylate) (PMMA) [39][40][41], poly(lactic-co-glycolic acid) (PLGA) [42] and poly-ε-caprolactone (PCL) [43][44], is extremely interesting for the fabrication of innovative multilayer structures to be used in drug delivery applications. In
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Published 21 Jan 2016

pH-Triggered release from surface-modified poly(lactic-co-glycolic acid) nanoparticles

  • Manuel Häuser,
  • Klaus Langer and
  • Monika Schönhoff

Beilstein J. Nanotechnol. 2015, 6, 2504–2512, doi:10.3762/bjnano.6.260

Graphical Abstract
  • Nanoparticles (NP) of poly(lactic-co-glycolic acid) (PLGA) represent a promising biodegradable drug delivery system. We suggest here a two-step release system of PLGA nanoparticles with a pH-tunable polymeric shell, providing an initial pH-triggered step, releasing a membrane-toxic cationic compound. PLGA
  • the nanoparticles with high concentrations of sodium chloride shows no further release and thus demonstrates the pH-driven release to be quantitative. Keywords: layer-by-layer self-assembly; pH-triggered release; PLGA nanoparticles; polyelectrolyte multilayers; weak polyelectrolyte; Introduction The
  • fulfilling this criterion is poly(lactic-co-glycolic acid) (PLGA), a copolymer consisting of lactic acid and glycolic acid, which has been approved by the authorities to be suitable for pharmaceutical application [5]. Nanoparticles of an appropriate size can be reliably assembled via an emulsion diffusion
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Published 30 Dec 2015

PLGA nanoparticles as a platform for vitamin D-based cancer therapy

  • Maria J. Ramalho,
  • Joana A. Loureiro,
  • Bárbara Gomes,
  • Manuela F. Frasco,
  • Manuel A. N. Coelho and
  • M. Carmo Pereira

Beilstein J. Nanotechnol. 2015, 6, 1306–1318, doi:10.3762/bjnano.6.135

Graphical Abstract
  • acid) (PLGA) nanoparticles were studied as drug delivery vehicles for calcitriol, the active form of vitamin D3. In vitro effects of calcitriol encapsulated in PLGA nanoparticles were evaluated with respect to free calcitriol on human pancreatic cell lines, S2-013 and hTERT-HPNE, and the lung cancer
  • to the free calcitriol results. At this concentration the inhibitory effect on nontumor cells (hTERT-HPNE) decreased to 65%. This study highlights the ability of PLGA nanoparticles to deliver vitamin D3 into cancer cells, with major effects regarding cancer cell cycle arrest and major changes in the
  • biocompatibility, biodegradability, mechanical strength, FDA approval and low synthesis complexity. One of the most attractive candidates is poly(lactic-co-glycolic acid) (PLGA), which is a copolymer of poly(lactic acid) (PLA) and poly(glycolic acid) (PGA) [18][19]. We expect that vitamin D3 encapsulation in these
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Published 12 Jun 2015

PVP-coated, negatively charged silver nanoparticles: A multi-center study of their physicochemical characteristics, cell culture and in vivo experiments

  • Sebastian Ahlberg,
  • Alexandra Antonopulos,
  • Jörg Diendorf,
  • Ralf Dringen,
  • Matthias Epple,
  • Rebekka Flöck,
  • Wolfgang Goedecke,
  • Christina Graf,
  • Nadine Haberl,
  • Jens Helmlinger,
  • Fabian Herzog,
  • Frederike Heuer,
  • Stephanie Hirn,
  • Christian Johannes,
  • Stefanie Kittler,
  • Manfred Köller,
  • Katrin Korn,
  • Wolfgang G. Kreyling,
  • Fritz Krombach,
  • Jürgen Lademann,
  • Kateryna Loza,
  • Eva M. Luther,
  • Marcelina Malissek,
  • Martina C. Meinke,
  • Daniel Nordmeyer,
  • Anne Pailliart,
  • Jörg Raabe,
  • Fiorenza Rancan,
  • Barbara Rothen-Rutishauser,
  • Eckart Rühl,
  • Carsten Schleh,
  • Andreas Seibel,
  • Christina Sengstock,
  • Lennart Treuel,
  • Annika Vogt,
  • Katrin Weber and
  • Reinhard Zellner

Beilstein J. Nanotechnol. 2014, 5, 1944–1965, doi:10.3762/bjnano.5.205

Graphical Abstract
  • that no silver agglomerates were found in the cell nucleus of hMSC. In addition to the particle size, the intracellular fate of nanoparticles within the cells is time- and dose-dependent [92]. As was shown by Cartiera et al. PLGA-nanoparticles were mainly found within early endosomes after 2 h of
  • when the medium was depleted of serum (data not shown), indicating that at least the discharge of particles or ions from vesicles or other pathways at the cell surface membrane requires carrier molecules outside the cells. Interestingly, Panyam et al. have previously shown that the exocytosis of PLGA
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Published 03 Nov 2014

Imaging the intracellular degradation of biodegradable polymer nanoparticles

  • Anne-Kathrin Barthel,
  • Martin Dass,
  • Melanie Dröge,
  • Jens-Michael Cramer,
  • Daniela Baumann,
  • Markus Urban,
  • Katharina Landfester,
  • Volker Mailänder and
  • Ingo Lieberwirth

Beilstein J. Nanotechnol. 2014, 5, 1905–1917, doi:10.3762/bjnano.5.201

Graphical Abstract
  • bovine serum albumin (BSA), which is a main component of FCS that is added to the cell medium. The results showed that BSA significantly increased the exocytosis of the tested PLGA nanoparticles [28]. Given that we used FCS in the cell medium, the high exocytosis might be responsible for the significant
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Published 29 Oct 2014

Antimicrobial nanospheres thin coatings prepared by advanced pulsed laser technique

  • Alina Maria Holban,
  • Valentina Grumezescu,
  • Alexandru Mihai Grumezescu,
  • Bogdan Ştefan Vasile,
  • Roxana Truşcă,
  • Rodica Cristescu,
  • Gabriel Socol and
  • Florin Iordache

Beilstein J. Nanotechnol. 2014, 5, 872–880, doi:10.3762/bjnano.5.99

Graphical Abstract
  • materials [37], metaloporphyrines [38] and for biomolecules, e.g., poly(lactic acid) (PLA) [39], poly(lactic-co-glycolic acid) PLGA [40], polyvinyl alcohol (PVA) [41] and fibrinogen [42]. Our recent reports have highlighted the capability of the laser processing technique to prepare thin coatings based on
  • polymeric microspheres. Thus, Socol et al., [43], firstly reported the novel deposition of PLGA–PVA, PLGA–PVA–BSA (bovine serum albumin) and PLGA–PVA–CS microspheres by matrix assisted pulsed laser evaporation (MAPLE) technique. SEM images of thin coatings reveal homogeneous and spherical-shaped particles
  • in the micrometric range. The average diameter of PLGA–PVA, PLGA–PVA–BSA (bovine serum albumin) and PLGA–PVA–CS particles ranged from 180 to 250 nm. Grumezescu et al., [34], reported the MAPLE fabrication of PLA–PVA–UA microsphere thin coatings. These thin coatings possessed a homogeneous shape and
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Published 18 Jun 2014
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