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Search for "cancer" in Full Text gives 281 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.
Polymer nanoparticles from low-energy nanoemulsions for biomedical applications
Beilstein J. Nanotechnol. 2023, 14, 339–350, doi:10.3762/bjnano.14.29
- the treatment of a vast number of diseases including cancer and neurological diseases. Continuous effort in the field of designing novel polymeric nanoparticle-based formulations might contribute to reduce the existing gap between preclinical and clinical models. This extensive research might overcome
Overview of mechanism and consequences of endothelial leakiness caused by metal and polymeric nanoparticles
Beilstein J. Nanotechnol. 2023, 14, 329–338, doi:10.3762/bjnano.14.28
- bidirectional vascular permeability, which may contribute to the formation of cancer metastases. In this review we are focusing on the effect of metal and polymeric NPs on mechanism and degree of induction of NanoEL, as well as on the benefits and risks of using NPs that induce endothelial leakiness. Keywords
- understanding of NP metabolism, NP toxicity, or their possible participation in unintended bidirectional vascular permeability, which may contribute to the formation of cancer metastases. For this reason, NPs with different physicochemical properties, which can cross the endothelial barrier in a controlled
- conditions, such as cancer, the distance between endothelial cells significantly widens (up to 2000 nm). Most nanomedicine capitalizes on the size of these gaps and relies on appropriately sized NPs to cross the gaps and accumulate at specific sites [31]. In the case of anticancer nanomedicine, an important
Recent progress in cancer cell membrane-based nanoparticles for biomedical applications
Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24
- strategies for cancer. Toxic side effects and individual differences in response to treatment have further limited the benefits of clinical treatment for patients. Biomimetic cancer cell membrane-based nanotechnology has provided a new approach for biomedicine to overcome these obstacles. Biomimetic
- nanoparticles exhibit various effects (e.g., homotypic targeting, prolonging drug circulation, regulating the immune system, and penetrating biological barriers) after encapsulation by cancer cell membranes. The sensitivity and specificity of diagnostic methods will also be improved by utilizing the properties
- of cancer cell membranes. In this review, different properties and functions of cancer cell membranes are presented. Utilizing these advantages, nanoparticles can exhibit unique therapeutic capabilities in various types of diseases, such as solid tumors, hematological malignancies, immune system
Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer
Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23
- selecting candidates for therapies with tyrosine kinase inhibitors against the human epidermal growth factor receptor (EGFR TKI therapies) and further monitoring cancer treatment efficacy and cancer development. Acquired resistance due to various genetic aberrations is an unavoidable problem during EGFR TKI
- intracellular internalization, and bring advantages over conventional nanocarriers. Keywords: co-delivery nanoparticles; combinatorial therapy; EGFR TKI resistance; non-small cell lung cancer (NSCLC); overcoming and preventing resistance; Introduction Among the malignant diseases, lung cancer takes the lead
- in mortality. Also, it is the second most frequently diagnosed cancer (11.4% of the total cases), surpassed only by female breast cancer (11.7%) [1][2][3]. According to the WHO International Agency for Research on Cancer in 2020 (GLOBOCAN database), around 1.8 million new lung mortalities were
Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems
Beilstein J. Nanotechnol. 2023, 14, 218–232, doi:10.3762/bjnano.14.21
- siRNA from the endosome. In another example, a supramolecular nanoparticle was prepared from a linear CyD-based polymer, hydrophilic polyethylene glycol bearing an adamantane at the end, and siRNA [64]. By attaching a human transferrin protein, this composite was steered to target cancer cells to
- nanoassemblies (pale green balls in the third row from the top). Due to high biocompatibility and tumor-targeting capacity of HA, these ternary nanoassemblies effectively entered cancer cells. Upon UV irradiation (365 nm), the azobenzene isomerizes from the trans form to the cis form, disassembling the α-CyD
- inclusion complex (thus, the ternary assembly is also disassembled). As the result, the siRNA cargo is released and shows excellent cytotoxicity against cancer cells. In Figure 5, NIR light is used (instead of UV in Figure 4) to release siRNA at the target site. As described in section 2.3, the NIR
Single-step extraction of small-diameter single-walled carbon nanotubes in the presence of riboflavin
Beilstein J. Nanotechnol. 2022, 13, 1564–1571, doi:10.3762/bjnano.13.130
- . Application trends of riboflavin-stabilized SWCNTs Small-diameter SWCNT–riboflavin conjugates represent a promising class of nanomaterials for cancer treatment and targeted riboflavin delivery [26][27][28]. It has been shown that riboflavin carrier protein is highly overexpressed in several cancer tissues
- such as melanoma, luminal 45 A breast cancer, and squamous cell carcinoma. Riboflavin-covered SWCNTs have immense potential in detecting tumors since riboflavin is selectively attached to the riboflavin carrier protein in the tumor cells while the photoluminescence increased by SWCNTs allows for high
In search of cytotoxic selectivity on cancer cells with biogenically synthesized Ag/AgCl nanoparticles
Beilstein J. Nanotechnol. 2022, 13, 1505–1519, doi:10.3762/bjnano.13.124
- , Saltillo Coahuila, 25294, México 10.3762/bjnano.13.124 Abstract Green synthesis may be a useful approach to achieve selective cytotoxicity of silver nanoparticles on cancer cells and healthy cells. In this study, the concomitant biosynthesis of silver (Ag)/silver chloride (AgCl) nanoparticles from
- pineapple peel extracts and their behavior on the breast cancer cell line MCF-7 is shown. Bioreactions were monitored at different temperatures. Fourier-transform infrared spectroscopy (FTIR), ultraviolet–visible spectroscopy (UV–vis), thermogravimetric analysis (TGA), X-ray diffraction (XRD), energy
- -dispersive X-ray spectroscopy (EDX), and transmission electron microscopy (TEM) techniques were used to characterize nanoparticle development. The breast cancer cell line MCF-7 was used as a test model to study the cytotoxic behavior of Ag/AgCl nanoparticles and, as a counterpart, the nanoparticles were also
Frequency-dependent nanomechanical profiling for medical diagnosis
Beilstein J. Nanotechnol. 2022, 13, 1483–1489, doi:10.3762/bjnano.13.122
- healthcare strategies that link routine AFM measurements with computer analysis, real-time communication with healthcare providers, and medical databases. This approach would be appropriate for diseases such as cancer, lupus, arteriosclerosis and arthritis, among others, which bring about significant
- healthcare strategies related to diseases or conditions that are associated with mechanical changes in the tissues involved. Some examples include cancer, arteriosclerosis, lupus, arthritis and glaucoma, among others. Within this strategy we highlight the development of application-specific sensors, real
- the bench-to-bed connection has not yet been clearly established, despite a variety of mechanobiological studies for diseases such as cancer [18][20] (we do recognize that industrial adoption of AFM methods does not necessarily result in citation of academic papers and are aware that AFM methods have
Facile preparation of Au- and BODIPY-grafted lipid nanoparticles for synergized photothermal therapy
Beilstein J. Nanotechnol. 2022, 13, 1432–1444, doi:10.3762/bjnano.13.118
- Yuran Wang Xudong Li Haijun Chen Yu Gao Cancer Metastasis Alert and Prevention Centre, College of Chemistry and Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou 350108, Fujian, China College of Chemistry, Key Laboratory of Molecule
- could be associated stably to Au-LNPs, and the release of BODIPY from AB-LNPs could be accelerated by laser irradiation. AB-LNPs are scalable and showed excellent photothermal effects. AB-LNPs showed enhanced cellular uptake efficiency compared to free BODIPY in 4T1 breast cancer cells. Under laser
- synergistic PTT in the treatment of cancer and other diseases. Keywords: BODIPY; gold nanoparticles; lipid nanoparticles; photothermal therapy; synergism; Introduction Photothermal therapy (PTT) relies on photothermal agents (PTAs) to convert light into heat energy to burn cancer cells. Due to its spatial
Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics
Beilstein J. Nanotechnol. 2022, 13, 1393–1407, doi:10.3762/bjnano.13.115
- : chitosan; docetaxel; intestinal tumors; oral drug delivery; PLGA; Introduction Cancer is one of the most common chronic diseases in the world, characterized by the uncontrolled proliferation and spread of cells [1]. To date, effective and safe treatment approaches for cancer treatment have not been fully
- developed, and researchers are still working on this issue. For many types of cancer, selective, targeted, and definitive treatment methods have not been developed yet. Colon carcinomas are the fourth most frequently diagnosed cancer type and still the third most leading cause of cancer-related death. They
- are among the most serious types of cancer affecting humanity every year on a global scale [2][3]. Colon carcinoma, which starts as polyps on the inner surface of the colon, is a malignancy that envelops the colon mucosa over time, progresses by invading the colon tissues, and is characterized by
Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications
Beilstein J. Nanotechnol. 2022, 13, 1068–1107, doi:10.3762/bjnano.13.93
- fast, low-cost, and convenient cancer imaging applications. The particle size of the CDs was 10.14 nm as calculated by TEM [64]. Zhai et al. compared different synthetic methods to find the most suitable route to obtain fluorescent CDs from the green precursor Setcreasea purpurea boom [66]. The
- +. The CDs were also found to be appropriate FL probes for imaging human colon cancer (HTC-116) cells. Recently, Lin et al. proposed a unique antimicrobial compound for the preservation of Atlantic mackerel by synthesizing antimicrobial CDs through a hydrothermal synthesis approach using food materials
- to target folate-receptor cancer cells [114]. Pork-based CDs without any surface-passivating agent were synthesized. Pork meat, itself, is composed of many organic molecules that can provide multiple heteroatoms in the CDs. The resulting CDs have excellent advantages such as a high QY of 17.3% and
Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration
Beilstein J. Nanotechnol. 2022, 13, 1051–1067, doi:10.3762/bjnano.13.92
- osteoblasts and inhibition of the development of osteosarcoma cancer cells in the work by Sumathra et al. (2018). The in vitro experiment was carried out by using the osteosarcoma MG-63 cell line. The MTT assay for the composites showed cell expansion and growth. The anticancer activity of cisplatin-loaded
Gelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading
Beilstein J. Nanotechnol. 2022, 13, 778–787, doi:10.3762/bjnano.13.68
- contrast to this, lysozyme as a crosslinkable macromolecule did not influence the mechanical properties. A good in vitro cell compatibility was found investigating blank GNPs and FITC-dextran-loaded GNPs in viability assays with the cancer cell line A549 and the human primary cell-derived hAELVi cell line
- that the transfection efficiency of cationized gelatin nanoparticles to myeloid leukemia cells (K562) highly depends on the elasticity [16]. Furthermore, it could be shown that stiffer particles were taken up faster in the alveolar epithelial cancer cell line A549 compared to their soft counterparts
Antibacterial activity of a berberine nanoformulation
Beilstein J. Nanotechnol. 2022, 13, 641–652, doi:10.3762/bjnano.13.56
- Canadensis [2]. Many studies have shown the pharmacological actions of BBR including antimicrobial [3][4], antiviral [5][6], anti-inflammatory [7] and antiparasitic effects [8], and effects against hyperlipidemia [9], hypoglycemia [10] and cancer [11]. BBR has the ability to inhibit or kill many pathogenic
Effects of substrate stiffness on the viscoelasticity and migration of prostate cancer cells examined by atomic force microscopy
Beilstein J. Nanotechnol. 2022, 13, 560–569, doi:10.3762/bjnano.13.47
- unclear how mechanical properties regulate the cellular response to the environmental matrix. In this study, atomic force microscopy (AFM) and laser confocal imaging were used to qualitatively evaluate the relationship between substrate stiffness and migration of prostate cancer (PCa) cells. Cells
- substrate stiffness and the mechanical properties of cells in prostate tumour metastasis, providing a basis for understanding the changes in the biomechanical properties at a single-cell level. Keywords: actin cytoskeleton; atomic force microscopy; migration; prostate cancer cells; substrate stiffness
- ; viscoelasticity; Introduction Prostate cancer is a common malignancy of the male urinary tract and has become the second most threatening type of cancer in male patients after lung cancer [1][2]. Clinical data indicate that 90% of patients have a survival rate of more than 10 years if the prostate tumour is
Detection and imaging of Hg(II) in vivo using glutathione-functionalized gold nanoparticles
Beilstein J. Nanotechnol. 2022, 13, 549–559, doi:10.3762/bjnano.13.46
- cancer cells. In another work, Basu et al. designed a novel sensing system using DNA-functionalized GNPs. GNPs have a strong binding affinity to phosphate and sugar groups in DNA [20]. The combined GNPs-DNA has unique physicochemical properties and was used to detect Mg2+. Furthermore, Liu et al
Stimuli-responsive polypeptide nanogels for trypsin inhibition
Beilstein J. Nanotechnol. 2022, 13, 538–548, doi:10.3762/bjnano.13.45
- pancreatitis may lead to chronic pancreatitis with a high risk of consecutive development of cancer [2][3]. The pancreas has exocrine and endocrine functions of which the exocrine function serves to secrete digestive enzymes, such as trypsin, into the intestine. Trypsin belongs to a group of serine proteases
Ethosomal (−)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects
Beilstein J. Nanotechnol. 2022, 13, 491–502, doi:10.3762/bjnano.13.41
- products due to its safety and many benefits as a medicinal source. Epigallocatechin-3-gallate (EGCG), one of the major components of green tea, is a catechin-derived compound with a high antioxidant activity. It also has a protective effect against cardiovascular diseases, diabetes, cancer, and
- dose determined based on cell viability results of 50% or more is appropriate [22][28]. In previous studies, the cytotoxic effect of EGCG, whose antioxidant effect has been proven many times, has been investigated, especially on cancer cell lines. Although there is no cytotoxicity study on the L929
- human cancer cells without causing toxicity problems in normal cells. In general, it has been confirmed that they are relatively nontoxic in healthy L929 cells but toxic in cancer cell lines [29]. Preparation and characterization of formulations Like many phenolic compounds, EGCG is not sufficiently
Zinc oxide nanostructures for fluorescence and Raman signal enhancement: a review
Beilstein J. Nanotechnol. 2022, 13, 472–490, doi:10.3762/bjnano.13.40
- been detected [113]. ZnO platforms are inexpensive to produce, non-toxic and biodegradable, showing potential for improving the detection of various molecules as fluorophores, dyes, or cancer biomarkers. Thus, the use of ZnO NPs as substrates for fluorescence enhancement is an alternative to overcome
- protein reactions. The study demonstrated that ZnO substrates can be employed as efficient nanoplatforms for rapid identification and screening of interacting protein pairs. A significant fluorescence amplification was reported for ZnO NRs substrates for the detection of two important cancer biomarkers
A non-enzymatic electrochemical hydrogen peroxide sensor based on copper oxide nanostructures
Beilstein J. Nanotechnol. 2022, 13, 424–436, doi:10.3762/bjnano.13.35
- [7], and cancer [8][9][10][11]. For this reason, targeted monitoring of the concentration of H2O2 in body fluids can be used in the diagnosis of these diseases [12][13][14][15]. Rapid and accurate determination and control of H2O2 concentration is an important task in many other areas, including
Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals
Beilstein J. Nanotechnol. 2022, 13, 284–291, doi:10.3762/bjnano.13.23
- , Beijing, P. R. China School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, P. R. China 10.3762/bjnano.13.23 Abstract Oxidative stress can lead to permanent and irreversible damage to cellular components and even cause cancer and other diseases. Therefore, the development of
- ], sepsis [6], cancer [7], and inflammatory diseases (e.g., periodontal disease and inflammatory bowel disease) [8][9]. Therefore, the development of antioxidative reagents is a crucial strategy to alleviate chronic diseases and maintain the redox balance. Increasingly efficient antioxidant materials are
Systematic studies into uniform synthetic protein nanoparticles
Beilstein J. Nanotechnol. 2022, 13, 274–283, doi:10.3762/bjnano.13.22
- molecules [7] and has been shown to be an attractive vehicle for hydrophobic drugs in several clinical and preclinical applications [8]. This feature is highlighted in the success of AbraxaneTM, a nanoparticle albumin bound (nab) technology to delivery paclitaxel – a hydrophobic cancer therapeutic
- . Paclitaxel was traditionally formulated through solubilization with harsh solvents, which led to adverse side effects and special administration instrumentation [9]. While AbraxaneTM was first FDA-approved for the treatment of metastatic breast cancer, it has since been investigated for other cancers
- -loaded HSA particles with diameters of approximately 130 nm [10][11]. Since then, AbraxaneTM has been used for non-small cell lung cancer, late-stage pancreatic cancer, and as a treatment for metastatic breast cancer [12][13]. Nevertheless, nab-based nanoparticles suffer from significant drawbacks, such
Photothermal ablation of murine melanomas by Fe3O4 nanoparticle clusters
Beilstein J. Nanotechnol. 2022, 13, 255–264, doi:10.3762/bjnano.13.20
- Xue Wang Lili Xuan Ying Pan Department of Obstetrics & Gynecology, China–Japan Union Hospital of Jilin University, Changchun, People’s Republic of China 10.3762/bjnano.13.20 Abstract Melanoma is one of the deadliest forms of cancer, for which therapeutic regimens are usually limited by the
- the promise of Fe3O4 NPCs as a new PTT option to treat melanoma. Keywords: Fe3O4 nanoparticle clusters; heat shock protein 70; melanoma; near infrared; photothermal therapy; Introduction The global incidence of melanoma, one of the deadliest forms of cancer, has kept increasing annually over the
- effects of alumina-coated Fe3O4 nanoparticles against bacteria upon exposure to NIR light [13]. Further studies with esophageal cancer demonstrate that Fe3O4 nanoparticles induce hyperthermia post absorption to suppress tumor growth in a dosage-dependent manner [14]. However, due to very high dosage
Engineered titania nanomaterials in advanced clinical applications
Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15
- reported by Rehman [8], who used the photodynamic properties of TiO2 for killing HeLa cancer cells. The hydrophobic nature of photosensitizers commonly used in photodynamic therapy led to selectivity and aggregation issues that jeopardize their effectiveness. Therefore, TiO2 nanoparticles (nps), which
- therapeutic window for a convenient timespan to significantly improve the remedy for several diseases, including cancer. TiO2 nanomaterials are often used as photosensitizers or as carriers for the delivery of photosensitizing agents, which enhances therapeutic efficacy by increasing the photothermal
- conversion efficiency and by an accumulation of photosensitizers in tumor sites. ROS-related cancer therapeutics such as photodynamic therapy, sonodynamic therapy, and chemical dynamic therapy showed great potential to significantly enhance the precision and efficacy of cancer therapeutics [14]. Neoplastic
Bacterial safety study of the production process of hemoglobin-based oxygen carriers
Beilstein J. Nanotechnol. 2022, 13, 114–126, doi:10.3762/bjnano.13.8
- with doxorubicin, a cytostatic drug used in chemotherapy for cancer treatment. These particles showed higher efficacy in inhibiting metabolic activity in cell culture in comparison to free doxorubicin [8]. To be used as an artificial oxygen carrier, hemoglobin is isolated from bovine blood. Compared to
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