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Search for "glutathione" in Full Text gives 57 result(s) in Beilstein Journal of Nanotechnology.
Novel roles for well-known players: from tobacco mosaic virus pests to enzymatically active assemblies
Beilstein J. Nanotechnol. 2016, 7, 613–629, doi:10.3762/bjnano.7.54
- nanometric grooves and cavities (see [46] for the most recent high-resolution cryo-EM reconstruction of TMV at 3.35 Å resolution). These have inspired a striking piece of investigation, as one of the repetitively arranged depressions resembles the substrate-binding site of glutathione peroxidase (GPx, EC
- 1.11.1.9), a natural selenoenzyme: Computer-aided design identified adjacent, adequately positioned amino acids of the viral CP which offered the chance to be modified into a glutathione-attracting pocket containing a catalytic selenocysteine (Sec) moiety [133]. A corresponding project thus investigated if
- exposed serine by a cysteine residue, which then was equipped with its analogue Sec through heterologous expression in a bacterial system auxotrophic in cysteine (Figure 7). Not only did this protein organize itself into higher-order complexes under suitable conditions, after trapping reduced glutathione
Nanostructured surfaces by supramolecular self-assembly of linear oligosilsesquioxanes with biocompatible side groups
Beilstein J. Nanotechnol. 2015, 6, 2377–2387, doi:10.3762/bjnano.6.244
- -acetylcysteine, cysteine hydrochloride or glutathione) can form specific, self-assembled nanostructures when deposited on mica by dip coating. The mechanism of adsorption is based on molecule-to-substrate interactions between carboxylic groups and mica. Intermolecular cross-linking by hydrogen bonds was also
- derivatives of N-acetylcysteine (NAC), cysteine hydrochloride (Cys-HCl) and glutathione (GSH). Such self-assembled PSAMs based on polysilsesquioxane materials are attractive for surface nanopatterning and bioengineering, including preparation of surfaces rich in organic groups typical of the extracellular
- silsesquioxanes (LPSQ-COOH/X) were prepared (Scheme 1, Table 1) by the two-step addition of organic thio-derivatives, i.e., thioglycolic acid, N-acetylcysteine (NAC), glutathione (GSH) and cysteine hydrochloride (Cys-HCl), to the side chains of vinyl-containing LPSQ precursors obtained by polycondensation of
An ISA-TAB-Nano based data collection framework to support data-driven modelling of nanotoxicology
Beilstein J. Nanotechnol. 2015, 6, 1978–1999, doi:10.3762/bjnano.6.202
- . For example, oxidative stress and inflammation might be detected via measuring the level of glutathione or various cytokine biomarkers respectively [97]. (These sub-lethal phenomena would not be considered “cytotoxicity” by all researchers [84].) The manner in which this template was designed to
- capture sub-lethal cytotoxicity data is similar to the design of the genotoxicity Assay file template discussed above: the “Parameter Value [Biomarker]” column entries would state, for example, “glutathione” (depending upon the assay), with “Measurement Value […]” columns recording the “increase in
Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme
Beilstein J. Nanotechnol. 2014, 5, 2293–2307, doi:10.3762/bjnano.5.238
- from the bark of the yew tree, and it combines with β-tubulin to promote polymerization by stopping the treadmill of tubulin protomers. MDR of cancer cells to PTX is based on the presence of, for example, mutant tubulin, or by a glutathione-mediated reaction. Enzyme–substrate interactions Thus, the
- corresponds to a conformation change of a β-tubulin subtype and reacts quickly to it. Therefore, it will not lose its efficacy as a drug [24][62][63]. Conclusion Above all, with respect to MDR of cancer cells by the existence of β-tubulin mutations or a glutathione-mediated reaction, the supramolecular DDMC
PVP-coated, negatively charged silver nanoparticles: A multi-center study of their physicochemical characteristics, cell culture and in vivo experiments
Beilstein J. Nanotechnol. 2014, 5, 1944–1965, doi:10.3762/bjnano.5.205
- nanoparticles neither caused toxicity nor oxidative stress, while an incubation for 4 h with 100 µM (10.8 µg mL−1) silver in the form of silver nitrate strongly damaged cultured astrocytes and deprived these cells almost completely of the important antioxidant glutathione [108]. The high resistance of cultured
Donor–acceptor graphene-based hybrid materials facilitating photo-induced electron-transfer reactions
Beilstein J. Nanotechnol. 2014, 5, 1580–1589, doi:10.3762/bjnano.5.170
- fluorescence quenching of the coumarin moiety. However, fluorescence is activated (on) and significantly enhanced inside the cells by glutathione-initiated dissociation. Donor–acceptor hybrids based on exfoliated graphene However, as mentioned earlier, the surface defects in the sp2-network of GO influence the
In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?
Beilstein J. Nanotechnol. 2014, 5, 1477–1490, doi:10.3762/bjnano.5.161
- the reductive capacity of glutathione (the cytosolic concentration of which is between 5 and 10 mM) may be used to displace a fluorescence resonance energy transfer (FRET) acceptor on the surface of the NP as confirmation of a successful NP localization to the cytosol [55]. Such experiments are in
- to positively charged NPs [121][122]. iii) Lipids present in membranes or second-messenger lipids wrap around NPs driven by hydrophilic/hydrophobic interaction and often result in formation of micelles [123][124]. iv) Thiols, present in glutathione or reduced proteins bind to the surface of noble
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