Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide

• Radmila Milenkovska,
• Nikola Geskovski,
• Dushko Shalabalija,
• Ljubica Mihailova,
• Petre Makreski,
• Dushko Lukarski,
• Igor Stojkovski,
• Maja Simonoska Crcarevska and
• Kristina Mladenovska

Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18

• , temozolomide (TMZ), a drug used for the treatment of anaplastic astrocytoma and glioblastoma multiforme (GBM), was incorporated into multiwalled carbon nanotubes (MWCNTs) and a MWCNTs–graphene (MWCNTs-G) hybrid compound, covalently functionalized with polyethylene glycol (PEG) 6000 and folic acid (FA), with an

• formulations of the hybrid CN MWCNTs-G compared to the corresponding MWCNTs were characterized by a similar or slightly higher TMZ content, larger particle size, similar surface charge, and slightly faster TMZ release, which can be attributed to the planar structure of graphene that promotes TMZ binding to the

• higher cytotoxicity of the hybrid CN. Additional decrease in the viability of cells was observed when GBM cells pre-treated with the corresponding CNs were exposed to irradiation, which could be ascribed to changes in size, surface charge, and release kinetics of TMZ and to irradiation-induced changes in

A review of metal-organic frameworks and polymers in mixed matrix membranes for CO₂ capture

• Charlotte Skjold Qvist Christensen,
• Nicholas Hansen,
• Mahboubeh Motadayen,
• Nina Lock,
• Martin Lahn Henriksen and
• Jonathan Quinson

Beilstein J. Nanotechnol. 2025, 16, 155–186, doi:10.3762/bjnano.16.14

• improve CO2 permeability and selectivity to enhance the efficiency of CO2 capture. A promising approach in this field involves hybrid polymer composite membranes known as mixed matrix membranes (MMMs) [15][16][17][18][19][20][21][22]. Among the diverse range of inorganic fillers integrated into MMMs

• CO2 capture specifically, Demir et al. [23] have outlined past and recent advances in MOF-based MMMs for CO2 separation with a focus on the influence of the filler, and Rangaraj et al. [5] have comprehensively reviewed the CO2 capture performance of various MOF-based MMMs and hybrid technologies

Clays enhanced with niobium: potential in wastewater treatment and reuse as pigment with antibacterial activity

• Silvia Jaerger,
• Patricia Appelt,
• Mario Antônio Alves da Cunha,
• Fabián Ccahuana Ayma,
• Ricardo Schneider,
• Carla Bittencourt and
• Fauze Jacó Anaissi

Beilstein J. Nanotechnol. 2025, 16, 141–154, doi:10.3762/bjnano.16.13

• for their potential as antibacterial hybrid pigments. The bentonite clay modified with niobium was prepared by a solution containing swelling clay mixed with niobium oxide (NbOx) and niobium phosphate (NbPh) in a water solution; after that, the suspension was calcinated. X-ray diffractometry, X-ray

• photocatalysts for treating solutions containing the MB dye (400 mg·L−1) at 25 °C. The results showed adsorption and photocatalysis efficiency above 94% for both samples. The blue-colored BEOx and BEPh samples were then applied as a hybrid pigment. The power pigment and its dispersion in colorless paint were

• evaluated by the CIEL*a*b* color space, and the ΔE parameters show values above 12, indicating a very strong color parameter difference. Subsequently, the efficacy of BEOx and BEPh as a hybrid pigment was assessed using the minimum inhibitory concentration (MIC) assay against two bacteria strains: Bacillus

TiO₂ immobilized on 2D mordenite: effect of hydrolysis conditions on structural, textural, and optical characteristics of the nanocomposites

• Marina G. Shelyapina,
• Rosario Isidro Yocupicio-Gaxiola,
• Gleb A. Valkovsky and
• Vitalii Petranovskii

Beilstein J. Nanotechnol. 2025, 16, 128–140, doi:10.3762/bjnano.16.12

• hybrid zeolite–CTAB aggregates, inorganic pillars are pre-formed in the CTAB layers, which will keep the zeolite lamellae from collapsing when burning the organic phase. The flexibility in the choice of material to form pillars creates a wide range of potential new materials for targeted applications

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

• Naths Grazia Sukubo,
• Paolo Bigini and
• Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

• unique physicochemical properties of these mannose-decorated hybrid NPs, such as controlled particle size (≈265 nm) and stability ensured by negative zeta potential, make them highly effective for receptor-mediated endocytosis and intracellular drug delivery [57]. Similarly, hyaluronic acid-coated NCs

• polarization by targeting TERF2IP, activating STAT3, and inhibiting NF-κB [70][71]. Innovative delivery systems for miRNAs have further advanced their therapeutic application. Liu et al. developed a hybrid nanovector with dual redox/pH-responsive properties for targeted miRNA delivery in cancer therapy. This

• macrophage-based systems for nanomedical applications and immunotherapeutic strategies in asthma treatment [112]. Researchers have developed an inhalable formulation of Roflumilast using lipid–polymer hybrid nanoparticles (LPHNPs) to improve its delivery to the lungs and specifically target AMs in COPD

Advanced atomic force microscopy techniques V

• Philipp Rahe,
• Ilko Bald,
• Nadine Hauptmann,
• Regina Hoffmann-Vogel,
• Harry Mönig and
• Michael Reichling

Beilstein J. Nanotechnol. 2025, 16, 54–56, doi:10.3762/bjnano.16.6

• Philipp Rahe Ilko Bald Nadine Hauptmann Regina Hoffmann-Vogel Harry Monig Michael Reichling Institut für Physik, Universität Osnabrück, Barbarastraße 7, 49076 Osnabrück, Germany Institute of Chemistry, Hybrid Nanostructures, University of Potsdam, Karl-Liebknecht-Straße 24–25, 14476 Potsdam

Orientation-dependent photonic bandgaps in gold-dust weevil scales and their titania bioreplicates

• Norma Salvadores Farran,
• Limin Wang,
• Primoz Pirih and
• Bodo D. Wilts

Beilstein J. Nanotechnol. 2025, 16, 1–10, doi:10.3762/bjnano.16.1

• templating process employed here, the 3D geometry did not significantly increase the porosity of titania. Our estimate for the effective refractive index of titania in the 3D lattice is in the range reported for pure titania thin films (1.95–2.55 [38], 1.72–2.03 [39]), hybrid silica/titania thin films (1.95

• [40], 1.50–1.95 [41] and hybrid organotitania (1.75–2.05 [42], 1.55–1.65 [43]). This is lower than the tabulated values of titania prepared by, for example, layer deposition (2.10 [44], 2.40 [45], see also [46][47]), but higher than that of pure silica replicas (1.50 [18]). This is not unexpected as

• step (130 °C). Raising the temperature slightly might increase the effective refractive index of titania before lattice degradation occurs. If the process could be additionally tuned by, for example, varying process times and chemical compositions (including hybrid sol/gels), a further reduction of

Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

• Hugo Felix Perini,
• Beatriz Sodré Matos,
• Carlo José Freire de Oliveira and
• Marcos Vinicius da Silva

Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127

• involves increased material waste and costs [34][35][53]. Regardless of the membrane-masking technique, various cell types can enhance the efficiency of delivery systems, including immune cells (phagocytes, lymphocytes, and NK cells) [54], erythrocytes [55], platelets [56], cancer cells [57] and hybrid

Electrochemical nanostructured CuBTC/FeBTC MOF composite sensor for enrofloxacin detection

• Thi Kim Ngan Nguyen,
• Tien Dat Doan,
• Huy Hieu Luu,
• Hoang Anh Nguyen,
• Thi Thu Ha Vu,
• Quang Hai Tran,
• Ha Tran Nguyen,
• Thanh Binh Dang,
• Thi Hai Yen Pham and
• Mai Ha Hoang

Beilstein J. Nanotechnol. 2024, 15, 1522–1535, doi:10.3762/bjnano.15.120

• sensor was presented by You et al. in 2002 [22]. MOFs are crystalline hybrid materials with network structures formed by the self-assembly of metal ions or metal clusters and organic ligands, which give them ultrahigh porosity and enormous internal surface area. However, using MOFs for electrochemical

• successfully synthesized using a solvothermal method. The mixture of these MOFs demonstrated a high surface area, substantial total pore volume, and small capillary diameters. This hybrid material was then utilized as an electrode material for an electrochemical sensor designed to detect enrofloxacin through

Integrating high-performance computing, machine learning, data management workflows, and infrastructures for multiscale simulations and nanomaterials technologies

• Fabio Le Piane,
• Mario Vozza,
• Matteo Baldoni and
• Francesco Mercuri

Beilstein J. Nanotechnol. 2024, 15, 1498–1521, doi:10.3762/bjnano.15.119

• largely missing. The development of MAMBO followed an hybrid approach mixing top-down and bottom-up processes. To accurately capture the distinct characteristics of concepts integral to the formulation of the MAMBO ontology (both the more general concepts and the more specific ones), we initially

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• hybrid nanoparticles (PLHNPs) have emerged as a novel delivery system that combines the advantages of both polymeric and lipid-based nanoparticles to overcome these challenges. This review explores the potential of PLHNPs to enhance the delivery and efficacy of phytochemicals for biomedical applications

• diseases. Keywords: bioavailability; phytochemical; polymer lipid hybrid nanoparticles; solubility; stability; surface modification; Introduction Phytochemicals are naturally occurring compounds found in plants (from the Greek word “phyton” meaning plant) [1]. These bioactive compounds are responsible

• , rapid metabolism, and instability under physiological conditions [9][10][11]. These challenges necessitate the development of advanced delivery systems to harness the full potential of phytochemicals in therapeutic applications. Polymer lipid hybrid nanoparticles (PLHNPs) represent an innovative class

Lithium niobate on insulator: an emerging nanophotonic crystal for optimized light control

• Midhun Murali,
• Amit Banerjee and
• Tanmoy Basu

Beilstein J. Nanotechnol. 2024, 15, 1415–1426, doi:10.3762/bjnano.15.114

• and hybrid devices with combined functionalities [16]. We focus on the DBR structure out of lithium niobate. To achieve PhC effects, one of the ways is creating alternating layers of LN and another material with a contrasting refractive index. We chose TiO2 and SiO2 as it has a considerable difference

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• small or large molecules from the current literature, we highlight the preclinical studies and their results to prove the strategies’ success and limitations. Keywords: antibody delivery; biopharmaceutical delivery; blood–brain barrier (BBB); CNS diseases; drug delivery; hybrid nanoparticles

• lipid NPs, polymeric NPs, liposomes, emulsions, and novel hybrid NPs and their potential use as DDSs in N2B delivery (Figure 4). Polymeric NPs Because of their tunable physicochemical characteristics, polymeric NPs are a potential vehicle for different drug delivery applications [71]. They can be

• intranasal administration of the formulation also showed better permeation in ex vivo studies with goat nasal mucosa and higher drug concentration in the brain in in vivo studies with Wistar rats compared to plain cannabidiol [116]. Hybrid nanoparticles Each NP class represents exclusive advantages for

Quantum-to-classical modeling of monolayer Ge₂Se₂ and its application in photovoltaic devices

• Anup Shrivastava,
• Shivani Saini,
• Dolly Kumari,
• Sanjai Singh and
• Jost Adam

Beilstein J. Nanotechnol. 2024, 15, 1153–1169, doi:10.3762/bjnano.15.94

• astonishing device performance. We use ab initio modeling for the material prediction, while classical drift–diffusion drives the device simulations. Hybrid functionals calculate electronic and optical properties to maintain high accuracy. The structural stability has been verified using phonon spectra. The E

• optoelectronic devices, including next-generation solar cells. The hybrid quantum-to-macroscopic methodology presented here applies to broader classes of 2D and 3D materials and structures, showing a path to the computational design of future photovoltaic materials. Keywords: 2D materials; density functional

• calculation to relax the structure at its most stable state (minimum energy) using the Broyden–Fletcher–Goldfarb–Shanno (BFGS) algorithm for a systematic computational study. It has been reported that the hybrid functional is more accurate in predicting the material behavior than local density approximation

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• , into the alginate polymer network. This can be achieved through various methods, including reduction reactions, electrochemical deposition, or deposition-precipitation. The resulting hybrid nanomaterials exhibit synergistic properties of both the inorganic nanoparticles and the alginate polymer

• properties. Oxidative and sensitive materials are loaded into sodium alginate gel, and the absence and concentration of hydrogen peroxide in water and milk can be analyzed by a colorimetric method [117]. In another work, an alginate hybrid silver magnetite nanocomposite (Fe3O4@AMALG12@Ag) with enhanced

Ca_n neutral clusters: a two-step G₀W₀ and DFT benchmark

• Sunila Bakhsh,
• Sameen Aslam,
• Muhammad Khalid,
• Muhammad Sohail,
• Sundas Zafar,
• Sumayya Abdul Wadood,
• Kareem Morsy and
• Muhammad Aamir Iqbal

Beilstein J. Nanotechnol. 2024, 15, 1010–1016, doi:10.3762/bjnano.15.82

• use of hybrid functionals generally improves accuracy for many systems, but it does not guarantee perfect results for all types of bonding or electron correlation effects. Overall, the accuracy of theoretically obtained structures is supported by the experimental data, which is lacking in this case

Recent progress on field-effect transistor-based biosensors: device perspective

• Billel Smaani,
• Fares Nafa,
• Mohamed Salah Benlatrech,
• Ismahan Mahdi,
• Hamza Akroum,
• Mohamed walid Azizi,
• Khaled Harrar and
• Sayan Kanungo

Beilstein J. Nanotechnol. 2024, 15, 977–994, doi:10.3762/bjnano.15.80

• hybrid partially gated design is reported as an exceptional device allowing digital gates with biosensing integration. Also, a hardware description language (Verilog-A) has been used for the modeling of each device structure to be incorporated into various system designs via electronic design automation

Electrospun nanofibers: building blocks for the repair of bone tissue

• Tuğrul Mert Serim,
• Gülin Amasya,
• Tuğba Eren-Böncü,
• Ceyda Tuba Şengel-Türk and
• Ayşe Nurten Özdemir

Beilstein J. Nanotechnol. 2024, 15, 941–953, doi:10.3762/bjnano.15.77

• , ethanol, formic acid, and tetrahydrofuran. Depending on the polymer type or the hybrid polymer composition, these organic solvents can be used alone or applied as mixtures in order to obtain suitable solution properties [67]. Surface tension The surface tension of the polymer liquid is important for the

• when preparing polymeric nanofiber formulations to obtain controlled and sustained drug release profiles. The polymers used in the preparation of polymeric nanofibers are generally categorized into four classes, namely, natural polymers, synthetic polymers, blends of these two classes (hybrid), and

Facile synthesis of Fe-based metal–organic frameworks from Fe₂O₃ nanoparticles and their application for CO₂/N₂ separation

• Van Nhieu Le,
• Hoai Duc Tran,
• Minh Tien Nguyen,
• Hai Bang Truong,
• Toan Minh Pham and
• Jinsoo Kim

Beilstein J. Nanotechnol. 2024, 15, 897–908, doi:10.3762/bjnano.15.74

• -organic frameworks (MOFs) are well-ordered porous hybrid structures assembled from the fundamental components of metal ion clusters and organic linkers. MOFs are well known as multipurpose materials that serve a broad range of applications because of their unique construction variants, enormous surface

• strength of the Lewis acid properties. Lower temperatures (approx. 150 °C) favor Fe(III), while higher temperatures up to 250 °C promote Fe(II) [9][10]. The MIL-100(Fe) structure is built from oxo-trimers of iron octahedra as SBUs together with bridges of benzene-1,3,5-tricarboxylate, yielding a hybrid

• supertetrahedral structure. Following that, the hybrid structures self-assemble in a certain sequence to form a topology resembling the MTN-type of zeolite seen in Zeolite Socony Mobil Thirty-Nine (ZSM-39) [11]. The MIL-100(Fe) structure has a cubic series containing two types of large chambers with average

Electron-induced ligand loss from iron tetracarbonyl methyl acrylate

• Hlib Lyshchuk,
• Atul Chaudhary,
• Thomas F. M. Luxford,
• Miloš Ranković,
• Jaroslav Kočišek,
• Juraj Fedor,
• Lisa McElwee-White and
• Pamir Nag

Beilstein J. Nanotechnol. 2024, 15, 797–807, doi:10.3762/bjnano.15.66

• set to around 100 (M/ΔM). DFT calculations DFT-based structure optimization calculations have been performed using Gaussian 16 software [30]. All calculations were conducted using the commonly employed hybrid functional B3LYP [31] with a 6-31++G(d,p) [32][33] basis set and included the GD3 empirical

Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material

• Veronika Pálos,
• Krisztina S. Nagy,
• Rita Pázmány,
• Krisztina Juriga-Tóth,
• Bálint Budavári,
• Judit Domokos,
• Dóra Szabó,
• Ákos Zsembery and
• Angela Jedlovszky-Hajdu

Beilstein J. Nanotechnol. 2024, 15, 781–796, doi:10.3762/bjnano.15.65

• (chitosan–silicone hybrid) fibers were made with zinc additives. They found that the scaffold had antibacterial activity against S. aureus, B. subtillis, E. coli, and P. aeruginosa bacterial strains [71]. Colinas et al. examined Zn-based coordination polymers in broth dilution and agar diffusion tests, and

Electron-induced deposition using Fe(CO)₄MA and Fe(CO)₅ – effect of MA ligand and process conditions

• Hannah Boeckers,
• Atul Chaudhary,
• Petra Martinović,
• Amy V. Walker,
• Lisa McElwee-White and
• Petra Swiderek

Beilstein J. Nanotechnol. 2024, 15, 500–516, doi:10.3762/bjnano.15.45

Aero-ZnS prepared by physical vapor transport on three-dimensional networks of sacrificial ZnO microtetrapods

• Veaceslav Ursaki,
• Tudor Braniste,
• Victor Zalamai,
• Emil Rusu,
• Vladimir Ciobanu,
• Vadim Morari,
• Daniel Podgornii,
• Pier Carlo Ricci,
• Rainer Adelung and
• Ion Tiginyanu

Beilstein J. Nanotechnol. 2024, 15, 490–499, doi:10.3762/bjnano.15.44

• ], and hybrid composite [26][27] materials. Aeromaterials have been prepared on the basis of sacrificial nano/microstructured templates. Nanofibrillated cellulose has been used as a sacrificial template for the preparation of inorganic nanotube networks, such as titanium dioxide, zinc oxide, and aluminum

Unveiling the nature of atomic defects in graphene on a metal surface

• Karl Rothe,
• Nicolas Néel and
• Jörg Kröger

Beilstein J. Nanotechnol. 2024, 15, 416–425, doi:10.3762/bjnano.15.37

• due to an increased graphene–metal interaction compared with Pt(111), although both graphene–metal hybrid structures belong to the weak-hybridization regime [43]. Another rationale is the deviation of the observed defects 1 and 2 from a monatomic vacancy site, which will further be explored in the

Investigating structural and electronic properties of neutral zinc clusters: a G₀W₀ and G₀W₀Г₀⁽¹⁾ benchmark

• Sunila Bakhsh,
• Muhammad Khalid,
• Sameen Aslam,
• Muhammad Sohail,
• Muhammad Aamir Iqbal,
• Mujtaba Ikram and
• Kareem Morsy

Beilstein J. Nanotechnol. 2024, 15, 310–316, doi:10.3762/bjnano.15.28

• optimization, within which the distinct structures were separated using the GGA (PBE) functional, and (ii) high-precision optimization by ABACUS using the “accurate” setting. PBE instead of the hybrid functional was used because of its low cost; also, it brings a non-empirical functional that can easily and