Facile synthesis of water-soluble carbon nano-onions under alkaline conditions

• Gaber Hashem Gaber Ahmed,
• Rosana Badía Laíño,
• Josefa Angela García Calzón and
• Marta Elena Díaz García

Beilstein J. Nanotechnol. 2016, 7, 758–766, doi:10.3762/bjnano.7.67

• functionalities in basic media. Given their closed structure, water soluble C-onions could be loaded with specific molecules or drugs in bio-medical applications while the delivery process could be monitored thanks to their exceptional PL properties. The field is open. Experimental Chemicals and reagents All the

Unraveling the neurotoxicity of titanium dioxide nanoparticles: focusing on molecular mechanisms

• Bin Song,
• Yanli Zhang,
• Jia Liu,
• Xiaoli Feng,
• Ting Zhou and
• Longquan Shao

Beilstein J. Nanotechnol. 2016, 7, 645–654, doi:10.3762/bjnano.7.57

• characteristics [1] including antibacterial, ultraviolet-absorbing, photocatalytic, and self-cleaning properties [2]. Thus, TiO2 NPs are widely used in cosmetics, sun screens, ceramics, paints, packaging, lithium batteries, the food industry, and in medical applications [3]. However, the rapid development of

Cantilever bending based on humidity-actuated mesoporous silica/silicon bilayers

• Christian Ganser,
• Gerhard Fritz-Popovski,
• Roland Morak,
• Parvin Sharifi,
• Benedetta Marmiroli,
• Barbara Sartori,
• Heinz Amenitsch,
• Thomas Griesser,
• Christian Teichert and
• Oskar Paris

Beilstein J. Nanotechnol. 2016, 7, 637–644, doi:10.3762/bjnano.7.56

• of surface energy Δγ of silica upon full wetting with water. Acknowledgements Financial support from the Federal Government of Styria in the Framework of the Human Technology Interface: Sensors for Medical Applications (HTI:SMApp) initiative under contract A3-22.M-5/2012-32 is gratefully

Time-dependent growth of crystalline Au⁰-nanoparticles in cyanobacteria as self-reproducing bioreactors: 2. Anabaena cylindrica

• Liz M. Rösken,
• Felix Cappel,
• Susanne Körsten,
• Christian B. Fischer,
• Andreas Schönleber,
• Sander van Smaalen,
• Stefan Geimer,
• Christian Beresko,
• Georg Ankerhold and
• Stefan Wehner

Beilstein J. Nanotechnol. 2016, 7, 312–327, doi:10.3762/bjnano.7.30

• since there are widespread possibilities of usage [1][2][3]. Especially Au0-nanoparticles are used, e.g., in heterogeneous catalysis [4][5][6] or in various medical applications [7][8]. There is a growing field of research in microbiological approaches for the production of nanoparticles since more than

Surface coating affects behavior of metallic nanoparticles in a biological environment

• Darija Domazet Jurašin,
• Marija Ćurlin,
• Ivona Capjak,
• Tea Crnković,
• Marija Lovrić,
• Michal Babič,
• Daniel Horák,
• Ivana Vinković Vrček and
• Srećko Gajović

Beilstein J. Nanotechnol. 2016, 7, 246–262, doi:10.3762/bjnano.7.23

• medical applications, which implies the need for strict information regarding their physicochemical characteristics and behavior in a biological environment. The currently developed AgNPs and SPIONs encompass a myriad of sizes and surface coatings, which affect NPs properties and may improve their

Simultaneous cancer control and diagnosis with magnetic nanohybrid materials

• Reza Saadat and
• Franz Renz

Beilstein J. Nanotechnol. 2016, 7, 121–125, doi:10.3762/bjnano.7.14

• can be assumed that the organic component bzimpy was linked to the MNP (see Table 2). In order to give the yield PET functionality to the MNP we chose the DOTA chelator. It is highly preferred in medical applications caused by the high stability of various metal ion–DOTA complexes [16]. In this study

Sonochemical co-deposition of antibacterial nanoparticles and dyes on textiles

• Ilana Perelshtein,
• Anat Lipovsky,
• Nina Perkas,
• Tzanko Tzanov and
• Aharon Gedanken

Beilstein J. Nanotechnol. 2016, 7, 1–8, doi:10.3762/bjnano.7.1

• properties and the dye fastness was studied for 72 h in saline solution aiming at medical applications. Keywords: antibacterial nanoparticles; coating stability; dyes; sonochemical coating; Introduction The preferred technique for coating with nanoparticles (NPs) in most scientific and industrial examples

An ISA-TAB-Nano based data collection framework to support data-driven modelling of nanotoxicology

• Richard L. Marchese Robinson,
• Mark T. D. Cronin,
• Andrea-Nicole Richarz and
• Robert Rallo

Beilstein J. Nanotechnol. 2015, 6, 1978–1999, doi:10.3762/bjnano.6.202

• Union [5].) Nanomaterials have been used and/or have been investigated for use in a diverse range of applications such as sunscreens, cosmetics, electronics and medical applications [2][4][6][7]. In addition to interest in the benefits offered by nanotechnology, concerns have also been raised about the

Nanofibers for drug delivery – incorporation and release of model molecules, influence of molecular weight and polymer structure

• Jakub Hrib,
• Jakub Sirc,
• Radka Hobzova,
• Zuzana Hampejsova,
• Zuzana Bosakova,
• Marcela Munzarova and
• Jiri Michalek

Beilstein J. Nanotechnol. 2015, 6, 1939–1945, doi:10.3762/bjnano.6.198

• molecular weights of 2,000, 6,000, 10,000 and 20,000 g/mol were selected as model molecules. Polyethylene glycol (PEG) is a hydrophilic polyether commercially available in various molecular weights with narrow distribution. It is widely used in various medical applications, for example as surfactant

Nanocuration workflows: Establishing best practices for identifying, inputting, and sharing data to inform decisions on nanomaterials

• Christina M. Powers,
• Karmann A. Mills,
• Stephanie A. Morris,
• Fred Klaessig,
• Sharon Gaheen,
• Nastassja Lewinski and
• Christine Ogilvie Hendren

Beilstein J. Nanotechnol. 2015, 6, 1860–1871, doi:10.3762/bjnano.6.189

• and any associated publications. In contrast, the purpose of RTI International’s Nanomaterial Registry (NR; https://www.nanomaterialregistry.org/) is to collect validated data from a broad field of accessible nanomaterial sources relevant to not only medical applications, but also the environmental

Synthesis, characterization and in vitro biocompatibility study of Au/TMC/Fe₃O₄ nanocomposites as a promising, nontoxic system for biomedical applications

• Hanieh Shirazi,
• Maryam Daneshpour,
• Soheila Kashanian and
• Kobra Omidfar

Beilstein J. Nanotechnol. 2015, 6, 1677–1689, doi:10.3762/bjnano.6.170

• distribution, facile and low cost synthesis process, and ease of surface modification, biological and medical applications using uncoated iron oxide nanoparticles are limited because of their tendency to aggregate and oxidize [9][19]. Covering their surface with organic molecules (e.g., biodegradable polymers

• . The efficacy of these TMC- and Au-containing magnetic nanostructures could benefit applications such as electrochemical labels, sensory probes, electronic conductors, therapeutic agents, organic photovoltaics, drug delivery in biological and medical applications, and catalysis due to their combined

Protein corona – from molecular adsorption to physiological complexity

• Lennart Treuel,
• Dominic Docter,
• Michael Maskos and
• Roland H. Stauber

Beilstein J. Nanotechnol. 2015, 6, 857–873, doi:10.3762/bjnano.6.88

• important parameter for the design and synthesis of nano-medical applications [28]. Some NPs (e.g., Au, Pd, Pt) are known as good catalysts in a range of different reactions [14][17][21][29][30][31][32][33][34][35]. A relevant example in the context of protein adsorption is the catalytic effect of Au NP

• also to develop NPs for desired transport in nano-medical applications. (a): Relation between the collision efficiency regarding the formation of agglomerates in a destabilized colloidal and the relative HSA concentration in solution [53]. Black dots: data points, black solid line drawn to guide the

Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques

• Anja Ostrowski,
• Daniel Nordmeyer,
• Alexander Boreham,
• Cornelia Holzhausen,
• Lars Mundhenk,
• Christina Graf,
• Martina C. Meinke,
• Annika Vogt,
• Sabrina Hadam,
• Jürgen Lademann,
• Eckart Rühl,
• Ulrike Alexiev and
• Achim D. Gruber

Beilstein J. Nanotechnol. 2015, 6, 263–280, doi:10.3762/bjnano.6.25

• , the risk of adverse and even toxic side effects as well as accumulation of NP in the body has to be considered [1][5]. Clearly, the mentioning of all current medical applications, developments and future visions on NP technology is by far beyond the scope of this review and excellent review articles

Mechanical properties of MDCK II cells exposed to gold nanorods

• Anna Pietuch,
• Bastian Rouven Brückner,
• David Schneider,
• Marco Tarantola,
• Christina Rosman,
• Carsten Sönnichsen and
• Andreas Janshoff

Beilstein J. Nanotechnol. 2015, 6, 223–231, doi:10.3762/bjnano.6.21

• (DNA, proteins, antibodies) with functional groups using self-assembly techniques relying on gold–thiol interaction. Since these NPs are engineered to interact with living cells it is essential to prove if there is no adverse impact on cell viability [5][10]. Prerequisite for successful medical

• applications is the design of biocompatible NPs that do not impair with cell viability, proliferation, and adhesion. Therefore assessing the cytotoxicity of nanoparticles is pivotal for nanoparticle research in general [11]. In vitro nanocytotoxicity studies are therefore necessary to minimize possible risks

Synthesis of boron nitride nanotubes and their applications

• Saban Kalay,
• Zehra Yilmaz,
• Ozlem Sen,
• Melis Emanet,
• Emine Kazanc and
• Mustafa Çulha

Beilstein J. Nanotechnol. 2015, 6, 84–102, doi:10.3762/bjnano.6.9

• ; chemical modifications; medical applications; synthesis methods; toxicity; Review Introduction Boron nitride nanotubes (BNNTs) are known as structural analogs of carbon nanotubes (CNTs) but with superior properties [1][2][3]. Although they have structural similarities, they significantly differ in their

Nanoencapsulation of ultra-small superparamagnetic particles of iron oxide into human serum albumin nanoparticles

• Matthias G. Wacker,
• Mahmut Altinok,
• Stephan Urfels and
• Johann Bauer

Beilstein J. Nanotechnol. 2014, 5, 2259–2266, doi:10.3762/bjnano.5.235

• Technische Universität Darmstadt, Technical Chemistry, D-64287 Darmstadt, Germany Merck KGaA, D-64287 Darmstadt, Germany 10.3762/bjnano.5.235 Abstract Human serum albumin nanoparticles have been utilized as drug delivery systems for a variety of medical applications. Since ultra-small superparamagnetic

Imaging the intracellular degradation of biodegradable polymer nanoparticles

• Anne-Kathrin Barthel,
• Martin Dass,
• Melanie Dröge,
• Jens-Michael Cramer,
• Daniela Baumann,
• Markus Urban,
• Katharina Landfester,
• Volker Mailänder and
• Ingo Lieberwirth

Beilstein J. Nanotechnol. 2014, 5, 1905–1917, doi:10.3762/bjnano.5.201

• living organisms, for example, the decomposition dynamics of resorbable threads in surgery or the surface compatibility of bone implants. In particular, materials based on poly(ε-caprolacton) and poly(lactic acid) have found their way as resorbable materials into medical applications. Preferentially, the

Precise quantification of silica and ceria nanoparticle uptake revealed by 3D fluorescence microscopy

• Adriano A. Torrano and
• Christoph Bräuchle

Beilstein J. Nanotechnol. 2014, 5, 1616–1624, doi:10.3762/bjnano.5.173

• of nanoparticles designed for medical applications. Experimental Nanoparticle characterization Nanoparticle size was determined by transmission electron microscopy (TEM). TEM micrographs were acquired by a JEM 2011 (JEOL, Japan) transmission electron microscope. The nanoparticle dispersion was

In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?

• Moritz Nazarenus,
• Qian Zhang,
• Mahmoud G. Soliman,
• Pablo del Pino,
• Beatriz Pelaz,
• Susana Carregal-Romero,
• Joanna Rejman,
• Barbara Rothen-Rutishauser,
• Martin J. D. Clift,
• Reinhard Zellner,
• G. Ulrich Nienhaus,
• James B. Delehanty,
• Igor L. Medintz and
• Wolfgang J. Parak

Beilstein J. Nanotechnol. 2014, 5, 1477–1490, doi:10.3762/bjnano.5.161

• ) with mammalian cells [1], as this topic is important for analyzing intended (e.g., medical applications [2][3][4]) and non-intended (e.g., contamination [5][6][7]) exposure of NPs to humans. However, there is a great number of available NPs made of many different materials [8][9][10] with a wide range

Exploring the retention properties of CaF₂ nanoparticles as possible additives for dental care application with tapping-mode atomic force microscope in liquid

• Matthias Wasem,
• Joachim Köser,
• Sylvia Hess,
• Enrico Gnecco and
• Ernst Meyer

Beilstein J. Nanotechnol. 2014, 5, 36–43, doi:10.3762/bjnano.5.4

• very interesting for application in science, technology and medical applications including dentistry [18]. In this context calcium fluoride is of high interest in saliva chemistry and in the context of reducing acid dissolution of teeth [19]. The outermost layer of the teeth, also called enamel, has

Cytotoxic and proinflammatory effects of PVP-coated silver nanoparticles after intratracheal instillation in rats

• Nadine Haberl,
• Stephanie Hirn,
• Alexander Wenk,
• Jörg Diendorf,
• Matthias Epple,
• Blair D. Johnston,
• Fritz Krombach,
• Wolfgang G. Kreyling and
• Carsten Schleh

Beilstein J. Nanotechnol. 2013, 4, 933–940, doi:10.3762/bjnano.4.105

• most promising nanomaterials, and their usage in medical applications and consumer products is growing rapidly. To evaluate possible adverse health effects, especially to the lungs, the current study focused on the cytotoxic and proinflammatory effects of AgNP after the intratracheal instillation in

• AgNP can induce moderate pulmonary toxicity, but only at rather high concentrations. Keywords: cytotoxicity; inflammation; pulmonary toxicity; silver nanoparticles; Introduction Silver nanoparticles (AgNP) are among the most promising nanomaterials, and their usage in medical applications and

Size-dependent characteristics of electrostatically actuated fluid-conveying carbon nanotubes based on modified couple stress theory

• Mir Masoud Seyyed Fakhrabadi,
• Abbas Rastgoo and
• Mohammad Taghi Ahmadian

Beilstein J. Nanotechnol. 2013, 4, 771–780, doi:10.3762/bjnano.4.88

• include chemical, physical, thermal, electrical and mechanical properties, in order to develop some novel systems and structures that can improve the quality of our daily lives. For example, many scientists all over the world are studying the medical applications of nanostructures in order to cure

Porous polymer coatings as substrates for the formation of high-fidelity micropatterns by quill-like pens

• Michael Hirtz,
• Marcus Lyon,
• Wenqian Feng,
• Andrea E. Holmes,
• Harald Fuchs and
• Pavel A. Levkin

Beilstein J. Nanotechnol. 2013, 4, 377–384, doi:10.3762/bjnano.4.44

• cell analysis) and medical applications in diagnostics such as the detection of pathogens or antibodies. Nitrocellulose films and nylon membranes are widely used as carriers for microarrays, usually with spot sizes in the range of 100 to 500 µm, easily accessible for current inkjet and spotting

A highly pH-sensitive nanowire field-effect transistor based on silicon on insulator

• Denis E. Presnov,
• Sergey V. Amitonov,
• Pavel A. Krutitskii,
• Valentina V. Kolybasova,
• Igor A. Devyatov,
• Vladimir A. Krupenin and
• Igor I. Soloviev

Beilstein J. Nanotechnol. 2013, 4, 330–335, doi:10.3762/bjnano.4.38

• be useful for biological and medical applications. A demonstration of such a local probe based on a vapour–liquid–solid-method (VLS) grown silicon-nanowire (SiNW) FET was given in [7]. The sensitivity of this bioprobe to pH change near its maximum value of 59 mV per unit pH was reached and the

Focused electron beam induced deposition: A perspective

• Michael Huth,
• Fabrizio Porrati,
• Christian Schwalb,
• Marcel Winhold,
• Roland Sachser,
• Maja Dukic,
• Jonathan Adams and
• Georg Fantner

Beilstein J. Nanotechnol. 2012, 3, 597–619, doi:10.3762/bjnano.3.70