Magnetic nanoparticles for biomedical NMR-based diagnostics

• Huilin Shao,
• Tae-Jong Yoon,
• Monty Liong,
• Ralph Weissleder and
• Hakho Lee

Beilstein J. Nanotechnol. 2010, 1, 142–154, doi:10.3762/bjnano.1.17

• /drugs, bacteria, and tumor cells, have been quantified. More recently, the capabilities of DMR technology have been further advanced with new developments such as miniaturized nuclear magnetic resonance detectors, better magnetic nanoparticles and novel conjugational methods. These developments have

• ; nuclear magnetic resonance; Introduction Rapid and sensitive measurement of clinically relevant biomarkers, pathogens and cells in biological samples would be invaluable for disease diagnosis, monitoring of malignancy, and for evaluating therapy efficacy in personalized medicine. To translate such

• targets. Another technology that has achieved considerable success is diagnostic magnetic resonance (DMR). Based on nuclear magnetic resonance (NMR) as the detection mechanism, DMR exploits MNPs as proximity sensors, which modulate the spin–spin relaxation time of water molecules adjacent to the