Fabrication and testing of polymer microneedles for transdermal drug delivery

• Vahid Ebrahiminejad,
• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2022, 13, 629–640, doi:10.3762/bjnano.13.55

• classified into solid, hollow, coated, hydrogel-forming, and dissolvable types, which depending on the specific medical applications [12][13], are fabricated using silicon, metal, ceramic, silica glass, carbohydrate, and polymers [7][14]. In recent years, polymeric MNs have gained a lot of interest due to

A chemiresistive sensor array based on polyaniline nanocomposites and machine learning classification

• Jiri Kroutil,
• Alexandr Laposa,
• Ali Ahmad,
• Jan Voves,
• Vojtech Povolny,
• Ladislav Klimsa,
• Marina Davydova and
• Miroslav Husak

Beilstein J. Nanotechnol. 2022, 13, 411–423, doi:10.3762/bjnano.13.34

• at room temperature (25 °C). The precipitate obtained after the polymerization was filtered and purified by 0.2 M hydrochloric acid and acetone. Subsequently, pure polyaniline was dried over silica gel in a desiccator for 24 h. Next, the dispersion solutions were prepared by mixing 24 mg PANI and 5

• dispersion solutions were deposited by a micropipette on the interdigitated electrode arrays. After that, the deposited sensor layers were dried using the integrated heating elements at 60 °C for 2 h and whole sensor array was subsequently dried in a desiccator over silica gel for 24 h. Before the deposition

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

• Zahra Nabizadeh,
• Mahmoud Nasrollahzadeh,
• Hamed Daemi,
• Mohamadreza Baghaban Eslaminejad,
• Ali Akbar Shabani,
• Mehdi Dadashpour,
• Majid Mirmohammadkhani and
• Davood Nasrabadi

Beilstein J. Nanotechnol. 2022, 13, 363–389, doi:10.3762/bjnano.13.31

• TE, there are other nanoscale tube-based compounds, which can potentially be used for biomedical purposes. Among these, silica nanotubes have the greatest potential for integration in biomaterials because of their biocompatibility, photoluminescence activity, and ease of surface modification. Silica

• nanotubes exhibit considerable results regarding bone TE due to their ability to provide a surface with proper roughness, which facilitates osteoblast attachment and proliferation, and can provide an active site for the deposition of inorganic calcium apatite [138]. In addition to silica, titanium dioxide

Investigation of a memory effect in a Au/(Ti–Cu)Ox-gradient thin film/TiAlV structure

• Damian Wojcieszak,
• Jarosław Domaradzki,
• Michał Mazur,
• Tomasz Kotwica and
• Danuta Kaczmarek

Beilstein J. Nanotechnol. 2022, 13, 265–273, doi:10.3762/bjnano.13.21

• requirements of the different characterization methods, thin gradient layers were deposited on silicon (Si), amorphous silica (SiO2) and conductive metallic substrates (Ti6Al4V). The resulting thickness of the prepared thin films was about 610 nm as measured using a Talysurf optical profiler (Tylor Hobson CCI

Engineered titania nanomaterials in advanced clinical applications

• Padmavati Sahare,
• Paulina Govea Alvarez,
• Juan Manual Sanchez Yanez,
• Gabriel Luna-Bárcenas,
• Samik Chakraborty,
• Sujay Paul and
• Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

• TiO2 nps [83]. TiO2 supported on silica nanospheres was checked for its antibacterial activity against E. coli, and the result demonstrated a more effective growth inhibition than that of commercial TiO2-P25 under ultraviolet and visible light [84]. Copper is well known for its antimicrobial properties

• /titanium dioxide nanocomposites against biofilm-forming and methicillin-resistant strains of Staphylococcus aureus and Pseudomonas aeruginosa [95]. In another novel approach, dip pen nanolithography and soft lithography were used to form a micropattern of a silica sol modified with TiO2 (5% and 10

• many years, titania has been employed as a colorant in food, cosmetics, and sunscreen. Moreover, Ti-containing metal alloys have been widely utilized in medical fields, because the have a higher biocompatibility than other vastly explored metal oxides such as silica, manganese oxide, and iron oxide

A comprehensive review on electrospun nanohybrid membranes for wastewater treatment

• Senuri Kumarage,
• Imalka Munaweera and
• Nilwala Kottegoda

Beilstein J. Nanotechnol. 2022, 13, 137–159, doi:10.3762/bjnano.13.10

• particulate matter. Ge et al. developed an electrospun nanocomposite with rare earth-fused polyurethane to adsorb volatile organic compounds, which are air pollutants [16]. Al-Attabi et al. fabricated a nanohybrid for the submicrometer aerosol particle size filtration by doping wrinkled silica into PAN via

• . developed a superhydrophilic and underwater superoleophobic nanofibrous membrane of PAN with hierarchically structured skin constructed by electrospraying silica nanoparticles (SiO2 NPs) mixed in a dilute PAN solution on the top surface of an electrospun PAN membrane. The SiO2 NPs have been used to increase

Sputtering onto liquids: a critical review

• Anastasiya Sergievskaya,
• Adrien Chauvin and
• Stephanos Konstantinidis

Beilstein J. Nanotechnol. 2022, 13, 10–53, doi:10.3762/bjnano.13.2

Irradiation-driven molecular dynamics simulation of the FEBID process for Pt(PF₃)₄

• Alexey Prosvetov,
• Alexey V. Verkhovtsev,
• Gennady Sushko and
• Andrey V. Solov’yov

Beilstein J. Nanotechnol. 2021, 12, 1151–1172, doi:10.3762/bjnano.12.86

• amorphous substrates, for example, amorphous silica or amorphous carbon, which are commonly used in FEBID and surface science experiments. The structure of precursor molecules, their interaction with a substrate, and the dynamics of nanostructure formation and growth are influenced by interatomic

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• silica nanoparticles showed a synergistic therapeutic effect in in vivo and in vitro models of liver cancer due to their superior superparamagnetic properties, hyperthermia, high CUR-loading capacity, and sensitivity to the microenvironment of the tumor [137]. Authors argue that the magnetic sensitivity

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

• (conventional and echogenic), niosomes, nanoemulsions, polymeric nanoparticles, chitosan nanocapsules, dendrimers, hydrogels, nanogels, gold nanoparticles, titania nanostructures, carbon nanostructures, mesoporous silica nanoparticles, fuel-free nano/micromotors. Keywords: smart nanomaterials; sonodynamic

• , dendrimers, and capsules), lipid-based carriers (including liposomes and solid lipid NP), and non-polymer-based structures (including nanomachines, gold NPs, titanium, carbon, and silica nanostructures) along with some other novel NPs which can trigger drug release after US activation. A discussion on these

• ]. Various nanostructures have been developed for free radical generation under US irradiation. A novel nanostructure was constructed based on a BNN-type NO-releasing molecule and superparamagnetic iron oxide nanoparticles (SPION)-encapsulated mesoporous silica NPs (MSN) which could generate NO free radicals

Recent progress in magnetic applications for micro- and nanorobots

• Ke Xu,
• Shuang Xu and
• Fanan Wei

Beilstein J. Nanotechnol. 2021, 12, 744–755, doi:10.3762/bjnano.12.58

• analyte. The magnetic bead (MaB) architecture is composed of a 15 nm iron oxide (Fe3O4) superparamagnetic core encased in a silica shell. The DNA strands are conjugated to the polymeric brush using a flexible linker. The brush permits passage of the nanoparticles through cell membranes, and prevents

A review of defect engineering, ion implantation, and nanofabrication using the helium ion microscope

• Frances I. Allen

Beilstein J. Nanotechnol. 2021, 12, 633–664, doi:10.3762/bjnano.12.52

Boosting of photocatalytic hydrogen evolution via chlorine doping of polymeric carbon nitride

• Malgorzata Aleksandrzak,
• Michalina Kijaczko,
• Wojciech Kukulka,
• Daria Baranowska,
• Martyna Baca,
• Beata Zielinska and
• Ewa Mijowska

Beilstein J. Nanotechnol. 2021, 12, 473–484, doi:10.3762/bjnano.12.38

• removal. Then, the reactor was irradiated with a Xe lamp (150 W) with an air mass filter (A.M. 1.5 G) to achieve a simulated solar light. The photocatalytic H2 evolution rate was analyzed by using a Young Lin 6500 gas chromatograph (GC, micro TCD detector, ValcoPLOT Molesieve 5 Å fused-silica column, and

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

• developed E-selectin-targeted porous silicon particles with capabilities for selective uptake to the BM [35]. The authors formulated a multistage carrier composed of porous silica microparticles that encapsulate nanoscale paclitaxel-loaded liposomes. The porous silica particles were decorated with E

• leukemia cell population, Mandal and co-workers developed mesoporous silica nanoparticles decorated with an anti-B220 antibody intended for B220+LSC targeting [53]. The daunorubicin-loaded targeted nanoparticles demonstrated selective efficacy against B220+/Mac1− cells, relative to B220− AML LSCs. In

• itself proved to be non-toxic to healthy BALB/c mice. The co-delivery strategy has the potential to overcome therapy-induced niche-mediated leukemia resistance in AML. Dong et al. developed a biomimetic NDDS composed of a mesoporous silica nanoparticulate core loaded with daunorubicin and coated with

Structural and optical characteristics determined by the sputtering deposition conditions of oxide thin films

• Petronela Prepelita,
• Florin Garoi and
• Valentin Craciun

Beilstein J. Nanotechnol. 2021, 12, 354–365, doi:10.3762/bjnano.12.29

• , respectively), in order to precisely control and regulate the flow of gases into the deposition chamber. Quartz (fused silica, NEGS2) slides with dimensions of 2 cm × 2 cm × 0.1 cm were used as substrates. Initially, all substrates were cleaned in an ultrasonic bath to ensure good reproducibility of the

Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management

• Uzma Azeem Awan,
• Abida Raza,
• Shaukat Ali,
• Rida Fatima Saeed and
• Nosheen Akhtar

Beilstein J. Nanotechnol. 2021, 12, 295–303, doi:10.3762/bjnano.12.24

• , such as DOX [18]. Advanced synergistic therapies, such as the combination of chemotherapy and photothermal therapy, have been applied to enhance the overall therapeutic efficacy [19]. This includes magnetic cores capped with gold nanorods, silica nanorattle gold shells, and DNA-based platforms loaded

Gold(I) N-heterocyclic carbene precursors for focused electron beam-induced deposition

• Cristiano Glessi,
• Aya Mahgoub,
• Cornelis W. Hagen and
• Mats Tilset

Beilstein J. Nanotechnol. 2021, 12, 257–269, doi:10.3762/bjnano.12.21

• purified through column chromatography (DCM, silica). The product was obtained as an off-white powder (100.3 mg, 89%). 1H NMR (400 MHz, CD2Cl2) δ 4.29 (q, J = 7.3 Hz, 4H, -CH2-), 1.44 (t, J = 7.3 Hz, 6H, -CH3); 13C NMR (101 MHz, CD2Cl2) δ 174.1 (NHC-C), 116.9 (=C-Cl), 46.3 (-CH2-), 16.0 (-CH3); MS (ESI

• evapouration and the resulting white solid was partially dissolved in dichloromethane (DCM), filtered, and purified through column chromatography (DCM, silica). The obtained orange powder was precipitated from layering of DCM and pentane. The product was obtained as a white powder (89.2 mg, 72%). 1H NMR (600

• yellow coloration of the suspension was observed. After 4 h of stirring in the dark the yellow suspension was filtered and concentrated to dryness. The solid was purified by column chromatography (silica, DCM) and an orange product was obtained. Upon recrystallization from layered DCM and pentane, white

Scanning transmission helium ion microscopy on carbon nanomembranes

• Daniel Emmrich,
• Annalena Wolff,
• Nikolaus Meyerbröker,
• Jörg K. N. Lindner,
• André Beyer and
• Armin Gölzhäuser

Beilstein J. Nanotechnol. 2021, 12, 222–231, doi:10.3762/bjnano.12.18

• [18], Hall measured the thickness of a silicon nitride membrane down to 5 nm using the bright-field signal [19]. A different detection method is the use of a microchannel plate (MCP). Woehl et al. were able to resolve the core–shell structure of silica-coated gold nanoparticles with an annular

A review on the biological effects of nanomaterials on silkworm (Bombyx mori)

• Sandra Senyo Fometu,
• Guohua Wu,
• Lin Ma and
• Joan Shine Davids

Beilstein J. Nanotechnol. 2021, 12, 190–202, doi:10.3762/bjnano.12.15

• germination of seeds prove that the incorporation of nanotechnology in agriculture can boost crop production and the use of nanoscale pesticides [35] can improve crop protection. Silica is an example of a nanomaterial used in the formulation of nanoscale pesticides, which are used to control pest incidence

• and Drosophila [129]. Also, liver damage was reported in mice following treatment with silica nanoparticles for three months [130]. Higher concentrations and sublethal doses of some nanomaterials result in higher mortality, poor cocoon quality, and lower body weight when compared to control groups

Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells

• Cynthia Kembuan,
• Helena Oliveira and
• Christina Graf

Beilstein J. Nanotechnol. 2021, 12, 35–48, doi:10.3762/bjnano.12.3

• of Applied Sciences, Fachbereich Chemie- und Biotechnologie, Stephanstr. 7, D-64295 Darmstadt, Germany 10.3762/bjnano.12.3 Abstract Upconversion nanoparticles (UCNPs), consisting of NaYF4 doped with 18% Yb and 2% Er, were coated with microporous silica shells with thickness values of 7 ± 2 and 21

• course of 24h, particles with thicker shells release fewer lanthanide ions than particles with thinner shells. However, even a 21 ± 3 nm thick silica layer does not entirely block the disintegration process of the UCNPs. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays and cell

• cytometry measurements performed on macrophages (RAW 264.7 cells) indicate that cells treated with amino-functionalized particles with a thicker silica shell have a higher viability than those incubated with UCNPs with a thinner silica shell, even if more particles with a thicker shell are taken up. This

Bio-imaging with the helium-ion microscope: A review

• Matthias Schmidt,
• James M. Byrne and
• Ilari J. Maasilta

Beilstein J. Nanotechnol. 2021, 12, 1–23, doi:10.3762/bjnano.12.1

• epithelial cells with silica nanoparticles with HIM at the Microscopy and Microanalytics Conference 2011 [11]. In their abstract, they suggested that Rutherford back-scattering imaging in the HIM enables the distinction of nanoparticles from cell surface structures at nanometre resolution. In a different

Free and partially encapsulated manganese ferrite nanoparticles in multiwall carbon nanotubes

• Saja Al-Khabouri,
• Salim Al-Harthi,
• Toru Maekawa,
• Mohamed E. Elzain,
• Ashraf Al-Hinai,
• Ahmed D. Al-Rawas,
• Abbsher M. Gismelseed,
• Ali A. Yousif and
• Myo Tay Zar Myint

Beilstein J. Nanotechnol. 2020, 11, 1891–1904, doi:10.3762/bjnano.11.170

• were attributed to an increase in the dipolar interparticle interactions due to the close packing of nanoparticles within the tubes [7]. There are several potential applications that use metal–metal oxide/CNTs hybrid systems. Carbon nanostructures decorated with titania and silica are used for the

Scanning transmission imaging in the helium ion microscope using a microchannel plate with a delay line detector

• Eduardo Serralta,
• Nico Klingner,
• Olivier De Castro,
• Michael Mousley,
• Santhana Eswara,
• Serge Duarte Pinto,
• Tom Wirtz and
• Gregor Hlawacek

Beilstein J. Nanotechnol. 2020, 11, 1854–1864, doi:10.3762/bjnano.11.167

• annular microchannel plate detector was used for investigating gold–silica core–shell nanoparticles in ADF mode [30]. These approaches require a physical aperture to restrict the acceptance angle when performed in BF, and a physical change of the distance between the sample and the annular detector to

Unravelling the interfacial interaction in mesoporous SiO₂@nickel phyllosilicate/TiO₂ core–shell nanostructures for photocatalytic activity

• Bridget K. Mutuma,
• Xiluva Mathebula,
• Isaac Nongwe,
• Bonakele P. Mtolo,
• Boitumelo J. Matsoso,
• Rudolph Erasmus,
• Zikhona Tetana and
• Neil J. Coville

Beilstein J. Nanotechnol. 2020, 11, 1834–1846, doi:10.3762/bjnano.11.165

• nanostructures are attractive candidates for photocatalysis owing to their tunable physicochemical properties, their interfacial contact effects, and their efficacy in charge-carrier separation. This study reports, for the first time, on the synthesis of mesoporous silica@nickel phyllosilicate/titania (mSiO2

• [24][25]. One method to maximize the SiO2–TiO2 interaction is via the synthesis of core–shell nanostructures or nanocomposites [18][19][26][27]. Ikeda et al. [26] reported an improved photodecomposition of acetic acid by using a titania core@hollow silica shell nanostructured catalyst. Similarly, Ren

• . Although rattle-type TiO2@void@SiO2 systems could provide high dye adsorption ability, a core–shell architecture (TiO2@SiO2) provides a better separation rate of the photogenerated electrons and holes by restricting the electron–hole recombination through the close interaction of silica with the titania

Nanocasting synthesis of BiFeO₃ nanoparticles with enhanced visible-light photocatalytic activity

• Thomas Cadenbach,
• Maria J. Benitez,
• A. Lucia Morales,
• Cesar Costa Vera,
• Luis Lascano,
• Francisco Quiroz,
• Alexis Debut and
• Karla Vizuete

Beilstein J. Nanotechnol. 2020, 11, 1822–1833, doi:10.3762/bjnano.11.164

• Fuerzas Armadas ESPE, Av. Gral. Rumiñahui s/n, Sangolquí, PO Box 171-5-231B, Ecuador 10.3762/bjnano.11.164 Abstract In this work, monodisperse BiFeO3 nanoparticles with a particle diameter of 5.5 nm were synthesized by a nanocasting technique using mesoporous silica SBA-15 as a hard template and pre

• diameter corresponding to the pore size of the porous matrix and, consequently, by a high specific surface area. Silica matrices, such as Santa Barbara Amorphous silica (SBA-15) or Korean Advanced Institute of Science and Technology silica (KIT-6), have been used successfully as hard templates to

• sieve. Mesoporous silica SBA-15 with a pore size diameter of approximately 8 nm was prepared according to the procedures describe elsewhere [38][42]. Please find the corresponding small-angle xrd pattern (Figure S3), BET analysis (Figure S4, Table S2) and a TEM image (Figure S5) of the synthesized SBA