Recent progress on field-effect transistor-based biosensors: device perspective

• Billel Smaani,
• Fares Nafa,
• Mohamed Salah Benlatrech,
• Ismahan Mahdi,
• Hamza Akroum,
• Mohamed walid Azizi,
• Khaled Harrar and
• Sayan Kanungo

Beilstein J. Nanotechnol. 2024, 15, 977–994, doi:10.3762/bjnano.15.80

• , biosensors have been extensively utilized in the field of medical sciences and clinical diagnostics [14]. They have been employed in cancer diagnosis [15], cardiovascular studies [16], and diabetes monitoring [17]. The application of biosensors in cancer diagnosis and therapy is very important due to the

Therapeutic effect of F127-folate@PLGA/CHL/IR780 nanoparticles on folate receptor-expressing cancer cells

• Thi Ngoc Han Pham,
• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan Thang Cao,
• Thanh-Danh Nguyen,
• Vy Tran Anh and
• Hieu Vu_Quang

Beilstein J. Nanotechnol. 2024, 15, 954–964, doi:10.3762/bjnano.15.78

• ). Additionally, the F127-folate@PLGA/CHL/IR780 nanoparticles exhibited a lower IC50 value against cancer cells than non-targeted F127@PLGA/CHL/IR780 nanoparticles. These findings suggest that the developed F127-folate@PLGA/CHL/IR780 nanoparticles hold promise as a theragnostic system for targeted cancer therapy

• ) (PLA) and poly(glycolic acid) (PGA), has been employed in the synthesis of nanoparticles for cancer diagnostics and therapy because of its excellent biocompatibility and biodegradability [1][2][3]. PLGA nanoparticles can be prepared via a variety of techniques, including single emulsion, double

• on the half-life of nanoparticles that are currently in circulation. The optimal nanoparticle size for cancer therapy was observed to vary between 50 and 200 nm [39][40]. In our study, the nanoparticles were tailored for in vivo drug administration; thus, our nanoparticle size was suitable for use in

Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material

• Veronika Pálos,
• Krisztina S. Nagy,
• Rita Pázmány,
• Krisztina Juriga-Tóth,
• Bálint Budavári,
• Judit Domokos,
• Dóra Szabó,
• Ákos Zsembery and
• Angela Jedlovszky-Hajdu

Beilstein J. Nanotechnol. 2024, 15, 781–796, doi:10.3762/bjnano.15.65

• )/hydroxyapatite in orthopedics [1][2]. Biocompatible polymers are widely used in biomedical fields, such as stents, drug delivery systems in cancer therapy, bone repair, dentistry, joint prostheses, and tissue engineering [2][3][4][5][6]. Polymers have several advantageous properties for these applications as

Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels

• Nabojit Das,
• Vikas,
• Akash Kumar,
• Sanjeev Soni and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 678–693, doi:10.3762/bjnano.15.56

• , electrochemical sensors, and photothermal therapy (PTT) [5]. These technologies are based on the principle of elastic scattering properties of metal nanoparticles and on the shift in the plasmon band, which is more prominent in the case of anisotropic nanoparticles in comparison to isotropic ones [6]. Several

• purposes. Also, gold nanoparticles possess an intrinsic capacity to liberate heat upon irradiation of NIR/IR lasers making them a suitable candidate for photothermal therapy (PTT). Previous studies reported morphology-dependent heat liberation in gold nanoparticles where anisotropic particles (gold

• potential to exhibit photothermal conversion which has been manifested for their application in minimal-invasive photothermal therapy (PTT). The photothermal conversion is known to be significantly governed by LSPR where the state/milieu of the nanoparticles can play an important role [18]. Significant

Exfoliation of titanium nitride using a non-thermal plasma process

• Priscila Jussiane Zambiazi,
• Dolores Ribeiro Ricci Lazar,
• Larissa Otubo,
• Rodrigo Fernando Brambilla de Souza,
• Almir Oliveira Neto and
• Cecilia Chaves Guedes-Silva

Beilstein J. Nanotechnol. 2024, 15, 631–637, doi:10.3762/bjnano.15.53

• exfoliation methods, offering promising prospects for applications in photoacoustic imaging and photothermal therapy of tumors because of their satisfactory absorption characteristics in the second near-infrared (NIR-II) region [5]. The non-thermal plasma (NTP) synthesis method enables the fabrication of 2D

Radiofrequency enhances drug release from responsive nanoflowers for hepatocellular carcinoma therapy

• Yanyan Wen,
• Ningning Song,
• Yueyou Peng,
• Weiwei Wu,
• Qixiong Lin,
• Minjie Cui,
• Rongrong Li,
• Qiufeng Yu,
• Sixue Wu,
• Yongkang Liang,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2024, 15, 569–579, doi:10.3762/bjnano.15.49

On the additive artificial intelligence-based discovery of nanoparticle neurodegenerative disease drug delivery systems

• Shan He,
• Julen Segura Abarrategi,
• Harbil Bediaga,
• Sonia Arrasate and
• Humberto González-Díaz

Beilstein J. Nanotechnol. 2024, 15, 535–555, doi:10.3762/bjnano.15.47

• similar systems to this research work such as NP systems, taking into account NP structure and coating agents, synthesis conditions of NPs and loaded drugs, cancer co-therapy drugs, or assay conditions [53][54][55][56][57]. Here we developed IFPTML models for the proposal of N2D3Ss containing NDD and NP

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• enhancing SOD, GPx, and CAT activities [166]. Second, nanoantioxidants can be used to support cancer therapies such as photodynamic therapy (PDT) and photothermal therapy (PTT) [167]. In this strategy, nanomaterials with antioxidant activities enhance PDT and PTT efficacy by reducing hypoxia in the tumor

• , Kharlamov et al. investigated 180 patients diagnosed with coronary artery disease (CAD). Their findings unveiled a notable regression of coronary atherosclerosis associated with plasmonic photothermal therapy using silica–gold NPs (SiO2-AuNPs) [177]. Metal-based NPs exhibit the ability to scavenge free

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• skeletal tissue, plasma creatine kinase, and tissue leukocyte infiltration) and trypanocidal effects (reduction of parasitemia) in an acute murine model [79]. A complementary use of Theracurmin® with BNZ therapy is suggested. Intravenous polycaprolactone Nps loaded with ursolic acid (UR-PCL), a natural

• , Pfizer-BioNTech COVID-19 in 2021 [99] and Moderna COVID-19 Vaccine in 2022 [100], after the approval in 2018 of Onpattro (Patisiran) [101], the first gene therapy based on lipid nanoparticles containing RNA interference, for the treatment of hereditary transthyretin-mediated amyloidosis. Vaccines made of

Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors

• Joyita Roy and
• Kunal Roy

Beilstein J. Nanotechnol. 2024, 15, 297–309, doi:10.3762/bjnano.15.27

• microenvironment (TME) prone to hypoxic conditions [46]. Insufficient oxygen reduces ROS generation, which decreases the efficacy of oxygen-dependent therapies, such as photodynamic therapy (PDT), chemodynamic therapy (CDT), and radiation therapy. The information derived from the positive contribution of the

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• photothermal therapy on a single platform has been developed in the form of vinorelbine-loaded polydopamine-coated iron oxide nanoparticles. Vinorelbine (VNB) is loaded on the surface of iron oxide nanoparticles produced by a solvothermal technique after coating with polydopamine (PDA) with varying weight

• cancer therapy agent, is included in the nanocomposite structure, and in vitro drug release studies under different pH conditions (pH 5.5 and 7.4) and photothermal activity at 808 nm NIR laser irradiation are investigated. The comprehensive integration of precise multifunctional nanoparticles design

• passive targeting and offer multimodal tumor therapy. In recent years, the use of nanotechnology-based cancer drugs has emerged as a promising alternative treatment approach. Utilizing various nanostructures as specific vehicles for drug delivery enhances efficacy and pharmacokinetic properties of

Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics

• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan-Thang Cao,
• Vy Tran-Anh and
• Hieu Vu Quang

Beilstein J. Nanotechnol. 2024, 15, 180–189, doi:10.3762/bjnano.15.17

• nowadays, since it enables both diagnosis and therapy at the same time while only using one carrier platform. Therefore, formulating a nanocarrier system that could serve as theragnostic agent by using simple techniques would be an advantage during production. In this project, we aimed to develop a

• and IR783 are also promising diagnostic choices. Encapsulation of IR780 in nanoparticles can be used for imaging and photothermal, photodynamic, and combinatorial cancer therapies [20][21][22]. IR780 is also utilized in PEG-PLA nanoparticles for photodynamic therapy of human breast cancer cells [23

• diagnoses, including tumor-targeted drug delivery, hyperthermia, photodynamic therapy, and imaging. Nanomedicines can be made from a variety of inert, biodegradable, and in vivo biocompatible materials. Poly(lactic-co-glycolic acid) is one of the most biodegradable and biocompatible copolymers owing to its

Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

• Le Thi Le,
• Hue Thi Nguyen,
• Liem Thanh Nguyen,
• Huy Quang Tran and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7

• , nanofiber scaffolds can act as a multifunctional tool in medical treatments, combining drug release for disease therapy, cell proliferation, wound healing, and antimicrobial effect [21][22][23][24][25]. Nanofibers of PLA functionalized with laponite (LAP)/amoxicillin (AMX) prolonged the drug release up to

• treatment of bone defects [21]. In dentistry, anti-infective nanofiber-based drug-release systems have been investigated for periodontal disease control, endodontic therapy, cariogenic microorganism control, and tissue reconstruction [25]. Due to the controlled drug release, BBR-loaded nanofiber scaffolds

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• infected with L. donovani. Artemisinin-NPs reduced the number of ex vivo infected macrophages and the intracellular infection of Leishmania donovani amastigotes (IC50 of 6.0 ± 1.4 µg/mL and 5.1 ± 0.9 µg/mL, respectively). Artemisinin-NPs showed better efficacy than free artemisinin after therapy in a mouse

• combination therapy. The authors functionalized the surface of PLGA-NPs with Eudragit L30D, a polymer that provides pH-dependent drug release and significantly improved targeted action, thus increasing the efficacy of the drug [45]. Curc-E-PLGA-NPs showed spherical morphology, with a hydrodynamic mean

• reactive oxygen/nitrogen metabolites, (ii) increased phagocytic activity, and (iii) increased lymphocyte proliferation [45]. Furthermore, curc-E-PLGA-NPs proved to be effective as an adjuvant in the therapy against leishmaniasis. Like curc, other leishmanicidal drugs have been encapsulated into polymeric

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• (Pilocarpus microphyllus), which has known activity against adult, young, and egg forms of Schistosoma mansoni [57]. Since this is an apolar molecule with poor solubility, the author proposed a nanosystem using liposomes to make this molecule more useful in schistosomiasis therapy. The results showed that

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• to confirm the uptake of CUR-HSA-MPs by cancer cells. Our studies revealed that HSA-MPs are potentially promising vehicles for increasing the solubility and bioavailability of CUR. Keywords: albumin submicron particles; cancer therapy; curcumin; drug delivery; Introduction Curcumin (CUR) is a

• into cancer cells, making them a promising option for cancer therapy. In addition, the surface modification of microparticles using substances such as antibodies and polymers suggests the potential for enhanced uptake, as previously demonstrated [55][56]. Nevertheless, further research should explore

Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

• Elangovan Sarathkumar,
• Rajasekharan S. Anjana and
• Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

• change [20][21]. Generally, photothermal nanomaterials are being used in cancer therapy, removal of bacterial biofilms, and sensing applications [22][23][24]. Photothermal nanomaterials produce heat in response to the irradiation of photons at a particular wavelength [23]. Similarly, when plasmonic

• particle size from 50 to 4.98 nm. In another study, the size-dependent photothermal conversion efficiency of platinum nanomaterials was studied by Depciuch et al. for cancer therapy. Spherical platinum nanoparticles with diameters of 2 and 80 nm were studied regarding the photothermal activity in colon

• (nanocages, nanorods, and nanohexapods) for photothermal therapy. All three nanostructures exhibited NIR absorption and could convert light into heat, with the gold nanohexapods having the highest efficiency [66] (Figure 6F,G). Branched gold nanostructures (Figure 6D,E) showed higher photothermal activity

Fragmentation of metal(II) bis(acetylacetonate) complexes induced by slow electrons

• Janina Kopyra and
• Hassan Abdoul-Carime

Beilstein J. Nanotechnol. 2023, 14, 980–987, doi:10.3762/bjnano.14.81

• beams), in plasma applications, or possibly in radiation therapy as radiosensitizers. Experimental We performed electron collision experiments with several metal acetylacetonate compounds, ML2, in a crossed-beam arrangement. According to the description given in [16][17][29], this arrangement consists

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• higher binding affinity and specificity, mAbs have received a lot of attention for the detection of selective cancer biomarkers and also for the treatment of various types of cancer. Antibody-conjugated nanoparticles (ACNPs) are an effective targeted therapy for the efficient delivery of

• -directed enzyme prodrug therapy, small molecule drug conjugates, and others are being investigated [2][3]. Targeted delivery with nanoparticles (NPs) has received a lot of attention because it reduces toxicity while also providing good drug compatibility and loadability. Furthermore, NPs increase drug

• potential and can be effectively used as imaging/therapeutic agents (Table 1). In some cases, ACNPs provide opportunities for image-guided therapy with overall theranostic applications. The NP-mediated targeted delivery ultimately provides advanced diagnostic and therapeutic options for early diagnosis and

Green SPIONs as a novel highly selective treatment for leishmaniasis: an in vitro study against Leishmania amazonensis intracellular amastigotes

• Brunno R. F. Verçoza,
• Robson R. Bernardo,
• Luiz Augusto S. de Oliveira and
• Juliany C. F. Rodrigues

Beilstein J. Nanotechnol. 2023, 14, 893–903, doi:10.3762/bjnano.14.73

• exhibit theranostic properties, that is, they can be used simultaneously for diagnosis and therapy. Thus, SPIONs have emerged as one of the best options for the development of new therapeutic methods. SPIONs offer several features such as good biocompatibility, degradability under moderate acid conditions

Nanoarchitectonics to entrap living cells in silica-based systems: encapsulations with yolk–shell and sepiolite nanomaterials

• Celia Martín-Morales,
• Jorge Fernández-Méndez,
• Pilar Aranda and
• Eduardo Ruiz-Hitzky

Beilstein J. Nanotechnol. 2023, 14, 522–534, doi:10.3762/bjnano.14.43

• confer a shell structure to the unicellular organisms to improve their inherent properties and functions. In fact, the so-called “cellular shellization” has been proposed to obtain a cell surface allowing for applications in advanced technologies and biomedicine including cell delivery and cell therapy

Microneedle patches – the future of drug delivery and vaccination?

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2023, 14, 494–495, doi:10.3762/bjnano.14.40

• . Hypodermic syringe injections are, of course, ubiquitous in modern medicine for drug therapy and vaccination, where oral administration is either not desirable or not possible. Delivery may be intravenous, intramuscular or percutaneous. Hypodermic needles of various dimensions are also used to extract venous

Specific absorption rate of randomly oriented magnetic nanoparticles in a static magnetic field

• Ruslan A. Rytov and
• Nikolai A. Usov

Beilstein J. Nanotechnol. 2023, 14, 485–493, doi:10.3762/bjnano.14.39

• hyperthermia; magnetic nanoparticles; magnetic particle imaging; specific absorption rate; static magnetic field; Introduction Magnetic nanoparticles, mainly iron oxides, are promising materials for the diagnosis and therapy of oncological diseases [1][2][3]. Important fields of application of magnetic

• environment, except for a certain area near the field-free point (FFP). This will allow one to localize the heat release in the tumor area with millimeter accuracy. The search for optimal assemblies for joint MH-MPI therapy is an urgent task in this research area. Experimental measurements of dynamic

• therapy since, in this case, the maximum heat release is concentrated in a well-localized region near the FFP. Also, it has been found that for nanoparticles of larger diameters, D ≥ 30 nm, the change in the assembly SAR with an increase in the dc magnetic field has a nonmonotonic character. Namely, in

Plasmonic nanotechnology for photothermal applications – an evaluation

• A. R. Indhu,
• L. Keerthana and
• Gnanaprakash Dharmalingam

Beilstein J. Nanotechnol. 2023, 14, 380–419, doi:10.3762/bjnano.14.33

• tunability of optothermal properties and enhanced stability, these nanostructures show a wide range of applications in optical sensors, steam generation, water desalination, thermal energy storage, and biomedical applications such as photothermal (PT) therapy. The PT effect, that is, the conversion of

• materials [7][8], such as Au nanoparticles (AuNPs), in photodynamic therapy [9][10][11]. Metal nanoparticles in general have been extensively explored in PPT applications due to their high free electron density and the possibility of intricate tuning of light absorption [12]. Noble metal nanoparticles with

• temperature and reactivity. With broad applications in therapy [22][23], laser combined imaging, solar vapour generation [24], and biosensors [25], the global market for PT devices is expected to be a multimillion dollar enterprise by 2025 [26]. This review will focus on concepts such as the theoretical

The steep road to nonviral nanomedicines: Frequent challenges and culprits in designing nanoparticles for gene therapy

• Yao Yao,
• Yeongun Ko,
• Grant Grasman,
• Jeffery E. Raymond and
• Joerg Lahann

Beilstein J. Nanotechnol. 2023, 14, 351–361, doi:10.3762/bjnano.14.30