The protein corona protects against size- and dose-dependent toxicity of amorphous silica nanoparticles

• Dominic Docter,
• Christoph Bantz,
• Dana Westmeier,
• Hajo J. Galla,
• Qiangbin Wang,
• James C. Kirkpatrick,
• Peter Nielsen,
• Michael Maskos and
• Roland H. Stauber

Beilstein J. Nanotechnol. 2014, 5, 1380–1392, doi:10.3762/bjnano.5.151

• modulate nanoparticle-induced processes such as opsonization which have direct consequences on the mode of interaction with cells, the efficacy of cellular NP uptake and thus, the organ targeting, biodistribution, and circulatio time of NP in vertebrates and non-vertebrates [22]. Our study indicates that

Optimizing the synthesis of CdS/ZnS core/shell semiconductor nanocrystals for bioimaging applications

• Li-wei Liu,
• Si-yi Hu,
• Ying Pan,
• Jia-qi Zhang,
• Yue-shu Feng and
• Xi-he Zhang

Beilstein J. Nanotechnol. 2014, 5, 919–926, doi:10.3762/bjnano.5.105

• in vivo imaging indicated the great potential of 470 nm laser excitation for autofluorescence-free QDs-based animal imaging. Further studies involving a systemic administration of the nanoparticles via the intravenous route and their subsequent studies of the biodistribution are required to gather

Near-infrared dye loaded polymeric nanoparticles for cancer imaging and therapy and cellular response after laser-induced heating

• Tingjun Lei,
• Alicia Fernandez-Fernandez,
• Romila Manchanda,
• Yen-Chih Huang and
• Anthony J. McGoron

Beilstein J. Nanotechnol. 2014, 5, 313–322, doi:10.3762/bjnano.5.35

• pharmacokinetics and biodistribution of IR820-PGMD NPs [24]. The present manuscript concentrates primarily on the in vitro response of cancer cells after hyperthermia. Therefore, this paper focuses not only on the cancer imaging and therapy capabilities of IR820-PGMD NPs, but also on exploring the cellular

• Figure 6B, respectively. These images show that the biodistribution of IR820-PGMD NPs is initially very similar to free IR820, as both were processed rapidly through hepatobiliary excretion and start to accumulate in the liver within the first 15 min. After 24 h, it seems that both free dye and NPs were

• plasma concentration 24 h after injection compared to free IR820. In addition, our biodistribution studies showed that kidney IR820 dye content was lower in NP form than in free IR820 form, which means less IR820 was excreted through the renal system when in NP form. This is consistent with kidney

Extracellular biosynthesis of gadolinium oxide (Gd₂O₃) nanoparticles, their biodistribution and bioconjugation with the chemically modified anticancer drug taxol

• Shadab Ali Khan,
• Sanjay Gambhir and
• Absar Ahmad

Beilstein J. Nanotechnol. 2014, 5, 249–257, doi:10.3762/bjnano.5.27

• treatment of cancer, we first synthesized extracellular, protein-capped, highly stable and well-dispersed gadolinium oxide (Gd2O3) nanoparticles by using thermophilic fungus Humicola sp. The biodistribution of the nanoparticles in rats was checked by radiolabelling with Tc-99m. Finally, these nanoparticles

• ) and X-ray photoemission spectroscopy (XPS). The Gd2O3–taxol bioconjugate was confirmed by UV–vis spectroscopy and fluorescence microscopy and was purified by using high performance liquid chromatography (HPLC). Keywords: bioconjugation; biodistribution; gadolinium oxide; humicola sp; transmission

• spectra was performed by using the Shirley algorithm. The chemically distinct species were resolved by a nonlinear least square fitting procedure. Radiolabelling and biodistribution studies Radiolabelling of gadolinium oxide (Gd2O3) nanoparticles with Tc-99m To fabricate Tc-99m–Gd2O3 nanoparticles, 10 mg