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Search for "cancer" in Full Text gives 287 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.
A non-enzymatic electrochemical hydrogen peroxide sensor based on copper oxide nanostructures
Beilstein J. Nanotechnol. 2022, 13, 424–436, doi:10.3762/bjnano.13.35
- [7], and cancer [8][9][10][11]. For this reason, targeted monitoring of the concentration of H2O2 in body fluids can be used in the diagnosis of these diseases [12][13][14][15]. Rapid and accurate determination and control of H2O2 concentration is an important task in many other areas, including
Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals
Beilstein J. Nanotechnol. 2022, 13, 284–291, doi:10.3762/bjnano.13.23
- , Beijing, P. R. China School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, P. R. China 10.3762/bjnano.13.23 Abstract Oxidative stress can lead to permanent and irreversible damage to cellular components and even cause cancer and other diseases. Therefore, the development of
- ], sepsis [6], cancer [7], and inflammatory diseases (e.g., periodontal disease and inflammatory bowel disease) [8][9]. Therefore, the development of antioxidative reagents is a crucial strategy to alleviate chronic diseases and maintain the redox balance. Increasingly efficient antioxidant materials are
Systematic studies into uniform synthetic protein nanoparticles
Beilstein J. Nanotechnol. 2022, 13, 274–283, doi:10.3762/bjnano.13.22
- molecules [7] and has been shown to be an attractive vehicle for hydrophobic drugs in several clinical and preclinical applications [8]. This feature is highlighted in the success of AbraxaneTM, a nanoparticle albumin bound (nab) technology to delivery paclitaxel – a hydrophobic cancer therapeutic
- . Paclitaxel was traditionally formulated through solubilization with harsh solvents, which led to adverse side effects and special administration instrumentation [9]. While AbraxaneTM was first FDA-approved for the treatment of metastatic breast cancer, it has since been investigated for other cancers
- -loaded HSA particles with diameters of approximately 130 nm [10][11]. Since then, AbraxaneTM has been used for non-small cell lung cancer, late-stage pancreatic cancer, and as a treatment for metastatic breast cancer [12][13]. Nevertheless, nab-based nanoparticles suffer from significant drawbacks, such
Photothermal ablation of murine melanomas by Fe3O4 nanoparticle clusters
Beilstein J. Nanotechnol. 2022, 13, 255–264, doi:10.3762/bjnano.13.20
- Xue Wang Lili Xuan Ying Pan Department of Obstetrics & Gynecology, China–Japan Union Hospital of Jilin University, Changchun, People’s Republic of China 10.3762/bjnano.13.20 Abstract Melanoma is one of the deadliest forms of cancer, for which therapeutic regimens are usually limited by the
- the promise of Fe3O4 NPCs as a new PTT option to treat melanoma. Keywords: Fe3O4 nanoparticle clusters; heat shock protein 70; melanoma; near infrared; photothermal therapy; Introduction The global incidence of melanoma, one of the deadliest forms of cancer, has kept increasing annually over the
- effects of alumina-coated Fe3O4 nanoparticles against bacteria upon exposure to NIR light [13]. Further studies with esophageal cancer demonstrate that Fe3O4 nanoparticles induce hyperthermia post absorption to suppress tumor growth in a dosage-dependent manner [14]. However, due to very high dosage
Engineered titania nanomaterials in advanced clinical applications
Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15
- reported by Rehman [8], who used the photodynamic properties of TiO2 for killing HeLa cancer cells. The hydrophobic nature of photosensitizers commonly used in photodynamic therapy led to selectivity and aggregation issues that jeopardize their effectiveness. Therefore, TiO2 nanoparticles (nps), which
- therapeutic window for a convenient timespan to significantly improve the remedy for several diseases, including cancer. TiO2 nanomaterials are often used as photosensitizers or as carriers for the delivery of photosensitizing agents, which enhances therapeutic efficacy by increasing the photothermal
- conversion efficiency and by an accumulation of photosensitizers in tumor sites. ROS-related cancer therapeutics such as photodynamic therapy, sonodynamic therapy, and chemical dynamic therapy showed great potential to significantly enhance the precision and efficacy of cancer therapeutics [14]. Neoplastic
Bacterial safety study of the production process of hemoglobin-based oxygen carriers
Beilstein J. Nanotechnol. 2022, 13, 114–126, doi:10.3762/bjnano.13.8
- with doxorubicin, a cytostatic drug used in chemotherapy for cancer treatment. These particles showed higher efficacy in inhibiting metabolic activity in cell culture in comparison to free doxorubicin [8]. To be used as an artificial oxygen carrier, hemoglobin is isolated from bovine blood. Compared to
Theranostic potential of self-luminescent branched polyethyleneimine-coated superparamagnetic iron oxide nanoparticles
Beilstein J. Nanotechnol. 2022, 13, 82–95, doi:10.3762/bjnano.13.6
- partial PEI oxidation during the synthesis. Here, we demonstrate in vitro dye-free optical imaging and successful gene transfection with luminescent SPION@bPEI, which was further modified for receptor-mediated delivery of the cargo selectively to cancer cell lines overexpressing the epidermal growth
- delivery of an anionic cargo. Besides, a strong intracellular optical signal supports the optically traceable nature of these nanoparticles. SPION@bPEI nanoparticles were further conjugated with Erbitux (Erb), which is an anti-EGFR antibody for targeting EGFR-overexpressing cancer cell lines. SPION@bPEI
- cancer [39][40]. Besides, SPIONs are already in the clinic as magnetic resonance imaging (MRI) agents and SPION@bPEI nanoparticles have a strong T2 signal (the signal that reflects the length of time it takes for the MR signal to decay in the transverse plane) [35]. In recent years, there has been a
Heating ability of elongated magnetic nanoparticles
Beilstein J. Nanotechnol. 2021, 12, 1404–1412, doi:10.3762/bjnano.12.104
- use in biomedicine, in particular, in magnetic hyperthermia [1][2][3][4], a new promising approach for cancer treatment. In this method, magnetic nanoparticles introduced into a tumor and excited by an alternating (ac) low-frequency magnetic field are able to warm up malignant tissues locally. In most
Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy
Beilstein J. Nanotechnol. 2021, 12, 1372–1379, doi:10.3762/bjnano.12.101
- Chemistry of Ministry of Education, And School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, Shandong, China Tianjin Medical University Cancer Institute & Hospital, Tianjin, 300060, China 10.3762/bjnano.12.101 Abstract The mechanical properties of cells are key to the
- regulation of cell activity, and hence to the health level of organisms. Here, the morphology and mechanical properties of normal pancreatic cells (HDPE6-C7) and pancreatic cancer cells (AsPC-1, MIA PaCa-2, BxPC-3) were studied by atomic force microscopy. In addition, the mechanical properties of MIA PaCa-2
- after treatment with different concentrations of doxorubicin hydrochloride (DOX) were also investigated. The results show the Young's modulus of normal cells is greater than that of three kinds of cancer cells. The Young's modulus of more aggressive cancer cell AsPC-1 is smaller than that of less
Biocompatibility and cytotoxicity in vitro of surface-functionalized drug-loaded spinel ferrite nanoparticles
Beilstein J. Nanotechnol. 2021, 12, 1339–1364, doi:10.3762/bjnano.12.99
- vitro compared to free drug controls. The IC50 values ranged from 0.81 to 3.97 μg/mL for HepG2 and HT144 cells, whereas IC50 values for normal lymphocytes were 10 to 35 times higher (18.35–43.04 µg/mL). Cobalt ferrite (CFO) and zinc ferrite (ZFO) NPs were highly genotoxic (p < 0.05) in cancer cell lines
- spheroid diameter and up to 74 ± 8.9% of cell death after two weeks. In addition, they also inhibited multidrug resistance (MDR) pump activity in both cell lines suggesting effectivity in MDR cancers. Among the tested MFe2O4 NPs, CFO nanocarriers were the most favorable for targeted cancer therapy due to
- studies; magnetic spinel ferrite nanoparticles; methotrexate; poly(isobutylene-alt-maleic anhydride); Introduction Cancer is the second leading cause of death and, as such, it is a global health concern [1]. It is caused by uncontrolled cell proliferation, reduced cell death rate, or both [2
Self-assembly of amino acids toward functional biomaterials
Beilstein J. Nanotechnol. 2021, 12, 1140–1150, doi:10.3762/bjnano.12.85
- cancer cells [50]. Furthermore, naphthalimide (NI) derivatives can also be used as end-capping materials for amino acids. Naphthalimide has unique photophysical properties and photostability as a luminescent material for aggregation-induced emission (AIE), which can display high emission properties in
- were used for the selective sensing of Fe3+ within cancer cells and imaging of Fe3+ [54]. Amino-acid-coordinated self-assembly. Coordination-driven self-assembly is a supramolecular self-assembly method based on metal-coordination bond formation, which has the advantages of fewer steps, fast final
- coordination of Mn2+, Fmoc-ʟ-L, and Ce6, a yield of 36 wt % can be obtained. After the uptake of FMC NPs by cancer cells, Mn2+ and Ce6 can be released in response to intracellular high levels of glutathione (GSH). Magnetic resonance imaging (MRI) results showed an almost complete elimination of the tumor three
pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages
Beilstein J. Nanotechnol. 2021, 12, 1127–1139, doi:10.3762/bjnano.12.84
- biocompatibility and magnetic properties, have found applications in drug delivery, magnetic resonance imaging and treatment of iron deficiencies [3][4][5][6]. The property of hyperthermia has been found to be beneficial in localized drug release, particularly in cancer therapy [7]. In anti-cancer therapy, IONPs
Use of nanosystems to improve the anticancer effects of curcumin
Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78
- compounds; Introduction According to the International Agency for Research on Cancer, approximately 9.5 million people worldwide die annually from malignant neoplasms [1]. Deaths are primarily due to cancer of the respiratory system (17%), liver (10%), colon and rectum (8%), breast (8%), and stomach (8
- , since it avoids bioavailability issues. However, this results in increased toxicity and side effects [3]. Therefore, one of the goals of new and/or improved cancer therapies is for the drug to only target malignant cells in sufficient concentrations and with minimal distribution to other tissues to
- avoid adverse effects as much as possible. Nanomedicine has recently emerged as an option for cancer treatments and the rationale for its use is based on various improvements seen when a nanosized material and/or drug is administered. It has been successfully used during diagnosis when controlled drug
An overview of microneedle applications, materials, and fabrication methods
Beilstein J. Nanotechnol. 2021, 12, 1034–1046, doi:10.3762/bjnano.12.77
- from cancer research (25% enhanced absorption of the protein cancer drug AvastinTM compared with conventional hypodermic delivery) [14]. Incorporation of drug-loaded nanoparticles in dissolving microneedles also shows promise for dose concentration, for example using the antimicrobial carvacrol (CAR
- skin diseases including cancer, via electrical impedance measurements [52]. Microneedle structure design Several factors should be considered when designing microneedles for skin penetration: (1) geometric features, such as length, diameter, tip size, and shape, (2) physical form: solid, hollow, side
Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications
Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64
- . reported that when the distance between the cell and the MB was increased to 5.5 µm, the exerted shear stress on the cell membrane suddenly decreased [78]. Schlicher et al. exposed prostate cancer cells (DU145) to 24 kHz US irradiation to investigate the cavitation events and the changes in the cell
- isothiocyanate (FITC)-labeled bovine serum albumin (BSA), FITC-labeled 150, 500, and 2000 kDa dextrans into DU145 prostate cancer cells. They blocked the endocytosis mechanism to assess whether the endocytic pathway was upregulated during US exposure. They showed that all of these fluorescent molecules were
- findings suggested that cavitation is strongly dependent on the expansion, concentration, and size of the ADV-generated MBs close to the cellular membrane and also the cell–MB distance [119]. Acoustic droplet vaporization shows promise for spatial control and acceleration of the thermal ablation of cancer
Recent progress in actuation technologies of micro/nanorobots
Beilstein J. Nanotechnol. 2021, 12, 756–765, doi:10.3762/bjnano.12.59
- contrast, micro/nanorobots can operate non-invasively in small, inaccessible spaces and play an important role in biomedicine and other fields, such as targeted drug delivery to treat cancer [1][2][3][4][5][6], nanosurgery [7][8], and environmental treatment [9][10][11]. In 1959, Feynman [12] first
- swing and spiral motion. At the same time, by applying a suitable magnetic field, the nanoeel can be accurately guided to a target location for drug release. Under a magnetic field of 10 mT and 7 Hz, drug delivery to cancer cells could be achieved. The efficiency of killing cancer cells is 35% in the
- cancer, Wang et al. [22] developed a new type of micro/nanorobot, which can observe the state of cancer. This robot uses multi-stage magnetic tweezers for manipulation, which can precisely move in living cells. The multi-stage magnetic tweezers are composed of six magnetic poles and six coils, installed
Recent progress in magnetic applications for micro- and nanorobots
Beilstein J. Nanotechnol. 2021, 12, 744–755, doi:10.3762/bjnano.12.58
- structure had a higher motion speed and could effectively suppress lateral drifting motion. In addition, MNRs with a hollow tubular structure [29], which could facilitate drug delivery and realize effective treatment of cancer by loading and releasing anticancer drugs, were proposed and fabricated. At the
- , with which cancer cells and non-cancerous cells can be distinguished. Furthermore, a cell sensor that uses MaBiDz for rapid detection and imaging of target mRNA biomarkers of metastatic breast cancer has been realized. Its function shows that it is likely to be used as a biomimetic organelle MNR in the
Fate and transformation of silver nanoparticles in different biological conditions
Beilstein J. Nanotechnol. 2021, 12, 665–679, doi:10.3762/bjnano.12.53
- , which listed more than 100 AgNP-containing food products [4]. The biomedical use of AgNPs represents the largest proportion of the market share [1] encompassing antimicrobial coatings on medical devices (catheters, stents, implants), wound dressings, targeted drug delivery, cancer therapy and
- diluted in different biological media. Acknowledgements The authors would like to acknowledge the Advanced Microscopy Laboratory (INMA-Universidad de Zaragoza) for the access to their instrumentation and expertise. Funding This study was based upon a collaborative work from COST Action CA 17140 "Cancer
The preparation temperature influences the physicochemical nature and activity of nanoceria
Beilstein J. Nanotechnol. 2021, 12, 525–540, doi:10.3762/bjnano.12.43
- component, including cancer, radiation damage, bacterial infection, sepsis, wounds, stroke-induced ischemia, retinal degeneration, and neurodegenerative diseases [10]. Other reviews provide more information on nanoceria synthesis methods and the resulting physicochemical properties of the products as well
A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization
Beilstein J. Nanotechnol. 2021, 12, 440–461, doi:10.3762/bjnano.12.36
- against a wide range of bacteria (i.e., Gram-negative [67], Gram-positive [31], and multiresistant bacteria (MR) [27][68][69][70][71]), fungi [69][72][73][74], and viruses [8][75][76][77] in addition to anti-inflammatory [78][79][80], anti-cancer [27][81], and anti-angiogenic properties [33][47][82
- ]. Silver has been widely used to heal ulcerative wounds and to treat burns. Due to the antimicrobial and anti-inflammatory properties of AgNPs, these particles can prevent bacterial infection at the wound area and accelerate healing [27][83]. AgNPs have been shown to improve the efficacy of cancer
The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors
Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31
- , Doha, Qatar 10.3762/bjnano.12.31 Abstract Nanomedicine has emerged as a novel cancer treatment and diagnostic modality, whose design constantly evolves towards increasing the safety and efficacy of the chemotherapeutic and diagnostic protocols. Molecular diagnostics, which create a great amount of
- efficacy of the cancer treatment. This article will focus on novel design strategies for nanoscale drug delivery systems, based on the unique molecular signatures of myeloid leukemia and EGFR/CD44-positive solid tumors, and the impact of novel discoveries in molecular tumor profiles on future
- , which usually results in therapy failure and noticeable side effects. Nanomedicine has emerged as a novel cancer treatment and diagnostic modality, whose design constantly evolves towards increasing the safety and efficacy of the chemotherapeutic and diagnostic protocols. Recently, a novel generation of
Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management
Beilstein J. Nanotechnol. 2021, 12, 295–303, doi:10.3762/bjnano.12.24
- Medical Toxicology Lab, Department of Zoology, Government College University Lahore, Lahore-54000, Pakistan 10.3762/bjnano.12.24 Abstract Two of the limitations associated with cancer treatment are the low efficacy and the high dose-related side effects of anticancer drugs. The purpose of the current
- based on chemotherapy and photothermal strategies appears to be a promising platform in cancer management. Keywords: chemotherapy; doxorubicin; gold nanorods; NIR laser; photothermal therapy; Introduction Despite the enormous advances in medical research, cancer is still the second most common cause
- of death worldwide from which 9.6 million people died in 2018 [1]. Hepatocellular carcinoma (HCC) is one of the major types of liver cancer with high incidence of mortality [2]. Currently, there are a number of treatment modalities, including chemotherapy, immunotherapy, targeted therapy, irradiation
Differences in surface chemistry of iron oxide nanoparticles result in different routes of internalization
Beilstein J. Nanotechnol. 2021, 12, 270–281, doi:10.3762/bjnano.12.22
- Barbora Svitkova Vlasta Zavisova Veronika Nemethova Martina Koneracka Miroslava Kretova Filip Razga Monika Ursinyova Alena Gabelova Cancer Research Institute, Biomedical Research Center of the Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovakia Institute of Experimental
- eligible for the targeted delivery of the drug-loaded particles to the tumor mass via an external magnetic field [2]. Furthermore, MNPs are promising biosensors [3] and antimicrobial tools [4], and they play an important role in the development of multifunctional theranostics to combat cancer [5]. MNPs are
- valuable in vitro model of human alveolar epithelial type-2 cells [21], which are considered as drivers of lung fibrosis [22] and lung tumor development [23]. Inhalation therapy represents a prospective non-invasive curative modality for lung cancer and a therapy for other lung illnesses [24]. Drug
The nanomorphology of cell surfaces of adhered osteoblasts
Beilstein J. Nanotechnol. 2021, 12, 242–256, doi:10.3762/bjnano.12.20
- breast cancer cells [30], and on keratinocytes [35]. In general, these features are associated with migration, receptor internalization, and micropinocytosis [30][36][37]. Membrane ruffling is regulated by a distinct signaling pathway [38] and the supporting actin is denser and more cross-linked [35
- ] compared to flat membrane regions. Three types of ruffles can be discriminated, namely (linear) dorsal, peripheral, and circular dorsal ruffles [36]. Colocalization with hyaluronan synthase has been found in a breast cancer cell line (MCF-7) [30]. Usually the error current, that is, the deviation between
A review on the biological effects of nanomaterials on silkworm (Bombyx mori)
Beilstein J. Nanotechnol. 2021, 12, 190–202, doi:10.3762/bjnano.12.15
- development, organogenesis, neuronal development, aging, inheritance, and cancer [84][85]. Aside from its rapid lifecycle, it is reported that the fruit fly produces genetically identical offspring when compared to mammalian models, which produce a smaller number of offspring at a time [86][87]. Also, the
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