Voltammetric determination of polyphenolic content in pomegranate juice using a poly(gallic acid)/multiwalled carbon nanotube modified electrode

• Refat Abdel-Hamid and
• Emad F. Newair

Beilstein J. Nanotechnol. 2016, 7, 1104–1112, doi:10.3762/bjnano.7.103

• ]. Due to the positive effects of polyphenol antioxidants on human health, the improvement of sensitive and robust methods for their determination gains more importance. Consequently, the measurement of the total polyphenolic content (TPC) is a good representation of the level of antioxidants that exist

NO gas sensing at room temperature using single titanium oxide nanodot sensors created by atomic force microscopy nanolithography

• Li-Yang Hong and
• Heh-Nan Lin

Beilstein J. Nanotechnol. 2016, 7, 1044–1051, doi:10.3762/bjnano.7.97

• fabrication of titanium oxide nanowire (NW) gas sensors [25][26]. NO gas sensing at low concentrations is beneficial for human health [1][2] and environmental monitoring [3]. Various types of metal oxide nanomaterials have been utilized for NO or NO2 gas sensing, e.g., SnO2 [12][15][16][17], ZnO [13][14][17

Tight junction between endothelial cells: the interaction between nanoparticles and blood vessels

• Yue Zhang and
• Wan-Xi Yang

Beilstein J. Nanotechnol. 2016, 7, 675–684, doi:10.3762/bjnano.7.60

• here whether nanoparticles can cause several adverse effects to human health. In this review, based on research on nanotoxicity, we mainly discuss the negative influence of nanoparticles on blood vessels in several aspects and the potential mechanism for nanoparticles to penetrate endothelial layers of

• into the arteriovenous plexus underneath the epidermis. NPs, in the form of multi-walled carbon nanotubes, also cause acute eye irritation after administration [30]. The respiratory system shows its unique role in the uptake of NPs, because inhaled NPs have noxious effects on human health. Apical

• most important are cytoxicity and genotoxicity. While considering nanoparticle effects on human health, we need to know the pathways they use to get into biological systems. Here, we discussed four different entrance pathways: oral administration, skin exposure, breathing intake, intravenous injection

Unraveling the neurotoxicity of titanium dioxide nanoparticles: focusing on molecular mechanisms

• Bin Song,
• Yanli Zhang,
• Jia Liu,
• Xiaoli Feng,
• Ting Zhou and
• Longquan Shao

Beilstein J. Nanotechnol. 2016, 7, 645–654, doi:10.3762/bjnano.7.57

• apoptosis. Human health and disease can be modulated by apoptosis [33][34]. Sheng et al. [35] found that TiO2 NPs induced apoptosis in primary hippocampal neurons. Elevated levels of Ca2+, cytochrome c, Bax, caspase-3, and caspase-12, as well as a reduction in mitochondrial membrane potential (MMP) and blc

Synthesis and applications of carbon nanomaterials for energy generation and storage

• Marco Notarianni,
• Jinzhang Liu,
• Kristy Vernon and
• Nunzio Motta

Beilstein J. Nanotechnol. 2016, 7, 149–196, doi:10.3762/bjnano.7.17

• composed of fossil fuels such as oil, gas and coal, which represented the best choice of energy production at competitive costs in the 20th and 21st century (Figure 1) [7]. Unfortunately, It has been proven that fossil fuels have catastrophic consequences for human health [8] and global warming [9] and

• grid technologies could help to provide energy to individual households when immediately needed and with a high efficiency. Nanotechnology could help to solve solar energy’s obstacles and meet energy expectations without compromising the environment and human health by creating new devices that are

Nanoinformatics for environmental health and biomedicine

• Rong Liu and
• Yoram Cohen

Beilstein J. Nanotechnol. 2015, 6, 2449–2451, doi:10.3762/bjnano.6.253

• impact of nanotechnology on the environment and human health. As a result, there is a global drive to ensure that the development of beneficial nanotechnologies is accomplished in a responsible manner so as to avoid adverse impacts on environmental and human health. In order to develop safe-by-design

Green and energy-efficient methods for the production of metallic nanoparticles

• Mitra Naghdi,
• Mehrdad Taheran,
• Satinder K. Brar,
• M. Verma,
• R. Y. Surampalli and
• J. R. Valero

Beilstein J. Nanotechnol. 2015, 6, 2354–2376, doi:10.3762/bjnano.6.243

• environment and human health [11]. Using biologically produced compounds, such as coffee and tea extract for reduction of Ag and Pd precursors to NPs is reported as an example of green methods with non-hazardous reactants [51]. Designing safer materials: Gathering information about the properties and impacts

• by-products that may need further degradation steps. Conventional analytical methods involve pretreatment steps that generate waste and, therefore, green analytical chemistry can be defined as the use of measurements that generate less waste and are thus safer to the environment and to human health

• preventive or protective properties with regard to human health. They are not essential for the human body to survive but they can act as antioxidant, enzyme stimulator, or antibacterial agent, and they can interfere with DNA to prevent the multiplication of cancer cells. Researchers found that several

Electrochemical behavior of polypyrrol/AuNP composites deposited by different electrochemical methods: sensing properties towards catechol

• Celia García-Hernández,
• Cristina García-Cabezón,
• Cristina Medina-Plaza,
• Fernando Martín-Pedrosa,
• Yolanda Blanco,
• José Antonio de Saja and
• María Luz Rodríguez-Méndez

Beilstein J. Nanotechnol. 2015, 6, 2052–2061, doi:10.3762/bjnano.6.209

• detection of phenolic compounds, which are strong antioxidant reagents present in foods, with beneficial effects on human health [23]. As phenols are electroactive compounds, they can be detected by amperometric or voltammetric techniques using graphite or platinum electrodes [24][25][26]. In addition

An ISA-TAB-Nano based data collection framework to support data-driven modelling of nanotoxicology

• Richard L. Marchese Robinson,
• Mark T. D. Cronin,
• Andrea-Nicole Richarz and
• Robert Rallo

Beilstein J. Nanotechnol. 2015, 6, 1978–1999, doi:10.3762/bjnano.6.202

• potential risk posed by nanomaterials to human health and the environment [3][4][7]. Various research initiatives have been (and are being) funded to advance scientific understanding of nanotechnology and nanosafety and to enable the appropriate selection, design and regulation of nanomaterials for

Nanocuration workflows: Establishing best practices for identifying, inputting, and sharing data to inform decisions on nanomaterials

• Christina M. Powers,
• Karmann A. Mills,
• Stephanie A. Morris,
• Fred Klaessig,
• Sharon Gaheen,
• Nastassja Lewinski and
• Christine Ogilvie Hendren

Beilstein J. Nanotechnol. 2015, 6, 1860–1871, doi:10.3762/bjnano.6.189

• implications of nanomaterials and their impact on human health and safety. While selection criteria regarding data sources remain a necessary element to the curation workflow, the NR uses an internally defined compliance score (minimal information about nanomaterials [MIAN]) to communicate the relative extent

Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory

• Marina E. Vance,
• Todd Kuiken,
• Eric P. Vejerano,
• Sean P. McGinnis,
• Michael F. Hochella Jr.,
• David Rejeski and
• Matthew S. Hull

Beilstein J. Nanotechnol. 2015, 6, 1769–1780, doi:10.3762/bjnano.6.181

• incorporated into consumer products, although research is still ongoing on their potential effects to the environment and human health. This research will continue long into the future. To document the penetration of nanotechnology in the consumer marketplace, the Woodrow Wilson International Center for

How decision analysis can further nanoinformatics

• Matthew E. Bates,
• Sabrina Larkin,
• Jeffrey M. Keisler and
• Igor Linkov

Beilstein J. Nanotechnol. 2015, 6, 1594–1600, doi:10.3762/bjnano.6.162

• research [20]. The MCDA process identified pertinent criteria: synthesis cost, material efficiency, energy consumption, life cycle environmental impacts, and risks to human health. A probability distribution of scores for each technology was specified for each criterion via author judgment and the

Using natural language processing techniques to inform research on nanotechnology

• Nastassja A. Lewinski and
• Bridget T. McInnes

Beilstein J. Nanotechnol. 2015, 6, 1439–1449, doi:10.3762/bjnano.6.149

• spearheaded efforts to “get it right the first time” by studying the potential human health and environmental impacts of ENMs in parallel with ENMs discovery and development. However, the creation and establishment of data repositories as well as algorithms to automatically analyze the collected resources has

• potential effects of commercialized ENMs on human health and environment. A wealth of data has been collected through large-scale centers, which in the U.S. include the Center for Biological and Environmental Nanotechnology (CBEN) and the two Centers for Environmental Implications of Nanotechnology (CEIN

• the human health or environmental impact of ENMs, it is important to recognize that risk is a function of exposure and hazard. Without exposure, there is no risk. All substances are potentially hazardous depending on the dose or concentration encountered. In addition, the biological response data of

Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure

• Giovanni N. Roviello,
• Domenica Musumeci,
• Valentina Roviello,
• Marina Pirtskhalava,
• Alexander Egoyan and
• Merab Mirtskhulava

Beilstein J. Nanotechnol. 2015, 6, 1338–1347, doi:10.3762/bjnano.6.138

• some cases covalently, the polyadenylic tail present at the 3’-terminus of mRNA, an event that was linked to cancer development. Even if these molecules are clearly dangerous to human health, the study of the structural characteristics on the basis of their poly(rA) binding ability could aid in

Biological responses to nanoscale particles

• Reinhard Zellner

Beilstein J. Nanotechnol. 2015, 6, 380–382, doi:10.3762/bjnano.6.37

• potentially negative effects cannot easily be predicted or derived from the known toxicity of the corresponding macroscopic material. Hence, major gaps in the knowledge necessary for assessing their risk to human health currently exist. There is also a lack of existing methodologies to improve techniques for

Gas sensing properties of nanocrystalline diamond at room temperature

• Marina Davydova,
• Pavel Kulha,
• Alexandr Laposa,
• Karel Hruska,
• Pavel Demo and
• Alexander Kromka

Beilstein J. Nanotechnol. 2014, 5, 2339–2345, doi:10.3762/bjnano.5.243

• electrodes; nanocrystalline diamond; response; Introduction Air pollution is one of the main environmental-health related threats. Increasing amounts of noxious pollutants are emitted into the atmosphere, resulting in damage to human health and the environment. There is great interest in using sensing

The gut wall provides an effective barrier against nanoparticle uptake

• Heike Sinnecker,
• Thorsten Krause,
• Sabine Koelling,
• Ingmar Lautenschläger and
• Andreas Frey

Beilstein J. Nanotechnol. 2014, 5, 2092–2101, doi:10.3762/bjnano.5.218

• products [1][2][3], incorporation of anthropogenic NPs, be it through inhalation or ingestion, becomes an issue. The public is increasingly worried about potential hazards such consumer good-borne NPs may pose to human health [4][5][6]. Besides that, work environments with metal grinders or welding

• (69 ± 14)% (luminal (33 ± 21)%, gut tissue including mucus (36 ± 14)%) of the total particle dose applied could be found when assayed through detection of the europium tracer. Discussion Potential hazards that incorporated NPs may pose to human health are subject of intense debates. A rapidly growing

Effects of surface functionalization on the adsorption of human serum albumin onto nanoparticles – a fluorescence correlation spectroscopy study

• Pauline Maffre,
• Stefan Brandholt,
• Karin Nienhaus,
• Li Shang,
• Wolfgang J. Parak and
• G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2014, 5, 2036–2047, doi:10.3762/bjnano.5.212

• scientific and commercial applications of nanoparticles (NPs) and other nanomaterials have been increasing at a rapid pace [1][2]. Human health can be adversely affected by NP exposure. A profound assessment of these risks, however, is not yet available because fundamental interactions of nanomaterials with

PVP-coated, negatively charged silver nanoparticles: A multi-center study of their physicochemical characteristics, cell culture and in vivo experiments

• Sebastian Ahlberg,
• Alexandra Antonopulos,
• Jörg Diendorf,
• Ralf Dringen,
• Matthias Epple,
• Rebekka Flöck,
• Wolfgang Goedecke,
• Christina Graf,
• Nadine Haberl,
• Jens Helmlinger,
• Fabian Herzog,
• Frederike Heuer,
• Stephanie Hirn,
• Christian Johannes,
• Stefanie Kittler,
• Manfred Köller,
• Katrin Korn,
• Wolfgang G. Kreyling,
• Fritz Krombach,
• Jürgen Lademann,
• Kateryna Loza,
• Eva M. Luther,
• Marcelina Malissek,
• Martina C. Meinke,
• Daniel Nordmeyer,
• Anne Pailliart,
• Jörg Raabe,
• Fiorenza Rancan,
• Barbara Rothen-Rutishauser,
• Eckart Rühl,
• Carsten Schleh,
• Andreas Seibel,
• Christina Sengstock,
• Lennart Treuel,
• Annika Vogt,
• Katrin Weber and
• Reinhard Zellner

Beilstein J. Nanotechnol. 2014, 5, 1944–1965, doi:10.3762/bjnano.5.205

• vitro experiments, representative silver nanoparticle concentrations are not expected to induce acute cytotoxic or pro-inflammatory effects after 24 h exposure in a realistic environmental setting, therefore implicating to have a low impact on the human health. However, bioaccumulation of silver

Biocompatibility of cerium dioxide and silicon dioxide nanoparticles with endothelial cells

• Claudia Strobel,
• Martin Förster and
• Ingrid Hilger

Beilstein J. Nanotechnol. 2014, 5, 1795–1807, doi:10.3762/bjnano.5.190

• markedly exposed to them in their everyday life. Once passing biological barriers, these nanoparticles are expected to interact with endothelial cells, leading to systemic alterations with distinct influences on human health. In the present study we observed the metabolic impact of differently sized CeO2

• not only from the consumption of products containing them, but also from their presence in the environment. Despite their widespread utilization, there is still uncertainty in the safety of these nanoparticles on human health, because appropriate experimental data are often contradictory. For example

Precise quantification of silica and ceria nanoparticle uptake revealed by 3D fluorescence microscopy

• Adriano A. Torrano and
• Christoph Bräuchle

Beilstein J. Nanotechnol. 2014, 5, 1616–1624, doi:10.3762/bjnano.5.173

• , pulmonary, and neurologic systems [24][25]. Therefore, endothelial cells such as the ones used in the present study (HUVEC and HMEC-1) represent a very appropriate model system to estimate the impact of nanoparticles on human health. Results and Discussion Particle_in_Cell-3D Particle_in_Cell-3D [5] is a

Mimicking exposures to acute and lifetime concentrations of inhaled silver nanoparticles by two different in vitro approaches

• Fabian Herzog,
• Kateryna Loza,
• Sandor Balog,
• Martin J. D. Clift,
• Matthias Epple,
• Peter Gehr,
• Alke Petri-Fink and
• Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2014, 5, 1357–1370, doi:10.3762/bjnano.5.149

• been demonstrated [11]. Therefore, the effects of Ag NPs on human health and the environment are currently increasingly explored [12]. Human interaction with Ag NPs can occur through the lung, skin, gastrointestinal tract, and bloodstream. However, inhalation of Ag NPs is a primary concern for humans

• scenarios, revealing a low impact of Ag NPs on human health. Nevertheless, secondary effects of Ag NPs, when incorporated in the biological environment over time, cannot be ruled out by in vitro experiments and chronic inhalation studies of Ag NPs need to be considered in the future. Experimental Cell

Injection of ligand-free gold and silver nanoparticles into murine embryos does not impact pre-implantation development

• Ulrike Taylor,
• Wiebke Garrels,
• Annette Barchanski,
• Svea Peterson,
• Laszlo Sajti,
• Andrea Lucas-Hahn,
• Lisa Gamrad,
• Ulrich Baulain,
• Sabine Klein,
• Wilfried A. Kues,
• Stephan Barcikowski and
• Detlef Rath

Beilstein J. Nanotechnol. 2014, 5, 677–688, doi:10.3762/bjnano.5.80

• . In particular, reprotoxicological aspects of these particles still need to be addressed so that the potential impacts of this development on human health can be reliably estimated. Therefore, in this study the toxicity of gold and silver nanoparticles on mammalian preimplantation development was