Involvement of two uptake mechanisms of gold and iron oxide nanoparticles in a co-exposure scenario using mouse macrophages

• Dimitri Vanhecke,
• Dagmar A. Kuhn,
• Dorleta Jimenez de Aberasturi,
• Sandor Balog,
• Ana Milosevic,
• Dominic Urban,
• Diana Peckys,
• Niels de Jonge,
• Wolfgang J. Parak,
• Alke Petri-Fink and
• Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2017, 8, 2396–2409, doi:10.3762/bjnano.8.239

• comprehensive groundwork has been laid to assess the possible adverse effects of nanotechnology on human health. In particular, a full understanding of how such engineered nanoparticles (NPs), i.e., objects with all three spatial dimensions below 100 nm [3], interact with mammalian cells is paramount to develop

Evaluating the toxicity of TiO₂-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach

• Alicja Mikolajczyk,
• Natalia Sizochenko,
• Ewa Mulkiewicz,
• Anna Malankowska,
• Michal Nischk,
• Przemyslaw Jurczak,
• Seishiro Hirano,
• Grzegorz Nowaczyk,
• Adriana Zaleska-Medynska,
• Jerzy Leszczynski,
• Agnieszka Gajewicz and
• Tomasz Puzyn

Beilstein J. Nanotechnol. 2017, 8, 2171–2180, doi:10.3762/bjnano.8.216

• only towards bacteria, but also exhibit detrimental effects to the environment and to human health. Many studies have been focused on ways to synthesize doped NPs, leveraging the photocatalytic (UV–vis active photocatalyt) and bactericidal properties, and minimizing the release of potentially toxic

• that offer a bunch of new opportunities for the advancement of nanotechnology could result in unknown risks to human health and the environment. Our attention should be focused both on the promise of new opportunities and on the responsibility of industries to guarantee the safety of their products for

• precursors, variations of the initial experimental conditions, and/or various endpoints of environmental and human health relevance will be necessary. Experimental Materials Titanium(IV) isopropoxide (TIP, 97%), palladium(II) chloride (5 wt % in 10 wt % HCl) and HAuCl4 (Au ≈ 52%) were purchased from Sigma

Needs and challenges for assessing the environmental impacts of engineered nanomaterials (ENMs)

• Michelle Romero-Franco,
• Hilary A. Godwin,
• Muhammad Bilal and
• Yoram Cohen

Beilstein J. Nanotechnol. 2017, 8, 989–1014, doi:10.3762/bjnano.8.101

• human health related risks in a systematic manner based on toxicity, dose response curves and quantitative exposure assessment. These frameworks (i.e., EIA and RA) have also been incorporated into ecological risk assessment (ERA) [13], which is used to evaluate the likelihood of adverse environmental

• – Review of Health and Environmental Safety: Human health and Ecological Risk Assessment (ENRHES RA) [46], Risk Quantification based on Probabilistic Mass Flow Modeling Analysis (PMFA Risk Assessment) [47], Forecasting of the Impacts of Nanomaterials in the Environment (FINE) based on Bayesian Networks (BN

• framework by individuals other than the developers is currently limited given the present unavailability of a software implementation of the framework. Nonetheless, this framework could serve to aid companies and regulators for assessing the potential exposure, human health and environmental hazards

Photocatalysis applications of some hybrid polymeric composites incorporating TiO₂ nanoparticles and their combinations with SiO₂/Fe₂O₃

• Andreea Laura Chibac,
• Tinca Buruiana,
• Violeta Melinte and
• Emil C. Buruiana

Beilstein J. Nanotechnol. 2017, 8, 272–286, doi:10.3762/bjnano.8.30

• then not entirely. As a result, the employment of the nanoparticles into real aquatic environments can lead to the runoff phenomenon that induces risks to human health and the environment. Given this observation and the fact that the catalytic activity of the hybrid polymeric films is almost the same

Microfluidic setup for on-line SERS monitoring using laser induced nanoparticle spots as SERS active substrate

• Oana-M. Buja,
• Ovidiu D. Gordan,
• Nicolae Leopold,
• Andreas Morschhauser,
• Jörg Nestler and
• Dietrich R. T. Zahn

Beilstein J. Nanotechnol. 2017, 8, 237–243, doi:10.3762/bjnano.8.26

• substrate. Keywords: gold nanoparticles; malachite green; microfluidic setup; SERS; silver nanoparticles; Introduction Over the past decade special attention has been given to the investigation of hazardous environmental chemicals with impact on human health [1][2][3][4]. Surface-enhanced Raman scattering

Sensitive detection of hydrocarbon gases using electrochemically Pd-modified ZnO chemiresistors

• Elena Dilonardo,
• Michele Penza,
• Marco Alvisi,
• Gennaro Cassano,
• Cinzia Di Franco,
• Francesco Palmisano,
• Luisa Torsi and
• Nicola Cioffi

Beilstein J. Nanotechnol. 2017, 8, 82–90, doi:10.3762/bjnano.8.9

• gaseous HCs is fundamental for environmental protection [2][3]. The direct exposure to HCs can negatively affect the human health, from irritation of the respiratory system to cancer [4][5]. Therefore, the selective detection of particular gaseous HCs in a complex matrix is one of the challenges in gas

• ][13][14]. Since a precise monitoring of HCs even at low concentrations can be beneficial to preserve the environment and human health, the improvement of cost-effective HCs gas sensors, including networked sensor-systems and new strategies for hydrocarbon sensing, is a matter of interest for the

Graphene-enhanced plasmonic nanohole arrays for environmental sensing in aqueous samples

• Christa Genslein,
• Peter Hausler,
• Eva-Maria Kirchner,
• Rudolf Bierl,
• Antje J. Baeumner and
• Thomas Hirsch

Beilstein J. Nanotechnol. 2016, 7, 1564–1573, doi:10.3762/bjnano.7.150

• , they can leach into the environment. The resulting wide distribution in aqueous systems, such as lakes and rivers, and disturbances of the ecological environment are caused by accumulation of PAEs in natural waters [2][3]. It has been reported that PAEs trigger adverse effects on human health and are

Development of adsorptive membranes by confinement of activated biochar into electrospun nanofibers

• Mehrdad Taheran,
• Mitra Naghdi,
• Satinder K. Brar,
• Emile Knystautas,
• Mausam Verma,
• Rao. Y. Surampalli and
• Jose. R. Valero

Beilstein J. Nanotechnol. 2016, 7, 1556–1563, doi:10.3762/bjnano.7.149

• metals and organic contaminants from water. Recently, increasing concentrations of pharmaceutically active compounds, especially antibiotics, such as chlortetracycline in water and wastewater sources has raised concerns about their potentially adverse impacts on environment and human health. In this

• effects on human health and environment. Chlortetracycline (CTC), a broad-spectrum antimicrobial agent, is commonly used as veterinary medicine for poultry, swine, and livestock [20]. This compound can enter the environment through the application of animal manure for agriculture, moving to rivers, ground

• waters and lakes by surface runoff [21]. Presence of CTC and similar compounds in water cycle has raised concerns over potential human health risks. Therefore, removal of PhACs from water sources is necessary. Adsorption of these compounds onto different media, such as carbonaceous materials is one

An efficient recyclable magnetic material for the selective removal of organic pollutants

• Clément Monteil,
• Nathalie Bar,
• Agnès Bee and
• Didier Villemin

Beilstein J. Nanotechnol. 2016, 7, 1447–1453, doi:10.3762/bjnano.7.136

• hazard for human health, even at low concentrations [1][2][3]. Many technologies such as photodegradation, biodegradation, the Fenton process, or extraction by liquid membranes have been developed to eliminate these compounds in wastewater [4][5][6]. Among them, adsorption-based methods are extensively

Ammonia gas sensors based on In₂O₃/PANI hetero-nanofibers operating at room temperature

• Qingxin Nie,
• Zengyuan Pang,
• Hangyi Lu,
• Yibing Cai and
• Qufu Wei

Beilstein J. Nanotechnol. 2016, 7, 1312–1321, doi:10.3762/bjnano.7.122

• pollution. Ammonia (NH3), as a highly toxic gas, can be emitted by natural and industrial sources and threaten human health [2][3][4]. NH3 at concentrations of 50 ppm may irritate the human respiratory system, skin and eyes [4]. Higher concentrations of NH3 will cause blindness, seizures, lung disease and

• sensor delivers the best performance. Therefore, In2O3/PANI-2 was selected to further investigate the sensing properties. As mentioned in the Introduction section, 50 ppm NH3 will cause harm to human health. Accordingly, the response of the In2O3/PANI-2 sensor to 50 ppm, 30 ppm and 10 ppm were

Voltammetric determination of polyphenolic content in pomegranate juice using a poly(gallic acid)/multiwalled carbon nanotube modified electrode

• Refat Abdel-Hamid and
• Emad F. Newair

Beilstein J. Nanotechnol. 2016, 7, 1104–1112, doi:10.3762/bjnano.7.103

• ]. Due to the positive effects of polyphenol antioxidants on human health, the improvement of sensitive and robust methods for their determination gains more importance. Consequently, the measurement of the total polyphenolic content (TPC) is a good representation of the level of antioxidants that exist

NO gas sensing at room temperature using single titanium oxide nanodot sensors created by atomic force microscopy nanolithography

• Li-Yang Hong and
• Heh-Nan Lin

Beilstein J. Nanotechnol. 2016, 7, 1044–1051, doi:10.3762/bjnano.7.97

• fabrication of titanium oxide nanowire (NW) gas sensors [25][26]. NO gas sensing at low concentrations is beneficial for human health [1][2] and environmental monitoring [3]. Various types of metal oxide nanomaterials have been utilized for NO or NO2 gas sensing, e.g., SnO2 [12][15][16][17], ZnO [13][14][17

Tight junction between endothelial cells: the interaction between nanoparticles and blood vessels

• Yue Zhang and
• Wan-Xi Yang

Beilstein J. Nanotechnol. 2016, 7, 675–684, doi:10.3762/bjnano.7.60

• here whether nanoparticles can cause several adverse effects to human health. In this review, based on research on nanotoxicity, we mainly discuss the negative influence of nanoparticles on blood vessels in several aspects and the potential mechanism for nanoparticles to penetrate endothelial layers of

• into the arteriovenous plexus underneath the epidermis. NPs, in the form of multi-walled carbon nanotubes, also cause acute eye irritation after administration [30]. The respiratory system shows its unique role in the uptake of NPs, because inhaled NPs have noxious effects on human health. Apical

• most important are cytoxicity and genotoxicity. While considering nanoparticle effects on human health, we need to know the pathways they use to get into biological systems. Here, we discussed four different entrance pathways: oral administration, skin exposure, breathing intake, intravenous injection

Unraveling the neurotoxicity of titanium dioxide nanoparticles: focusing on molecular mechanisms

• Bin Song,
• Yanli Zhang,
• Jia Liu,
• Xiaoli Feng,
• Ting Zhou and
• Longquan Shao

Beilstein J. Nanotechnol. 2016, 7, 645–654, doi:10.3762/bjnano.7.57

• apoptosis. Human health and disease can be modulated by apoptosis [33][34]. Sheng et al. [35] found that TiO2 NPs induced apoptosis in primary hippocampal neurons. Elevated levels of Ca2+, cytochrome c, Bax, caspase-3, and caspase-12, as well as a reduction in mitochondrial membrane potential (MMP) and blc

Synthesis and applications of carbon nanomaterials for energy generation and storage

• Marco Notarianni,
• Jinzhang Liu,
• Kristy Vernon and
• Nunzio Motta

Beilstein J. Nanotechnol. 2016, 7, 149–196, doi:10.3762/bjnano.7.17

• composed of fossil fuels such as oil, gas and coal, which represented the best choice of energy production at competitive costs in the 20th and 21st century (Figure 1) [7]. Unfortunately, It has been proven that fossil fuels have catastrophic consequences for human health [8] and global warming [9] and

• grid technologies could help to provide energy to individual households when immediately needed and with a high efficiency. Nanotechnology could help to solve solar energy’s obstacles and meet energy expectations without compromising the environment and human health by creating new devices that are

Nanoinformatics for environmental health and biomedicine

• Rong Liu and
• Yoram Cohen

Beilstein J. Nanotechnol. 2015, 6, 2449–2451, doi:10.3762/bjnano.6.253

• impact of nanotechnology on the environment and human health. As a result, there is a global drive to ensure that the development of beneficial nanotechnologies is accomplished in a responsible manner so as to avoid adverse impacts on environmental and human health. In order to develop safe-by-design

Green and energy-efficient methods for the production of metallic nanoparticles

• Mitra Naghdi,
• Mehrdad Taheran,
• Satinder K. Brar,
• M. Verma,
• R. Y. Surampalli and
• J. R. Valero

Beilstein J. Nanotechnol. 2015, 6, 2354–2376, doi:10.3762/bjnano.6.243

• environment and human health [11]. Using biologically produced compounds, such as coffee and tea extract for reduction of Ag and Pd precursors to NPs is reported as an example of green methods with non-hazardous reactants [51]. Designing safer materials: Gathering information about the properties and impacts

• by-products that may need further degradation steps. Conventional analytical methods involve pretreatment steps that generate waste and, therefore, green analytical chemistry can be defined as the use of measurements that generate less waste and are thus safer to the environment and to human health

• preventive or protective properties with regard to human health. They are not essential for the human body to survive but they can act as antioxidant, enzyme stimulator, or antibacterial agent, and they can interfere with DNA to prevent the multiplication of cancer cells. Researchers found that several

Electrochemical behavior of polypyrrol/AuNP composites deposited by different electrochemical methods: sensing properties towards catechol

• Celia García-Hernández,
• Cristina García-Cabezón,
• Cristina Medina-Plaza,
• Fernando Martín-Pedrosa,
• Yolanda Blanco,
• José Antonio de Saja and
• María Luz Rodríguez-Méndez

Beilstein J. Nanotechnol. 2015, 6, 2052–2061, doi:10.3762/bjnano.6.209

• detection of phenolic compounds, which are strong antioxidant reagents present in foods, with beneficial effects on human health [23]. As phenols are electroactive compounds, they can be detected by amperometric or voltammetric techniques using graphite or platinum electrodes [24][25][26]. In addition

An ISA-TAB-Nano based data collection framework to support data-driven modelling of nanotoxicology

• Richard L. Marchese Robinson,
• Mark T. D. Cronin,
• Andrea-Nicole Richarz and
• Robert Rallo

Beilstein J. Nanotechnol. 2015, 6, 1978–1999, doi:10.3762/bjnano.6.202

• potential risk posed by nanomaterials to human health and the environment [3][4][7]. Various research initiatives have been (and are being) funded to advance scientific understanding of nanotechnology and nanosafety and to enable the appropriate selection, design and regulation of nanomaterials for

Nanocuration workflows: Establishing best practices for identifying, inputting, and sharing data to inform decisions on nanomaterials

• Christina M. Powers,
• Karmann A. Mills,
• Stephanie A. Morris,
• Fred Klaessig,
• Sharon Gaheen,
• Nastassja Lewinski and
• Christine Ogilvie Hendren

Beilstein J. Nanotechnol. 2015, 6, 1860–1871, doi:10.3762/bjnano.6.189

• implications of nanomaterials and their impact on human health and safety. While selection criteria regarding data sources remain a necessary element to the curation workflow, the NR uses an internally defined compliance score (minimal information about nanomaterials [MIAN]) to communicate the relative extent

Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory

• Marina E. Vance,
• Todd Kuiken,
• Eric P. Vejerano,
• Sean P. McGinnis,
• Michael F. Hochella Jr.,
• David Rejeski and
• Matthew S. Hull

Beilstein J. Nanotechnol. 2015, 6, 1769–1780, doi:10.3762/bjnano.6.181

• incorporated into consumer products, although research is still ongoing on their potential effects to the environment and human health. This research will continue long into the future. To document the penetration of nanotechnology in the consumer marketplace, the Woodrow Wilson International Center for

How decision analysis can further nanoinformatics

• Matthew E. Bates,
• Sabrina Larkin,
• Jeffrey M. Keisler and
• Igor Linkov

Beilstein J. Nanotechnol. 2015, 6, 1594–1600, doi:10.3762/bjnano.6.162

• research [20]. The MCDA process identified pertinent criteria: synthesis cost, material efficiency, energy consumption, life cycle environmental impacts, and risks to human health. A probability distribution of scores for each technology was specified for each criterion via author judgment and the

Using natural language processing techniques to inform research on nanotechnology

• Nastassja A. Lewinski and
• Bridget T. McInnes

Beilstein J. Nanotechnol. 2015, 6, 1439–1449, doi:10.3762/bjnano.6.149

• spearheaded efforts to “get it right the first time” by studying the potential human health and environmental impacts of ENMs in parallel with ENMs discovery and development. However, the creation and establishment of data repositories as well as algorithms to automatically analyze the collected resources has

• potential effects of commercialized ENMs on human health and environment. A wealth of data has been collected through large-scale centers, which in the U.S. include the Center for Biological and Environmental Nanotechnology (CBEN) and the two Centers for Environmental Implications of Nanotechnology (CEIN

• the human health or environmental impact of ENMs, it is important to recognize that risk is a function of exposure and hazard. Without exposure, there is no risk. All substances are potentially hazardous depending on the dose or concentration encountered. In addition, the biological response data of

Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure

• Giovanni N. Roviello,
• Domenica Musumeci,
• Valentina Roviello,
• Marina Pirtskhalava,
• Alexander Egoyan and
• Merab Mirtskhulava

Beilstein J. Nanotechnol. 2015, 6, 1338–1347, doi:10.3762/bjnano.6.138

• some cases covalently, the polyadenylic tail present at the 3’-terminus of mRNA, an event that was linked to cancer development. Even if these molecules are clearly dangerous to human health, the study of the structural characteristics on the basis of their poly(rA) binding ability could aid in

Biological responses to nanoscale particles

• Reinhard Zellner

Beilstein J. Nanotechnol. 2015, 6, 380–382, doi:10.3762/bjnano.6.37

• potentially negative effects cannot easily be predicted or derived from the known toxicity of the corresponding macroscopic material. Hence, major gaps in the knowledge necessary for assessing their risk to human health currently exist. There is also a lack of existing methodologies to improve techniques for