Magnetic-Fe/Fe₃O₄-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

• Hongwang Wang,
• Tej B. Shrestha,
• Matthew T. Basel,
• Raj K. Dani,
• Gwi-Moon Seo,
• Sivasai Balivada,
• Marla M. Pyle,
• Heidy Prock,
• Olga B. Koper,
• Prem S. Thapa,
• David Moore,
• Ping Li,
• Viktor Chikan,
• Deryl L. Troyer and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2012, 3, 444–455, doi:10.3762/bjnano.3.51

• the payload of tumor-homing double-stable RAW264.7 cells; (2) Release of chemotherapeutic SN38 at the cancer site by means of the self-containing Tet-On Advanced system; (3) Provide localized magnetic hyperthermia to enhance the cancer treatment, both by killing cancer cells through magnetic heating

• prodrug to the tumor site, and, upon activation of a previously silenced gene with doxycycline, significantly increased survival in a murine pancreatic cancer model in mice was observed [28]. Hyperthermia uses heat to kill cancer cells [29]. Numerous clinical trials have demonstrated that the combination

• of hyperthermia with radiation therapy and chemotherapy can greatly improve the efficacy of cancer treatment [30][31]. Ultrasmall magnetic nanoparticles generate heat efficiently in an alternating magnetic field (AMF). Due to their superior properties, such as negligible or low toxicity

Improvement of the oxidation stability of cobalt nanoparticles

• Celin Dobbrow and
• Annette M. Schmidt

Beilstein J. Nanotechnol. 2012, 3, 75–81, doi:10.3762/bjnano.3.9

• to their application potential in data storage [1] and in sensor applications [2], as well as for biomedical uses in therapy and diagnosis. By opening novel mechanisms for drug targeting [3], controlled drug release, hyperthermia [4][5] and imaging applications [6][7] there is a need for well

Preparation and characterization of supported magnetic nanoparticles prepared by reverse micelles

• Ulf Wiedwald,
• Luyang Han,
• Johannes Biskupek,
• Ute Kaiser and
• Paul Ziemann

Beilstein J. Nanotechnol. 2010, 1, 24–47, doi:10.3762/bjnano.1.5

• the medical field [7], e.g., in hyperthermia [8], contrast enhancing in magnetic resonance imaging [9][10] or the use as cell markers [9] which in-turn can be read out by highly-sensitive devices like TMR-sensors [11]. Moreover, magnetic NPs are thought to improve a variety of catalytic reactions [12