Interaction of dermatologically relevant nanoparticles with skin cells and skin

• Annika Vogt,
• Fiorenza Rancan,
• Sebastian Ahlberg,
• Berouz Nazemi,
• Chun Sik Choe,
• Maxim E. Darvin,
• Sabrina Hadam,
• Ulrike Blume-Peytavi,
• Kateryna Loza,
• Jörg Diendorf,
• Matthias Epple,
• Christina Graf,
• Eckart Rühl,
• Martina C. Meinke and
• Jürgen Lademann

Beilstein J. Nanotechnol. 2014, 5, 2363–2373, doi:10.3762/bjnano.5.245

• toxicity were also shown for iron oxide nanoparticles [44]. In our group, we established protocols for the detection of free radicals in cells and in whole skin by electron paramagnetic resonance (EPR) spectroscopy. To detect nanoparticle-induced free radicals in cells, EPR on cell suspensions by using the

Nanoencapsulation of ultra-small superparamagnetic particles of iron oxide into human serum albumin nanoparticles

• Matthias G. Wacker,
• Mahmut Altinok,
• Stephan Urfels and
• Johann Bauer

Beilstein J. Nanotechnol. 2014, 5, 2259–2266, doi:10.3762/bjnano.5.235

• = 6 nm). Additionally, the specific (mass dependant) magnetization of the particles was determined at a temperature of 300 K (Figure 2). Surface modification of magnetite nanoparticles Iron oxide nanoparticles were chemically modified by using a combination of citrate and tetramethylammonium hydroxide

Biopolymer colloids for controlling and templating inorganic synthesis

• Laura C. Preiss,
• Katharina Landfester and
• Rafael Muñoz-Espí

Beilstein J. Nanotechnol. 2014, 5, 2129–2138, doi:10.3762/bjnano.5.222

• ] demonstrated the synthesis of iron oxide nanoparticles in a semi-interpenetrating polymer network of alginate and poly(N-isopropylacrylamide). Gold and AuNi alloy gelatin nanocomposites were developed by Brayner et al. [84]. A gelatin network incorporating metallic nanoparticles was obtained after reduction of

PVP-coated, negatively charged silver nanoparticles: A multi-center study of their physicochemical characteristics, cell culture and in vivo experiments

• Sebastian Ahlberg,
• Alexandra Antonopulos,
• Jörg Diendorf,
• Ralf Dringen,
• Matthias Epple,
• Rebekka Flöck,
• Wolfgang Goedecke,
• Christina Graf,
• Nadine Haberl,
• Jens Helmlinger,
• Fabian Herzog,
• Frederike Heuer,
• Stephanie Hirn,
• Christian Johannes,
• Stefanie Kittler,
• Manfred Köller,
• Katrin Korn,
• Wolfgang G. Kreyling,
• Fritz Krombach,
• Jürgen Lademann,
• Kateryna Loza,
• Eva M. Luther,
• Marcelina Malissek,
• Martina C. Meinke,
• Daniel Nordmeyer,
• Anne Pailliart,
• Jörg Raabe,
• Fiorenza Rancan,
• Barbara Rothen-Rutishauser,
• Eckart Rühl,
• Carsten Schleh,
• Andreas Seibel,
• Christina Sengstock,
• Lennart Treuel,
• Annika Vogt,
• Katrin Weber and
• Reinhard Zellner

Beilstein J. Nanotechnol. 2014, 5, 1944–1965, doi:10.3762/bjnano.5.205

• astrocytes against silver nanoparticle-induced toxicity is consistent with the reported tolerance of astrocytes against the potential toxicity of large amounts of accumulated iron oxide nanoparticles [107], whereas astrocytes are quite vulnerable to copper oxide nanoparticles [106]. Cultured astrocytes

Biocompatibility of cerium dioxide and silicon dioxide nanoparticles with endothelial cells

• Claudia Strobel,
• Martin Förster and
• Ingrid Hilger

Beilstein J. Nanotechnol. 2014, 5, 1795–1807, doi:10.3762/bjnano.5.190

• also known for other metal oxide nanoparticles, such as TiO2 nanoparticles [34] or iron oxide nanoparticles [35]. This indicates that the peri-nuclear accumulation is not dependent on the nanoparticle chemistry. Although the concentration-dependent nanoparticle exposure revealed no obvious differences

Influence of surface-modified maghemite nanoparticles on in vitro survival of human stem cells

• Michal Babič,
• Daniel Horák,
• Lyubov L. Lukash,
• Tetiana A. Ruban,
• Yurii N. Kolomiets,
• Svitlana P. Shpylova and
• Oksana A. Grypych

Beilstein J. Nanotechnol. 2014, 5, 1732–1737, doi:10.3762/bjnano.5.183

• labeling of cells in order to track them both in diagnostics and therapeutics [1][2]. For example, mesenchymal [3], neural [4], and bone marrow [5] stem cells, as well as other cells are widely labeled by surface-coated iron oxide nanoparticles. Other applications of nanoparticles involve the delivery of

• for the above mentioned purposes [9]. Monosized iron oxide nanoparticles, sometimes called ultra-small superparamagnetic iron oxide nanoparticles, play the dominant role. Quantum dots, gold and, recently, also upconversion nanoparticles are used less frequently. The main advantages of iron oxides

• ), although many cells were destroyed after treatment with the nanoparticles (Figure 3f). Obviously, unmodified γ-Fe2O3 particles were not internalized by the cells and could be responsible for cell death. The influence of iron oxide nanoparticles on the morphology of the vital organs of mice after unitary

A sonochemical approach to the direct surface functionalization of superparamagnetic iron oxide nanoparticles with (3-aminopropyl)triethoxysilane

• Bashiru Kayode Sodipo and
• Azlan Abdul Aziz

Beilstein J. Nanotechnol. 2014, 5, 1472–1476, doi:10.3762/bjnano.5.160

• Sains Malaysia, 11800 Pulau Pinang, Malaysia 10.3762/bjnano.5.160 Abstract We report a sonochemical method of functionalizing superparamagnetic iron oxide nanoparticles (SPION) with (3-aminopropyl)triethoxysilane (APTES). Mechanical stirring, localized hot spots and other unique conditions generated by

• ; superparamagnetic iron oxide nanoparticles (SPION); Findings Superparamagnetic iron oxide nanoparticles (SPION) have a wide range of applications in biomedical research and development. The main drawbacks of SPION are a high surface energy, van der Waals forces of attraction and dipole to dipole interactions that

PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system

• Paula M. Castillo,
• Mario de la Mata,
• Maria F. Casula,
• José A. Sánchez-Alcázar and
• Ana P. Zaderenko

Beilstein J. Nanotechnol. 2014, 5, 1312–1319, doi:10.3762/bjnano.5.144

• by means of nano-formulations cover a wide range of organic nanomaterials [11][12][13][14][15][16][17][18][19]. Noticeably, a cyclodextrin-containing polymer–CPT nano-formulation is currently undergoing phase II clinical trials [20]. Superparamagnetic iron oxide nanoparticles (SPION) are particularly

Manipulation of isolated brain nerve terminals by an external magnetic field using D-mannose-coated γ-Fe₂O₃ nano-sized particles and assessment of their effects on glutamate transport

• Tatiana Borisova,
• Natalia Krisanova,
• Arsenii Borуsov,
• Roman Sivko,
• Ludmila Ostapchenko,
• Michal Babic and
• Daniel Horak

Beilstein J. Nanotechnol. 2014, 5, 778–788, doi:10.3762/bjnano.5.90

• showed both negative and positive effects [1]. One of the concerns is that nanoparticles can potentially harm the function of or have toxic effects on human nerve cells owing to their ability to pass through biological membranes [2]. Superparamagnetic iron oxide nanoparticles are considered as promising

• away, the inner magnetization of nanoparticles disappears, and therefore their agglomeration, which carries the risk of embolization of the capillary vessels, can be avoided [3]. A key issue for enhancing of permeability of iron oxide nanoparticles through the cell membrane is the modification of their

• surface. In this context, biocompatible polymers can be attached to the surface of the nanoparticles to avoid their agglomeration and enhance their non-specific intracellular uptake [4]. Magnetic resonance imaging could be used for tracking labeled cells in vivo by using iron oxide nanoparticles coated by

Extracellular biosynthesis of gadolinium oxide (Gd₂O₃) nanoparticles, their biodistribution and bioconjugation with the chemically modified anticancer drug taxol

• Shadab Ali Khan,
• Sanjay Gambhir and
• Absar Ahmad

Beilstein J. Nanotechnol. 2014, 5, 249–257, doi:10.3762/bjnano.5.27

• extended the work of biosynthesis of Gd2O3 nanoparticles to bioconjugation with taxol. Bioconjugation of taxol with gold and iron oxide nanoparticles has also been reported [15][16]. Taxol is one of the most important anticancer drugs used for breast, ovarian and lung cancers [17][18]. The potent

Effect of spherical Au nanoparticles on nanofriction and wear reduction in dry and liquid environments

• Dave Maharaj and
• Bharat Bhushan

Beilstein J. Nanotechnol. 2012, 3, 759–772, doi:10.3762/bjnano.3.85

• treatment, nanoparticles are either functionalized with biomolecules that recognize and attach to the cancer cells, [6][7] or in the case of iron-oxide nanoparticles, the nanoparticles are directed by an external magnetic field [9]. The cells are destroyed by drugs that coat the nanoparticles or by

• release of this agent on contact with hydrocarbons is used as an indication of the presence of oil on recovery of the nanoparticles [10]. In contaminant removal, nanocomposites composed of collagen and superparamagnetic iron-oxide nanoparticles (SPIONs) have been investigated. The collagen selectively

Magnetic-Fe/Fe₃O₄-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

• Hongwang Wang,
• Tej B. Shrestha,
• Matthew T. Basel,
• Raj K. Dani,
• Gwi-Moon Seo,
• Sivasai Balivada,
• Marla M. Pyle,
• Heidy Prock,
• Olga B. Koper,
• Prem S. Thapa,
• David Moore,
• Ping Li,
• Viktor Chikan,
• Deryl L. Troyer and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2012, 3, 444–455, doi:10.3762/bjnano.3.51

• dopamine to SN38 Dopamine has been reported as a robust anchor to immobilize functional groups on the surface of iron oxide nanoparticles [39][40][41][42][43][44][45]. Introducing polyethylene glycol to the dopamine anchor can greatly improve both the solubility and biocompatibility of iron oxide

• oxide nanoparticles. Flow cytometry Flow cytometry was used to determine the percentage of cells loaded with MNP. The cells were plated in six-well plates at a density of 300,000 cm−2 and allowed to attach overnight. The next day, the cells reached 70% confluence. They were then incubated with 0, 20, 40

• removed and 0 to 320 µg/mL of SN38-loaded Fe/Fe3O4 nanoparticles in fresh medium was added. After 24 h, the medium was removed; the cells were washed with 1× PBS three times, and stained with Prussian blue and counter stained by nuclear fast red to confirm that the loaded nanoparticles were iron/iron

Magnetic nanoparticles for biomedical NMR-based diagnostics

• Huilin Shao,
• Tae-Jong Yoon,
• Monty Liong,
• Ralph Weissleder and
• Hakho Lee

Beilstein J. Nanotechnol. 2010, 1, 142–154, doi:10.3762/bjnano.1.17

• ][21][22][23][24][25]. A variety of chemical methods, ranging from traditional wet chemistry to high-temperature thermal decomposition, have been employed to synthesize MNPs. Colloidal iron oxide nanoparticles, which are used as clinical magnetic resonance imaging (MRI) contrast agents, are generally

• and their representative strategies described below have been shown to be uniquely suited for DMR applications. Cross-linked iron oxide nanoparticles Cross-linked iron oxide (CLIO) nanoparticles have been widely used for DMR applications on account of their excellent stability and biocompatibility [13

• assays developed to datea. Acknowledgements The authors thank N. Sergeyev for providing cross-linked dextran-coated iron oxide nanoparticles; Y. Fisher-Jeffes for reviewing the manuscript. This work was supported in part by NIH Grants (2RO1EB004626, U01-HL080731, U54-CA119349 and T32-CA79443). H. Shao

Magnetic coupling mechanisms in particle/thin film composite systems

• Giovanni A. Badini Confalonieri,
• Philipp Szary,
• Durgamadhab Mishra,
• Maria J. Benitez,
• Mathias Feyen,
• An Hui Lu,
• Leonardo Agudo,
• Gunther Eggeler,
• Oleg Petracic and
• Hartmut Zabel

Beilstein J. Nanotechnol. 2010, 1, 101–107, doi:10.3762/bjnano.1.12

• magnetic force microscopy. Moreover, an exchange bias effect was found, which is likely to be due to oxygen exchange between the iron oxide and the Co layer, and thus forming of an antiferromagnetic CoO layer at the γ-Fe2O3/Co interface. Keywords: exchange bias; iron oxide nanoparticles; nanoparticle self

• the particle/film interface by oxygen exchange from both the iron oxide and the organic oleic acid to the Co layer. In the event of oxygen exchange between the iron oxide nanoparticles and the Co layer, it is reasonable to expect a change in stoichiometry of the nanoparticles, at least at the surface