Overview of mechanism and consequences of endothelial leakiness caused by metal and polymeric nanoparticles

• Magdalena Lasak and
• Karol Ciepluch

Beilstein J. Nanotechnol. 2023, 14, 329–338, doi:10.3762/bjnano.14.28

• Magdalena Lasak Karol Ciepluch Division of Medical Biology, Jan Kochanowski University in Kielce, Uniwersytecka Street 7, Kielce, Poland 10.3762/bjnano.14.28 Abstract Nanoparticles (NPs) exhibit unique physicochemical properties that enable them to overcome biological barriers and to be

• increasing the access to the target sites in the organism. This type of interaction can lead to NP-modulated endothelial leakiness (NanoEL). The most important factors determining NanoEL are the physicochemical properties of the NPs. NP-modulated endothelial leakiness can lead to the discovery of new

• [18][19][20][21][22][23]. NPs exhibit unique physicochemical properties that enable them to overcome biological barriers, such as negative surface charge and sizes from 5 to 50 nm. Moreover, most of the administered NPs eventually end up in the bloodstream, which facilitates their interaction with the

Biocatalytic synthesis and ordered self-assembly of silica nanoparticles via a silica-binding peptide

• Mustafa Gungormus

Beilstein J. Nanotechnol. 2023, 14, 280–290, doi:10.3762/bjnano.14.25

• -range homogeneity of self-assembly of as-synthesized SiO2 particles formed with NH3 alone and NH3 + 1 mM SiBP. Amino acid sequence and physicochemical properties of the SiBP. Reaction contents for the different conditions studied. Supporting Information Supporting Information features mass spectra of

• synthesis and assembly of SiO2 nanoparticles into gels or opal-like ordered structures. Experimental Synthesis of the peptide The SiBP was commercially synthesized (Genscript, NJ, USA) at <98% purity via 9-fluorenylmethoxycarbonyl (F-moc) chemistry methods. The amino acid sequence and physicochemical

• properties of the SiBP are shown in Table 1. Synthesis of SiO2 particles The particles were synthesized based on the method described by Stöber and co-workers [42]. Tetraethyl orthosilicate (TEOS) (Alfa Aesar, Ward Hill, MA, USA) was used as the precursor, a 1:1 mixture of ethanol/deionized water was used as

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• microenvironment, and tumor cells, (ii) delivering large payloads of active substances with different physicochemical properties, such as small-molecular drugs and siRNA, to the site of action, and (iii) limiting drug resistance [91]. Nanotherapy can change the landscape of clinical lung cancer treatment by

• task limited by extracellular and intracellular challenges. Combinatorial therapy further complicates the right-time, right-place co-delivery of siRNA with other active ingredients due to the differences in the physicochemical properties, delivery, and stability problems. The nanoparticle core for

• physicochemical properties (polar headgroup, linker region, and type and length of hydrophobic domain), PEG amount, PEG lipid alkyl length, as well as the physicochemical properties of the LNPs (zeta potential, pKa value, and structure and conformation of the lipid bilayer) will result in improved targeting

Two-step single-reactor synthesis of oleic acid- or undecylenic acid-stabilized magnetic nanoparticles by thermal decomposition

• Mykhailo Nahorniak,
• Pamela Pasetto,
• Jean-Marc Greneche,
• Volodymyr Samaryk,
• Sandy Auguste,
• Anthony Rousseau,
• Nataliya Nosova and
• Serhii Varvarenko

Beilstein J. Nanotechnol. 2023, 14, 11–22, doi:10.3762/bjnano.14.2

• as the initial precursor. The properties of the synthesized materials were studied using various methods. Results and Discussion The physicochemical properties of NPM synthesized via thermal decomposition depend on many factors, such as selection of precursors and organic stabilizers, ligand

Facile preparation of Au- and BODIPY-grafted lipid nanoparticles for synergized photothermal therapy

• Yuran Wang,
• Xudong Li,
• Haijun Chen and
• Yu Gao

Beilstein J. Nanotechnol. 2022, 13, 1432–1444, doi:10.3762/bjnano.13.118

• materials. In addition, AB-LNPs could cause severe cytotoxicity when exposed to only a very low dose of laser irradiation (0.5 W/cm2, 60 s), which is beneficial to clinical application. Conclusion AB-LNPs were prepared by simply mixing Au-LNPs with BDP. The physicochemical properties of AB-LNPs were closely

Supramolecular assembly of pentamidine and polymeric cyclodextrin bimetallic core–shell nanoarchitectures

• Alexandru-Milentie Hada,
• Nina Burduja,
• Marco Abbate,
• Claudio Stagno,
• Guy Caljon,
• Louis Maes,
• Nicola Micale,
• Massimiliano Cordaro,
• Angela Scala,
• Antonino Mazzaglia and
• Anna Piperno

Beilstein J. Nanotechnol. 2022, 13, 1361–1369, doi:10.3762/bjnano.13.112

• nanostructures endowed with unique physicochemical properties. Recently, we have proposed a straightforward synthetic strategy that exploits the properties of polymeric β-cyclodextrin (PolyCD) to act as both the reducing and stabilizing agent to produce monodispersed and stable gold-based NPs either as

• composed of gold and/or silver, are versatile agents endowed with unique physicochemical properties, which recently have drawn great interest for a variety of applications ranging from catalysis to nanomedicine [1][2][3]. The size of the NPs is a key parameter that defines their optical properties

Design of surface nanostructures for chirality sensing based on quartz crystal microbalance

• Yinglin Ma,
• Xiangyun Xiao and
• Qingmin Ji

Beilstein J. Nanotechnol. 2022, 13, 1201–1219, doi:10.3762/bjnano.13.100

• . A similar QCM response is also seen for gelatin. As physicochemical properties of BSA and gelatin are different, it was inferred that the chiral sensing effect of this system could be applied to various protein species. The authors further employed fluorescent titration measurements to study the

Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications

• Aisha Kanwal,
• Naheed Bibi,
• Sajjad Hyder,
• Arif Muhammad,
• Hao Ren,
• Jiangtao Liu and
• Zhongli Lei

Beilstein J. Nanotechnol. 2022, 13, 1068–1107, doi:10.3762/bjnano.13.93

• their functional properties [5][6]. These exceptional optical and physicochemical properties make them ideal for transdisciplinary research. Fluorescent CDs can be manufactured using inexpensive, naturally rich carbon sources in an environmentally friendly manner. By adjusting the surface chemistry of

Design of a biomimetic, small-scale artificial leaf surface for the study of environmental interactions

• Miriam Anna Huth,
• Axel Huth,
• Lukas Schreiber and
• Kerstin Koch

Beilstein J. Nanotechnol. 2022, 13, 944–957, doi:10.3762/bjnano.13.83

• physicochemical properties due to the cuticle and, in particular, due to the epicuticular waxes deposited on it. In previous studies, bio-inspired technical surfaces were often used with surface properties only partially corresponding to those of the natural surfaces. In the present work, an artificial leaf

• developed that mimics the physicochemical properties of a natural leaf surface. The morphology of the recrystallized structures was not a 1:1 copy of the native structures, but the properties were still transferred. This proves that the thermal evaporation process made it possible to transfer the surface

• , which mimics the physicochemical properties of a natural leaf. The thermal evaporation process allowed for a homogeneous coating of the glass with three-dimensional structures. By coating with the medium amount of wax (1400 µg), the wettability and the wax composition of the wheat leaf surface could be

Solar-light-driven LaFe_xNi_1−xO₃ perovskite oxides for photocatalytic Fenton-like reaction to degrade organic pollutants

• Chao-Wei Huang,
• Shu-Yu Hsu,
• Jun-Han Lin,
• Yun Jhou,
• Wei-Yu Chen,
• Kun-Yi Andrew Lin,
• Yu-Tang Lin and
• Van-Huy Nguyen

Beilstein J. Nanotechnol. 2022, 13, 882–895, doi:10.3762/bjnano.13.79

• degradation. Though it was proven that Mn-doped LaFeO3 could enhance the activity of heterogeneous photo-Fenton-like reactions, the influence of Mn content on the activity was not significant [30]. Phan et al. verified that Cu-doped LaFeO3 exhibited physicochemical properties to decolorize methlyorgane

Hierarchical Bi₂WO₆/TiO₂-nanotube composites derived from natural cellulose for visible-light photocatalytic treatment of pollutants

• Zehao Lin,
• Zhan Yang and
• Jianguo Huang

Beilstein J. Nanotechnol. 2022, 13, 745–762, doi:10.3762/bjnano.13.66

• photocorrosion [20]. Among them, the Aurivillius phase bismuth tungstate (Bi2WO6) material is applied in visible-light photocatalysis due to its effective response to visible light and stable physicochemical properties [21]. Bi2WO6 is formed by the alternating growth of (Bi2O2)2+ and perovskite-structured (WO4)2

Design and selection of peptides to block the SARS-CoV-2 receptor binding domain by molecular docking

• Kendra Ramirez-Acosta,
• Ivan A. Rosales-Fuerte,
• J. Eduardo Perez-Sanchez,
• Alfredo Nuñez-Rivera,
• Josue Juarez and
• Ruben D. Cadena-Nava

Beilstein J. Nanotechnol. 2022, 13, 699–711, doi:10.3762/bjnano.13.62

• physical and biochemical properties of the potential peptides. Summary of the physicochemical properties of the final peptide candidates. Secondary structure and contact area of peptides. The secondary structure is presented as the number of amino acids in each structure divided by the total number of

• ); distribution of electrostatic potential on the surface of APD peptide candidates docked to the SARS-CoV-2 RBD (Figure S2); secondary structure, docking, and distribution of electrostatic charges of aligned peptides (Figure S3); physicochemical properties, hydrogen bonds, and hydrophobic interactions of the

Nanoarchitectonics of the cathode to improve the reversibility of Li–O₂ batteries

• Hien Thi Thu Pham,
• Jonghyeok Yun,
• So Yeun Kim,
• Sang A Han,
• Jung Ho Kim,
• Jong-Won Lee and
• Min-Sik Park

Beilstein J. Nanotechnol. 2022, 13, 689–698, doi:10.3762/bjnano.13.61

• blocked, resulting in a decrease of the electrochemical performance of LOBs [9]. In addition to the pore structure of the cathode, the morphology and physicochemical properties of Li2O2 directly affect the overpotential and round-trip efficiency of LOBs during cycling [10][11]. The morphologies and

• physicochemical properties of Li2O2 are reported to be dependent on many factors, including the pore structure of cathode. The electrical conductivity of the cathode is also essential for securing long-term cyclability as well as rate capability [12]. In this respect, various types of carbon materials have been

• as promising cathode materials for LOBs. The surface area and pore volume of the ZnxCoy–C/CNT composites could be controlled by adjusting the Zn/Co ratio during synthesis. The chemical composition of ZnxCoy particles directly affects their physicochemical properties such as BET surface area, pore

Antibacterial activity of a berberine nanoformulation

• Hue Thi Nguyen,
• Tuyet Nhung Pham,
• Anh-Tuan Le,
• Nguyen Thanh Thuy,
• Tran Quang Huy and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2022, 13, 641–652, doi:10.3762/bjnano.13.56

• of glycerol on the physicochemical properties of BBR NPs was investigated by UV–vis absorption and FTIR spectroscopy. The UV–vis absorption spectra of pure BBR and BBR NP solutions in distilled water at the same concentration are shown in Figure 1. Glycerol has no absorption band in the UV–vis

• BBR in a 2.0 mL Eppendorf tube containing 1.0 mL of distilled water. The tube was placed in an ultrasonic bath for 30 min at room temperature. Then, the BBR solution was centrifuged at a speed of 5000 rpm for 5 min. The supernatant liquid was withdrawn as saturated BBR solution. Physicochemical

• properties of BBR NPs UV–vis absorption spectra of the aqueous solutions of pure BBR and BBR NPs having the same concentration were measured in the wavelength range of 200–550 nm using a UV–vis spectrophotometer (6850 UV/Vis, Jenway). The chemical bonding characteristics of pure BBR powder and BBR NPs

Detection and imaging of Hg(II) in vivo using glutathione-functionalized gold nanoparticles

• Gufeng Li,
• Shaoqing Li,
• Rui Wang,
• Min Yang,
• Lizhu Zhang,
• Yanli Zhang,
• Wenrong Yang and
• Hongbin Wang

Beilstein J. Nanotechnol. 2022, 13, 549–559, doi:10.3762/bjnano.13.46

• cancer cells. In another work, Basu et al. designed a novel sensing system using DNA-functionalized GNPs. GNPs have a strong binding affinity to phosphate and sugar groups in DNA [20]. The combined GNPs-DNA has unique physicochemical properties and was used to detect Mg2+. Furthermore, Liu et al

Stimuli-responsive polypeptide nanogels for trypsin inhibition

• Petr Šálek,
• Jana Dvořáková,
• Sviatoslav Hladysh,
• Diana Oleshchuk,
• Ewa Pavlova,
• Jan Kučka and
• Vladimír Proks

Beilstein J. Nanotechnol. 2022, 13, 538–548, doi:10.3762/bjnano.13.45

• -responsive behavior of the nanogels As the formed polypeptides are polyelectrolytes, their stimuli-responsive behavior was studied [26]. Here, biocompatible and biodegradable PHEG-Tyr and biocompatible Nα-Lys-NG were incubated at different pH values and temperatures to study their physicochemical properties

Ethosomal (−)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects

• Çiğdem Yücel,
• Gökçe Şeker Karatoprak,
• Sena Yalçıntaş and
• Tuğba Eren Böncü

Beilstein J. Nanotechnol. 2022, 13, 491–502, doi:10.3762/bjnano.13.41

• at 4 °C (correlation coefficient, r2 = 0.994) and 22 days at 25 °C (r2 = 0.991), respectively. In ETHGs, it was determined that the gel was transparent at 4 °C, and transparent/yellowish at 25 °C, ± 60% relative humidity. The gel system showed good physicochemical properties at both 4 and 25 °C. The

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

• Zahra Nabizadeh,
• Mahmoud Nasrollahzadeh,
• Hamed Daemi,
• Mohamadreza Baghaban Eslaminejad,
• Ali Akbar Shabani,
• Mehdi Dadashpour,
• Majid Mirmohammadkhani and
• Davood Nasrabadi

Beilstein J. Nanotechnol. 2022, 13, 363–389, doi:10.3762/bjnano.13.31

• carbon, silicon, boron, and halloysite clay sheets and possess unique physicochemical properties. Among nanotube structures, much attention has been paid to carbon nanotubes (CNTs) because of their excellent mechanical and tensile strength properties, thermal and electrical conductivity, and high surface

Engineered titania nanomaterials in advanced clinical applications

• Padmavati Sahare,
• Paulina Govea Alvarez,
• Juan Manual Sanchez Yanez,
• Gabriel Luna-Bárcenas,
• Samik Chakraborty,
• Sujay Paul and
• Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

• . The advancement of this novel inorganic nanomaterial in theranostic nanomedicine might lead to an era of technology that can be used in real-world clinical settings. Review Effect of physicochemical properties of TiO2 on biocompatibility Biocompatibility is considered as one of the most important

• considered as a valuable antimicrobial agent due to its photocatalytic activity and self-cleaning properties. Several factors might affect the physicochemical properties of TiO2 nps. Crystal structure and shape are the most critical factors responsible for their antimicrobial property [76]. TiO2 has

Theoretical understanding of electronic and mechanical properties of 1T′ transition metal dichalcogenide crystals

• Seyedeh Alieh Kazemi,
• Sadegh Imani Yengejeh,
• Vei Wang,
• William Wen and
• Yun Wang

Beilstein J. Nanotechnol. 2022, 13, 160–171, doi:10.3762/bjnano.13.11

• of layered 1T′ TMD crystals have rarely been studied. As TMD monolayers do not have interlayer interactions, their physicochemical properties will differ from those of layered TMD materials. In this study, the electronic and mechanical characteristics of a range of 1T′ TMDs are systematically

A comprehensive review on electrospun nanohybrid membranes for wastewater treatment

• Senuri Kumarage,
• Imalka Munaweera and
• Nilwala Kottegoda

Beilstein J. Nanotechnol. 2022, 13, 137–159, doi:10.3762/bjnano.13.10

• different physicochemical properties of the solvents, such as the electrical conductivity, inherent viscosity of the polymers, and the difference of solubility parameters of the solvent and the polymer [36]. Moreover, they have reported that entanglement concentrations of the polymers varied significantly

Tin dioxide nanomaterial-based photocatalysts for nitrogen oxide oxidation: a review

• Viet Van Pham,
• Hong-Huy Tran,
• Thao Kim Truong and
• Thi Minh Cao

Beilstein J. Nanotechnol. 2022, 13, 96–113, doi:10.3762/bjnano.13.7

• [47]. Surface and defect states Structural defects and lattice imperfections usually bestow most of the properties exploited for applications of SnO2 materials as they influence various physicochemical properties and reactions on the surface. Most important are defect states of materials, including

Sputtering onto liquids: a critical review

• Anastasiya Sergievskaya,
• Adrien Chauvin and
• Stephanos Konstantinidis

Beilstein J. Nanotechnol. 2022, 13, 10–53, doi:10.3762/bjnano.13.2

• position [42][47]. In the case of the SoL process, the abovementioned contributions may also impact the liquid temperature but also its physicochemical properties as plasma electrons, ions, and radiation may induce, for example, bond breaking in the liquid molecules. In Figure 5, we report some of our

• presence of a temperature gradient might influence the physicochemical properties of the host liquid and the transport of matter inside the liquid medium. It is possible to sputter two or more elements simultaneously by setting up the sputtering apparatuses identical to the one presented in Figure 3 with

• gauge, the electric power supply, and the gas inlets. Sputtering processes have been studied and developed for a long time [7][8] and have been implemented in the coating industry to deposit nanometer-scale films onto various solid substrates. Such functional coatings must have tailored physicochemical

Chemical vapor deposition of germanium-rich CrGe_x nanowires

• Vladislav Dřínek,
• Stanislav Tiagulskyi,
• Roman Yatskiv,
• Jan Grym,
• Radek Fajgar,
• Věra Jandová,
• Martin Koštejn and
• Jaroslav Kupčík

Beilstein J. Nanotechnol. 2021, 12, 1365–1371, doi:10.3762/bjnano.12.100

• even replace them due to their better physicochemical properties. However, while research on plenty of metal silicides is already underway, we are only at the beginning with germanides. For example, CuSix has been studied extensively for some time. There is even an important application of copper

Self-assembly of Eucalyptus gunnii wax tubules and pure ß-diketone on HOPG and glass

• Miriam Anna Huth,
• Axel Huth and
• Kerstin Koch

Beilstein J. Nanotechnol. 2021, 12, 939–949, doi:10.3762/bjnano.12.70

• used to study their recrystallization by SEM and AFM. Experimental Substrates used for recrystallization Recrystallization experiments of a wax solution and a ß-diketone solution were done on two substrates with different physicochemical properties. Glass microscope coverslips were used as polar