Surface-enhanced Raman scattering of water in aqueous dispersions of silver nanoparticles

• Paulina Filipczak,
• Krzysztof Hałagan,
• Jacek Ulański and
• Marcin Kozanecki

Beilstein J. Nanotechnol. 2021, 12, 497–506, doi:10.3762/bjnano.12.40

• by the changes in the Raman spectra of water. Two types of agents can be distinguished: destructive agents (e.g., most ions, temperature, polar molecules) and structure-ordering agents (e.g., apolar molecules, biological macromolecules, or hydrophobic surfaces [19]). The intensity of the OH

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

• ponatinib and SAR302503 are hydrophobic drugs and were co-encapsulated inside the hydrophobic core of PEG–PLA micelles by solvent displacement nanoprecipitation. The results demonstrated that the targeted NDDS enabled a high availability of the drugs inside the BM, which is a prerequisite for overcoming the

A review on the green and sustainable synthesis of silver nanoparticles and one-dimensional silver nanostructures

• Sina Kaabipour and
• Shohreh Hemmati

Beilstein J. Nanotechnol. 2021, 12, 102–136, doi:10.3762/bjnano.12.9

• fatty acids in a hydrophobic solvent such as alkanes [235]. There is a water phase inside the microemulsions which is also referred to as the water pool where the reactants are present [235]. The water pool is where the silver ions are reduced into silver atoms which then form AgNPs [152]. The reverse

Self-assembly and spectroscopic fingerprints of photoactive pyrenyl tectons on hBN/Cu(111)

• Domenik M. Zimmermann,
• Knud Seufert,
• Luka Ðorđević,
• Tobias Hoh,
• Sushobhan Joshi,
• Tomas Marangoni,
• Davide Bonifazi and
• Willi Auwärter

Beilstein J. Nanotechnol. 2020, 11, 1470–1483, doi:10.3762/bjnano.11.130

• length 0.29 nm ± 0.05 nm) or was positioned in the hydrophobic pocket between the pyridyl group and the pyrene core of an adjacent molecule (see d2 and d3). trans-like-disubstituted pyrene Figure 3 shows the STM images of the surface after the deposition of the trans-like-disubstituted pyrene derivative

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

• Matías Guerrero Correa,
• Fernanda B. Martínez,
• Cristian Patiño Vidal,
• Camilo Streitt,
• Juan Escrig and
• Carol Lopez de Dicastillo

Beilstein J. Nanotechnol. 2020, 11, 1450–1469, doi:10.3762/bjnano.11.129

• , slightly attract NPs [158]. In addition, the double membrane acts as a selective physical barrier against hydrophobic compounds, such as detergents and antibiotics. On the other hand, Gram-positive bacteria have a higher permeability, even with a thick layer of peptidoglycan, since the single membrane is

• ]. Silver, gold, zinc oxide, and titanium dioxide NPs can be attracted to the cell wall by electrostatic attraction [161], van der Waals forces [162], and hydrophobic interactions [163], inducing changes in the shape, function and permeability of the cells. Proteins and DNA Proteins play a fundamental role

Photothermally active nanoparticles as a promising tool for eliminating bacteria and biofilms

• Mykola Borzenkov,
• Piersandro Pallavicini,
• Angelo Taglietti,
• Laura D’Alfonso,
• Maddalena Collini and
• Giuseppe Chirico

Beilstein J. Nanotechnol. 2020, 11, 1134–1146, doi:10.3762/bjnano.11.98

• biofilm viable count was ≈2.5–6.0 log cycle upon laser excitation with different gold nanoparticle concentrations. Previously, the same research group studied the photothermal bactericidal activity of hydrophilic and hydrophobic functionalized gold nanorods against S. aureus and Propionibacterium acnes by

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

• Maria Suciu,
• Corina M. Ionescu,
• Alexandra Ciorita,
• Septimiu C. Tripon,
• Dragos Nica,
• Hani Al-Salami and
• Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

• hydrophobic surfaces that induce aggregation and/or the formation of large clusters. When in contact with biological structures, this mechanism provokes capillary clotting and reduces tissue and cellular absorption. To prevent this, nanoparticles are coated with stabilizers, which are added during preparation

• commonly used for SPION coating, yielding good nanoparticle stability and no cytotoxicity. It is currently the preferred coating for MRI nanoparticles [54][76][84]. Depending on the type of emulsifier used, the coating can be hydrophilic or hydrophobic, but it is common to use hydrophilic polymers, such as

• PVA or PEG, for drug release studies [33][76] because the hydrophobic polymers are rapidly uptaken by macrophages [85]. SPIONs coated with a mixture of PVA and polyvinyl amine were shown to induce very active mitochondrial and endocytic processes in cells and to be highly toxic to cells due to the

A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans

• Selene Acosta,
• Carlos Moreno-Aguilar,
• Dania Hernández-Sánchez,
• Beatriz Morales-Cruzado,
• Erick Sarmiento-Gomez,
• Carla Bittencourt,
• Luis Octavio Sánchez-Vargas and
• Mildred Quintana

Beilstein J. Nanotechnol. 2020, 11, 1054–1061, doi:10.3762/bjnano.11.90

• negatively affected, resulting in the interaction by H-bond formation. Thus, FLG and Ce6 interact by means of π–π stacking, Ce6–Ce6 transition dipole, hydrogen bond formation, hydrophobic, and electron-donor interactions [36]. The observed changes in the UV–vis spectrum of FLG- Ce6 corroborates the TEM

Uniform Fe₃O₄/Gd₂O₃-DHCA nanocubes for dual-mode magnetic resonance imaging

• Miao Qin,
• Yueyou Peng,
• Mengjie Xu,
• Hui Yan,
• Yizhu Cheng,
• Xiumei Zhang,
• Di Huang,
• Weiyi Chen and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2020, 11, 1000–1009, doi:10.3762/bjnano.11.84

• distributed Fe3O4/Gd2O3 composites. FGOA nanocubes are hydrophobic since they are covered by oleic acid, which is enriched in alkyl groups. In order to increase the hydrophilicity of FGOA nanocubes so they could be used as a contrast agent in vivo, FGOA was exchanged with DHCA via the ligand-exchange method

• the mixture to precipitate the nanocubes. Then, the hydrophobic nanocubes were collected by centrifugation at 8000 rpm for 5 min, washed several times using ethanol and hexane and the final product, the FGOA nanocubes, was resuspended in 3 mL of hexane. Synthesis of Fe3O4-OA nanocubes 0.92 g of ferric

• ethanol was added to precipitate the nanocubes. Next, the hydrophobic nanocubes were collected by centrifugation at 8000 rpm for 5 min, washed several times using ethanol and hexane and the final product, the Fe3O4-OA nanocubes, was resuspended in 3 mL of hexane. Synthesis of Gd2O3-OA nanoparticles 0.334

A 3D-polyphenylalanine network inside porous alumina: Synthesis and characterization of an inorganic–organic composite membrane

• Jonathan Stott and
• Jörg J. Schneider

Beilstein J. Nanotechnol. 2020, 11, 938–951, doi:10.3762/bjnano.11.78

• Fores et al. The authors realized peptide hydrogels in a porous melamine foam for use in continuous flow chemistry [30]. Other polyelectrolytes such as poly(acrylic acid) were prepared using an ozone-induced grafting process for cellulose fibers [31]. Hydrophobic foams of poly(γ-benzyl-ʟ-glutamate-co-ʟ

• chose phenylalanine as an aromatic and hydrophobic amino acid to achieve a good interaction with slightly water-soluble compounds (e.g. chloroanilic acid) in aqueous solutions. Due the lack of amino groups in the side chain of phenylalanine, no further protection groups are needed for NCA-synthesis and

• therefore phenylalanine serves as an ideal and straightforward test bed. To the best of our knowledge, in situ formation and grafting of hydrophobic organo-gels within an inorganic porous environment has not been studied so far. As an inorganic substrate, sintered porous alumina membranes were

Preparation, characterization and photocatalytic performance of heterostructured CuO–ZnO-loaded composite nanofiber membranes

• Wei Fang,
• Liang Yu and
• Lan Xu

Beilstein J. Nanotechnol. 2020, 11, 631–650, doi:10.3762/bjnano.11.50

• PVDF/PAN weight ratios are displayed in Figure 4. All CNFMs are hydrophobic, and the hydrophobicity of the CNFMs decreases slightly with decreasing weight ratio. The reason might be that the hydrophobicity of pure PVDF nanofiber membranes (NFMs) is higher than that of pure PAN NFMs. Also, nanofiber

Silver-decorated gel-shell nanobeads: physicochemical characterization and evaluation of antibacterial properties

• Marta Bartel,
• Katarzyna Markowska,
• Marcin Strawski,
• Krystyna Wolska and
• Maciej Mazur

Beilstein J. Nanotechnol. 2020, 11, 620–630, doi:10.3762/bjnano.11.49

• reduction of AgNO3 with sodium borohydride). Since polystyrene is hydrophobic, the adsorption of hydrophilic Ag species in aqueous medium results in a decrease of the Gibbs surface free energy. The advantage of this method is its simplicity. However, even though it was demonstrated that the resulting

• structures are stable in aqueous solution, this may not be the case after addition of surfactants or the exchange of the solvent for a more hydrophobic one. Zhao et al. [23] proposed to incorporate silver nanoparticles into polystyrene/polystyrene sulfonate particles through accumulation of a silver complex

Adsorptive removal of bulky dye molecules from water with mesoporous polyaniline-derived carbon

• Hyung Jun An,
• Jong Min Park,
• Nazmul Abedin Khan and
• Sung Hwa Jhung

Beilstein J. Nanotechnol. 2020, 11, 597–605, doi:10.3762/bjnano.11.47

• ) 8.1 times that of commercial, activated carbon for AR1. The remarkable adsorption of AR1 and JGB over KOH-900 could be explained by the combined mechanisms of hydrophobic, π–π, electrostatic and van der Waals interactions. Keywords: acid red 1; adsorption; bulky dye molecules; Janus green B

• other adsorbent, KOH-900 showed the highest performance in AR1 adsorption, as shown in Figure 3. Therefore, hydrophobic interaction can be suggested as a plausible mechanism for AR1 and JGB adsorption. This mechanism, which has been suggested earlier in adsorption of malachite green [52], aromatics [64

• the bulky dye molecules. In summary, the remarkable adsorption of AR1 and JGB over KOH-900 can be explained by the combined mechanisms of hydrophobic, π–π, electrostatic and van der Waals interactions. Competitiveness of KOH-900 in adsorption of dyes Based on the remarkable performance of KOH-900 in

Identification of physicochemical properties that modulate nanoparticle aggregation in blood

• Ludovica Soddu,
• Duong N. Trinh,
• Eimear Dunne,
• Dermot Kenny,
• Giorgia Bernardini,
• Ida Kokalari,
• Arianna Marucco,
• Marco P. Monopoli and
• Ivana Fenoglio

Beilstein J. Nanotechnol. 2020, 11, 550–567, doi:10.3762/bjnano.11.44

• interact with the proteins [22]. The affinity of a protein for a certain surface and the mode of interaction rise from the interplay of electrostatic interactions, hydrogen bondings, and hydrophobic forces [32]. Both nanomaterials are negatively charged at physiological pH. However, SNPs exhibit a less

• groups/nm2 [31][32]. Both surfaces exhibit surface sites able to form hydrogen bonds or hydrophobic interaction with proteins. However, such tendency may be different since hydrogen bond formation obeys geometrical constraints due to the directional character of this bond. On the other hand, both silica

• and carbon surfaces exhibit hydrophobic patches, i.e., siloxane bridges and carbon–carbon bonds, respectively. These moieties have a different nature, exhibiting a higher dipolar character. Previous studies reported fibrinogen-induced aggregation for silica nanoparticles [23][40]. However, in these

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

• various forces, mostly electrostatic interactions, hydrogen bonding, covalent bonding, host–guest interactions and other interactions (e.g., hydrophobic and biospecific recognition) as shown in Figure 3. Electrostatic interactions The LbL assemblies were originally applied to both charged planar

• calixarene units covalently bound in various ways. Although there are many reports on calixerene [59], cyclodextrins offer a wide scope for such interactions in biological applications. They could act as a host for many biomolecules or drugs via hydrogen bonding, hydrophobic interaction or van der Waals

• thickening at elevated temperatures was responsible for trapping the macromolecules inside the capsules. The hydrophobic molecules could be loaded into multilayer capsules by changing the state of the capsules from open to closed via a polarity change [73]. Alternatively, water soluble, positively charged

Preparation and in vivo evaluation of glyco-gold nanoparticles carrying synthetic mycobacterial hexaarabinofuranoside

• Gennady L. Burygin,
• Polina I. Abronina,
• Nikita M. Podvalnyy,
• Sergey A. Staroverov,
• Leonid O. Kononov and
• Lev A. Dykman

Beilstein J. Nanotechnol. 2020, 11, 480–493, doi:10.3762/bjnano.11.39

• -induced coagulation (due to electrostatic and hydrophobic interactions and structural-mechanical stability factors) [57][97][98]. The minimal stabilizing concentrations for both glycosides 1 and 2 were found to be 100 μg·mL−1. This concentration was used to conjugate antigens 1 and 2 with GNPs, which gave

• may be related to the formation of reaction solutions with modified structures featuring different supramolecular assemblies of the reagents (supramers [104]) in solution. In a similar fashion, solutions of Ara6C2NH2-GNPs 3 with the shorter and more hydrophobic С2 spacer aglycon might form tighter

Brome mosaic virus-like particles as siRNA nanocarriers for biomedical purposes

• Alfredo Nuñez-Rivera,
• Pierrick G. J. Fournier,
• Danna L. Arellano,
• Ana G. Rodriguez-Hernandez,
• Rafael Vazquez-Duhalt and
• Ruben D. Cadena-Nava

Beilstein J. Nanotechnol. 2020, 11, 372–382, doi:10.3762/bjnano.11.28

• internalization of VLPs In order to test the cell internalization of VLPs, BMV and CCMV VLPs were loaded with NanoOrange, a hydrophobic fluorescent dye. Both BMV and CCMV viruses have hydrophobic residues in their capsid protein in which hydrophobic molecules, such as NanoOrange, are bound. Due to the high

• internalization To visualize the cell internalization, viruses were loaded with NanoOrange. These are hydrophobic molecules that bind to the hydrophobic domains of the capsid proteins of BMV and CCMV. NanoOrange (NanoOrange™ Protein Quantitation Kit; ThermoFisher Scientific) were incubated with 1 µg of BMV or

Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine

• Valentina Francia,
• Daphne Montizaan and
• Anna Salvati

Beilstein J. Nanotechnol. 2020, 11, 338–353, doi:10.3762/bjnano.11.25

• side effects [6]. Additionally, nanomedicines can encapsulate different types of hydrophilic and hydrophobic drugs, and they can be designed to control their release profile [7]. Several other characteristics of nanomaterials such as size, material, shape, surface charge, hydrophobicity, roughness, and

• specific carriers) [72][73], membrane bending, which occurs through different mechanisms, including the insertion of hydrophobic protein motifs in the membrane, local recruitment of membrane-bending domains, or scaffolding by proteins (the classic example being clathrin) [72][73][77][78], and scission of

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

• that could be either hydrophobic or a polyelectrolyte enabled the creation of numerous systems [8]. Depending on their structure, copolymers may also form self-assemblies. This is typically the case for amphiphilic block copolymers, which can form in aqueous solution polymer nanoobjects such as

• micelles or vesicles. The driving forces of this assembly are a loss of entropy during the self-assembly and different interactions acting on the monomer units of the polymer. Whereas polymer/polymer interactions are favored for the hydrophobic block, interactions between the hydrophobic block and water

• are strongly disfavored, leading to the isolation of the hydrophobic block into core or membranes [9]. In the last twenty years, thousands of papers have been published on this topic and the reader is referred to recent reviews [10][11][12][13][14]. Basically, the desired properties of an ideal

Molecular architectonics of DNA for functional nanoarchitectures

• Debasis Ghosh,
• Lakshmi P. Datta and
• Thimmaiah Govindaraju

Beilstein J. Nanotechnol. 2020, 11, 124–140, doi:10.3762/bjnano.11.11

• acid (PNA) dimers (clamps) via WC and Hoogsteen base pairing interactions (Figure 6) [75]. The hydrogen bonding interactions, along with hydrophobic interactions, imparted by the nucleobases and the NDI core, facilitated the formation of versatile nano- and microarchitectures. The morphological

• hydrophobic effects and characteristic optical responses to monitor the insertion mechanism. Notably, the position of conjugation and the number of porphyrin units were crucial parameters that significantly affected the insertion process. Asanuma and co-workers incorporated six methyl red chromophores into a

• of DNA, and this concept has been exploited by Trau and co-workers to analyze the different interaction patterns of methylated and nonmethylated DNA with gold nanoparticles [22]. The consistent and high methylation level of genomes makes the DNA more hydrophobic, while the distinct methylation in

Internalization mechanisms of cell-penetrating peptides

• Ivana Ruseska and
• Andreas Zimmer

Beilstein J. Nanotechnol. 2020, 11, 101–123, doi:10.3762/bjnano.11.10

• [20]. The second class within this classification scheme is formed by CPPs which noncovalently complex their cargo. They occur mostly as amphipathic peptides, consisting of a hydrophilic and a hydrophobic domain. Pep-1 and MPG are amphipathic peptides which are reported to form stable, noncovalent

• complexes with cargo molecules through electrostatic interaction. Pep-1 has successfully been used to deliver small peptides and proteins into cells, while MPG has shown to efficiently deliver small interfering RNA (siRNA) into cultured cell lines [3][10]. The interplay between hydrophilic and hydrophobic

• sequentially hydrophilic and hydrophobic amino acids in their primary structure [5][21]. This group includes MPG, penetratin, CADY, pVec, and other peptides. Secondary amphipathic peptides commonly have less than 20 amino acids in their sequence and are able to take their α-helix or β-sheet conformation after

Recent progress in perovskite solar cells: the perovskite layer

• Xianfeng Dai,
• Ke Xu and
• Fanan Wei

Beilstein J. Nanotechnol. 2020, 11, 51–60, doi:10.3762/bjnano.11.5

• improves the adhesion of the perovskite ink to hydrophobic substrates, effectively inhibiting the solution flow dynamics in the drying perovskite ink layer leading to compact and uniform perovskite films. The very small amount of surfactant additive has no adverse effect on the optoelectronic properties of

• new 2D/3D perovskite materials by incorporating hydrophobic alkylammonium salts with halogen functional groups (2-chloroethylammonium chloride and 2-bromoethylammonium bromide) into formamidinium-based 3D perovskites. By adjusting the relative amount of the ammonium salts the mixing ratio of the 2D

• and 3D perovskite phases could be controlled. The hydrophobic alkylammonium cations remarkably enhanced the humidity resistance of the 2D/3D mixtures. In addition, the halogen functional groups in the alkylammonium salts could cause changes of the electron cloud distribution and also enhance the

An investigation on the drag reduction performance of bioinspired pipeline surfaces with transverse microgrooves

• Weili Liu,
• Hongjian Ni,
• Peng Wang and
• Yi Zhou

Beilstein J. Nanotechnol. 2020, 11, 24–40, doi:10.3762/bjnano.11.3

• the drag [12]. It is well known that organisms found in nature provide substantial inspiration for solving engineering problems. Bionic research has found that some natural organisms form a specific surface structure with antidrag [13], antiwear [14][15], and hydrophobic [16][17] performance through

Fully amino acid-based hydrogel as potential scaffold for cell culturing and drug delivery

• Dávid Juriga,
• Evelin Sipos,
• Orsolya Hegedűs,
• Gábor Varga,
• Miklós Zrínyi,
• Krisztina S. Nagy and
• Angéla Jedlovszky-Hajdú

Beilstein J. Nanotechnol. 2019, 10, 2579–2593, doi:10.3762/bjnano.10.249

• with different swelling properties (and also different stiffness). The PSI-based gels show a low swelling degree at pH 8 due to the hydrophobic character of the PSI backbone (Figure 2a). Since PSI is insoluble in water, the Huggins interaction parameter increases in an aqueous medium, hence, the gels

Small protein sequences can induce cellular uptake of complex nanohybrids

• Jan-Philip Merkl,
• Malak Safi,
• Christian Schmidtke,
• Fadi Aldeek,
• Johannes Ostermann,
• Tatiana Domitrovic,
• Sebastian Gärtner,
• John E. Johnson,
• Horst Weller and
• Hedi Mattoussi

Beilstein J. Nanotechnol. 2019, 10, 2477–2482, doi:10.3762/bjnano.10.238

• (not to scale). The central QD (red, yellow, blue = core/shell/shell) is embedded in a crosslinked polymer micelle, consisting of a hydrophobic block (red) and an amphiphilic block (PEO). Interaction of the QDs with AuNPs (purple) is driven by the amine functional group. Gold nanoparticles are His