Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• , and because of that, it is resistant to low pH values [23]. So, when nanoparticles with this material are orally administered, they resist against gastric secretions and release the drug in the intestine. This protects many drugs and increases their bioavailability [24]. Inorganic nanoparticles (IN

Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells

• Eloïse Equy,
• Jordana Hirtzel,
• Sophie Hellé,
• Béatrice Heurtault,
• Eric Mathieu,
• Morgane Rabineau,
• Vincent Ball and
• Lydie Ploux

Beilstein J. Nanotechnol. 2023, 14, 1208–1224, doi:10.3762/bjnano.14.100

• already widely used in biology. Its hydrodynamic radius of about 4 nm at pH 7 makes it possible to envisage NP sizes close to 10 nm [20]. Chassepot and Ball prepared eumelanin-like particles in the presence of albumin, whose sizes decreased with the amount of protein down to 30 nm in diameter [14]. The

• hydrodynamic diameter of 3–4 nm at physiological pH [20]. The resulting number N of nanoparticles per milliliter and self-polymerization reaction yield η obtained with BSA/DA ratios of 3 and 10 were calculated with Equation 1 and Equation 2, respectively: where V is the volume of the NP solution remainder

• concentration might have led to an increase in the Stern layer thickness, resulting in a larger hydrodynamic diameter measured by DLS. The size of BSA/PDA NPs remained stable as a function of pH at acidic pH, but increased moderately under alkaline conditions (Figure 3e). Chen et al. reported that PDA NPs

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• promising biological properties, particularly antioxidant activity. However, its medical applications are limited due to its low water solubility, bioavailability, and pH-instability. CUR-loaded albumin microparticles (CUR-HSA-MPs) of submicron size in the range of 800 to 900 nm and a zeta potential of −15

• mV were prepared. The CUR loading efficiency was up to 65%. A maximum release of 37% of the encapsulated CUR was observed within 6 h when the CUR-HSA-MPs were dispersed in 50% ethanol in PBS at pH 7, while in RPMI 1640 medium the release was 7%. This demonstrates a sustainable release. The in vitro

• release of CUR for 6 h. The cumulative release of CUR was 35% when dispersed in 50% ethanol in PBS at pH 7, and 7% when dispersed in RPMI 1640 medium. However, the release in PBS (pH 7.4) was less than 1% after 96 h, as shown in Figure 5. Sustained release is a desirable property in the treatment of

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• induce conformational changes, which result in denaturation and loss of activity [43]. Similarly, electrostatic interactions between oppositely charged NPs and antibodies result in weak interactions where the antibodies are easily detached due to small changes in pH or ionic strength [44]. Covalent

• binding Covalent binding of antibodies can be achieved either by adding functional groups on the NP surfaces or by chemical modification of antibodies. Covalent attachment provides high stability, prominent reproducibility, and strong interaction; therefore, changes of pH or ionic strength do not affect

• of antibodies on the NP surfaces, because at physiological pH (pH 7), the most reactive amine groups are situated in the Fab region, which further leads to the loss of biological activity [50][51]. To avoid this, other techniques with oriented immobilization are mostly preferred for conjugation

Ni, Co, Zn, and Cu metal-organic framework-based nanomaterials for electrochemical reduction of CO₂: A review

• Ha Huu Do and
• Hai Bang Truong

Beilstein J. Nanotechnol. 2023, 14, 904–911, doi:10.3762/bjnano.14.74

• products, as shown in Figure 1. In addition to the properties of the catalyst material, other parameters, such as potential, pH, solvent, and temperature, also determine the formation of desired products. MOFs nanomaterials for electrocatalytic reduction of CO2 Ni-based MOFs nanomaterials Two-dimensional

Green SPIONs as a novel highly selective treatment for leishmaniasis: an in vitro study against Leishmania amazonensis intracellular amastigotes

• Brunno R. F. Verçoza,
• Robson R. Bernardo,
• Luiz Augusto S. de Oliveira and
• Juliany C. F. Rodrigues

Beilstein J. Nanotechnol. 2023, 14, 893–903, doi:10.3762/bjnano.14.73

• promastigotes (control and treated cells) were washed in phosphate-buffered saline (PBS) pH 7.2 and adhered for 10 min on glass coverslips previously coated with poly-ʟ-lysine (Sigma-Aldrich, Germany). The intracellular amastigotes were obtained after infection of RAW 264.7 macrophages at a ratio of ten

• parasites to one macrophage. After treatment, cells were washed in PBS pH 7.2, fixed, and dehydrated, as described in [9]. Finally, cells were observed using a DM2500 optical microscope (Leica Microsystem, Germany) in bright-field mode. Electron microscopy analysis Control and treated cells were washed in

• PBS pH 7.2, fixed, and post-fixed according to previously published protocols [23]. Then, cells were processed for scanning electron microscopy and chemical element mapping analysis as described in [9]. The micrographs were obtained using a TESCAN VEGA 3 LMU scanning electron microscope operating at

Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies

• Giuliana Muraca,
• María Esperanza Ruiz,
• Rocío C. Gambaro,
• Sebastián Scioli-Montoto,
• María Laura Sbaraglini,
• Gisel Padula,
• José Sebastián Cisneros,
• Cecilia Yamil Chain,
• Vera A. Álvarez,
• Cristián Huck-Iriart,
• Guillermo R. Castro,
• María Belén Piñero,
• Matias Ildebrando Marchetto,
• Catalina Alba Soto,
• Germán A. Islan and
• Alan Talevi

Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66

• . A Platinum EPS C8 (150 mm × 4.6 mm, 5 μm, GraceTM, Columbia, MD, USA) column was used; the mobile phase consisted of a mixture of methanol and 0.02% phosphoric acid solution (60:40) for a final pH of 2.5. The system was operated isocratically at a 1.0 mL/min flow rate and the detection was performed

• at 324 nm. The volume of injection was 20 μL. In vitro benznidazole release assay The release of BNZ from the nanoparticles was performed in a rotating paddle apparatus (Vision Classic 6, Hanson Research, Chatsworth, CA, USA) at 75 rpm using 500 mL of KH2PO4 buffer (pH 6.8) as the dissolution medium

Silver nanoparticles loaded on lactose/alginate: in situ synthesis, catalytic degradation, and pH-dependent antibacterial activity

• Nguyen Thi Thanh Tu,
• T. Lan-Anh Vo,
• T. Thu-Trang Ho,
• Kim-Phuong T. Dang,
• Van-Dung Le,
• Phan Nhat Minh,
• Chi-Hien Dang,
• Vinh-Thien Tran,
• Van-Su Dang,
• Tran Thi Kim Chi,
• Hieu Vu-Quang,
• Radek Fajgar,
• Thi-Lan-Huong Nguyen,
• Van-Dat Doan and
• Thanh-Danh Nguyen

Beilstein J. Nanotechnol. 2023, 14, 781–792, doi:10.3762/bjnano.14.64

• catalytic performance in degrading the pollutants methyl orange and rhodamine B. The antibacterial activity of the nanocomposite is pH-dependent, related to the alterations in surface properties of the nanocomposite at different pH values. At pH 6, the nanocomposite demonstrated the highest antibacterial

• properties of AgNPs can be influenced by factors such as size, pH value, and ionic strength of the medium [28][29][30][31]. Extensive research has been dedicated to control the size and shape of AgNPs through the application of various capping agents. In addition to their antimicrobial properties, AgNPs are

• nanocomposites using saccharides, such as alginate, cyclodextrin, and lactose. This method allows for the loading of metallic ions onto the nanocomposite, followed by their reduction to nanoparticles [36][37]. The nanocomposite matrix can release silver in appropriate environments, exhibiting pH-dependent

Carboxylic acids and light interact to affect nanoceria stability and dissolution in acidic aqueous environments

• Matthew L. Hancock,
• Eric A. Grulke and
• Robert A. Yokel

Beilstein J. Nanotechnol. 2023, 14, 762–780, doi:10.3762/bjnano.14.63

• dissolution and stabilization have been previously studied in vitro using acidic aqueous environments. Nanoceria agglomerated in the presence of some carboxylic acids over 30 weeks, and degraded in others, at pH 4.5 (i.e., the pH value in phagolysosomes). Plants release carboxylic acids, and cerium

• within the rhizosphere [12][13]. Colloid stability of nanoceria is affected by temperature, pH, surface structure, surface-adsorbed organic and inorganic ligands, and metal/nonmetal ions and their concentrations in the solution surrounding the particles [14]. Nanoceria interacts with soil and plant roots

• , where it is known to dissolve and transform in the presence of chelating agents at low pH [15]. In cucumber plants, there is clear evidence of ceria uptake and transport throughout the plant. A fraction of the ceria formed cerium carboxyl complexes. No phytotoxicity was reported to the plant itself [16

In situ magnesiothermic reduction synthesis of a Ge@C composite for high-performance lithium-ion batterie anodes

• Ha Tran Huu,
• Ngoc Phi Nguyen,
• Vuong Hoang Ngo,
• Huy Hoang Luc,
• Minh Kha Le,
• Minh Thu Nguyen,
• My Loan Phung Le,
• Hye Rim Kim,
• In Young Kim,
• Sung Jin Kim,
• Van Man Tran and
• Vien Vo

Beilstein J. Nanotechnol. 2023, 14, 751–761, doi:10.3762/bjnano.14.62

• at 180 °C for 12 h. After cooling to room temperature, the solid was collected and rinsed with DI water to neutral pH. The dried solid was denoted as Ge/C-HT180. Solid-state reaction coupling to synthesize Ge/C-SS750 composite Relevant amounts of Ge and BC-800 at a mass ratio of 2:5 were well ground

A graphene quantum dots–glassy carbon electrode-based electrochemical sensor for monitoring malathion

• Sanju Tanwar,
• Aditi Sharma and
• Dhirendra Mathur

Beilstein J. Nanotechnol. 2023, 14, 701–710, doi:10.3762/bjnano.14.56

• , differential pulse voltammetry experiments were conducted with 0.1 M phosphate-buffered saline at pH 7. Results and Discussion Characterization of graphene quantum dots The UV–vis absorption spectrum of the GQDs in distilled water is depicted in Figure 2a, which shows two prominent absorption peaks around 270

• voltammetry (DPV) analysis was conducted with various concentrations of malathion in 0.1 M PBS (pH 7) at a scan rate of 50 mV·s−1. Different concentrations of malathion were detected. The oxidative desulfurization of malathion into malaoxon (Figure 8) results in a current peak (centered at +1.9 V) at the GQDs

The microstrain-accompanied structural phase transition from h-MoO₃ to α-MoO₃ investigated by in situ X-ray diffraction

• Zeqian Zhang,
• Honglong Shi,
• Boxiang Zhuang,
• Minting Luo and
• Zhenfei Hu

Beilstein J. Nanotechnol. 2023, 14, 692–700, doi:10.3762/bjnano.14.55

• procedure, 6.2 g of ammonium heptamolybdate was dissolved in 100 mL of deionized water and stirred for 30 min at room temperature. Nitric acid was then added to the solution to reduce the pH to 1. After stirring for another 15 min, the solution was transferred into a 200 mL Teflon-lined autoclave and heated

Metal-organic framework-based nanomaterials as opto-electrochemical sensors for the detection of antibiotics and hormones: A review

• Akeem Adeyemi Oladipo,
• Saba Derakhshan Oskouei and
• Mustafa Gazi

Beilstein J. Nanotechnol. 2023, 14, 631–673, doi:10.3762/bjnano.14.52

ZnO-decorated SiC@C hybrids with strong electromagnetic absorption

• Liqun Duan,
• Zhiqian Yang,
• Yilu Xia,
• Xiaoqing Dai,
• Jian’an Wu and
• Minqian Sun

Beilstein J. Nanotechnol. 2023, 14, 565–573, doi:10.3762/bjnano.14.47

• ZnNO3·6H2O (0.5, 1, 2, 3, and 4 mmol), 50 mL H2O, and 8 mL PEG were mixed together. After that, 40 mg SiC@C nanowires was added to the above solution, followed by magnetic stirring for 20 min. At 60 °C, NH3·H2O was added dropwise until pH 9–10. After 2 h of continual stirring, the products were obtained

Carbon nanotube-cellulose ink for rapid solvent identification

• Tiago Amarante,
• Thiago H. R. Cunha,
• Claudio Laudares,
• Ana P. M. Barboza,
• Ana Carolina dos Santos,
• Cíntia L. Pereira,
• Vinicius Ornelas,
• Bernardo R. A. Neves,
• André S. Ferlauto and
• Rodrigo G. Lacerda

Beilstein J. Nanotechnol. 2023, 14, 535–543, doi:10.3762/bjnano.14.44

• transistors, transparent conductors, gas sensors, supercapacitors, and pH sensors [41][42][47][48][49][50][51][52][53][54][55]. Different approaches to ink printing methods have been explored, such as aerosol jet, inkjet, syringe, roll-to-roll printing, and stamp methods [1][41][50]. In this work, we report a

Nanoarchitectonics to entrap living cells in silica-based systems: encapsulations with yolk–shell and sepiolite nanomaterials

• Celia Martín-Morales,
• Jorge Fernández-Méndez,
• Pilar Aranda and
• Eduardo Ruiz-Hitzky

Beilstein J. Nanotechnol. 2023, 14, 522–534, doi:10.3762/bjnano.14.43

• nanoparticles to reach the desired weight percentage (5.0% to 7.0%). Eventually, the concentrated cell biomass (33% to 40% v/v) was then added and the mixture was placed in a 7 cm diameter Petri dish, where it gelled at room temperature after the addition of 0.2 M KOH to achieve pH 7–8. Table 1 gathers the

The origin of black and white coloration of the Asian tiger mosquito Aedes albopictus (Diptera: Culicidae)

• Manuela Rebora,
• Gianandrea Salerno,
• Silvana Piersanti,
• Alexander Kovalev and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2023, 14, 496–508, doi:10.3762/bjnano.14.41

• cacodylate buffer (Electron Microscopy Sciences, Hatfield, England), pH 7.2. The fixed legs were repeatedly rinsed in sodium cacodylate buffer and post-fixed for 1 h at 4 °C in 1% osmium tetroxide in sodium cacodylate buffer (Electron Microscopy Sciences). The samples were then repeatedly washed in the same

Mixed oxides with corundum-type structure obtained from recycling can seals as paint pigments: color stability

• Dienifer F. L. Horsth,
• Julia de O. Primo,
• Nayara Balaba,
• Fauze J. Anaissi and
• Carla Bittencourt

Beilstein J. Nanotechnol. 2023, 14, 467–477, doi:10.3762/bjnano.14.37

• solution containing the Al3+ ions had an acid pH value of 0.45 [1]. Obtaining boehmite (γ-AlO(OH)) The pH value was modified to obtain the boehmite phase by adding sodium hydroxide (NaOH) until pH 8. After precipitation, the oxide hydroxide was vacuum filtered and oven-dried at 70 °C [1][13]. Boehmite

Evaluation of electrosynthesized reduced graphene oxide–Ni/Fe/Co-based (oxy)hydroxide catalysts towards the oxygen evolution reaction

• Karolina Cysewska,
• Marcin Łapiński,
• Marcin Zając,
• Jakub Karczewski,
• Piotr Jasiński and
• Sebastian Molin

Beilstein J. Nanotechnol. 2023, 14, 420–433, doi:10.3762/bjnano.14.34

• 1 M KOH (Stanlab, pH ≈13.9). Before each electrochemical experiment, the electrode was stabilized during cyclic voltammetry (CV) by sweeping the potential from 1.1 to 1.6 V vs RHE for at least 20 cycles with a scan rate of 100 mV·s−1. Linear scan voltammetry (LSV) was performed from 1.1 to 2 V vs

Plasmonic nanotechnology for photothermal applications – an evaluation

• A. R. Indhu,
• L. Keerthana and
• Gnanaprakash Dharmalingam

Beilstein J. Nanotechnol. 2023, 14, 380–419, doi:10.3762/bjnano.14.33

Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities

• Akif Hakan Kurt,
• Elif Berna Olutas,
• Fatma Avcioglu,
• Hamza Karakuş,
• Mehmet Ali Sungur,
• Cansu Kara Oztabag and
• Muhammet Yıldırım

Beilstein J. Nanotechnol. 2023, 14, 362–376, doi:10.3762/bjnano.14.31

• potentials, both regarding sign and numbers, clearly reveals that the stability of the NPs has changed significantly. Various studies have reported that in cell culture medium, there are pH-induced changes of NP conformation, particle size, stability, and functionality. Therefore, the nature of the cell

• activities against multidrug-resistant E. coli strains when compared to Ag NPs or quercetin treatments [78]. Here, factors such as low NP concentrations, high bacterial concentration, nanoparticle size, and ambient pH may have played a role in obtaining such low antibacterial inhibition results. Furthermore

Bismuth-based nanostructured photocatalysts for the remediation of antibiotics and organic dyes

• Akeem Adeyemi Oladipo and
• Faisal Suleiman Mustafa

Beilstein J. Nanotechnol. 2023, 14, 291–321, doi:10.3762/bjnano.14.26

• pH value of the effluent, the dosage of the photocatalyst, the initial concentration of the target pollutant, the dosage of oxidants, and the type of light source. To lower the overall cost of water treatment, the photocatalyst must be effective under all types of light, including direct sunlight, UV

• light, and simulated sunlight. Several Bi-based photocatalysts are visible-light-driven because of the bandgap, making them useful in a variety of situations. The solution pH value is a critical parameter when it comes to the photocatalytic degradation of textile dyes and antibiotics. The point of zero

• charge (pHpzc) of the photocatalysts, the effluent matrices, and the speciation of the target pollutants at various pH values all affect how well the photocatalytic process degrades pollutants. To avoid additional cost associated with pH adjustment of the effluent, an effective photocatalyst needs to

Biocatalytic synthesis and ordered self-assembly of silica nanoparticles via a silica-binding peptide

• Mustafa Gungormus

Beilstein J. Nanotechnol. 2023, 14, 280–290, doi:10.3762/bjnano.14.25

• molecular crowding-like effects, preventing efficient assembly of the particles. Therefore, tailoring intermolecular interactions between nanoparticles by modifying the particle surfaces or through external influences such as temperature, pH value, templates, and magnetic or flow fields, is important to

• achieved by reducing the negative surface charge of the SiO2 particles. The surface of the SiO2 particles is negatively charged above pH 2–3 [39][40]. Therefore, the as-synthesized particles exhibit little cohesion because of electrostatic repulsion. Usually, a post-assembly sintering process or long

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• anticancer effects [76]. After QT was delivered to tumor tissue by the active targeting ability of the membrane, the sensitivity to radiotherapy was effectively improved, and a strong anticancer effect was exerted under X-ray irradiation [76]. Gong et al. designed a pH-responsive multifunctional biomimetic

• , it has also been demonstrated that cell membrane coating does not affect the ability to generate ROS during treatment [82]. Tumor growth and progression are accompanied by an abnormal microenvironment (e.g., low pH, local hypoxia, overexpression of glutathione (GSH), and high levels of H2O2) [39

• middle cerebral artery occlusion rats. The infarct area of rats treated with 4T1 breast cancer membrane-coated pH-sensitive polymeric nanoparticles loaded with succinobucol (MPP/SCB) was significantly reduced on T2W MRI compared with bare nanoparticles (PP/SCB) and saline (tMCAO). (a) Experimental

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• , the pH-responsive linker between HA and PEG is hydrolyzed, leading to the cleavage of the HA layer. This, in turn, decreases the NP size and enables faster tumor diffusion, improved internalization, and drug release at the site of action. These nanocarriers exhibited a high degree of tumor homing, low

• toxicity, and efficient tumor inhibition in vitro and in a tumor mouse model [97]. An additional example of multilayered cleavable pH-responsive nanoparticles for KRAS mutated cancer is described in Table 2. Multistage drug delivery systems: Multistage nanocarriers address the issue of heterogenous

• )-functionalized nanoporous silica particles loaded with a poly(ʟ-glutamic acid) pH-cleavable linker–doxorubicin conjugate, which self-assembles into NPs after its release from the iNPG [114]. Li et al. designed a multistage nanocarrier for NSCLC targeting, composed of icotinib-loaded amphiphilic chitosan micelles