From iron coordination compounds to metal oxide nanoparticles

• Mihail Iacob,
• Carmen Racles,
• Codrin Tugui,
• George Stiubianu,
• Adrian Bele,
• Liviu Sacarescu,
• Daniel Timpu and
• Maria Cazacu

Beilstein J. Nanotechnol. 2016, 7, 2074–2087, doi:10.3762/bjnano.7.198

• iron oxide nanoparticles and their use in an extremely large number of applications is motivated by stability, biocompatibility, magnetic properties and their availability. However, certain applications require a rigorous selection of the nanoparticles by size and shape because these parameters

A novel electrochemical nanobiosensor for the ultrasensitive and specific detection of femtomolar-level gastric cancer biomarker miRNA-106a

• Maryam Daneshpour,
• Kobra Omidfar and
• Hossein Ghanbarian

Beilstein J. Nanotechnol. 2016, 7, 2023–2036, doi:10.3762/bjnano.7.193

• electrochemical characteristics, high surface-to-volume ratio, remarkable surface energy, and great biocompatibility, gold nanoparticles have been one of the most common choices for labeling in electrochemical biosensors [35]. In the present study, we fabricated a simple, sensitive, and specific electrochemical

Facile fabrication of luminescent organic dots by thermolysis of citric acid in urea melt, and their use for cell staining and polyelectrolyte microcapsule labelling

• Nadezhda M. Zholobak,
• Anton L. Popov,
• Alexander B. Shcherbakov,
• Nelly R. Popova,
• Mykhailo M. Guzyk,
• Valeriy P. Antonovich,
• Alla V. Yegorova,
• Yuliya V. Scrypynets,
• Inna I. Leonenko,
• Alexander Ye. Baranchikov and
• Vladimir K. Ivanov

Beilstein J. Nanotechnol. 2016, 7, 1905–1917, doi:10.3762/bjnano.7.182

• solubility, outstanding biocompatibility, resistance to photobleaching, chemical inertness and excellent suitability for biological applications (one- and multiphoton bioimaging [9][10][11][12][13][14][15][16], biosensorics [9][10][11][12][17] and biomolecules/drug delivery [12][13][15]). Since the discovery

Low temperature co-fired ceramic packaging of CMOS capacitive sensor chip towards cell viability monitoring

• Niina Halonen,
• Joni Kilpijärvi,
• Maciej Sobocinski,
• Timir Datta-Chaudhuri,
• Antti Hassinen,
• Someshekar B. Prakash,
• Peter Möller,
• Pamela Abshire,
• Sakari Kellokumpu and
• Anita Lloyd Spetz

Beilstein J. Nanotechnol. 2016, 7, 1871–1877, doi:10.3762/bjnano.7.179

• [23]. Human lung epithelial cells (BEAS2B) were cultivated on the chip to verify the biocompatibility of the package material. Responses were obtained on dry chips, chips covered with only cell growth medium (DMEM), and chips covered with a solution of cells in DMEM, demonstrating the robustness and

• due to mechanical disturbance caused by the procedure. Biocompatibility of the LTCC package The earlier reported [23] biocompatibility of the LTCC package to cell culture was also confirmed here for the new LTCC material by growing BEAS2B cells on a dummy chip and on the surrounding LTCC. The

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

• Huijuan Zhang,
• Fuqiang Wu,
• Yazhen Li,
• Xiping Yang,
• Jiamei Huang,
• Tingting Lv,
• Yingying Zhang,
• Jianzhong Chen,
• Haijun Chen,
• Yu Gao,
• Guannan Liu and
• Lee Jia

Beilstein J. Nanotechnol. 2016, 7, 1861–1870, doi:10.3762/bjnano.7.178

• ]. Because the side effects of MIF are closely related with its dosage, some studies have been implemented to find the optimum dosage of MIF [7] or to develop new formulations for MIF to improve its bioavailability [8]. Chitosan (Cs) is a basic polysaccharide found in nature with good biocompatibility and

3D printing of mineral–polymer bone substitutes based on sodium alginate and calcium phosphate

• Aleksey A. Egorov,
• Alexander Yu. Fedotov,
• Anton V. Mironov,
• Vladimir S. Komlev,
• Vladimir K. Popov and
• Yury V. Zobkov

Beilstein J. Nanotechnol. 2016, 7, 1794–1799, doi:10.3762/bjnano.7.172

• popular biomaterial because of a number of key advantages: convenient precursors, nontoxic, excellent biocompatibility and appropriate biodegradability [5][6][7]. Additionally, CPs are widely used for bone graft substitution due to their chemical affinity to the bone mineral content [8]. One of the

Numerical investigation of depth profiling capabilities of helium and neon ions in ion microscopy

• Patrick Philipp,
• Lukasz Rzeznik and
• Tom Wirtz

Beilstein J. Nanotechnol. 2016, 7, 1749–1760, doi:10.3762/bjnano.7.168

• + irradiation of polyimide (PI) and polyethersulfone improves the moisture uptake in the films [7]. Further applications include metal adhesion on polymer surface [8], novel inorganic films by ion bombardment of polymers [9], surface morphology for biocompatibility [10], etch resistance of polymers [11

Influence of hydrothermal synthesis parameters on the properties of hydroxyapatite nanoparticles

• Sylwia Kuśnieruk,
• Jacek Wojnarowicz,
• Agnieszka Chodara,
• Tadeusz Chudoba,
• Stanislaw Gierlotka and
• Witold Lojkowski

Beilstein J. Nanotechnol. 2016, 7, 1586–1601, doi:10.3762/bjnano.7.153

• and investors. Hydroxyapatite is characterized by its biocompatibility and osteoconductivity. The material has been commonly and successfully used in regenerative medicine and in drug delivery systems [3][4]. Nanostructured hydroxyapatite particles can be applied as building blocks for damaged enamel

Photothermal effect of gold nanostar patterns inkjet-printed on coated paper substrates with different permeability

• Mykola Borzenkov,
• Anni Määttänen,
• Petri Ihalainen,
• Maddalena Collini,
• Elisa Cabrini,
• Giacomo Dacarro,
• Piersandro Pallavicini and
• Giuseppe Chirico

Beilstein J. Nanotechnol. 2016, 7, 1480–1485, doi:10.3762/bjnano.7.140

• printing because of their conductive and thermal properties [1][8]. Within the existing types of metal nanoparticles, the beneficial properties of gold, such as good biocompatibility, excellent resistance to oxidation and acids, and high affinity to thiol containing biomolecules promote the applicability

• be printed on smart gold-based devices. Moreover, it should be noted, that the non-permeable paper displays also good biocompatibility at least for in-vitro applications, due to its latex coating [24]. Therefore, further steps of this research will employ non-permeable paper as printing substrate

Viability and proliferation of endothelial cells upon exposure to GaN nanoparticles

• Tudor Braniste,
• Ion Tiginyanu,
• Tibor Horvath,
• Simion Raevschi,
• Serghei Cebotari,
• Marco Lux,
• Axel Haverich and
• Andres Hilfiker

Beilstein J. Nanotechnol. 2016, 7, 1330–1337, doi:10.3762/bjnano.7.124

• cells grown on surfaces functionalized with GaN nanoparticles demonstrated excellent adhesion and proliferation, suggesting good biocompatibility of the nanostructured GaN. Keywords: endothelial cells; GaN nanoparticles; proliferation; surface functionalization; Introduction The development of new

• living cells and different types of nanoparticles of specific shape, surface charge, and chemical composition [4]. For example, elongated, rod-like gold (Au) nanoparticles affect the viability of endothelial cells more than spherical ones, which have better biocompatibility [5]. However, multiwalled

• field). In comparison to other materials intensively investigated in this area (such as boron nitride nanotubes [13], barium titanate [14], or hydroxyapatite [15]), nanoscale GaN, in addition to its biocompatibility, shows strong enhancement of the piezoelectric properties compared to the bulk material

Straightforward and robust synthesis of monodisperse surface-functionalized gold nanoclusters

• Silvia Varela-Aramburu,
• Richard Wirth,
• Chian-Hui Lai,
• Guillermo Orts-Gil and
• Peter H. Seeberger

Beilstein J. Nanotechnol. 2016, 7, 1278–1283, doi:10.3762/bjnano.7.118

• Nanoparticles ranging in size from 1 to 100 nm are ideal tools to study biological processes [1][2]. Many different materials, including gold, have been used to create nanoparticles [3][4][5][6]. Gold nanoparticles are an attractive platform because of their biocompatibility, low toxicity, and low

Reasons and remedies for the agglomeration of multilayered graphene and carbon nanotubes in polymers

• Rasheed Atif and
• Fawad Inam

Beilstein J. Nanotechnol. 2016, 7, 1174–1196, doi:10.3762/bjnano.7.109

• bones. However, some researchers reported that CNTs exhibit cytotoxicity to human dermal cells. Potential health hazards could also arise from inhalation. The discrepancy in such biocompatibility results can be attributed to the complicated physicochemical interactions between CNTs and biological cells

• nanocomposites and to gain knowledge about their biocompatibility and performance in living organisms. One of the main issues in the production of polymer nanocomposites is the dispersion state of fillers, because MLG and CNTs tend to agglomerate due to van der Waals forces. The agglomeration can be avoided by

Multiwalled carbon nanotube hybrids as MRI contrast agents

• Nikodem Kuźnik and
• Mateusz M. Tomczyk

Beilstein J. Nanotechnol. 2016, 7, 1086–1103, doi:10.3762/bjnano.7.102

• biocompatibility and thus biodistribution which is followed, finally, by surface modifications leading to amphiphilic or specifically targeted behavior. Moreover, their magnetic, electric and photoluminescence properties can be adjusted and exploited for desired modalities. There are visions on the application of

• their potential as CAs exclusively in one of the MRI modes (T1 or T2). Further requirements consisted in better biocompatibility with the targeting of tumor cells, coupling with stem cells as well as crossing the cell membrane and blood–brain barrier. Finally, involving CNT activity in other diagnostic

• nanoparticles belong to the group of SPIOs known as MRI CAs [46][47], while the resulting behavior after coupling with MWCNT is determined as an entire, new SPIO–MWCNT hybrid. More thorough studies of SPIO impact on the properties and biocompatibility of hybrids should be encouraged. Magnetic properties The

Improved biocompatibility and efficient labeling of neural stem cells with poly(L-lysine)-coated maghemite nanoparticles

• Igor M. Pongrac,
• Marina Dobrivojević,
• Lada Brkić Ahmed,
• Michal Babič,
• Miroslav Šlouf,
• Daniel Horák and
• Srećko Gajović

Beilstein J. Nanotechnol. 2016, 7, 926–936, doi:10.3762/bjnano.7.84

• . Their properties can be modified by coating with different biocompatible polymers. To test if a coating polymer, poly(L-lysine), can improve the biocompatibility of nanoparticles applied to neural stem cells, poly(L-lysine)-coated maghemite nanoparticles were prepared and characterized. We evaluated

• -lysine)-coated maghemite and nanomag®-D-spio nanoparticles showed that they preserve their identity as neural stem cells and their potential to differentiate into all three major neural cell types (neurons, astrocytes and oligodendrocytes). Conclusion: Improved biocompatibility and efficient cell

• using PLL-γ-Fe2O3 nanoparticles for cell labeling [22], the detailed analysis on biocompatibility of PLL-γ-Fe2O3 nanoparticles was not described, neither the method of nanoparticle cell uptake defined. Better cellular uptake of PLL-γ-Fe2O3 nanoparticles, when compared to nanomag®-D-spio was similar to

Hierarchical coassembly of DNA–triptycene hybrid molecular building blocks and zinc protoporphyrin IX

• Rina Kumari,
• Sumit Singh,
• Mohan Monisha,
• Sourav Bhowmick,
• Anindya Roy,
• Neeladri Das and
• Prolay Das

Beilstein J. Nanotechnol. 2016, 7, 697–707, doi:10.3762/bjnano.7.62

• are biologically highly relevant molecules and their biocompatibility is notable. Porphyrin derivatives are widely used as photosensitizers in PDT to produce reactive oxygen species (ROS). Reportedly, Zn PpIX can interact with dsDNA in “outside stacking mode”. Therefore, the rationale to use Zn PpIX

Tight junction between endothelial cells: the interaction between nanoparticles and blood vessels

• Yue Zhang and
• Wan-Xi Yang

Beilstein J. Nanotechnol. 2016, 7, 675–684, doi:10.3762/bjnano.7.60

• the changing status of signalling pathways based on kinases. In a study using primary osteoblasts as material to evaluate the biocompatibility of 20 nm and 40 nm Au NPs, the Au NPs increased the level of ERK phosphorylation/total ERK [76]. Also, a study of potential mechanisms of Ag-NP toxicity using

Gold nanoparticles covalently assembled onto vesicle structures as possible biosensing platform

• M. Fátima Barroso,
• M. Alejandra Luna,
• Juan S. Flores Tabares,
• Cristina Delerue-Matos,
• N. Mariano Correa,
• Fernando Moyano and
• Patricia G. Molina

Beilstein J. Nanotechnol. 2016, 7, 655–663, doi:10.3762/bjnano.7.58

• , biodegradability and biocompatibility, so that they are utilized as versatile carriers in the fields of medical and analytical applications [1][2][3][4]. Several strategies employing vesicles in analytical fields have been reported, namely their use as signal amplifiers in the development of biosensors [3][5] to

Comparison of the interactions of daunorubicin in a free form and attached to single-walled carbon nanotubes with model lipid membranes

• Dorota Matyszewska

Beilstein J. Nanotechnol. 2016, 7, 524–532, doi:10.3762/bjnano.7.46

• stability, robustness, high drug carrying capacity and ability to penetrate cell membranes [15]. Although toxicity of the nanotubes is an issue, it strongly depends on the dimensions and type of functionalization, which may significantly increase their biocompatibility [16][17]. There are different

Surface coating affects behavior of metallic nanoparticles in a biological environment

• Darija Domazet Jurašin,
• Marija Ćurlin,
• Ivona Capjak,
• Tea Crnković,
• Marija Lovrić,
• Michal Babič,
• Daniel Horák,
• Ivana Vinković Vrček and
• Srećko Gajović

Beilstein J. Nanotechnol. 2016, 7, 246–262, doi:10.3762/bjnano.7.23

• biocompatibility. This study is aimed to evaluate the effects of surface coating on colloidal stability and behavior of AgNPs and SPIONs in modelled biological environments using dynamic and electrophoretic light scattering techniques, as well as transmission electron microscopy to visualize the behavior of the NP

• biological media, may be achieved by electrostatic or steric repulsions [30][31][32]. Various types of surface coatings have been shown to affect NP properties, particularly to improve their biocompatibility and stability against agglomeration [30][33][34][35]. Proteins or biologically-compatible surfactants

• AgNPs and SPIONs with various coatings are used in many nanotherapeutic and consumer products [44], it has become critical to fill the knowledge gap surrounding the mechanisms of colloidal destabilization including the role of surface coating in the biocompatibility of metallic NP. The systematically

Fabrication and characterization of novel multilayered structures by stereocomplexion of poly(D-lactic acid)/poly(L-lactic acid) and self-assembly of polyelectrolytes

• Elena Dellacasa,
• Li Zhao,
• Gesheng Yang,
• Laura Pastorino and
• Gleb B. Sukhorukov

Beilstein J. Nanotechnol. 2016, 7, 81–90, doi:10.3762/bjnano.7.10

• morphology was evaluated by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) measurements. The experimental results confirm the successful fabrication of this innovative system, and its full biocompatibility makes it worthy of further characterization as a promising drug carrier

• for sustained release. Keywords: biocompatibility; layer-by-layer assembly; microcapsules; poly(lactic acids); stereocomplex; Introduction The polycationic/polyanionic layer-by-layer (LBL) deposition on surfaces has been widely studied since the first description by Decher et al. [1][2][3]. The

• aliphatic polyester poly(lactic acid) (PLA) has been widely used in the biomedical field due to its extraordinary biocompatibility, biodegradability and mechanical properties [19][30][31][32][33]. Lactic acid, which is the degraded product from PLA, is fully biocompatible in human bodies, and therefore

pH-Triggered release from surface-modified poly(lactic-co-glycolic acid) nanoparticles

• Manuel Häuser,
• Klaus Langer and
• Monika Schönhoff

Beilstein J. Nanotechnol. 2015, 6, 2504–2512, doi:10.3762/bjnano.6.260

• biocompatibility and its hydrolytic biodegradability which varies in dependence of the relative molar ratio of the monomeric compounds [9]. Subsequent optimization of PLGA-based nanostructures is generally required in order to add specific properties, such as reduced opsonisation [10], a prolonged half-life [11

Silica-coated upconversion lanthanide nanoparticles: The effect of crystal design on morphology, structure and optical properties

• Uliana Kostiv,
• Miroslav Šlouf,
• Hana Macková,
• Alexander Zhigunov,
• Hana Engstová,
• Katarína Smolková,
• Petr Ježek and
• Daniel Horák

Beilstein J. Nanotechnol. 2015, 6, 2290–2299, doi:10.3762/bjnano.6.235

• enable further functionalization and increase biocompatibility and stability in aqueous media, preventing particle aggregation. Keywords: lanthanide; nanoparticles; oleylamine; silica; upconversion; Introduction Due to their unique physicochemical properties, nanometer-scale materials are finding

• functionalization and biocompatibility [27]. We herein report the preparation of OM–NaYF4:Yb3+/Er3+ nanoparticles with controlled morphology, size, composition, phase and luminescence. Thorough particle characterization was performed to elucidate the relationship between synthetic conditions and particle structure

Fabrication of hybrid nanocomposite scaffolds by incorporating ligand-free hydroxyapatite nanoparticles into biodegradable polymer scaffolds and release studies

• Balazs Farkas,
• Marina Rodio,
• Ilaria Romano,
• Alberto Diaspro,
• Romuald Intartaglia and
• Szabolcs Beke

Beilstein J. Nanotechnol. 2015, 6, 2217–2223, doi:10.3762/bjnano.6.227

• of chemical similarity between synthetic HA and the natural bone mineral, a large number of studies have introduced synthetic HA as bone replacement material for biomedical applications [3][4]. The benefits of synthetic HA, most notably its biocompatibility, slow biodegradability and good

Electrochemical coating of dental implants with anodic porous titania for enhanced osteointegration

• Amirreza Shayganpour,
• Alberto Rebaudi,
• Pierpaolo Cortella,
• Alberto Diaspro and
• Marco Salerno

Beilstein J. Nanotechnol. 2015, 6, 2183–2192, doi:10.3762/bjnano.6.224

• dental and orthopedic implants, thanks to its very good strength, corrosion resistance and biocompatibility [1][2]. Despite the very high success rate of Ti dental implants (>90%), there is still room for optimization of osteointegration, particularly for diabetics, smokers and oncology patients [3]. As

• explored for APA also [10][11][12]. Generally speaking, oxide inertness provides biocompatibility, while controlled porous patterning allows for tuning the roughness for optimized stimulation of living-cell response. The role of nanotopography in guiding cell differentiation and tissue generation is not

Temperature-dependent breakdown of hydrogen peroxide-treated ZnO and TiO₂ nanoparticle agglomerates

• Sinan Sabuncu and
• Mustafa Çulha

Beilstein J. Nanotechnol. 2015, 6, 1897–1903, doi:10.3762/bjnano.6.193

• quantities is nearly impossible using current approaches, the surface chemistry can only be considered as an alternative to reduce the possible toxic effects. An appropriate functional group on the NP surface may improve biocompatibility and stability in various environments. In our previous study, we