Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems

• Agnes-Valencia Weiss and
• Marc Schneider

Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95

• article, we discuss examples highlighting the influence of elasticity in nanoscale biological interactions focusing on mucosal delivery and on tumor targeting. Besides this, we discuss the influence of different measurement settings using atomic force microscopy for the determination of mechanical

• during formulation development. There is a clear trend for biological interactions among particles of the same material. However, different mechanical properties are expected when comparing across these particles. This topic will be discussed in the subsequent section. Nanoparticle elasticity and

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• stability and solubility [9]. The complexation occurs mainly through hydrophobic interactions in protein cavities [10][11]. In a recent study, zein nanoparticles loaded with CUR have been studied for their potential in treating brain tumors, and the results have demonstrated a reduction in the proliferation

• cytotoxicity. However, the cytotoxicity and the interaction of cells with CUR-HSA-MPs depends also on cell uptake of particles and interactions between particles and cells [42]. Our results were in line with those previously reported by Zhang and co-workers [43]. The authors reported that cell viability of

Density functional theory study of Au-fcc/Ge and Au-hcp/Ge interfaces

• Olga Sikora,
• Małgorzata Sternik,
• Benedykt R. Jany,
• Franciszek Krok,
• Przemysław Piekarz and
• Andrzej M. Oleś

Beilstein J. Nanotechnol. 2023, 14, 1093–1105, doi:10.3762/bjnano.14.90

• layer of 15 Å was selected for each structure to eliminate interactions between the two surfaces. The conditions for ending the optimization loops for electronic and ionic degrees of freedom were defined by the total energy difference between the steps of 10−8 eV and between the internal forces of 10−2

• distance (dint). Comparing variants T1 and T2, we notice the big discrepancy between their interfacial energies (−0.6 J/m2). The favored T1 structure is characterized by a larger Au rumpling parameter, arising from interactions between interfacial Au atoms with atoms from the next Ge layer, and a smaller

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

• Jonathan-Gabriel Nimz,
• Pichayut Rerkshanandana,
• Chiraphat Kloypan,
• Ulrich Kalus,
• Saranya Chaiwaree,
• Axel Pruß,
• Radostina Georgieva,
• Yu Xiong and
• Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

• might not be their Hb content. In their work from 2013, Yan et al. [40] showed how the formation of a protein corona influences particle–cell interactions. Especially bovine serum albumin (BSA) showed an ambivalent effect. On the one hand, the corona, which consisted mainly of BSA, reduced the direct

• arise spontaneously from C3 by hydrolysis, could be considered here. Moghimi et al. report numerous possible interactions of the complement system with, among others, nanoparticles as a drug delivery system [44]. The authors also discussed the possible effects of spontaneously forming water shells and

• emerging hydrogen bonds, altered surface structures, and possible interactions between proteins and particles, in particular polymers such as HbMPs [45][46]. The adsorption of various plasma proteins seems to not only enhance the chance of complement activation but also to promote phagocytosis directly, as

Exploring internal structures and properties of terpolymer fibers via real-space characterizations

• Michael R. Roenbeck and
• Kenneth E. Strawhecker

Beilstein J. Nanotechnol. 2023, 14, 1004–1017, doi:10.3762/bjnano.14.83

• nanoscale fibrils we observe. Despite the randomly sequenced terpolymer chemistry, nanoscale fibrils still clearly form in Technora®. The branched network likely results from local variations in the strength of intermolecular interactions. For example, misalignment between adjacent molecules (e.g., due to

• molecular “bends” within DPE molecules) or weak intermolecular interactions (e.g., due to distributions in monomers capable of intermolecular hydrogen bonding) may make it energetically favorable for sets of molecules to branch apart at different junctures rather than to remain together within a fibril

• stiffness (or “stiffness”), quantified in [N/m], makes no assumptions about tip–substrate interactions such as tip size or shape. It is primarily useful for semi-quantitative mapping to show the relative fluctuations in stiffness within different regions. However, stiffness itself is not a material property

Fragmentation of metal(II) bis(acetylacetonate) complexes induced by slow electrons

• Janina Kopyra and
• Hassan Abdoul-Carime

Beilstein J. Nanotechnol. 2023, 14, 980–987, doi:10.3762/bjnano.14.81

• attachment. The reported data may contribute to a better understanding of the physical chemistry underlying the electron–molecule interactions, which is crucial for potential applications of these molecular systems in the deposition of nanoscale structures. Keywords: dissociative electron attachment; gas

Isolation of cubic Si₃P₄ in the form of nanocrystals

• Polina K. Nikiforova,
• Sergei S. Bubenov,
• Vadim B. Platonov,
• Andrey S. Kumskov,
• Nikolay N. Kononov,
• Tatyana A. Kuznetsova and
• Sergey G. Dorofeev

Beilstein J. Nanotechnol. 2023, 14, 971–979, doi:10.3762/bjnano.14.80

• credited to a significant contribution of van der Waals interactions in the studied structure (The P–P distance in the vacancy was 3.22 Å, which is lower than the doubled van der Waals radius of phosphorus [35]). Slight shifts of frequencies are not uncommon for DFT calculations in such cases even when

Metal-organic framework-based nanomaterials for CO₂ storage: A review

• Ha Huu Do,
• Iqra Rabani and
• Hai Bang Truong

Beilstein J. Nanotechnol. 2023, 14, 964–970, doi:10.3762/bjnano.14.79

• ]. This discrepancy can be attributed to the presence of unsaturated Cu metal centers within the MOF structure, which facilitate interactions with CO2 molecules. Additionally, the MOF-74 family, built from metal(II) oxide chains linked by 2,5-dioxido-1,4-benzenedicarboxylate, exhibited a high CO2

• interactions with other chemical species. Extensive literature has been devoted to the investigation of MOFs with OMSs. Notably, HKUST-1, featuring copper OMSs, displayed a CO2 uptake of 4.1 mmol·g−1 at 298 K and 1 bar [22]. The effectiveness of OMSs has been exemplified in a study conducted by Caskey and

• −1. This discrepancy was attributed to the shorter length of the Mg–O bonds, which facilitated enhanced electrostatic interactions between the Mg sites and CO2 molecules. Moreover, Mg-MOF-74 exhibited a higher heat of adsorption than other variants. Kim et al. synthesized bimetallic MOFs

Prediction of cytotoxicity of heavy metals adsorbed on nano-TiO₂ with periodic table descriptors using machine learning approaches

• Joyita Roy,
• Souvik Pore and
• Kunal Roy

Beilstein J. Nanotechnol. 2023, 14, 939–950, doi:10.3762/bjnano.14.77

• interpret and can be calculated quickly without the involvement of expert personnel. These descriptors simplify the nanostructure property calculation and determine the nanoscale interactions without much computational intervention. The use of such descriptors saves time; the descriptors are also cost

Upscaling the urea method synthesis of CoAl layered double hydroxides

• Camilo Jaramillo-Hernández,
• Víctor Oestreicher,
• Martín Mizrahi and
• Gonzalo Abellán

Beilstein J. Nanotechnol. 2023, 14, 927–938, doi:10.3762/bjnano.14.76

• -layer interactions and chemical composition. One of the most interesting families is that of layered double hydroxides (LDHs), which are characterized by having a positive charge, hence the name “anionic clays”. This family exhibits hydrotalcite-like structures consisting of infinite positively charged

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• different spatial orientations due to their asymmetric nature. Additionally, the functionalization also alters the surface composition and morphology of the NPs. The nature of interactions between NPs and antibodies is directly related to the type of functional groups present on the NPs surface and the

• induce conformational changes, which result in denaturation and loss of activity [43]. Similarly, electrostatic interactions between oppositely charged NPs and antibodies result in weak interactions where the antibodies are easily detached due to small changes in pH or ionic strength [44]. Covalent

• trials yet. It is still very important that researchers understand better the chemistry between NPs and antibodies to develop improved ACNPs. Current knowledge of targeted delivery, tumor vasculature, and interactions of ACNPs in the human body is very limited and, hence, results in failure in clinical

Ni, Co, Zn, and Cu metal-organic framework-based nanomaterials for electrochemical reduction of CO₂: A review

• Ha Huu Do and
• Hai Bang Truong

Beilstein J. Nanotechnol. 2023, 14, 904–911, doi:10.3762/bjnano.14.74

• ) indicated superior catalytic activity compared to MIL-125(Ti). Notably, MOF-210 has established a remarkable record in CO2 adsorption among all porous materials, boasting an adsorption capacity of 2870 mg·g−1 [34]. Such properties facilitate favorable interactions between CO2 molecules and catalytic sites

• played a pivotal role in promoting interactions between active species and transition states. Notably, Bi centers in CAU-17 are the main active sites in the generation of HCOO–, after which these intermediates would move to open Cu metal sites (HKUST-1), thus improving activity. In an interesting study

Two-dimensional molecular networks at the solid/liquid interface and the role of alkyl chains in their building blocks

• Suyi Liu,
• Yasuo Norikane and
• Yoshihiro Kikkawa

Beilstein J. Nanotechnol. 2023, 14, 872–892, doi:10.3762/bjnano.14.72

• and desirable nanoarchitectures. Scanning tunneling microscopy is a powerful tool for revealing the molecular conformations, arrangements, and orientations of two-dimensional (2D) networks on surfaces. The fabrication of 2D assemblies involves non-covalent interactions that play a significant role in

• the molecular arrangement and orientation. Among the non-covalent interactions, dispersion interactions that derive from alkyl chain units are believed to be weak. However, alkyl chains play an important role in the adsorption onto substrates, as well as in the in-plane intermolecular interactions. In

• synthesis of molecular building blocks have enabled the construction of well-organized nanoarchitectures with various dimensions [8][9][10][11]. These characteristic structural formations are governed by self-assembly processes via non-covalent intermolecular interactions, such as hydrogen bonding, metal

N-Heterocyclic carbene-based gold etchants

• Robert B. Chevalier,
• Justin Pantano,
• Matthew K. Kiesewetter and
• Jason R. Dwyer

Beilstein J. Nanotechnol. 2023, 14, 865–871, doi:10.3762/bjnano.14.71

• clearly undesirable that an effort to form a stable monolayer could result in removal of underlying material, but similarly undesirable effects have been reported in the gold–thiol SAM literature. For example, gold–sulfur interactions can lead to a weaker bonding of gold surface atoms to the bulk. This

Biomimetics on the micro- and nanoscale – The 25th anniversary of the lotus effect

• Matthias Mail,
• Kerstin Koch,
• Thomas Speck,
• William M. Megill and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2023, 14, 850–856, doi:10.3762/bjnano.14.69

• biological processes and surface interactions involved in the bioselective adhesion of mammalian cells. The second topic of the review was on repellence of microbes on protein-based material surfaces, highlighting the importance of materials made of recombinant spider silk proteins. Biomaterials that

• production technologies allow for application-specific modification to develop adjustable, bioactive materials as shown in this review article. In the paper "Design of a biomimetic, small-scale artificial leaf surface for the study of environmental interactions" by Huth et al. [10], the authors developed wax

• -coated artificial leaf surfaces with chemical composition and wettability of wheat (Triticum aestivum) leaves. Such artificial leaves are of interest for in vitro studies of interactions of plant surfaces with living organisms and the non-living environment, as demonstrated by Huth et al. [11], where the

Ultralow-energy amorphization of contaminated silicon samples investigated by molecular dynamics

• Grégoire R. N. Defoort-Levkov,
• Alan Bahm and
• Patrick Philipp

Beilstein J. Nanotechnol. 2023, 14, 834–849, doi:10.3762/bjnano.14.68

• . Furthermore, several domains of nanotechnology and industry use nanoscaled samples that need to be controlled to an extreme level of precision. To reduce the irradiation-induced damage and to limit the interactions of the ions with the sample, low-energy ion beams are used because of their low implantation

• breaking of bonds in the sample. The second one is the Morse potential [32] used to model the interactions of the argon particles with other species. Since argon atoms interact only very weakly with the sample atoms, a simple Morse potential is enough to describe these interactions. ReaxFF potentials are

• derived from quantum mechanics calculations [33][34] and allow one to model the formation and breaking of bonds with good precision and reasonable computation costs. For our simulations, this information is of critical importance since it allows us to describe precisely the interactions taking place

Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies

• Giuliana Muraca,
• María Esperanza Ruiz,
• Rocío C. Gambaro,
• Sebastián Scioli-Montoto,
• María Laura Sbaraglini,
• Gisel Padula,
• José Sebastián Cisneros,
• Cecilia Yamil Chain,
• Vera A. Álvarez,
• Cristián Huck-Iriart,
• Guillermo R. Castro,
• María Belén Piñero,
• Matias Ildebrando Marchetto,
• Catalina Alba Soto,
• Germán A. Islan and
• Alan Talevi

Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66

• used to analyze the nanoparticle surface composition and determine the possible interactions among the formulation components (Figure 4). The BNZ spectrum presented its characteristic peaks at 3264 cm−1 corresponding to N–H in the secondary amide bond, 1652 cm−1 to C=O in the amide, 1523–1400 cm−1 to N

Carboxylic acids and light interact to affect nanoceria stability and dissolution in acidic aqueous environments

• Matthew L. Hancock,
• Eric A. Grulke and
• Robert A. Yokel

Beilstein J. Nanotechnol. 2023, 14, 762–780, doi:10.3762/bjnano.14.63

• interactions play a critical role in biological processes [30]. Nanoceria dissolution Nanoceria dissolution or agglomeration is pH-dependent and influenced by carboxylic acids. Nanoceria dissolution in aqueous solution was shown to be pH-dependent with dissolution occurring at pH values less than 7 [31

Control of morphology and crystallinity of CNTs in flame synthesis with one-dimensional reaction zone

• Muhammad Hilmi Ibrahim,
• Norikhwan Hamzah,
• Mohd Zamri Mohd Yusop,
• Ni Luh Wulan Septiani and
• Mohd Fairus Mohd Yasin

Beilstein J. Nanotechnol. 2023, 14, 741–750, doi:10.3762/bjnano.14.61

• defects and disorders of the sp2-hybridized sidewalls, while the G′ peak at 2500–2900 cm−1 represents photon–phonon interactions [27]. The absence of a low-frequency peak below 200 cm−1, usually assigned to the A1g symmetry radial breathing mode, which is the main characteristic of SWCNTs [28], indicates

Cross-sectional Kelvin probe force microscopy on III–V epitaxial multilayer stacks: challenges and perspectives

• Mattia da Lisca,
• José Alvarez,
• James P. Connolly,
• Nicolas Vaissiere,
• Karim Mekhazni,
• Jean Decobert and
• Jean-Paul Kleider

Beilstein J. Nanotechnol. 2023, 14, 725–737, doi:10.3762/bjnano.14.59

• resolution. In particular, in AM-KPFM the electrical force between the tip and the sample is directly evaluated, whereas in FM-KPFM the gradient of the force is analysed. As a result, FM-KPFM is more sensitive to local tip apex–sample surface interactions; therefore, long-range electrostatic interactions of

The microstrain-accompanied structural phase transition from h-MoO₃ to α-MoO₃ investigated by in situ X-ray diffraction

• Zeqian Zhang,
• Honglong Shi,
• Boxiang Zhuang,
• Minting Luo and
• Zhenfei Hu

Beilstein J. Nanotechnol. 2023, 14, 692–700, doi:10.3762/bjnano.14.55

• octahedron layers in the ⟨100⟩α direction. The octahedron layers are bonded by van der Waals interactions in the ⟨010⟩α direction, crystalizing into the α-MoO3 structure. Keywords: microstrain; molybdenum oxide; phase transition; thermal expansion; Introduction Molybdenum exhibits oxidation states ranging

• MoO6 zigzag octahedra chains. The octahedra chains reconstruct into octahedron layers through corner sharing in the ⟨100⟩α direction. The octahedron layers stack in the ⟨010⟩α direction, coupled by van der Waals interactions, to form the α-MoO3 structure by shifting by a/2 between two neighbouring

• octahedron layers in the ⟨100⟩α direction, coupled by van der Waals interactions, and the octahedron layers stack in the ⟨010⟩α direction by shifting by a/2. Experimental Hydrothermal synthesis of h-MoO3 Molybdenum oxide h-MoO3 was synthesized by a traditional hydrothermal synthesis method. In a routine

Investigations on the optical forces from three mainstream optical resonances in all-dielectric nanostructure arrays

• Guangdong Wang and
• Zhanghua Han

Beilstein J. Nanotechnol. 2023, 14, 674–682, doi:10.3762/bjnano.14.53

• continuum (BIC)) which are current in focus nanophotonics research topics, all-dielectric nanostructures have proved themselves to be a good platform for light–matter interactions and an advantageous alternative to their plasmonic counterparts. A TD resonance is produced by the flow of electric currents on

Metal-organic framework-based nanomaterials as opto-electrochemical sensors for the detection of antibiotics and hormones: A review

• Akeem Adeyemi Oladipo,
• Saba Derakhshan Oskouei and
• Mustafa Gazi

Beilstein J. Nanotechnol. 2023, 14, 631–673, doi:10.3762/bjnano.14.52

• luminescence, and a desirable adsorption capacity that can enhance MOF–target analyte interactions and transduce these interactions into measurable optical responses. A nanoscale MOF (In-sbdc) with a significant quantum yield of 13% and stable emission in water, for instance, was synthesised by Liu et al. [42

• redox reaction during the electron deactivation process. For effective quenching, a complex driven by either hydrophobic, van der Waals, or π–π-stacking interactions is generated between the electron donor and the electron acceptor with a separation on a sub-nanometre length scale. The complexation of

• nanocomposites. Because of their large surface area, ordered structure, tunable physico-chemical properties, and good absorbability, MOFs exhibit high potential among the various materials used for electrochemical sensor electrodes [63]. Strong interactions between the functional groups of MOFs and the target

Suspension feeding in Copepoda (Crustacea) – a numerical model of setae acting in concert

• Alexander E. Filippov,
• Wencke Krings and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2023, 14, 603–615, doi:10.3762/bjnano.14.50

• to establish contact with the particles by inertial impaction and capture and transport them to the mouth opening [14][15][16][17][18]. These interactions (i.e., making contact with and handling of or manipulating particles) were previously documented in detail through observation under a binocular

Thermal transport in kinked nanowires through simulation

• Alexander N. Robillard,
• Graham W. Gibson and
• Ralf Meyer

Beilstein J. Nanotechnol. 2023, 14, 586–602, doi:10.3762/bjnano.14.49

• °. After this point, the conductance begins to increase again. As this is not due to lattice orientation, this effect must be due to the interactions of travelling phonons with the surfaces of the wire due to the kink angle. In the PMC simulation, phonons are reflected from a surface after collision based