In vitro and in vivo interactions of selected nanoparticles with rodent serum proteins and their consequences in biokinetics

• Wolfgang G. Kreyling,
• Stefanie Fertsch-Gapp,
• Martin Schäffler,
• Blair D. Johnston,
• Nadine Haberl,
• Christian Pfeiffer,
• Jörg Diendorf,
• Carsten Schleh,
• Stephanie Hirn,
• Manuela Semmler-Behnke,
• Matthias Epple and
• Wolfgang J. Parak

Beilstein J. Nanotechnol. 2014, 5, 1699–1711, doi:10.3762/bjnano.5.180

• responses in tissues and cells cannot be neglected a priori but require thorough investigations. Therefore, we studied the interactions and protein binding kinetics of blood serum proteins with a number of engineered NP as a function of their physicochemical properties. Here we show by in vitro incubation

• spheres (AuNP), surface-modified with the same ionic ligand; as well as 5 nm AuNP with five different surface modifications on the binding to serum proteins by using proteomics analyses. We found that the binding of numerous serum proteins depended strongly on the physicochemical properties of the AuNP

• . These in vitro results helped us substantially in the interpretation of our numerous in vivo biokinetics studies performed in rodents using the same NP. These had shown that not only the physicochemical properties determined the AuNP translocation from the organ of intake towards blood circulation and

In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?

• Moritz Nazarenus,
• Qian Zhang,
• Mahmoud G. Soliman,
• Pablo del Pino,
• Beatriz Pelaz,
• Susana Carregal-Romero,
• Joanna Rejman,
• Barbara Rothen-Rutishauser,
• Martin J. D. Clift,
• Reinhard Zellner,
• G. Ulrich Nienhaus,
• James B. Delehanty,
• Igor L. Medintz and
• Wolfgang J. Parak

Beilstein J. Nanotechnol. 2014, 5, 1477–1490, doi:10.3762/bjnano.5.161

• penetration, which need to be considered in in vivo experiments, can be neglected. The kinetics of internalization can depend strongly on the physicochemical properties of the NPs, the type of cells, and other parameters. Cellular uptake studies of NPs require as much characterization of the NP materials as

• physicochemical properties of the NPs can be found. One, however, has to be aware that many physicochemical properties of NPs, such as size, shape, charge, and colloidal stability are highly entangled [14]. The physicochemical properties are not intrinsically associated with the NPs, but result from the

• consider for all correlations between the NP–cell interactions and the physicochemical properties of the NPs. Reports, in which no characterization of colloidal properties has been performed, therefore have to be regarded very critically. Unfortunately, many NPs are not colloidally stable in cell culture

Nanoporous composites prepared by a combination of SBA-15 with Mg–Al mixed oxides. Water vapor sorption properties

• Amaury Pérez-Verdejo,
• Alvaro Sampieri,
• Heriberto Pfeiffer,
• Mayra Ruiz-Reyes,
• Juana-Deisy Santamaría and
• Geolar Fetter

Beilstein J. Nanotechnol. 2014, 5, 1226–1234, doi:10.3762/bjnano.5.136

• hydrophobic–hydrophilic character, among other physicochemical properties. The most studied multifunctional materials are the hybrids, which are good candidates for biomedical applications, e.g., biosensors, artificial bonds and bioadsorbents [4][5]. Instead, a few works report the design of purely inorganic

• candidates to be combined homogenously with mesoporous siliceous materials to improve their physicochemical properties. Hydrotalcites are lamellar materials with basic properties, but with a relative low surface area and poor mesoporosity [12]. Thus, large molecules accessibility toward active sites is a

Functionalized nanostructures for enhanced photocatalytic performance under solar light

• Liejin Guo,
• Dengwei Jing,
• Maochang Liu,
• Yubin Chen,
• Shaohua Shen,
• Jinwen Shi and
• Kai Zhang

Beilstein J. Nanotechnol. 2014, 5, 994–1004, doi:10.3762/bjnano.5.113

• have been reported to be effective to enhance photocatalytic H2 evolution on CdS [25]. Low-cost WC was also used as efficient cocatalyst on CdS because of its low overpotential for hydrogen production and proper physicochemical properties [26]. The Xu group has studied the effect of NiS working as a

Controlling mechanical properties of bio-inspired hydrogels by modulating nano-scale, inter-polymeric junctions

• Seonki Hong,
• Hyukjin Lee and
• Haeshin Lee

Beilstein J. Nanotechnol. 2014, 5, 887–894, doi:10.3762/bjnano.5.101

• ). This result strongly suggests that one can control physicochemical properties of a wide variety of PEG-containing biomaterials by designing effective conjugation chemistry. We chose PEG hydrogels as an example. Effect of the amine group in PEG gelation I: mechanical properties of hydrogels To explore

• importance of catecholamine quinone tanning. Thus, the results demonstrated herein can be a useful toolkit to further control physicochemical properties of biomaterials. Conclusion In summary, we demonstrated that the particular quinone tanning process simultaneously involved with catechol and amine was

Nanostructure sensitization of transition metal oxides for visible-light photocatalysis

• Hongjun Chen and
• Lianzhou Wang

Beilstein J. Nanotechnol. 2014, 5, 696–710, doi:10.3762/bjnano.5.82

• research area of photocatalysis has attracted increasing attention. Compared with bulk materials, nanomaterials often exhibit unusual features such as large surface areas, diverse morphologies and size-dependent physicochemical properties. Size-dependent properties include an increased absorption

• solution for the photosensitizers to anchor. The hybridization of exfoliated nanosheets with nanosized photosensitizers often shows a tunable electronic structure and new physicochemical properties. All these features attribute to a promising future of nanostructure sensitization in the ion-exchangeable

Morphological characterization of fullerene–androsterone conjugates

• Alberto Ruiz,
• Margarita Suárez,
• Nazario Martin,
• Fernando Albericio and
• Hortensia Rodríguez

Beilstein J. Nanotechnol. 2014, 5, 374–379, doi:10.3762/bjnano.5.43

• testosterone, the most prevalent androgen in males. The conjugation of steroids to other chemically or biologically relevant molecules is a common approach in the search for new biomedical and chemical applications. The coupling of C60 with a steroid changes the physicochemical properties of this molecule

En route to controlled catalytic CVD synthesis of densely packed and vertically aligned nitrogen-doped carbon nanotube arrays

• Slawomir Boncel,
• Sebastian W. Pattinson,
• Valérie Geiser,
• Milo S. P. Shaffer and
• Krzysztof K. K. Koziol

Beilstein J. Nanotechnol. 2014, 5, 219–233, doi:10.3762/bjnano.5.24

• ] atoms has been frequently used to enhance or tune their physicochemical properties. Among the elemental dopants, nitrogen emerges as of particular interest in electronics since N-CNTs should be characterized by a higher electrical conductivity (n-doping). Consequently, the significance of N-CNTs in a

Functionalised zinc oxide nanowire gas sensors: Enhanced NO₂ gas sensor response by chemical modification of nanowire surfaces

• Eric R. Waclawik,
• Jin Chang,
• Andrea Ponzoni,
• Isabella Concina,
• Dario Zappa,
• Elisabetta Comini,
• Nunzio Motta,
• Guido Faglia and
• Giorgio Sberveglieri

Beilstein J. Nanotechnol. 2012, 3, 368–377, doi:10.3762/bjnano.3.43

• the desired power source. A case in point is the monitoring of gas emissions remotely, in outdoor environments where mains power may be unavailable. For this application, highly responsive, low-power and thus low-temperature gas sensors would be advantageous. Both the structural and physicochemical

• properties of metal-oxide films utilised in solid-state chemical sensors have proven to strongly affect the gas response in these devices. Not only do simple structural elements such as grain size play a significant role in gas response, but also crystallite shape, crystallographic orientation, film

Surface functionalization of aluminosilicate nanotubes with organic molecules

• Wei Ma,
• Weng On Yah,
• Hideyuki Otsuka and
• Atsushi Takahara

Beilstein J. Nanotechnol. 2012, 3, 82–100, doi:10.3762/bjnano.3.10

• negative charge to imogolite, which restricts the effective motion of positively charged species on the imogolite surface. Poly(3-hexyl thiophene)/imogolite nanofiber hybrid Polythiophenes are one of the well-known families of conductive polymers, and their physicochemical properties, such as their

Impact of cell shape in hierarchically structured plant surfaces on the attachment of male Colorado potato beetles (Leptinotarsa decemlineata)

• Bettina Prüm,
• Robin Seidel,
• Holger Florian Bohn and
• Thomas Speck

Beilstein J. Nanotechnol. 2012, 3, 57–64, doi:10.3762/bjnano.3.7

• higher forces. Due to the softness of the petals, increased traction forces might be associated with a possible punching of the surface due to the forces applied by the claws [21]. The influence of the physicochemical properties of surfaces on insect attachment has been discussed in several studies [21

Characterization of protein adsorption onto FePt nanoparticles using dual-focus fluorescence correlation spectroscopy

• Pauline Maffre,
• Karin Nienhaus,
• Faheem Amin,
• Wolfgang J. Parak and
• G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2011, 2, 374–383, doi:10.3762/bjnano.2.43

• well-controlled physicochemical properties including size, shape, charge, chemical composition and solubility. Many of these NPs have already found their way into consumer products. Owing to their small size, NPs may potentially invade all parts of the human body including tissues, cells and even

Dynamics of capillary infiltration of liquids into a highly aligned multi-walled carbon nanotube film

• Sławomir Boncel,
• Krzysztof Z. Walczak and
• Krzysztof K. K. Koziol

Beilstein J. Nanotechnol. 2011, 2, 311–317, doi:10.3762/bjnano.2.36

• material can potentially be used in a production of ultra-light hydrophobic composites exhibiting other superb physicochemical properties originating from the as-synthesised nanotubes. Experimental A solution of ferrocene (6 wt %, 98%, Acros Organics) in toluene (spectrophotometric grade, d = 0.86 g/cm3

The effect of surface anisotropy in the slippery zone of Nepenthes alata pitchers on beetle attachment

• Elena V. Gorb and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2011, 2, 302–310, doi:10.3762/bjnano.2.35

• surfaces than on their replicas may be explained by the different mechanical and physicochemical properties of both substrates. We surmise that the softer and more compliant material of the plant tissue promotes insect interlocking due to easier indentation of claw tips into a softer substrate. This effect