Mechanistic insights into endosomal escape by sodium oleate-modified liposomes

• Ebrahim Sadaqa,
• Satrialdi,
• Fransiska Kurniawan and
• Diky Mudhakir

Beilstein J. Nanotechnol. 2024, 15, 1667–1685, doi:10.3762/bjnano.15.131

• elucidate the mechanistic role of sodium oleate in promoting endosomal escape and compared the performance of SO-Lipo with unmodified liposomes (Unmodified-Lipo) and Aurein 1.2-modified liposomes (AUR-Lipo). Liposomes were prepared using the thin-film hydration method, resulting in Unmodified-Lipo, SO-Lipo

• mechanism, facilitating cytosolic delivery with reduced cytotoxicity. This approach offers a safer and more effective option for targeted drug delivery applications. Keywords: Aurein 1.2; endosomal escape; fusogenic effect; molecular dynamics simulation; sodium oleate; Introduction The quest for efficient

• escape efficacy of SO with Aurein 1.2 (AUR), a well-established endosomal escape peptide known for its efficacy both in vitro and in vivo, serving as a positive control [12]. Our findings have the potential to significantly advance the development of safer and more effective liposomal drug delivery